Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: A case-control study

Cytokine

Volumn 76, Issue 2, 2015, Pages 138-143

  Wan, Bing ^a   Zhang, Hao ^a   Fu, Haiyan ^a   Chen, Yikun ^a   Yang, Liping ^a   Yin, Jiangtao ^a   Wan, Yin ^a   Shi, Yongqing ^a  

^a AFFILIATED HOSPITAL OF JIANGSU UNIVERSITY   (China)

Author keywords

Inflammation; Interleukin 11; Sepsis; Thrombocytopenia

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 11; INTERLEUKIN 6; PROCALCITONIN; RECOMBINANT INTERLEUKIN 11; TUMOR NECROSIS FACTOR ALPHA; CALCITONIN; IL11 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; TNF PROTEIN, HUMAN;

ADULT; AGED; APACHE; ARTICLE; BLOOD CLOTTING DISORDER; CASE CONTROL STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG WITHDRAWAL; FEMALE; HEART VENTRICLE EXTRASYSTOLE; HUMAN; INFLAMMATION; INJECTION SITE REACTION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PAROXYSMAL ATRIAL FIBRILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RASH; SEPSIS; SINUS TACHYCARDIA; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT OUTCOME; ADOLESCENT; BLOOD; BLOOD CELL COUNT; COMPLICATION; IMMUNOLOGY; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; APACHE; BLOOD CELL COUNT; CALCITONIN; CASE-CONTROL STUDIES; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-11; INTERLEUKIN-6; MALE; MIDDLE AGED; PLATELET COUNT; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; SEPSIS; THROMBOCYTOPENIA; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84943659315     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2015.08.001     Document Type: Article

References (22)

1. Cohen J. The immunopathogenesis of sepsis. Nature 2002, 420:885-891.
2. Ernst M., Najdovska M., Grail D., Lundgren-May T., Buchert M., Tye H., et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J Clin Invest 2008, 118:1727-1738.
3. Chen Q., Rabach L., Noble P., Zheng T., Lee C.G., Homer R.J., et al. IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2005, 174:2305-2313.
4. Yang L., Wang R., Gao Y., Xu X., Fu K., Wang S., et al. The protective role of interleukin-11 against neutron radiation injury in mouse intestines via MEK/ERK and PI3K/Akt dependent pathways. Dig Dis Sci 2014, 59:1406-1414.
5. Burnett A.F., Biju P.G., Lui H., Hauer-Jensen M. Oral interleukin 11 as a countermeasure to lethal total-body irradiation in a murine model. Radiat Res 2013, 180:595-602.
6. Opal S.M., Keith J.C., Jhung J., Palardy J.E., Parejo N., Marchese E., et al. Orally administered recombinant human interleukin-11 is protective in experimental neutropenic sepsis. J Infect Dis 2003, 187:70-76.
7. Maeshima K., Takahashi T., Nakahira K., Shimizu H., Fujii H., Katayama H., et al. A protective role of interleukin 11 on hepatic injury in acute endotoxemia. Shock 2004, 21:134-138.
8. McCloy M.P., Roberts I.A., Howarth L.J., Watts T.L., Murray N.A. Interleukin-11 levels in healthy and thrombocytopenic neonates. Pediatr Res 2002, 51:756-760.
9. Jarnicki A., Putoczki T., Ernst M. Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?. Cell Div 2010, 5:14.
10. Hui P., Cook D.J., Lim W., Fraser G.A., Arnold D.M. The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review. Chest 2011, 139:271-278.
11. Xiang B., Zhang G., Guo L., Li X.A., Morris A.J., Daugherty A., et al. Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Nat Commun 2013, 4:2657.
12. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 2003, 31:1250-1256.
13. Wan B., Fu H., Yin J., Xu F. Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis: a randomized controlled trial. Scand J Gastroenterol 2014, 49:1375-1384.
14. Alt E., Amann-Vesti B.R., Madl C., Funk G., Koppensteiner R. Platelet aggregation and blood rheology in severe sepsis/septic shock: relation to the sepsis-related organ failure assessment (SOFA) score. Clin Hemorheol Microcirc 2004, 30:107-115.
15. Arai T., Kumasaka K., Nagata K., Okita T., Oomura T., Hoshiai A., et al. Prediction of blood culture results by measuring procalcitonin levels and other inflammatory biomarkers. Am J Emerg Med 2014, 32:330-333.
16. Hattori T., Nishiyama H., Kato H., Ikegami S., Nagayama M., Asami S., et al. Clinical value of procalcitonin for patients with suspected bloodstream infection. Am J Clin Pathol 2014, 141:43-51.
17. Leli C., Cardaccia A., Ferranti M., Cesarini A., D'Alo F., Ferri C., et al. Procalcitonin better than C-reactive protein, erythrocyte sedimentation rate, and white blood cell count in predicting DNAemia in patients with sepsis. Scand J Infect Dis 2014, 46:745-752.
18. Kuhara T., Tanaka A., Yamauchi K., Iwatsuki K. Bovine lactoferrin ingestion protects against inflammation via IL-11 induction in the small intestine of mice with hepatitis. Br J Nutr 2014, 111:1801-1810.
19. Goldman S.J. Preclinical biology of interleukin 11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity. Stem Cells 1995, 13:462-471.
20. Vadhan-Raj S. Management of chemotherapy-induced thrombocytopenia: current status of thrombopoietic agents. Semin Hematol 2009, 46:S26-S32.
21. Louria-Hayon I., Frelin C., Ruston J., Gish G., Jin J., Kofler M.M., et al. Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling. Proc Natl Acad Sci U S A 2013, 110:20599-20604.
22. Semple J.W., Freedman J. Platelets and innate immunity. Cell Mol Life Sci 2010, 67:499-511.