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Volumn 33, Issue 43, 2015, Pages 5838-5844

Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression

Author keywords

Cancer vaccines; Invariant natural killer T cells; Liposomes; Long peptides; Melanoma; Galactosylceramide

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CANCER VACCINE; CD4 ANTIGEN; CD8 ANTIGEN; DOPACHROME TAUTOMERASE; GAMMA INTERFERON; INTERLEUKIN 2; LIPOSOME; MACROGOL; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; ALPHA-GALACTOSYLCERAMIDE; DOPACHROME ISOMERASE; GALACTOSYLCERAMIDE; IMMUNOLOGIC FACTOR; ISOMERASE;

EID: 84944035926     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.08.083     Document Type: Article
Times cited : (33)

References (44)
  • 1
    • 79251555315 scopus 로고    scopus 로고
    • Recent developments in cancer vaccines
    • Palucka K., Ueno H., Banchereau J. Recent developments in cancer vaccines. J Immunol 2011, 186(3):1325-1331.
    • (2011) J Immunol , vol.186 , Issue.3 , pp. 1325-1331
    • Palucka, K.1    Ueno, H.2    Banchereau, J.3
  • 4
    • 79956079190 scopus 로고    scopus 로고
    • Immunological mechanisms of vaccination
    • Pulendran B., Ahmed R. Immunological mechanisms of vaccination. Nat Immunol 2011, 12(6):509-517.
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 509-517
    • Pulendran, B.1    Ahmed, R.2
  • 5
    • 0029798058 scopus 로고    scopus 로고
    • Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction
    • Toes R.E., Offringa R., Blom R.J., Melief C.J., Kast W.M. Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction. Proc Natl Acad Sci U S A 1996, 93(15):7855-7860.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.15 , pp. 7855-7860
    • Toes, R.E.1    Offringa, R.2    Blom, R.J.3    Melief, C.J.4    Kast, W.M.5
  • 6
    • 44849109375 scopus 로고    scopus 로고
    • Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged. DC-focused antigen presentation
    • Bijker M.S., van den Eeden S.J., Franken K.L., Melief C.J., van der Burg S.H., Offringa R. Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged. DC-focused antigen presentation. Eur J Immunol 2008, 38(4):1033-1042.
    • (2008) Eur J Immunol , vol.38 , Issue.4 , pp. 1033-1042
    • Bijker, M.S.1    van den Eeden, S.J.2    Franken, K.L.3    Melief, C.J.4    van der Burg, S.H.5    Offringa, R.6
  • 7
    • 70350546309 scopus 로고    scopus 로고
    • The contrasting roles of NKT cells in tumor immunity
    • Berzofsky J.A., Terabe M. The contrasting roles of NKT cells in tumor immunity. Curr Mol Med 2009, 9(6):667-672.
    • (2009) Curr Mol Med , vol.9 , Issue.6 , pp. 667-672
    • Berzofsky, J.A.1    Terabe, M.2
  • 8
    • 2542448243 scopus 로고    scopus 로고
    • CD1: antigen presentation and T cell function
    • Brigl M., Brenner M.B. CD1: antigen presentation and T cell function. Annu Rev Immunol 2004, 22:817-890.
    • (2004) Annu Rev Immunol , vol.22 , pp. 817-890
    • Brigl, M.1    Brenner, M.B.2
  • 9
    • 33847361128 scopus 로고    scopus 로고
    • Invariant NKT cells amplify the innate immune response to lipopolysaccharide
    • Nagarajan N.A., Kronenberg M. Invariant NKT cells amplify the innate immune response to lipopolysaccharide. J Immunol (Baltim MD: 1950) 2007, 178(5):2706-2713.
    • (2007) J Immunol (Baltim MD: 1950) , vol.178 , Issue.5 , pp. 2706-2713
    • Nagarajan, N.A.1    Kronenberg, M.2
  • 10
    • 0035071525 scopus 로고    scopus 로고
    • NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma
    • Smyth M.J., Crowe N.Y., Godfrey D.I. NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int Immunol 2001, 13(4):459-463.
    • (2001) Int Immunol , vol.13 , Issue.4 , pp. 459-463
    • Smyth, M.J.1    Crowe, N.Y.2    Godfrey, D.I.3
  • 11
    • 0037082487 scopus 로고    scopus 로고
    • Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide
    • Smyth M.J., Crowe N.Y., Pellicci D.G., Kyparissoudis K., Kelly J.M., Takeda K., et al. Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. Blood 2002, 99(4):1259-1266.
    • (2002) Blood , vol.99 , Issue.4 , pp. 1259-1266
    • Smyth, M.J.1    Crowe, N.Y.2    Pellicci, D.G.3    Kyparissoudis, K.4    Kelly, J.M.5    Takeda, K.6
  • 12
    • 10744230210 scopus 로고    scopus 로고
    • NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells
    • Hermans I.F., Silk J.D., Gileadi U., Salio M., Mathew B., Ritter G., et al. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol 2003, 171(10):5140-5147.
    • (2003) J Immunol , vol.171 , Issue.10 , pp. 5140-5147
    • Hermans, I.F.1    Silk, J.D.2    Gileadi, U.3    Salio, M.4    Mathew, B.5    Ritter, G.6
  • 13
    • 79960450420 scopus 로고    scopus 로고
    • Clinical experience with α-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection
    • Schneiders F.L., Scheper R.J., von Blomberg B.M.E., Woltman A.M., Janssen H.L.A., van den Eertwegh A.J.M., et al. Clinical experience with α-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection. Clin Immunol 2011, 140(2):130-141.
    • (2011) Clin Immunol , vol.140 , Issue.2 , pp. 130-141
    • Schneiders, F.L.1    Scheper, R.J.2    von Blomberg, B.M.E.3    Woltman, A.M.4    Janssen, H.L.A.5    van den Eertwegh, A.J.M.6
  • 14
    • 77954314391 scopus 로고    scopus 로고
    • Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand
    • Petersen T.R., Sika-Paotonu D., Knight D.A., Dickgreber N., Farrand K.J., Ronchese F., et al. Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand. Immunol Cell Biol 2010, 88(5):596-604.
    • (2010) Immunol Cell Biol , vol.88 , Issue.5 , pp. 596-604
    • Petersen, T.R.1    Sika-Paotonu, D.2    Knight, D.A.3    Dickgreber, N.4    Farrand, K.J.5    Ronchese, F.6
  • 15
    • 19544368809 scopus 로고    scopus 로고
    • The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway
    • Boileau C., Pelletier J.P., Tardif G., Fahmi H., Laufer S., Lavigne M., et al. The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway. Ann Rheum Dis 2005, 64(6):891-898.
    • (2005) Ann Rheum Dis , vol.64 , Issue.6 , pp. 891-898
    • Boileau, C.1    Pelletier, J.P.2    Tardif, G.3    Fahmi, H.4    Laufer, S.5    Lavigne, M.6
  • 16
    • 33746644520 scopus 로고    scopus 로고
    • Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
    • Fujii S.-i., Shimizu K., Hemmi H., Fukui M., Bonito A.J., Chen G., et al. Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice. Proc Natl Acad Sci 2006, 103(30):11252-11257.
    • (2006) Proc Natl Acad Sci , vol.103 , Issue.30 , pp. 11252-11257
    • Fujii, S.-I.1    Shimizu, K.2    Hemmi, H.3    Fukui, M.4    Bonito, A.J.5    Chen, G.6
  • 17
    • 0037787982 scopus 로고    scopus 로고
    • Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein
    • Fujii S., Shimizu K., Smith C., Bonifaz L., Steinman R.M. Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med 2003, 198(2):267-279.
    • (2003) J Exp Med , vol.198 , Issue.2 , pp. 267-279
    • Fujii, S.1    Shimizu, K.2    Smith, C.3    Bonifaz, L.4    Steinman, R.M.5
  • 18
    • 84881492861 scopus 로고    scopus 로고
    • The nanoparticulation by octaarginine-modified liposome improves α-galactosylceramide-mediated antitumor therapy via systemic administration
    • Nakamura T., Yamazaki D., Yamauchi J., Harashima H. The nanoparticulation by octaarginine-modified liposome improves α-galactosylceramide-mediated antitumor therapy via systemic administration. J Control Release 2013, 171(2):216-224.
    • (2013) J Control Release , vol.171 , Issue.2 , pp. 216-224
    • Nakamura, T.1    Yamazaki, D.2    Yamauchi, J.3    Harashima, H.4
  • 19
    • 58149104377 scopus 로고    scopus 로고
    • Harnessing invariant NKT cells in vaccination strategies
    • Cerundolo V., Silk J.D., Masri S.H., Salio M. Harnessing invariant NKT cells in vaccination strategies. Nat Rev Immunol 2009, 9(1):28-38.
    • (2009) Nat Rev Immunol , vol.9 , Issue.1 , pp. 28-38
    • Cerundolo, V.1    Silk, J.D.2    Masri, S.H.3    Salio, M.4
  • 20
    • 67349171859 scopus 로고    scopus 로고
    • Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy
    • Thapa P., Zhang G., Xia C., Gelbard A., Overwijk W.W., Liu C., et al. Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy. Vaccine 2009, 27(25-26):3484-3488.
    • (2009) Vaccine , vol.27 , Issue.25-26 , pp. 3484-3488
    • Thapa, P.1    Zhang, G.2    Xia, C.3    Gelbard, A.4    Overwijk, W.W.5    Liu, C.6
  • 21
    • 33744791458 scopus 로고    scopus 로고
    • Particulate delivery systems for vaccines: what can we expect?
    • Bramwell V.W., Perrie Y. Particulate delivery systems for vaccines: what can we expect?. J Pharm Pharmacol 2006, 58(6):717-728.
    • (2006) J Pharm Pharmacol , vol.58 , Issue.6 , pp. 717-728
    • Bramwell, V.W.1    Perrie, Y.2
  • 22
    • 34249291291 scopus 로고    scopus 로고
    • Mechanism of adjuvant activity of cationic liposome: phosphorylation of a MAP kinase ERK and induction of chemokines
    • Yan W., Chen W., Huang L. Mechanism of adjuvant activity of cationic liposome: phosphorylation of a MAP kinase ERK and induction of chemokines. Mol Immunol 2007, 44(15):3672-3681.
    • (2007) Mol Immunol , vol.44 , Issue.15 , pp. 3672-3681
    • Yan, W.1    Chen, W.2    Huang, L.3
  • 23
    • 48749099116 scopus 로고    scopus 로고
    • Reactive oxygen species play a central role in the activity of cationic liposome based cancer vaccine
    • Yan W., Chen W., Huang L. Reactive oxygen species play a central role in the activity of cationic liposome based cancer vaccine. J Control Release 2008, 130(1):22-28.
    • (2008) J Control Release , vol.130 , Issue.1 , pp. 22-28
    • Yan, W.1    Chen, W.2    Huang, L.3
  • 25
    • 0030982397 scopus 로고    scopus 로고
    • Lymphatic uptake and biodistribution of liposomes after subcutaneous injection II. Influence of liposomal size, lipid compostion and lipid dose
    • Oussoren C., Zuidema J., Crommelin D.J., Storm G. Lymphatic uptake and biodistribution of liposomes after subcutaneous injection II. Influence of liposomal size, lipid compostion and lipid dose. Biochim Biophys Acta 1997, 1328(2):261-272.
    • (1997) Biochim Biophys Acta , vol.1328 , Issue.2 , pp. 261-272
    • Oussoren, C.1    Zuidema, J.2    Crommelin, D.J.3    Storm, G.4
  • 26
    • 84857913863 scopus 로고    scopus 로고
    • Pegylation of DDA:TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responses
    • Kaur R., Bramwell V.W., Kirby D.J., Perrie Y. Pegylation of DDA:TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responses. J Control Release 2012, 158(1):72-77.
    • (2012) J Control Release , vol.158 , Issue.1 , pp. 72-77
    • Kaur, R.1    Bramwell, V.W.2    Kirby, D.J.3    Perrie, Y.4
  • 27
    • 0031041233 scopus 로고    scopus 로고
    • Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
    • Bloom M.B., Perry-Lalley D., Robbins P.F., Li Y., el-Gamil M., Rosenberg S.A., et al. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J Exp Med 1997, 185(3):453-459.
    • (1997) J Exp Med , vol.185 , Issue.3 , pp. 453-459
    • Bloom, M.B.1    Perry-Lalley, D.2    Robbins, P.F.3    Li, Y.4    el-Gamil, M.5    Rosenberg, S.A.6
  • 28
    • 85012373035 scopus 로고
    • Diffusion of univalent ions across the lamellae of swollen phospholipids
    • Bangham A.D., Standish M.M., Watkins J.C. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 1965, 13(1):238-252.
    • (1965) J Mol Biol , vol.13 , Issue.1 , pp. 238-252
    • Bangham, A.D.1    Standish, M.M.2    Watkins, J.C.3
  • 29
    • 19544385277 scopus 로고    scopus 로고
    • Efficient synthesis of alpha-galactosyl ceramide analogues using glycosyl iodide donors
    • Du W., Gervay-Hague J. Efficient synthesis of alpha-galactosyl ceramide analogues using glycosyl iodide donors. Org Lett 2005, 7(10):2063-2065.
    • (2005) Org Lett , vol.7 , Issue.10 , pp. 2063-2065
    • Du, W.1    Gervay-Hague, J.2
  • 30
    • 0037173538 scopus 로고    scopus 로고
    • A method for the incorporation of ovalbumin into immune stimulating complexes prepared by the hydration method
    • Konnings S., Copland M.J., Davies N.M., Rades T. A method for the incorporation of ovalbumin into immune stimulating complexes prepared by the hydration method. Int J Pharm 2002, 241(2):385-389.
    • (2002) Int J Pharm , vol.241 , Issue.2 , pp. 385-389
    • Konnings, S.1    Copland, M.J.2    Davies, N.M.3    Rades, T.4
  • 31
    • 84901742841 scopus 로고    scopus 로고
    • Physical characterization of synthetic phosphatidylinositol dimannosides and analogues in binary systems with phosphatidylcholine
    • Hubert M., Larsen D.S., Hayman C.M., Rades T., Hook S. Physical characterization of synthetic phosphatidylinositol dimannosides and analogues in binary systems with phosphatidylcholine. Mol Pharm 2014, 11(3):913-921.
    • (2014) Mol Pharm , vol.11 , Issue.3 , pp. 913-921
    • Hubert, M.1    Larsen, D.S.2    Hayman, C.M.3    Rades, T.4    Hook, S.5
  • 33
    • 0028025074 scopus 로고
    • An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans
    • Lantz O., Bendelac A. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med 1994, 180(3):1097-1106.
    • (1994) J Exp Med , vol.180 , Issue.3 , pp. 1097-1106
    • Lantz, O.1    Bendelac, A.2
  • 34
    • 84918562759 scopus 로고    scopus 로고
    • Modified thermoresponsive Poloxamer 407 and chitosan sol-gels as potential sustained-release vaccine delivery systems
    • Kojarunchitt T., Baldursdottir S., Dong Y.-D., Boyd B.J., Rades T., Hook S. Modified thermoresponsive Poloxamer 407 and chitosan sol-gels as potential sustained-release vaccine delivery systems. Eur J Pharm Biopharm 2015, 89:74-81.
    • (2015) Eur J Pharm Biopharm , vol.89 , pp. 74-81
    • Kojarunchitt, T.1    Baldursdottir, S.2    Dong, Y.-D.3    Boyd, B.J.4    Rades, T.5    Hook, S.6
  • 35
    • 67249139762 scopus 로고    scopus 로고
    • Cationic liposomes loaded with proapoptotic peptide d-(KLAKLAK)2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy
    • Ko Y.T., Falcao C., Torchilin V.P. Cationic liposomes loaded with proapoptotic peptide d-(KLAKLAK)2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy. Mol Pharm 2009, 6(3):971-977.
    • (2009) Mol Pharm , vol.6 , Issue.3 , pp. 971-977
    • Ko, Y.T.1    Falcao, C.2    Torchilin, V.P.3
  • 36
    • 84880839905 scopus 로고    scopus 로고
    • Adjuvant effect of cationic liposomes for subunit influenza vaccine: influence of antigen loading method, cholesterol and immune modulators
    • Barnier-Quer C., Elsharkawy A., Romeijn S., Kros A., Jiskoot W. Adjuvant effect of cationic liposomes for subunit influenza vaccine: influence of antigen loading method, cholesterol and immune modulators. Pharmaceutics 2013, 5(3):392-410.
    • (2013) Pharmaceutics , vol.5 , Issue.3 , pp. 392-410
    • Barnier-Quer, C.1    Elsharkawy, A.2    Romeijn, S.3    Kros, A.4    Jiskoot, W.5
  • 37
    • 79952968002 scopus 로고    scopus 로고
    • Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA) 3beta-[N-(N',N'-dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-dioleoyl-3-trimethylammonium propane (DOTAP): prolonged liposome retention mediates stronger Th1 responses
    • Henriksen-Lacey M., Christensen D., Bramwell V.W., Lindenstrom T., Agger E.M., Andersen P., et al. Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA) 3beta-[N-(N',N'-dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-dioleoyl-3-trimethylammonium propane (DOTAP): prolonged liposome retention mediates stronger Th1 responses. Mol Pharm 2011, 8(1):153-161.
    • (2011) Mol Pharm , vol.8 , Issue.1 , pp. 153-161
    • Henriksen-Lacey, M.1    Christensen, D.2    Bramwell, V.W.3    Lindenstrom, T.4    Agger, E.M.5    Andersen, P.6
  • 39
    • 42549138499 scopus 로고    scopus 로고
    • Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
    • Melief C.J.M., van der Burg S.H. Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines. Nat Rev Cancer 2008, 8(5):351-360.
    • (2008) Nat Rev Cancer , vol.8 , Issue.5 , pp. 351-360
    • Melief, C.J.M.1    van der Burg, S.H.2
  • 40
    • 67349170777 scopus 로고    scopus 로고
    • Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens
    • Courtney A.N., Nehete P.N., Nehete B.P., Thapa P., Zhou D., Sastry K.J. Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens. Vaccine 2009, 27(25-26):3335-3341.
    • (2009) Vaccine , vol.27 , Issue.25-26 , pp. 3335-3341
    • Courtney, A.N.1    Nehete, P.N.2    Nehete, B.P.3    Thapa, P.4    Zhou, D.5    Sastry, K.J.6
  • 42
    • 84866441994 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetics of 188Re-liposomes and their comparative therapeutic efficacy with 5-fluorouracil in C26 colonic peritoneal carcinomatosis mice
    • Tsai C.C., Chang C.H., Chen L.C., Chang Y.J., Lan K.L., Wu Y.H., et al. Biodistribution and pharmacokinetics of 188Re-liposomes and their comparative therapeutic efficacy with 5-fluorouracil in C26 colonic peritoneal carcinomatosis mice. Int J Nanomed 2011, 6:2607-2619.
    • (2011) Int J Nanomed , vol.6 , pp. 2607-2619
    • Tsai, C.C.1    Chang, C.H.2    Chen, L.C.3    Chang, Y.J.4    Lan, K.L.5    Wu, Y.H.6
  • 43
    • 84860650784 scopus 로고    scopus 로고
    • Virus-like particles and alpha-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses
    • McKee S.J., Young V.L., Clow F., Hayman C.M., Baird M.A., Hermans I.F., et al. Virus-like particles and alpha-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses. J Control Release 2012, 159(3):338-345.
    • (2012) J Control Release , vol.159 , Issue.3 , pp. 338-345
    • McKee, S.J.1    Young, V.L.2    Clow, F.3    Hayman, C.M.4    Baird, M.A.5    Hermans, I.F.6
  • 44
    • 51549096629 scopus 로고    scopus 로고
    • Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity
    • Bourquin C., Anz D., Zwiorek K., Lanz A.L., Fuchs S., Weigel S., et al. Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity. J Immunol 2008, 181(5):2990-2998.
    • (2008) J Immunol , vol.181 , Issue.5 , pp. 2990-2998
    • Bourquin, C.1    Anz, D.2    Zwiorek, K.3    Lanz, A.L.4    Fuchs, S.5    Weigel, S.6


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