IFN-γ prevents adenosine receptor (A2bR) upregulation to sustain the macrophage activation response

Journal of Immunology

Volumn 195, Issue 8, 2015, Pages 3828-3837

  Cohen, Heather B ^a,c   Ward, Amanda ^a   Hamidzadeh, Kajal ^a   Ravid, Katya ^b   Mosser, David M ^a  

^a University of Maryland   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMD Serono Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE 2B RECEPTOR; ADENOSINE RECEPTOR; ARGINASE 1; CD39 ANTIGEN; GAMMA INTERFERON; HEME OXYGENASE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 33; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADENOSINE A2B RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; DESENSITIZATION; DOWN REGULATION; FEMALE; GENE DELETION; GENE OVEREXPRESSION; HOST RESISTANCE; HYDROLYSIS; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION; ANIMAL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; UPREGULATION;

ANIMALS; FEMALE; INTERFERON-GAMMA; INTERLEUKIN-12; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, KNOCKOUT; RECEPTOR, ADENOSINE A2B; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84943565907     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1501139     Document Type: Article

References (32)

1. Maisonneuve, C., S. Bertholet, D. J. Philpott, and E. De Gregorio. 2014. Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants. Proc. Natl. Acad. Sci. USA 111:12294-12299.
2. Mosser, D. M., and J. P. Edwards. 2008. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8:958-969.
3. Cohen, H. B., K. T. Briggs, J. P. Marino, K. Ravid, S. C. Robson, and D. M. Mosser. 2013. TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses. Blood 122:1935-1945.
4. Haskó, G., D. G. Kuhel, J. F. Chen, M. A. Schwarzschild, E. A. Deitch, J. G. Mabley, A. Marton, and C. Szabó. 2000. Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J. 14:2065-2074.
5. Haskó, G., and P. Pacher. 2012. Regulation of macrophage function by adenosine. Arterioscler. Thromb. Vasc. Biol. 32:865-869.
6. Schoenborn, J. R., and C. B. Wilson. 2007. Regulation of interferon-gamma during innate and adaptive immune responses. Adv. Immunol. 96:41-101.
7. Scharton, T. M., and P. Scott. 1993. Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 178:567-577.
8. Hu, X., S. D. Chakravarty, and L. B. Ivashkiv. 2008. Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunol. Rev. 226:41-56.
9. Gordon, R. A., G. Grigoriev, A. Lee, G. D. Kalliolias, and L. B. Ivashkiv. 2012. The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor a and counter-regulated by the synovial fluid microenvironment. Arthritis Rheum. 64:3119-3128.
10. Haskó, G., J. Linden, B. Cronstein, and P. Pacher. 2008. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug Discov. 7:759-770.
11. St Hilaire, C., S. H. Carroll, H. Chen, and K. Ravid. 2009. Mechanisms of induction of adenosine receptor genes and its functional significance. J. Cell. Physiol. 218:35-44.
12. Yang, D., Y. Zhang, H. G. Nguyen, M. Koupenova, A. K. Chauhan, M. Makitalo, M. R. Jones, C. St Hilaire, D. C. Seldin, P. Toselli, et al. 2006. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J. Clin. Invest. 116:1913-1923.
13. Johnson, C. R., D. Kitz, and J. R. Little. 1983. A method for the derivation and continuous propagation of cloned murine bone marrow macrophages. J. Immunol. Methods 65:319-332.
14. Edwards, J. P., X. Zhang, K. A. Frauwirth, and D. M. Mosser. 2006. Biochemical and functional characterization of three activated macrophage populations. J. Leukoc. Biol. 80:1298-1307.
15. Fleming, B. D., P. Chandrasekaran, L. A. Dillon, E. Dalby, R. Suresh, A. Sarkar, N. M. El-Sayed, and D. M. Mosser. 2015. The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling. J. Leukoc. Biol. 98:395-407.
16. Schroder, K., P. J. Hertzog, T. Ravasi, and D. A. Hume. 2004. Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75:163-189.
17. Ji, X., Y. C. Kim, D. G. Ahern, J. Linden, and K. A. Jacobson. 2001. [3H]MRS 1754, a selective antagonist radioligand for A (2B) adenosine receptors. Biochem. Pharmacol. 61:657-663.
18. Ito, R., M. Shin-Ya, T. Kishida, A. Urano, R. Takada, J. Sakagami, J. Imanishi, M. Kita, Y. Ueda, Y. Iwakura, et al. 2006. Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice. Clin. Exp. Immunol. 146:330-338.
19. Koupenova, M., and K. Ravid. 2013. Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism. J. Cell. Physiol. DOI: 10.1002/jcp. 24352.
20. Fredholm, B. B. 2007. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 14:1315-1323.
21. Ohta, A., and M. Sitkovsky. 2001. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414:916-920.
22. Edwards, J. P., X. Zhang, and D. M. Mosser. 2009. The expression of heparinbinding epidermal growth factor-like growth factor by regulatory macrophages. J. Immunol. 182:1929-1939.
23. Fredholm, B. B., E. Irenius, B. Kull, and G. Schulte. 2001. Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem. Pharmacol. 61:443-448.
24. Sun, Y., Y. Duan, A. S. Eisenstein, W. Hu, A. Quintana, W. K. Lam, Y. Wang, Z. Wu, K. Ravid, and P. Huang. 2012. A novel mechanism of control of NFkB activation and inflammation involving A2B adenosine receptors. J. Cell Sci. 125:4507-4517.
25. St Hilaire, C., M. Koupenova, S. H. Carroll, B. D. Smith, and K. Ravid. 2008. TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD (P) H oxidase 4. Biochem. Biophys. Res. Commun. 375:292-296.
26. Kong, T., K. A. Westerman, M. Faigle, H. K. Eltzschig, and S. P. Colgan. 2006. HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J. 20:2242-2250.
27. Xu, Y., K. Ravid, and B. D. Smith. 2008. Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling. J. Biol. Chem. 283:14213-14220.
28. Belikoff, B. G., L. J. Vaickus, M. Sitkovsky, and D. G. Remick. 2012. A2B adenosine receptor expression by myeloid cells is proinflammatory in murine allergic-airway inflammation. J. Immunol. 189:3707-3713.
29. Hu, X., J. Chen, L. Wang, and L. B. Ivashkiv. 2007. Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J. Leukoc. Biol. 82:237-243.
30. St Hilaire, C., D. Yang, B. M. Schreiber, and K. Ravid. 2008. B-Myb regulates the A (2B) adenosine receptor in vascular smooth muscle cells. J. Cell. Biochem. 103:1962-1974.
31. Michetti, P., M. Stelle, P. Juillerat, M. Gassull, F. J. Heil, E. Stange, C. Mottet, J.-J. Gonvers, V. Pittet, J.-P. Vader, et al. 2009. Appropriateness of therapy for active Crohn's disease: Results of a multidisciplinary international expert panel-EPACT II. J. Crohn's Colitis 3:232-240.
32. Sottofattori, E., M. Anzaldi, and L. Ottonello. 2001. HPLC determination of adenosine in human synovial fluid. J. Pharm. Biomed. Anal. 24:1143-1146.