-
1
-
-
84882630671
-
Telomerase at the intersection of cancer and aging
-
Bernardes de Jesus, B.&Blasco, M. A. Telomerase at the intersection of cancer and aging. Trends Genet 29, 513-520 (2013).
-
(2013)
Trends Genet
, vol.29
, pp. 513-520
-
-
Bernardes De Jesus, B.1
Blasco, M.A.2
-
2
-
-
84862617605
-
Wnt/b-catenin signaling regulates telomerase in stem cells and cancer cells
-
Hoffmeyer, K. et al. Wnt/b-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336, 1549-1554 (2012).
-
(2012)
Science
, vol.336
, pp. 1549-1554
-
-
Hoffmeyer, K.1
-
3
-
-
84870616090
-
Telomerase directly regulates NF-kB-dependent transcription
-
Ghosh, A. et al. Telomerase directly regulates NF-kB-dependent transcription. Nat Cell Biol 14, 1270-1281 (2012).
-
(2012)
Nat Cell Biol
, vol.14
, pp. 1270-1281
-
-
Ghosh, A.1
-
4
-
-
79953153022
-
Identification of PITX1 as a TERT suppressor gene located on human chromosome 5
-
Qi, D. L. et al. Identification of PITX1 as a TERT suppressor gene located on human chromosome 5. Mol Cell Biol 31, 1624-1636 (2011).
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1624-1636
-
-
Qi, D.L.1
-
5
-
-
20444426889
-
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity
-
Kolfschoten, I. G. et al. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell 121, 849-858 (2005).
-
(2005)
Cell
, vol.121
, pp. 849-858
-
-
Kolfschoten, I.G.1
-
6
-
-
33847267349
-
Decreased PITX1 homeobox gene expression in human lung cancer
-
Chen, Y. et al. Decreased PITX1 homeobox gene expression in human lung cancer. Lung Cancer 55, 287-294 (2007).
-
(2007)
Lung Cancer
, vol.55
, pp. 287-294
-
-
Chen, Y.1
-
7
-
-
39849094036
-
Expression of pituitary homeobox 1 gene in human gastric carcinogenesis and its clinicopathological significance
-
Chen, Y. N., Chen, H., Xu, Y., Zhang, X. & Luo, Y. Expression of pituitary homeobox 1 gene in human gastric carcinogenesis and its clinicopathological significance. World J Gastroenterol 14, 292-297 (2008).
-
(2008)
World J Gastroenterol
, vol.14
, pp. 292-297
-
-
Chen, Y.N.1
Chen, H.2
Xu, Y.3
Zhang, X.4
Luo, Y.5
-
8
-
-
27744567515
-
Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
-
Lord, R. V. et al. Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. Surgery 138, 924-931 (2005).
-
(2005)
Surgery
, vol.138
, pp. 924-931
-
-
Lord, R.V.1
-
9
-
-
84893024960
-
PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia
-
Nakabayashi, M. et al. PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia. Oncol Lett 7, 750-754 (2014).
-
(2014)
Oncol Lett
, vol.7
, pp. 750-754
-
-
Nakabayashi, M.1
-
10
-
-
84880604654
-
Decreased PITX1 gene expression in human cutaneousmalignant melanoma and its clinicopathological significance
-
Osaki, M. et al. Decreased PITX1 gene expression in human cutaneousmalignant melanoma and its clinicopathological significance. Eur J Dermatol 23, 344-349 (2013).
-
(2013)
Eur J Dermatol
, vol.23
, pp. 344-349
-
-
Osaki, M.1
-
11
-
-
84858126071
-
MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review
-
Iorio, M. V. & Croce, C. M. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 4, 143-159 (2012).
-
(2012)
EMBO Mol Med
, vol.4
, pp. 143-159
-
-
Iorio, M.V.1
Croce, C.M.2
-
12
-
-
77956339881
-
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
-
Medina, P. P., Nolde, M. & Slack, F. J. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467, 86-90 (2010).
-
(2010)
Nature
, vol.467
, pp. 86-90
-
-
Medina, P.P.1
Nolde, M.2
Slack, F.J.3
-
13
-
-
84880570961
-
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
-
Song, S. J. et al. MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell 154, 311-324 (2013).
-
(2013)
Cell
, vol.154
, pp. 311-324
-
-
Song, S.J.1
-
14
-
-
84898430214
-
MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer
-
Valeri, N. et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell 25, 469-483 (2014).
-
(2014)
Cancer Cell
, vol.25
, pp. 469-483
-
-
Valeri, N.1
-
15
-
-
84901236372
-
MicroRNA-21 regulates hTERT via PTEN in hypertrophic scar fibroblasts
-
Zhu, H. Y. et al. MicroRNA-21 regulates hTERT via PTEN in hypertrophic scar fibroblasts. PLoS One 9, e97114 (2014).
-
(2014)
PLoS One
, vol.9
-
-
Zhu, H.Y.1
-
16
-
-
77954382780
-
Mir-17-92, a cluster of miRNAs in the midst of the cancer network
-
Olive, V., Jiang, I. & He, L. mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol 42, 1348-1354 (2010).
-
(2010)
Int J Biochem Cell Biol
, vol.42
, pp. 1348-1354
-
-
Olive, V.1
Jiang, I.2
He, L.3
-
17
-
-
34250879111
-
Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia
-
Landais, S., Landry, S., Legault, P. & Rassart, E. Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res 67, 5699-5707 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 5699-5707
-
-
Landais, S.1
Landry, S.2
Legault, P.3
Rassart, E.4
-
18
-
-
72849120988
-
MiR-19 is a key oncogenic component ofmir-17-92
-
Olive, V. et al. miR-19 is a key oncogenic component ofmir-17-92. Genes Dev 23, 2839-2849 (2009).
-
(2009)
Genes Dev
, vol.23
, pp. 2839-2849
-
-
Olive, V.1
-
19
-
-
77950518606
-
Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia
-
Mavrakis, K. J. et al. Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia. Nat Cell Biol 12, 372-379 (2010).
-
(2010)
Nat Cell Biol
, vol.12
, pp. 372-379
-
-
Mavrakis, K.J.1
-
20
-
-
83555173262
-
Regulation of miR-19 to breast cancer chemoresistance through targeting PTEN
-
Liang, Z., Li, Y., Huang, K.,Wagar, N. & Shim, H. Regulation of miR-19 to breast cancer chemoresistance through targeting PTEN. Pharm Res 28, 3091-3100 (2011).
-
(2011)
Pharm Res
, vol.28
, pp. 3091-3100
-
-
Liang, Z.1
Li, Y.2
Huang, K.3
Wagar, N.4
Shim, H.5
-
21
-
-
0032168370
-
Expression of mouse telomerase catalytic subunit in embryos and adult tissues
-
Martín-Rivera, L., Herrera, E., Albar, J. P. & Blasco, M. A. Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc Natl Acad Sci USA 95, 10471-10476 (1998).
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10471-10476
-
-
Martín-Rivera, L.1
Herrera, E.2
Albar, J.P.3
Blasco, M.A.4
-
22
-
-
84858750992
-
Regulation of the human catalytic subunit of telomerase (hTERT)
-
Daniel, M., Peek, G. W. & Tollefsbol, T. O. Regulation of the human catalytic subunit of telomerase (hTERT). Gene 498, 135-146 (2012).
-
(2012)
Gene
, vol.498
, pp. 135-146
-
-
Daniel, M.1
Peek, G.W.2
Tollefsbol, T.O.3
-
23
-
-
84898636273
-
Telomeres and telomerase in T cells of tumor immunity
-
Qian, Y., Yang, L. & Cao, S. Telomeres and telomerase in T cells of tumor immunity. Cell Immunol 289, 63-69 (2014).
-
(2014)
Cell Immunol
, vol.289
, pp. 63-69
-
-
Qian, Y.1
Yang, L.2
Cao, S.3
-
24
-
-
84857406235
-
PI3K signalling: The path to discovery and understanding
-
Vanhaesebroeck, B., Stephens, L. & Hawkins, P. PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol 13, 195-203 (2012).
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 195-203
-
-
Vanhaesebroeck, B.1
Stephens, L.2
Hawkins, P.3
-
25
-
-
33646398872
-
The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels
-
Zhou, C., Bae-Jump, V. L., Whang, Y. E., Gehrig, P. A. & Boggess, J. F. The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels. Gynecol Oncol 101, 305-310 (2006).
-
(2006)
Gynecol Oncol
, vol.101
, pp. 305-310
-
-
Zhou, C.1
Bae-Jump, V.L.2
Whang, Y.E.3
Gehrig, P.A.4
Boggess, J.F.5
-
26
-
-
0037427086
-
HTERT associates with human telomeres and enhances genomic stability and DNA repair
-
Sharma, G. G. et al. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 22, 131-146 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 131-146
-
-
Sharma, G.G.1
-
27
-
-
2342449399
-
Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma
-
Ota, A. et al. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res 64, 3087-3095 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 3087-3095
-
-
Ota, A.1
-
28
-
-
33144490646
-
A microRNA expression signature of human solid tumors defines cancer gene targets
-
Volinia, S. et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 103, 2257-2261 (2006).
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 2257-2261
-
-
Volinia, S.1
-
29
-
-
54249158400
-
Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling
-
Petrocca, F., Vecchione, A. & Croce, C. M. Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res 68, 8191-8194 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 8191-8194
-
-
Petrocca, F.1
Vecchione, A.2
Croce, C.M.3
-
30
-
-
20444467290
-
A microRNA polycistron as a potential human oncogene
-
He, L. et al. A microRNA polycistron as a potential human oncogene. Nature 435, 828-833 (2005).
-
(2005)
Nature
, vol.435
, pp. 828-833
-
-
He, L.1
-
31
-
-
34250879111
-
Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia
-
Landais, S., Landry, S., Legault, P. & Rassart, E. Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res 67, 5699-5707 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 5699-5707
-
-
Landais, S.1
Landry, S.2
Legault, P.3
Rassart, E.4
-
32
-
-
66149126085
-
Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signalregulated kinase/mitogen-activated protein kinase pathway suppression
-
Hoeflich, K. P. et al. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signalregulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Res 69, 3042-3051 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 3042-3051
-
-
Hoeflich, K.P.1
-
33
-
-
20444467290
-
A microRNA polycistron as a potential human oncogene
-
He, L. et al. A microRNA polycistron as a potential human oncogene. Nature 435, 828-833(2005).
-
(2005)
Nature
, vol.435
, pp. 828-833
-
-
He, L.1
-
34
-
-
72849125619
-
Genetic dissection of the miR-17,92 cluster of microRNAs in Mycinduced B-cell lymphomas
-
Mu, P. et al. Genetic dissection of the miR-17,92 cluster of microRNAs in Mycinduced B-cell lymphomas. Gnes Dev 23, 2806-2811 (2009).
-
(2009)
Gnes Dev
, vol.23
, pp. 2806-2811
-
-
Mu, P.1
-
35
-
-
34748900267
-
Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells
-
Lu, Y., Thomson, J.M., Wong, H. Y., Hammond, S. M. & Hogan, B. L. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol 310, 442-453 (2007).
-
(2007)
Dev Biol
, vol.310
, pp. 442-453
-
-
Lu, Y.1
Thomson, J.M.2
Wong, H.Y.3
Hammond, S.M.4
Hogan, B.L.5
-
36
-
-
84896943877
-
Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer
-
Wu, C. et al. Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer. Tohoku J Exp Med 232, 85-95 (2014).
-
(2014)
Tohoku J Exp Med
, vol.232
, pp. 85-95
-
-
Wu, C.1
-
37
-
-
84867898027
-
A miR-19 regulon that controls NF-kB signaling
-
Gantier, M. P. et al. A miR-19 regulon that controls NF-kB signaling. Nucleic Acids Res 40, 8048-8058 (2012).
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 8048-8058
-
-
Gantier, M.P.1
-
38
-
-
84890899629
-
Treatment of BRAF-mutant melanoma: The role of vemurafenib and other therapies
-
Jang, S. & Atkins, M. B. Treatment of BRAF-mutant melanoma: the role of vemurafenib and other therapies. Clin Pharmacol Ther 95, 24-31 (2014).
-
(2014)
Clin Pharmacol Ther
, vol.95
, pp. 24-31
-
-
Jang, S.1
Atkins, M.B.2
-
39
-
-
84896766487
-
High iodine blocks a Notch/miR-19 loop activated by the BRAF(V600E) oncoprotein and restores the response to TGFb in thyroid follicular cells
-
Fuziwara, C. S. & Kimura, E. T. High iodine blocks a Notch/miR-19 loop activated by the BRAF(V600E) oncoprotein and restores the response to TGFb in thyroid follicular cells. Thyroid 24, 453-462 (2014).
-
(2014)
Thyroid
, vol.24
, pp. 453-462
-
-
Fuziwara, C.S.1
Kimura, E.T.2
-
40
-
-
3042600380
-
BRAF point mutations in primary melanoma show different prevalences by subtype
-
Sasaki, Y. et al. BRAF point mutations in primary melanoma show different prevalences by subtype. J Invest Dermatol 123, 177-183 (2004).
-
(2004)
J Invest Dermatol
, vol.123
, pp. 177-183
-
-
Sasaki, Y.1
-
41
-
-
84867572383
-
Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells
-
Kurokawa, K. et al. Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells. J Gastroenterol 47, 883-895 (2012).
-
(2012)
J Gastroenterol
, vol.47
, pp. 883-895
-
-
Kurokawa, K.1
-
42
-
-
84896943877
-
Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer
-
Wu, C. et al. Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer. Tohoku J Exp Med 232, 85-95 (2014).
-
(2014)
Tohoku J Exp Med
, vol.232
, pp. 85-95
-
-
Wu, C.1
-
43
-
-
84885464686
-
MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells
-
Wu, Q. et al. MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells. J Cell Sci 126, 4220-4229 (2013).
-
(2013)
J Cell Sci
, vol.126
, pp. 4220-4229
-
-
Wu, Q.1
-
44
-
-
84903585828
-
BRAF mutations in patients with non-small cell lung cancer: A systematic review and meta-analysis
-
Chen, D. et al. BRAF mutations in patients with non-small cell lung cancer: a systematic review and meta-analysis. PLoS One 9, e101354 (2014).
-
(2014)
PLoS One
, vol.9
-
-
Chen, D.1
-
45
-
-
53749086690
-
BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: A 15-year median follow-up study
-
Elisei, R. et al. BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study. J Clin Endocrinol Metab 93, 3943-3949 (2008).
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 3943-3949
-
-
Elisei, R.1
-
46
-
-
32044455746
-
BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
-
Li, W. Q. et al. BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. Mol Cancer 5, 2 (2006).
-
(2006)
Mol Cancer
, vol.5
, pp. 2
-
-
Li, W.Q.1
-
47
-
-
0346728596
-
Determinants of BRAF mutations in primary melanomas
-
Maldonado, J. L. et al. Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst 95, 1878-1890 (2003).
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1878-1890
-
-
Maldonado, J.L.1
-
48
-
-
84887030724
-
The transfer of human artificial chromosomes via cryopreserved microcells
-
Uno, N. et al. The transfer of human artificial chromosomes via cryopreserved microcells. Cytotechnology 65, 803-809 (2013).
-
(2013)
Cytotechnology
, vol.65
, pp. 803-809
-
-
Uno, N.1
|