Crosstalk between Hippo and TGFβ: Subcellular Localization of YAP/TAZ/Smad Complexes

Journal of Molecular Biology

Volumn 427, Issue 21, 2015, Pages 3407-3415

  Grannas, Karin ^a   Arngården, Linda ^a   Lönn, Peter ^a   Mazurkiewicz, Magdalena ^b   Blokzijl, Andries ^a   Zieba, Agata ^a   Söderberg, Ola ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Hippo; in situ PLA; interaction; Smad; TGF

Indexed keywords

SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMALL INTERFERING RNA; TAZ PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; YAP PROTEIN; HIPPO PROTEIN, HUMAN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; RECEPTOR REGULATED SMAD PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMAD2 PROTEIN, HUMAN; TAZ PROTEIN, HUMAN; TRANSCRIPTION FACTOR; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ARTICLE; CELL DENSITY; CELL NUCLEUS; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; HIPPO PATHWAY; HT 29 CELL LINE; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA SIGNALING PATHWAY; COLON; COLON TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE, TUMOR; COLON; COLONIC NEOPLASMS; HUMANS; PHOSPHOPROTEINS; PROTEIN INTERACTION MAPS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SMAD PROTEINS, RECEPTOR-REGULATED; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84944274337     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2015.04.015     Document Type: Article

References (17)

1. K.F. Harvey, X. Zhang, and D.M. Thomas The Hippo pathway and human cancer Nat Rev Cancer 13 2013 246 257
2. F.-X. Yu, and K.-L. Guan The Hippo pathway: regulators and regulations Genes Dev 27 2013 355 371
3. X. Varelas, and et al. The crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway Dev Cell 19 2010 831 844
4. X. Varelas The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease Development 141 2014 1614 1626
5. B. Zhao, and et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Genes Dev 21 2007 2747 2761
6. X. Varelas, and et al. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal Nat Cell Biol 10 2008 837 848
7. F. Nallet-Staub, and et al. Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation Dev Cell 32 2015 640 651
8. M. Narimatsu, P. Samavarchi-Tehrani, X. Varelas, L. Jeffrey, and Wrana Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling Dev Cell 32 2015 652 656
9. C.-H. Heldin, and A. Moustakas Role of Smads in TGFβ signaling Cell Tissue Res 347 2012 21 36
10. A. Sundqvist, and et al. Specific interactions between Smad proteins and AP-1 components determine TGF[beta]-induced breast cancer cell invasion Oncogene 32 2013 3606 3615
11. Y. Mu, S. Gudey, and M. Landström Non-Smad signaling pathways Cell Tissue Res 347 2012 11 20
12. Y.E. Zhang Non-Smad pathways in TGF-[beta] signaling Cell Res 19 2009 128 139
13. A. Zieba, and et al. Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase Mol Cell Proteomics 11 2012 M111.013482
14. O. Soderberg, and et al. Direct observation of individual endogenous protein complexes in situ by proximity ligation Nat Methods 3 2006 995 1000
15. B. Koos, and et al. Analysis of protein interactions in situ by proximity ligation assays H.G. Fienberg, G.P. Nolan, High-dimensional single cell analysis 377 2014 Springer Berlin Heidelberg 111 126
16. A.-C. de Gouville, and et al. Inhibition of TGF-β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis Br J Pharmacol 145 2005 166 177
17. U. Persson, and et al. The L45 loop in type I receptors for TGF-β family members is a critical determinant in specifying Smad isoform activation FEBS Lett 434 1998 83 87