How effective are common medications: A perspective based on meta-analyses of major drugs

BMC Medicine

Volumn 13, Issue 1, 2015, Pages

  Leucht, Stefan ^a   Helfer, Bartosz ^a   Gartlehner, Gerald ^b,c   Davis, John M ^d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b DANUBE UNIVERSITY KREMS   (Austria)

^c RTI INTERNATIONAL   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Absolute risk or response difference; Common medications; Depression; Drug classes; Drug efficacy; Mean difference; Medication efficacy; Meta analysis; Percentage response ratio; Pharmacological interventions; Schizophrenia; Standardized mean difference

Indexed keywords

ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; OXYCODONE; PARACETAMOL;

ARTICLE; DRUG EFFICACY; EFFECT SIZE; EVIDENCE BASED MEDICINE; HUMAN; MEDICAL DECISION MAKING; MEDICAL EDUCATION; META ANALYSIS; MONOTHERAPY; OUTCOME ASSESSMENT; PERSONALIZED MEDICINE; PRACTICE GUIDELINE; META ANALYSIS (TOPIC); RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT OUTCOME;

HUMANS; META-ANALYSIS AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84943584113     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-015-0494-1     Document Type: Article

References (32)

1. Bastian H, Glasziou P, Chalmers I. Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? PLoS Med. 2010;7:e1000326. doi: 10.1371/journal.pmed.1000326.
2. Gigerenzer G, Muir Gray J. Better doctors, better patients, better decisions: Envisioning health care 2020. Cambridge, MA: MIT Press; 2011.
3. Lenzer J. Unnecessary care: are doctors in denial and is profit driven healthcare to blame? BMJ. 2012;345:e6230. doi: 10.1136/bmj.e6230.
4. Leucht S, Hierl S, Kissling W, Dold M, Davis JM. Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses. Br J Psychiatry. 2012;200:97-106. doi: 10.1192/bjp.bp.111.096594.
5. Aitken M, Kleinrock M, Lyle J, Caskey L. Medicine use and shifting costs of healthcare. A review of the use of medicines in the United States in 2013. Danbury, CT: IMS Institute for Healthcare Informatics; 2014.
6. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988.
7. Shea BJ, Hamel C, Wells GA, Bouter LM, Kristjansson E, Grimshaw J, et al. AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol. 2009;62:1013-20. doi: 10.1016/j.jclinepi.2008.10.009.
8. Khan M, Santana J, Donnellan C, Preston C, Moayyedi P. Medical treatments in the short term management of reflux oesophagitis. Cochrane Database Syst Rev. 2007;2:CD003244. doi: 10.1002/14651858.CD003244.pub2.
9. Moore RA, Derry S, McQuay HJ, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011;9:CD008659. doi: 10.1002/14651858.CD008659.pub2.
10. Law M, Morris JK, Jordan R, Wald N. Headaches and the treatment of blood pressure: results from a meta-analysis of 94 randomized placebo-controlled trials with 24,000 participants. Circulation. 2005;112:2301-6. doi: 10.1161/CIRCULATIONAHA.104.529628.
11. Antithrombotic Trialists C, Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009;373:1849-60. doi: 10.1016/S0140-6736(09)60503-1.
12. Undurraga J, Baldessarini RJ. Randomized, placebo-controlled trials of antidepressants for acute major depression: thirty-year meta-analytic review. Neuropsychopharmacology. 2012;37:851-64. doi: 10.1038/npp.2011.306.
13. Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003;41:582-92. doi: 10.1097/01.MLR.0000062554.74615.4C.
14. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ. 2003;326:1423. doi: 10.1136/bmj.326.7404.1423.
15. Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005;366:1267-78. doi: 10.1016/S0140-6736(05)67394-1.
16. Turnbull F, Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet. 2003;362:1527-35.
17. Saenz A, Fernandez-Esteban I, Mataix A, Ausejo M, Roque M, Moher D. Metformin monotherapy for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2005;3:CD002966. doi: 10.1002/14651858.CD002966.pub3.
18. Boussageon R, Supper I, Bejan-Angoulvant T, Kellou N, Cucherat M, Boissel JP, et al. Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials. PLoS Med. 2012;9:e1001204. doi: 10.1371/journal.pmed.1001204.
19. Covey J. A meta-analysis of the effects of presenting treatment benefits in different formats. Med Decis Making. 2007;27:638-54. doi: 10.1177/0272989X07306783.
20. Glue P, Donovan MR, Kolluri S, Emir B. Meta-analysis of relapse prevention antidepressant trials in depressive disorders. Aust N Z J Psychiatry. 2010;44:697-705. doi: 10.3109/00048671003705441.
21. van Deemter K. Not exactly: In praise of vagueness. Oxford: Oxford University Press; 2010.
22. Kahneman D. Thinking fast and slow. New York, NY: Farrar, Straus and Giroux; 2011.
23. Birks J. Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev. 2006;1:CD005593. doi: 10.1002/14651858.CD005593.
24. Faraone SV, Buitelaar J. Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. Eur Child Adolesc Psychiatry. 2010;19:353-64. doi: 10.1007/s00787-009-0054-3.
25. Holbrook AM, Crowther R, Lotter A, Cheng C, King D. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ. 2000;162:225-33.
26. Leucht S, Arbter D, Engel RR, Kissling W, Davis JM. How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials. Mol Psychiatry. 2009;14:429-47. doi: 10.1038/sj.mp.4002136.
27. MacLean C, Newberry S, Maglione M, McMahon M, Ranganath V, Suttorp M, et al. Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med. 2008;148:197-213.
28. Nabi G, Cody JD, Ellis G, Herbison P, Hay-Smith J. Anticholinergic drugs versus placebo for overactive bladder syndrome in adults. Cochrane Database Syst Rev. 2006;4:CD003781. doi: 10.1002/14651858.CD003781.pub2.
29. Sin DD, Man J, Sharpe H, Gan WQ, Man SF. Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysis. JAMA. 2004;292:367-76. doi: 10.1001/jama.292.3.367.
30. Barr RG, Bourbeau J, Camargo CA, Ram FS. Tiotropium for stable chronic obstructive pulmonary disease: A meta-analysis. Thorax. 2006;61:854-62. doi: 10.1136/thx.2006.063271.
31. Derry CJ, Derry S, Moore RA. Sumatriptan (oral route of administration) for acute migraine attacks in adults. Cochrane Database Syst Rev. 2012;2:CD008615. doi: 10.1002/14651858.CD008615.pub2.
32. Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, et al. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004;351:2498-508. doi: 10.1056/NEJMoa033447.