Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 21, 2015, Pages 4980-4982

  Cornec, Anne Sophie ^a   James, Michael J ^b   Kovalevich, Jane ^b   Trojanowski, John Q ^b   Lee, Virginia M Y ^b   Smith, Amos B ^a   Ballatore, Carlo ^a,b   Brunden, Kurt R ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CNS drug discovery; Microtubule stabilization; Pharmacodynamic; Pharmacokinetic; Triazolopyrimidine

Indexed keywords

(S) 3 (4 (5 CHLORO 7 ((1,1,1 TRIFLUOROPROPAN 2 YL)AMINO) [1,2,4]TRIAZOLO[1,5 ALPHA]PYRIMIDIN 6 YL) 3,5 DIFLUOROPHENOXY) PROPAN 1 OL; ALPHA TUBULIN; CARBOXYLIC ACID; DRUG METABOLITE; HYDROXYL GROUP; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; 3-(4-(5-CHLORO-7-((1,1,1-TRIFLUOROPROPAN-2-YL)AMINO)-(1,2,4)TRIAZOLO(1,5-A)PYRIMIDIN-6-YL)-3,5-DIFLUOROPHENOXY)-PROPAN-1-OL; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; MICROTUBULE; MOUSE; NONHUMAN; OXIDATION KINETICS; ANIMAL; BRAIN; CONFORMATION; METABOLISM;

ANIMALS; BRAIN; MICE; MICROTUBULES; MOLECULAR CONFORMATION; PYRIMIDINES; TRIAZOLES;

EID: 84944173890     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.03.002     Document Type: Article

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