Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 41, 2015, Pages 12806-12811

  Luo, Haiming ^a   Hernandez, Reinier ^b   Hong, Hao ^a   Graves, Stephen A ^b   Yang, Yunan ^a   England, Christopher G ^b   Theuer, Charles P ^c   Nickles, Robert J ^b   Cai, Weibo ^a,b,d,e  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c TRACON Pharmaceuticals Inc   (United States)

^d Wisconsin Electric Machines and Power Electronics Consortium   (United States)

^e UNIVERSITY OF WISCONSIN   (United States)

Author keywords

Bispecific antibody fragment; CD105; EGFR; Glioblastoma; Positron emission tomography (PET)

Indexed keywords

ANTIBODY CONJUGATE; BISPECIFIC ANTIBODY; BISPECIFIC ANTIBODY FRAGMENT; COPPER 64; ENDOGLIN; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; TETRAZINE DERIVATIVE; UNCLASSIFIED DRUG; CANCER ANTIBODY; CONTRAST MEDIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BINDING AFFINITY; BRAIN CANCER; CANCER DIAGNOSIS; CLICK CHEMISTRY; CONFERENCE PAPER; CONTROLLED STUDY; EARLY DIAGNOSIS; FUNCTIONAL NEUROIMAGING; HUMAN; HUMAN CELL; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN TARGETING; TUMOR VOLUME; ANIMAL; BRAIN TUMOR; CHEMISTRY; DIAGNOSTIC IMAGING; EXPERIMENTAL NEOPLASM; RADIOGRAPHY;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, NEOPLASM; BRAIN NEOPLASMS; CLICK CHEMISTRY; CONTRAST MEDIA; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; NEOPLASMS, EXPERIMENTAL; POSITRON-EMISSION TOMOGRAPHY; RADIOGRAPHY;

EID: 84944244546     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1509667112     Document Type: Article

References (45)

1. Etzioni R, et al (2003) The case for early detection Nat Rev Cancer 3(4):243-252.
2. James ML, Gambhir SS (2012) A molecular imaging primer: Modalities, imaging agents, and applications Physiol Rev 92(2):897-965.
3. Gambhir SS (2002) Molecular imaging of cancer with positron emission tomography Nat Rev Cancer 2(9):683-693.
4. Larson SM (2004) Positron emission tomography-based molecular imaging in human cancer: Exploring the link between hypoxia and accelerated glucose metabolism Clin Cancer Res 10(7):2203-2204.
5. Abouzied MM, Crawford ES, Nabi HA (2005) 18F-FDG imaging: Pitfalls and artifacts J Nucl Med Technol 33(3):145-155; quiz 162-163.
6. Selzner M, et al (2004) Does the novel PET/CT imaging modality impact on the treatment of patients with metastatic colorectal cancer of the liver? Ann Surg 240(6): 1027-1034; discussion 1035-1036.
7. Hussain T, Nguyen QT (2014) Molecular imaging for cancer diagnosis and surgery Adv Drug Deliv Rev 66:90-100.
8. Knowles SM, Wu AM (2012) Advances in immuno-positron emission tomography: Antibodies for molecular imaging in oncology J Clin Oncol 30(31):3884-3892.
9. Holliger P, Hudson PJ (2005) Engineered antibody fragments and the rise of single domains Nat Biotechnol 23(9):1126-1136.
10. Behr TM, et al (1995) Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives Cancer Res 55(17): 3825-3834.
11. Grünberg J, et al (2005) In vivo evaluation of 177Lu-And 67/64Cu-labeled recombinant fragments of antibody chCE7 for radioimmunotherapy and PET imaging of L1-CAM-positive tumors Clin Cancer Res 11(14):5112-5120.
12. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: The next generation Cell 144(5):646-674.
13. Kontermann RE (2012) Dual targeting strategies with bispecific antibodies MAbs 4(2): 182-197.
14. Luo H, Hong H, Yang SP, Cai W (2014) Design and applications of bispecific heterodimers: Molecular imaging and beyond Mol Pharm 11(6):1750-1761.
15. Scott AM, Wolchok JD, Old LJ (2012) Antibody therapy of cancer Nat Rev Cancer 12(4):278-287.
16. DiGiandomenico A, et al (2014) A multifunctional bispecific antibody protects against Pseudomonas aeruginosa Sci Transl Med 6(262):262ra155.
17. Rossin R, et al (2010) In vivo chemistry for pretargeted tumor imaging in live mice Angew Chem Int Ed Engl 49(19):3375-3378.
18. van Cruijsen H, Giaccone G, Hoekman K (2005) Epidermal growth factor receptor and angiogenesis: Opportunities for combined anticancer strategies Int J Cancer 117(6): 883-888.
19. Smith SJ, et al (2012) CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma Acta Neuropathol 124(1): 99-110.
20. Hong H, Chen F, Zhang Y, Cai W (2014) New radiotracers for imaging of vascular targets in angiogenesis-related diseases Adv Drug Deliv Rev 76:2-20.
21. Hong H, et al (2012) Multimodality imaging of breast cancer experimental lung metastasis with bioluminescence and a monoclonal antibody dual-labeled with 89Zr and IRDye 800CW Mol Pharm 9(8):2339-2349.
22. Chakravarty R, et al (2014) Matching the decay half-life with the biological half-life: ImmunoPET imaging with (44)Sc-labeled cetuximab Fab fragment Bioconjug Chem 25(12):2197-2204.
23. Zhang Y, et al (2013) PET imaging of CD105/endoglin expression with a 61/64Cu-labeled Fab antibody fragment Eur J Nucl Med Mol Imaging 40(5):759-767.
24. Hong H, et al (2013) Positron emission tomography imaging of tumor angiogenesis with a (61/64)Cu-labeled F(ab')(2) antibody fragment Mol Pharm 10(2):709-716.
25. Uhlén M, et al (2015) Proteomics Tissue-based map of the human proteome Science 347(6220):1260419.
26. Stupp R, et al.; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma N Engl J Med 352(10):987-996.
27. Brennan CW, et al.; TCGA Research Network (2013) The somatic genomic landscape of glioblastoma Cell 155(2):462-477.
28. Padfield E, Ellis HP, Kurian KM (2015) Current therapeutic advances targeting EGFR and EGFRvIII in glioblastoma Front Oncol 5:5.
29. Carlsson SK, Brothers SP, Wahlestedt C (2014) Emerging treatment strategies for glioblastoma multiforme EMBO Mol Med 6(11):1359-1370.
30. De Luca A, et al (2008) The role of the EGFR signaling in tumor microenvironment J Cell Physiol 214(3):559-567.
31. Barbu I, Craiţoiu S, Simionescu CE, Drəgnei AM, Margaritescu C (2013) CD105 microvessels density, VEGF, EGFR-1 and c-erbB-2 and their prognostic correlation in different subtypes of cervical adenocarcinoma Rom J Morphol Embryol 54(3): 519-530.
32. Patel M, Vogelbaum MA, Barnett GH, Jalali R, Ahluwalia MS (2012) Molecular targeted therapy in recurrent glioblastoma: Current challenges and future directions Expert Opin Investig Drugs 21(9):1247-1266.
33. Zhang Y, et al (2011) Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA PLoS One 6(12): e28005.
34. Spiess C, et al (2013) Bispecific antibodies with natural architecture produced by coculture of bacteria expressing two distinct half-Antibodies Nat Biotechnol 31(8): 753-758.
35. Lewis SM, et al (2014) Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface Nat Biotechnol 32(2):191-198.
36. Witte MD, et al (2013) Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry Nat Protoc 8(9):1808-1819.
37. Witte MD, et al (2012) Preparation of unnatural N-to-N and C-to-C protein fusions Proc Natl Acad Sci USA 109(30):11993-11998.
38. Blackman ML, Royzen M, Fox JM (2008) Tetrazine ligation: Fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity J Am Chem Soc 130(41): 13518-13519.
39. Zeng D, Zeglis BM, Lewis JS, Anderson CJ (2013) The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals J Nucl Med 54(6): 829-832.
40. Zeglis BM, et al (2013) A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry J Nucl Med 54(8):1389-1396.
41. Almeida JP, Chaichana KL, Rincon-Torroella J, Quinones-Hinojosa A (2015) The value of extent of resection of glioblastomas: Clinical evidence and current approach Curr Neurol Neurosci Rep 15(2):517.
42. Muselaers CH, et al (2014) Optical imaging of renal cell carcinoma with anti-carbonic anhydrase IX monoclonal antibody girentuximab J Nucl Med 55(6):1035-1040.
43. van den Berg NS, Valdés-Olmos RA, van der Poel HG, van Leeuwen FW (2013) Sentinel lymph node biopsy for prostate cancer: A hybrid approach J Nucl Med 54(4):493-496.
44. van Dam GM, et al (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-? targeting: First in-human results Nat Med 17(10): 1315-1319.
45. Sheridan C (2015) Amgen's bispecific antibody puffs across finish line Nat Biotechnol 33(3):219-221.