Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease

GLIA

Volumn 63, Issue 12, 2015, Pages 2285-2297

  Minkel, Heather R ^a,b   Anwer, Tooba Z ^a,b   Arps, Kara M ^a,b   Brenner, Michael ^b,c   Olsen, Michelle L ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

Gliosis; GLT 1; Glutamate homeostasis; Kir4.1; Potassium buffering

Indexed keywords

BARIUM ION; GLUTAMIC ACID; MESSENGER RNA; POTASSIUM ION; EXCITATORY AMINO ACID TRANSPORTER 2; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ10 (CHANNEL); POTASSIUM; SLC1A2 PROTEIN, MOUSE;

ALEXANDER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; ATAXIA; BRAIN REGION; BRAIN STEM; CELL FUNCTION; CELL MEMBRANE DEPOLARIZATION; DYSPHAGIA; DYSPHONIA; FEMALE; GENE; GENE MUTATION; GLIAL FIBRILLARY ACIDIC PROTEIN GENE; MALE; MOUSE; MYOCLONUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RHOMBENCEPHALON; SPINAL CORD; ANIMAL; BRAIN CORTEX; CELL CULTURE; FAR WESTERN BLOTTING; GENETICS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL; METABOLISM; PATCH CLAMP TECHNIQUE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TISSUE CULTURE TECHNIQUE; TRANSGENIC MOUSE;

ALEXANDER DISEASE; ANIMALS; ASTROCYTES; BLOTTING, FAR-WESTERN; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID TRANSPORTER 2; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIALS; MICE, TRANSGENIC; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RHOMBENCEPHALON; RNA, MESSENGER; SPINAL CORD; TISSUE CULTURE TECHNIQUES;

EID: 84943586191     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22893     Document Type: Article

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