Antidepressant, anxiolytic and antinociceptive activities of constituents from rosmarinus officinalis

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 18, Issue 4, 2015, Pages 448-459

  Abdelhalim, Abeer ^a,b   Karim, Nasiara ^c   Chebib, Mary ^a   Aburjai, Talal ^d   Khan, Imran ^c   Johnston, Graham A R ^a   Hanrahan, Jane R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b TAIBAH UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF MALAKAND   (Pakistan)

^d UNIVERSITY OF JORDAN   (Jordan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CIRSIMARITIN; DIAZEPAM; FLUMAZENIL; IMIPRAMINE; PENTETRAZOLE; ROSMANOL; ROSMARINUS OFFICINALIS EXTRACT; SALVIGENIN; TRAMADOL; UNCLASSIFIED DRUG; ANALGESIC AGENT; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; DITERPENE; FLAVONE DERIVATIVE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ANTINOCICEPTION; ANXIETY ASSESSMENT; ANXIETY DISORDER; ARTICLE; BINDING AFFINITY; BINDING SITE; CENTRAL NERVOUS SYSTEM FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DARK BOX PARADIGM; DEPRESSION; DRUG DOSE COMPARISON; DRUG STRUCTURE; ELEVATED PLUS MAZE TEST; EXPERIMENTAL BEHAVIORAL TEST; FORCED SWIM TEST; HOT PLATE TEST; LIGHT BOX PARADIGM; MALE; MOUSE; NONHUMAN; RESPONSE TIME; ROSEMARY; TAIL IMMERSION TEST; TAIL SUSPENSION TEST; TOXICITY TESTING; TRANQUILIZING ACTIVITY; ANIMAL; ANXIETY; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; PAIN; ROSMARINUS;

ANALGESICS; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; ANXIETY; BINDING SITES; DEPRESSION; DISEASE MODELS, ANIMAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONES; MALE; MICE; PAIN; RECEPTORS, GABA-A; ROSMARINUS; TOXICITY TESTS, ACUTE;

EID: 84944057694     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j3pw38     Document Type: Article

References (40)

1. Gonzalez-Trujano ME, Pena EI, Martinez AL, Moreno J, Guevara-Fefer P, Deciga-Campos M, et al. Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. J Ethnopharmacol. 2007;111:476-82. Epub 2007/01/16.
2. Erkan N, Ayranci G, Ayranci E. Antioxidant activities of rosemary (Rosmarinus Officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol. Food Chem. 2008;110:76-82.
3. Duke JA. Alzheimaretto. J Med Food. 1998;1:53.
4. Perry EK, Pickering AT, Wang WW, Houghton P, Perry NSL. Medicinal Plants and Alzheimer's Disease: Integrating Ethnobotanical and Contemporary Scientific Evidence. The Journal of Alternative and Complementary Medicine. 1998;4:419.
5. Ozarowski M, Mikolajczak PL, Bogacz A, Gryszczynska A, Kujawska M, Jodynis-Liebert J, et al. Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. Fitoterapia. 2013;91:261-71.
6. Kosaka K, Yokoi T. Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in T98G human glioblastoma cells. Biol Pharm Bull. 2003;26:1620-2. Epub 2003/11/06.
7. Crutcher KA, Scott SA, Liang S, Everson WV, Weingartner J. Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. J Neurosci. 1993;13:2540-50. Epub 1993/06/01.
8. Hold KM, Sirisoma NS, Ikeda T, Narahashi T, Casida JE. Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci USA. 2000;97:3826-31. Epub 2000/03/22.
9. Takeda H, Tsuji M, Inazu M, Egashira T, Matsumiya T. Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice. Eur J Pharmacol. 2002;449:261-7. Epub 2002/08/09.
10. Takeda H, Tsuji M, Miyamoto J, Matsumiya T. Rosmarinic acid and caffeic acid reduce the defensive freezing behavior of mice exposed to conditioned fear stress. Psychopharmacology (Berl). 2002;164:233-5. Epub 2002/10/31.
11. Pereira P, Tysca D, Oliveira P, da Silva Brum LF, Picada JN, Ardenghi P. Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacol Res. 2005;52:199-203. Epub 2005/07/20.
12. Kim SJ, Kim JS, Cho HS, Lee HJ, Kim SY, Kim S, et al. Carnosol, a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells. Neuroreport. 2006;17:1729-33. Epub 2006/10/19.
13. Krnjevic K, Schwartz S. The action of gammaaminobutyric acid on cortical neurones. Experimental brain research Experimentelle Hirnforschung. 1967;3:320-36.
14. Ticku MK. Differences in gamma-aminobutyric acid receptor sensitivity in inbred strains of mice. J Neurochem. 1979;33:1135-8.
15. Hanrahan JR, Chebib M, Johnston GAR. Flavonoid modulation of GABAA receptors. Br J Pharmacol. 2011;163:234–45.
16. Walters RJ, Hadley SH, Morris KDW, Amin J. Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms. Nat Neurosi. 2000;3:1274-81.
17. Kavvadias D, Monschein V, Sand P, Riederer P, Schreier P. Constituents of Sage (Salvia officinalis) with in vitro Affinity to Human Brain Benzodiazepine Receptor. Planta Med. 2003;69:113-7.
18. Abdelhalim A, Chebib M, Aburjai T, Johnston GAR, Hanrahan JR. GABAA Receptor Modulation by Compounds Isolated from Salvia triloba L. Adv Biol Chem. 2014;4:148-59. Epub 21 March 2014.
19. Adebiyi OE, Abatan MO. Phytochemical and acute toxicity of ethanolic extract of Enantia chlorantha (oliv) stem bark in albino rats. Interdiscip Toxicol. 2013;6:145-51.
20. Janssen PA, Niemegeers CJE, Dony JGH. The inhibitory effect of fentanyl and other morphinelike analgesics on the warm water induced tail withdrawal reflex in rats. Arzneimittelforschung. 1963;13:502–7.
21. Tita B, Abdel-Haq H, Vitalone A, Mazzanti G, Saso L. Analgesic properties of Epilobium angustifolium, evaluated by the hot plate test and the writhing test. Farmaco. 2001;56(5-7):341-3. Epub 2001/08/03.
22. Squires RF, Saederup E, Crawley JN, Skolnick P, Paul SM. Convulsant potencies of tetrazoles are highly correlated with actions on GABA / benzodiazepine / picrotoxin receptor complexes in brain. Life Sci. 1984;35:1439–44.
23. Karim N, Curmi J, Gavande N, Johnston GAR, Hanrahan JR, Tierney ML, et al. 2'-Methoxy-6- methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA-A receptors. Br J Pharmacol. 2012;165:880-96.
24. Bourin M, Hascoet M. The mouse light/dark box test. Eur J Pharmacol. 2003;463(1-3):55-65. Epub 2003/02/26.
25. Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl). 1985;85(3):367-70. Epub 1985/01/01.
26. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol. 1978;47(4):379-91. Epub 1978/02/15.
27. Marder M, Viola H, Wasowski C, Fernández S, Medina JH, Paladini AC. 6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS. Pharmacol Biochem Behav. 2003;75:537-45.
28. Fernandez SP, Wasowski C, Paladini AC, Marder M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur J Pharmacol. 2005;512:189-98. Epub 2005/04/21.
29. Fernandez SP, Wasowski C, Loscalzo LM, Granger RE, Johnston GA, Paladini AC, et al. Central nervous system depressant action of flavonoid glycosides. Eur J Pharmacol. 2006;539:168-76. Epub 2006/05/16.
30. Martínez MC, Fernandez SP, Loscalzo LM, Wasowski C, Paladini AC, Marder M, et al. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacol Biochem Behav. 2009;92:291-6.
31. Loscalzo LM, Wasowski C, Paladini AC, Marder M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur J Pharmacol. 2008;580:306-13. Epub 2007/12/01.
32. Agarwal OP. The anti-inflammatory action of nepitrin, a flavonoid. Agents Actions. 1982;12:298-302. Epub 1982/07/01.
33. Rujjanawate C, Kanjanapothi D, Panthong A. Pharmacological effect and toxicity of alkaloidsfrom Gelsemium elegans Benth. J Ethnopharmacol. 2003;89:91-5.
34. Waszkielewicz AM, Gunia A, Szkaradek N, Sloczynska K, Krupinska S, Marona H. Ion channels as drug targets in central nervous system disorders. Curr Med Chem. 2013;20(10):1241-85. Epub 2013/02/16.
35. Chang FC, Tsai HY, Yu MC, Yi PL, Lin JG. The central serotonergic system mediates the analgesic effect of electroacupuncture on ZUSANLI (ST36) acupoints. J Biomed Sci. 2004;11(2):179-85. Epub 2004/02/18.
36. Klusa V, Germane S, Svirskis S, Opmane B, Wikberg JE. The gamma(2)-MSH peptide mediates a central analgesic effect via a GABA-ergic mechanism that is independent from activation of melanocortin receptors. Neuropeptides. 2001;35(1):50-7. Epub 2001/05/11.
37. Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci. 2002;23(5):238-45. Epub 2002/05/15.
38. Mohler H. The GABA system in anxiety and depression and its therapeutic potential. Neuropharmacology. 2012;62(1):42-53. Epub 2011/09/06.
39. Akanmu MA, Olowookere TA, Atunwa SA, Ibrahim BO, Lamidi OF, Adams PA, et al. Neuropharmacological effects of Nigerian honey in mice. Afr J Tradit Complement Altern Med. 2011;8(3):230-49. Epub 2011/01/01.
40. Karim N, Gavande N, Wellendorph P, Johnston GA, Hanrahan JR, Chebib M. 3-Hydroxy-2'- methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABAA receptor subtypes. Biochem Pharmacol. 2011;82:1971-83.