Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 41, 2015, Pages 12794-12799

  Gautam, Avneesh Kumar ^a   Panse, Yogesh ^a   Ghosh, Payel ^b   Reza, Malik Johid ^a   Mullick, Jayati ^c   Sahu, Arvind ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

^b UNIVERSITY OF PUNE   (India)

^c NATIONAL INSTITUTE OF VIROLOGY   (India)

Author keywords

Cofactor activity; Complement regulation; Immune evasion; Kaposica; RCA protein

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; COMPLEMENT COMPONENT C1R; KAPOSICA; PROTEIN DERIVATIVE; REGULATOR PROTEIN; REGULATORS OF COMPLEMENT ACTIVATION; UNCLASSIFIED DRUG; CFI PROTEIN, HUMAN; COMPLEMENT COMPONENT C3B; COMPLEMENT FACTOR I; KSHV COMPLEMENT CONTROL PROTEIN, HERPESVIRUS 8; MULTIPROTEIN COMPLEX; VIRAL PROTEIN;

CONFERENCE PAPER; CONTROLLED STUDY; GENE MUTATION; IMMUNE EVASION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS; CHEMISTRY; GENETICS; HUMAN; HUMAN HERPESVIRUS 8; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

COMPLEMENT C3B; COMPLEMENT FACTOR I; HERPESVIRUS 8, HUMAN; HUMANS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; VIRAL PROTEINS;

EID: 84944188105     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1506449112     Document Type: Article

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