Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial

Archives of Gerontology and Geriatrics

Volumn 61, Issue 3, 2015, Pages 443-451

  Nishida, Yuichiro ^a   Tanaka, Keitaro ^a   Hara, Megumi ^a   Hirao, Noriko ^b   Tanaka, Hiroaki ^b   Tobina, Takuro ^c   Ikeda, Masaharu ^d   Yamato, Hiroshi ^e   Ohta, Masanori ^e  

^a SAGA UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c UNIVERSITY OF NAGASAKI   (Japan)

^d Fukuseikai Hospital   (Japan)

^e UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Aerobic exercise; Aging; HDL C; Inflammation; Interleukins

Indexed keywords

ADIPONECTIN; CYTOKINE; GAMMA INTERFERON; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 15; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYMPHOTOXIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; IL4 PROTEIN, HUMAN; TNF PROTEIN, HUMAN;

AGED; ANALYTICAL PARAMETERS; ARTICLE; BENCH STEP EXERCISE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CORRELATIONAL STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HOME CARE; HUMAN; HUMAN EXPERIMENT; INFLAMMATORY STATUS FACTOR; JAPANESE (PEOPLE); KINESIOTHERAPY; LACTATE THRESHOLD; NORMAL HUMAN; POSTMENOPAUSE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; EXERCISE; JAPAN; MALE; OUTCOME ASSESSMENT; PHYSIOLOGY; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CHOLESTEROL, HDL; CYTOKINES; EXERCISE; EXERCISE THERAPY; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; INTERLEUKIN-4; INTERLEUKIN-6; INTERLEUKIN-8; JAPAN; LIPIDS; MALE; OUTCOME ASSESSMENT (HEALTH CARE); TUMOR NECROSIS FACTOR-ALPHA;

EID: 84943449624     PISSN: 01674943     EISSN: 18726976     Source Type: Journal    
DOI: 10.1016/j.archger.2015.06.017     Document Type: Article

References (49)

1. Ando D., Hosaka Y., Suzuki K., Yamagata Z. Effects of exercise training on circulating high molecular weight adiponectin and adiponectin oligomer composition: a randomized controlled trial. Journal of Atherosclerosis and Thrombosis 2009, 16:733-739.
2. Ayabe M., Yahiro T., Mori Y., Takayama K., Tobina T., Higuchi H., et al. Simple assessment of lactate threshold by means of the bench stepping in older population. International Journal of Sport and Health Science 2003, 1:207-215.
3. Balducci S., Zanuso S., Nicolucci A., Fernando F., Cavallo S., Cardelli P., et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutrition Metabolism and Cardiovascular Diseases 2010, 20:608-617.
4. Beavers K.M., Brinkley T.E., Nicklas B.J. Effect of exercise training on chronic inflammation. Clinica Chimica Acta 2010, 411:785-793.
5. Ferrucci L., Corsi A., Lauretani F., Bandinelli S., Bartali B., Taub D.D., et al. The origins of age-related proinflammatory state. Blood 2005, 105:2294-2299.
6. Forsythe L.K., Wallace J.M., Livingstone M.B. Obesity and inflammation: the effects of weight loss. Nutrition Research Reviews 2008, 21:117-133.
7. Gerszten R.E., Garcia-Zepeda E.A., Lim Y.C., Yoshida M., Ding H.A., Gimbrone M.A., et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999, 398:718-723.
8. Goldhammer E., Tanchilevitch A., Maor I., Beniamini Y., Rosenschein U., Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. International Journal of Cardiology 2005, 100:93-99.
9. Hardardottir I., Grunfeld C., Feingold K.R. Effects of endotoxin and cytokines on lipid metabolism. Current Opinion in Lipidology 1994, 5:207-215.
10. Harris T.B., Ferrucci L., Tracy R.P., Corti M.C., Wacholder S., Ettinger W.H., et al. Associations of elevated interleukin-6 and c-reactive protein levels with mortality in the elderly. The American Journal of Medicine 1999, 106:506-512.
11. Harvey E.J., Ramji D.P. Interferon-γ and atherosclerosis: pro- or anti-atherogenic?. Cardiovascular Research 2005, 67:11-20.
12. Houtkamp M.A., van Der Wal A.C., de Boer O.J., van Der Loos C.M., de Boer P.A., Moorman A.F., et al. Interleukin-15 expression in atherosclerotic plaques: an alternative pathway for T-cell activation in atherosclerosis?. Arteriosclerosis Thrombosis and Vascular Biology 2001, 21:1208-1213.
13. Kashiwagi A., Kasuga M., Araki E., Oka Y., Hanafusa T., Ito H., et al. Committee on the Standardization of Diabetes Mellitus-Related Laboratory Testing of Japan Diabetes: international clinical harmonization of glycated hemoglobin in Japan: From Japan diabetes society to national glycohemoglobin standardization program values. Journal of Diabetes Investigation 2012, 3:39-40.
14. Kumagai S., Shono N., Kondo Y., Nishizumi M. The effect of endurance training on the relationships between sex hormone binding globulin, high density lipoprotein cholesterol, apoprotein A1 and physical fitness in pre-menopausal women with mild obesity. International Journal of Obesity and Related Metabolic Disorders 1994.
15. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2002, 105:1135-1143.
16. Loprinzi P.D. Frequency of moderate-to-vigorous physical activity (MVPA) is a greater predictor of systemic inflammation than total weekly volume of MVPA: implications for physical activity promotion. Physiology & Behavior 2015, 141:46-50.
17. Marques E.A., Mota J., Viana J.L., Tuna D., Figueiredo P., Guimaraes J.T., et al. Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women. Archives of Gerontology and Geriatrics 2013, 57:226-233.
18. Mori Y., Tobina T., Shirasaya K., Kiyonaga A., Shindo M., Tanaka H. Long-term effects of home-based bench-stepping exercise training on healthcare expenditure for elderly Japanese. Journal of Epidemiology 2011, 21:363-369.
19. Motoyama M., Sunami Y., Kinoshita F., Irie T., Sasaki J., Arakawa K., et al. The effects of long-term low intensity aerobic training and detraining on serum lipid and lipoprotein concentrations in elderly men and women. European Journal of Applied Physiology and Occupational Physiology 1995, 70:126-131.
20. Nagano H., Mitchell R.N., Taylor M.K., Hasegawa S., Tilney N.L., Libby P. Interferon-γ deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. The Journal of Clinical Investigation 1997, 100:550-557.
21. Nishida Y., Higaki Y., Taguchi N., Hara M., Nakamura K., Nanri H., et al. Objectively measured physical activity and inflammatory cytokine levels in middle-aged Japanese people. Preventive Medicine 2014, 64:81-87.
22. Ohashi R., Mu H., Wang X., Yao Q., Chen C. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. The Quarterly Journal of Medicine 2005, 98:845-856.
23. Ohta M., Hirao N., Mori Y., Doi Y., Takigami C., Eguchi M., et al. Effects of step exercise on leptin resistance and oxidative stress in elderly females. Japanese Journal of Cardiovascular Diseases & Diagnosis and Prevention 2008, 43:55-62. (in Japanese).
24. Ohta M., Hirao N., Mori Y., Takigami C., Eguchi M., Tanaka H., et al. Effects of bench step exercise on arterial stiffness in post-menopausal women: Contribution of IGF-1 bioactivity and nitric oxide production. Growth Hormone & IGF Research 2012, 22:36-41.
25. Pai J.K., Pischon T., Ma J., Manson J.E., Hankinson S.E., Joshipura K., et al. Inflammatory markers and the risk of coronary heart disease in men and women. The New England Journal of Medicine 2004, 351:2599-2610.
26. Palmefors H., DuttaRoy S., Rundqvist B., Borjesson M. The effect of physical activity or exercise on key biomarkers in atherosclerosis-a systematic review. Atherosclerosis 2014, 235:150-161.
27. Penninx B.W., Kritchevsky S.B., Newman A.B., Nicklas B.J., Simonsick E.M., Rubin S., et al. Inflammatory markers and incident mobility limitation in the elderly. Journal of the American Geriatrics Society 2004, 52:1105-1113.
28. Raisanen-Sokolowski A., Glysing-Jensen T., Koglin J., Russell M.E. Reduced transplant arteriosclerosis in murine cardiac allografts placed in interferon-γ knockout recipients. The American Journal of Pathology 1998, 152:359-365.
29. Reed J.L., De Souza M.J., Williams N.I. Effects of exercise combined with caloric restriction on inflammatory cytokines. Applied Physiology Nutrition and Metabolism 2010, 35:573-582.
30. Ridker P.M., Rifai N., Pfeffer M., Sacks F., Lepage S., Braunwald E. Elevation of tumor necrosis factor-α and increased risk of recurrent coronary events after myocardial infarction. Circulation 2000, 101:2149-2153.
31. Ridker P.M., Rifai N., Stampfer M.J., Hennekens C.H. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000, 101:1767-1772.
32. Riedl I., Yoshioka M., Nishida Y., Tobina T., Paradis R., Shono N., et al. Regulation of skeletal muscle transcriptome in elderly men after 6 weeks of endurance training at lactate threshold intensity. Experimental Gerontology 2010, 45:896-903.
33. Ross R. Atherosclerosis-an inflammatory disease. The New England Journal of Medicine 1999, 340:115-126.
34. Roubenoff R. Catabolism of aging: is it an inflammatory process?. Current Opinion in Clinical Nutrition and Metabolic Care 2003, 6:295-299.
35. Sasaki J., Urata H., Tanabe Y., Kinoshita A., Tanaka H., Shindo M., et al. Mild exercise therapy increases serum high density lipoprotein2 cholesterol levels in patients with essential hypertension. The American Journal of the Medical Sciences 1989, 297:220-223.
36. Schroder K., Hertzog P.J., Ravasi T., Hume D.A. Interferon: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology 2004, 75:163-189.
37. Smith J.K., Dykes R., Douglas J.E., Krishnaswamy G., Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA 1999, 281:1722-1727.
38. Sunami Y., Motoyama M., Kinoshita F., Mizooka Y., Sueta K., Matsunaga A., et al. Effects of low-intensity aerobic training on the high-density lipoprotein cholesterol concentration in healthy elderly subjects. Metabolism: Clinical and Experimental 1999, 48:984-988.
39. Tam C.S., Covington J.D., Ravussin E., Redman L.M., Pennington C.T. Little evidence of systemic and adipose tissue inflammation in overweight individuals. Frontiers in Genetics 2012, 3:58.
40. Tellides G., Tereb D.A., Kirkiles-Smith N.C., Kim R.W., Wilson J.H., Schechner J.S., et al. Interferon-γ elicits arteriosclerosis in the absence of leukocytes. Nature 2000, 403:207-211.
41. ACSM's guideline for exercise testing and prescription 2011, 114-141. Lippincott Williams & Wilkins, Philadelphia. 9th ed. W.R. Thompson, N.F. Gordon, L.S. Pescatello (Eds.).
42. Tokmakidis S.P., Leger L.A., Pilianidis T.C. Failure to obtain a unique threshold on the blood lactate concentration curve during exercise. European Journal of Applied Physiology and Occupational Physiology 1998, 77:333-342.
43. Urata H., Sasaki J., Tanabe Y., Kiyonaga A., Yoshida T., Tanaka H., et al. Effect of mild aerobic exercise on serum lipids and apolipoproteins in patients with coronary artery disease. Japanese Heart Journal 1987, 28:27-34.
44. Volpato S., Palmieri E., Fellin R., Zuliani G. Acute phase markers are associated with reduced plasma lipid levels in a population of hospitalized elderly patients. Gerontology 2000, 46:22-27.
45. Wanderley F.A., Moreira A., Sokhatska O., Palmares C., Moreira P., Sandercock G., et al. Differential responses of adiposity, inflammation and autonomic function to aerobic versus resistance training in older adults. Experimental Gerontology 2013, 48:326-333.
46. Welty F.K. How do elevated triglycerides and low HDL-cholesterol affect inflammation and atherothrombosis?. Current Cardiology Reports 2013, 15:400.
47. Whitman S.C., Ravisankar P., Elam H., Daugherty A. Exogenous interferon-γ enhances atherosclerosis in apolipoprotein E-/- mice. The American Journal of Pathology 2000, 157:1819-1824.
48. Yoshida T., Chida M., Ichioka M., Suda Y. Blood lactate parameters related to aerobic capacity and endurance performance. European Journal of Applied Physiology and Occupational Physiology 1987, 56:7-11.
49. Zuliani G., Volpato S., Ble A., Bandinelli S., Corsi A.M., Lauretani F., et al. High interleukin-6 plasma levels are associated with low HDL-c levels in community-dwelling older adults: The inchianti study. Atherosclerosis 2007, 192:384-390.