Distinct Polarity Cues Direct Taz/Yap and TGFβ Receptor Localization to Differentially Control TGFβ-Induced Smad Signaling

Developmental Cell

Volumn 32, Issue 5, 2015, Pages 652-656

  Narimatsu, Masahiro ^a   Samavarchi Tehrani, Payman ^a   Varelas, Xaralabos ^b   Wrana, Jeffrey L ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

SMAD PROTEIN; TAZ PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG; YAP PROTEIN; EPHRIN RECEPTOR A4; NUCLEAR PROTEIN; TAZ PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; YY1AP1 PROTEIN, HUMAN;

ARTICLE; BLASTOCYST; BREAST EPITHELIUM CELL; CELL DENSITY; CELL MEMBRANE; CONTACT INHIBITION; CYTOPLASM; HOMEOSTASIS; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; INNER CELL MASS; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CELL CULTURE; CELL POLARITY; CELL PROLIFERATION; CONFOCAL MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL POLARITY; CELL PROLIFERATION; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICROSCOPY, CONFOCAL; NUCLEAR PROTEINS; PHOSPHORYLATION; RECEPTOR, EPHA4; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84924326220     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2015.02.019     Document Type: Article

References (19)

1. Alarcon V.B. Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo. Biol. Reprod. 2010, 83:347-358.
2. Alarcón C., Zaromytidou A.I., Xi Q., Gao S., Yu J., Fujisawa S., Barlas A., Miller A.N., Manova-Todorova K., Macias M.J., et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 2009, 139:757-769.
3. Beyer T.A., Weiss A., Khomchuk Y., Huang K., Ogunjimi A.A., Varelas X., Wrana J.L. Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells. Cell Rep. 2013, 5:1611-1624.
4. Fujii M., Toyoda T., Nakanishi H., Yatabe Y., Sato A., Matsudaira Y., Ito H., Murakami H., Kondo Y., Kondo E., et al. TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J.Exp. Med. 2012, 209:479-494.
5. Hiemer S.E., Szymaniak A.D., Varelas X. The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells. J.Biol. Chem. 2014, 289:13461-13474.
6. Hines W.C., Su Y., Kuhn I., Polyak K., Bissell M.J. Sorting out the FACS: a devil in the details. Cell Rep. 2014, 6:779-781.
7. Lee M.J., Ran Byun M., Furutani-Seiki M., Hong J.H., Jung H.S. YAP and TAZ regulate skin wound healing. J.Invest. Dermatol. 2014, 134:518-525.
8. Lian I., Kim J., Okazawa H., Zhao J., Zhao B., Yu J., Chinnaiyan A., Israel M.A., Goldstein L.S., Abujarour R., et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010, 24:1106-1118.
9. Liu F., Lagares D., Choi K.M., Stopfer L., Marinković A., Vrbanac V., Probst C.K., Hiemer S.E., Sisson T.H., Horowitz J.C., et al. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 2015, 308:L344-L357.
10. Mahoney J.E., Mori M., Szymaniak A.D., Varelas X., Cardoso W.V. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev. Cell 2014, 30:137-150.
11. Massagué J. TGFβ signalling in context. Nat. Rev. Mol. Cell Biol. 2012, 13:616-630.
12. Murphy S.J., Doré J.J., Edens M., Coffey R.J., Barnard J.A., Mitchell H., Wilkes M., Leof E.B. Differential trafficking of transforming growth factor-beta receptors and ligand in polarized epithelial cells. Mol. Biol. Cell 2004, 15:2853-2862.
13. Nallet-Staub F., Yin X., Gilbert C., Marsaud V., Ben Mimoun S., Javelaud D., Leof E.B., Mauviel A. Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation. Dev. Cell 2015, 32:640-651. this issue.
14. Sun Y., Yong K.M., Villa-Diaz L.G., Zhang X., Chen W., Philson R., Weng S., Xu H., Krebsbach P.H., Fu J. Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells. Nat. Mater. 2014, 13:599-604.
15. Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R., Rao B.M., Dembowy J., Yaffe M.B., Zandstra P.W., Wrana J.L. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat. Cell Biol. 2008, 10:837-848.
16. Varelas X., Samavarchi-Tehrani P., Narimatsu M., Weiss A., Cockburn K., Larsen B.G., Rossant J., Wrana J.L. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev. Cell 2010, 19:831-844.
17. Yang J.Y., Cho S.W., An J.H., Jung J.Y., Kim S.W., Kim S.Y., Kim J.E., Shin C.S. Osteoblast-targeted overexpression of TAZ increases bone mass invivo. PLoS ONE 2013, 8:e56585.
18. Yao M., Wang Y., Zhang P., Chen H., Xu Z., Jiao J., Yuan Z. BMP2-SMAD signaling represses the proliferation of embryonic neural stem cells through YAP. J.Neurosci. 2014, 34:12039-12048.
19. Zhang H., von Gise A., Liu Q., Hu T., Tian X., He L., Pu W., Huang X., He L., Cai C.L., et al. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J.Biol. Chem. 2014, 289:18681-18692.