-
1
-
-
84881572631
-
-
More information is available online
-
Cancer Facts and Statistics. More information is available online: http://www. cancer.org/research/cancerfactsstatistics/. The American Cancer Society 2014.
-
Cancer Facts and Statistics
-
-
-
2
-
-
44249111440
-
EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxa-liplatin failure in patients with metastatic colorectal cancer
-
Sobrero AF, Maurel J, Fehrenbacher L, Scheithauer W, Abubakr YA, Lutz MP et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxa-liplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 2311–2319.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2311-2319
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
Scheithauer, W.4
Abubakr, Y.A.5
Lutz, M.P.6
-
3
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25: 1658–1664.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
-
4
-
-
36148941301
-
Cetuximab for the treatment of colorectal cancer
-
Jonker DJ, O'Callaghan CJ, Karapetis CS, Zalcberg JR, Tu D, Au HJ et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007; 357: 2040–2048.
-
(2007)
N Engl J Med
, vol.357
, pp. 2040-2048
-
-
Jonker, D.J.1
O'callaghan, C.J.2
Karapetis, C.S.3
Zalcberg, J.R.4
Tu, D.5
Au, H.J.6
-
5
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337–345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
-
6
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lievre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008; 26: 374–379.
-
(2008)
J Clin Oncol
, vol.26
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.B.2
Boige, V.3
Cayre, A.4
Le Corre, D.5
Buc, E.6
-
7
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, O'Callaghan CJ, Tu D, Tebbutt NC et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008; 359: 1757–1765.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
O'callaghan, C.J.4
Tu, D.5
Tebbutt, N.C.6
-
8
-
-
77349091815
-
NetPath: A public resource of curated signal transduction pathways
-
Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK et al. NetPath: a public resource of curated signal transduction pathways. Genome Biol 2010; 11: R3.
-
(2010)
Genome Biol
, vol.11
, pp. R3
-
-
Kandasamy, K.1
Mohan, S.S.2
Raju, R.3
Keerthikumar, S.4
Kumar, G.S.5
Venugopal, A.K.6
-
9
-
-
79957523828
-
KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
-
De Roock W, De Vriendt V, Normanno N, Ciardiello F, Tejpar S. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol 2011; 12: 594–603.
-
(2011)
Lancet Oncol
, vol.12
, pp. 594-603
-
-
de Roock, W.1
de Vriendt, V.2
Normanno, N.3
Ciardiello, F.4
Tejpar, S.5
-
10
-
-
73349094741
-
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
-
Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 2009; 27: 5924–5930.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5924-5930
-
-
Laurent-Puig, P.1
Cayre, A.2
Manceau, G.3
Buc, E.4
Bachet, J.B.5
Lecomte, T.6
-
11
-
-
25144491785
-
Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: An immunohistochemical and chromogenic in situ hybridization study
-
Shia J, Klimstra DS, Li AR, Qin J, Saltz L, Teruya-Feldstein J et al. Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study. Modern Pathol 2005; 18: 1350–1356.
-
(2005)
Modern Pathol
, vol.18
, pp. 1350-1356
-
-
Shia, J.1
Klimstra, D.S.2
Li, A.R.3
Qin, J.4
Saltz, L.5
Teruya-Feldstein, J.6
-
12
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005; 23: 1803–1810.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
Shah, M.4
Schwartz, G.K.5
Tse, A.6
-
13
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22: 1201–1208.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer, P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
15
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003; 21: 2787–2799.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
16
-
-
66749120729
-
A gene expression predictor of response to EGFR-targeted therapy stratifies progression-free survival to cetuximab in KRAS wild-type metastatic colorectal cancer
-
Balko JM, Black EP. A gene expression predictor of response to EGFR-targeted therapy stratifies progression-free survival to cetuximab in KRAS wild-type metastatic colorectal cancer. BMC cancer 2009; 9: 145.
-
(2009)
BMC Cancer
, vol.9
-
-
Balko, J.M.1
Black, E.P.2
-
17
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S, Garrett CR, Meropol NJ, Basik M, Harbison CT, Wu S et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007; 25: 3230–3237.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
Basik, M.4
Harbison, C.T.5
Wu, S.6
-
18
-
-
84873027952
-
Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes
-
Pentheroudakis G, Kotoula V, De Roock W, Kouvatseas G, Papakostas P, Makatsoris T et al. Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC cancer 2013; 13: 49.
-
(2013)
BMC Cancer
, vol.13
-
-
Pentheroudakis, G.1
Kotoula, V.2
de Roock, W.3
Kouvatseas, G.4
Papakostas, P.5
Makatsoris, T.6
-
19
-
-
40949135397
-
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
-
Jhawer M, Goel S, Wilson AJ, Montagna C, Ling YH, Byun DS et al. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res 2008; 68: 1953–1961.
-
(2008)
Cancer Res
, vol.68
, pp. 1953-1961
-
-
Jhawer, M.1
Goel, S.2
Wilson, A.J.3
Montagna, C.4
Ling, Y.H.5
Byun, D.S.6
-
20
-
-
84898016427
-
Oncofinder, a new method for the analysis of intracellular signaling pathway activation using transcriptomic data
-
Buzdin AA, Zhavoronkov AA, Korzinkin MB, Venkova LS, Zenin AA, Smirnov PY et al. Oncofinder, a new method for the analysis of intracellular signaling pathway activation using transcriptomic data. Front Genet 2014; 5: 55.
-
(2014)
Front Genet
, vol.5
, pp. 55
-
-
Buzdin, A.A.1
Zhavoronkov, A.A.2
Korzinkin, M.B.3
Venkova, L.S.4
Zenin, A.A.5
Smirnov, P.Y.6
-
21
-
-
84920927962
-
The OncoFinder algorithm for minimizing the errors introduced by the high-throughput methods of transcriptome analysis
-
Buzdin AA, Zhavoronkov A, Korzinkin M, Roumiantsev SA, Aliper AM, Venkova LS et al. The OncoFinder algorithm for minimizing the errors introduced by the high-throughput methods of transcriptome analysis. Front Mol Biosci 2014; 1.
-
(2014)
Front Mol Biosci
, vol.1
-
-
Buzdin, A.A.1
Zhavoronkov, A.2
Korzinkin, M.3
Roumiantsev, S.A.4
Aliper, A.M.5
Venkova, L.S.6
-
22
-
-
84910088739
-
Signaling pathway activation profiles make better markers of cancer than expression of individual genes
-
Borisov NM, Terekhanova NV, Aliper AM, Venkova LS, Smirnov PY, Roumiantsev S et al. Signaling pathway activation profiles make better markers of cancer than expression of individual genes. Oncotarget 2014; 5: 10198–10205.
-
(2014)
Oncotarget
, vol.5
, pp. 10198-10205
-
-
Borisov, N.M.1
Terekhanova, N.V.2
Aliper, A.M.3
Venkova, L.S.4
Smirnov, P.Y.5
Roumiantsev, S.6
-
23
-
-
33846946523
-
Personal mouse colonies give hope for pancreatic cancer patients
-
Garber K. Personal mouse colonies give hope for pancreatic cancer patients. J Natl Cancer Inst 2007; 99: 105–107.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 105-107
-
-
Garber, K.1
-
24
-
-
84856695586
-
Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft
-
Morelli MP, Calvo E, Ordonez E, Wick MJ, Viqueira BR, Lopez-Casas PP et al. Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft. J Clin Oncol 2012; 30: e45–e48.
-
(2012)
J Clin Oncol
, vol.30
, pp. e45-e48
-
-
Morelli, M.P.1
Calvo, E.2
Ordonez, E.3
Wick, M.J.4
Viqueira, B.R.5
Lopez-Casas, P.P.6
-
25
-
-
80051588648
-
A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer
-
Hidalgo M, Bruckheimer E, Rajeshkumar NV, Garrido-Laguna I, De Oliveira E, Rubio-Viqueira B et al. A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer. Mol Cancer Ther 2011; 10: 1311–1316.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1311-1316
-
-
Hidalgo, M.1
Bruckheimer, E.2
Rajeshkumar, N.V.3
Garrido-Laguna, I.4
de Oliveira, E.5
Rubio-Viqueira, B.6
-
26
-
-
33748088524
-
An in vivo platform for translational drug development in pancreatic cancer
-
Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C et al. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res 2006; 12: 4652–4661.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4652-4661
-
-
Rubio-Viqueira, B.1
Jimeno, A.2
Cusatis, G.3
Zhang, X.4
Iacobuzio-Donahue, C.5
Karikari, C.6
-
27
-
-
84902545660
-
Patient-derived xenografts for individualized care in advanced sarcoma
-
Stebbing J, Paz K, Schwartz GK, Wexler LH, Maki R, Pollock RE et al. Patient-derived xenografts for individualized care in advanced sarcoma. Cancer 2014; 120: 2006–2015.
-
(2014)
Cancer
, vol.120
, pp. 2006-2015
-
-
Stebbing, J.1
Paz, K.2
Schwartz, G.K.3
Wexler, L.H.4
Maki, R.5
Pollock, R.E.6
-
28
-
-
0036081355
-
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
-
Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002; 30: 207–210.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 207-210
-
-
Edgar, R.1
Domrachev, M.2
Lash, A.E.3
-
29
-
-
28744458859
-
Bio-conductor: Open software development for computational biology and bioinfor-matics
-
Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S et al. Bio-conductor: open software development for computational biology and bioinfor-matics. Genome Biol 2004; 5: R80.
-
(2004)
Genome Biol
, vol.5
-
-
Gentleman, R.C.1
Carey, V.J.2
Bates, D.M.3
Bolstad, B.4
Dettling, M.5
Dudoit, S.6
-
31
-
-
33846923608
-
Inducing pairwise gene interactions from time-series data by EDA based bayesian network
-
Dai C, Liu J. Inducing pairwise gene interactions from time-series data by EDA based bayesian network. Conf Proc IEEE Eng Med Bio Soc 2005; 7: 7746–7749.
-
(2005)
Conf Proc IEEE Eng Med Bio Soc
, vol.7
, pp. 7746-7749
-
-
Dai, C.1
Liu, J.2
-
32
-
-
77950571895
-
Gene expression-based prognostic signatures in lung cancer: Ready for clinical use?
-
Subramanian J, Simon R. Gene expression-based prognostic signatures in lung cancer: ready for clinical use? J Natl Cancer Inst 2010; 102: 464–474.
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 464-474
-
-
Subramanian, J.1
Simon, R.2
-
33
-
-
84910070046
-
Novel robust biomarkers for human bladder cancer based on activation of intracellular signaling pathways
-
Lezhnina K, Kovalchuk O, Zhavoronkov AA, Korzinkin MB, Zabolotneva AA, She-gay PV et al. Novel robust biomarkers for human bladder cancer based on activation of intracellular signaling pathways. Oncotarget 2014; 5: 9022–9032.
-
(2014)
Oncotarget
, vol.5
, pp. 9022-9032
-
-
Lezhnina, K.1
Kovalchuk, O.2
Zhavoronkov, A.A.3
Korzinkin, M.B.4
Zabolotneva, A.A.5
She-Gay, P.V.6
-
34
-
-
0032521433
-
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
-
Sparks AB, Morin PJ, Vogelstein B, Kinzler KW. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998; 58: 1130–1134.
-
(1998)
Cancer Res
, vol.58
, pp. 1130-1134
-
-
Sparks, A.B.1
Morin, P.J.2
Vogelstein, B.3
Kinzler, K.W.4
-
35
-
-
84863230264
-
Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling
-
Horst D, Chen J, Morikawa T, Ogino S, Kirchner T, Shivdasani RA. Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling. Cancer Res 2012; 72: 1547–1556.
-
(2012)
Cancer Res
, vol.72
, pp. 1547-1556
-
-
Horst, D.1
Chen, J.2
Morikawa, T.3
Ogino, S.4
Kirchner, T.5
Shivdasani, R.A.6
-
36
-
-
0025634118
-
P53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
-
Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JK et al. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 1990; 50: 7717–7722.
-
(1990)
Cancer Res
, vol.50
, pp. 7717-7722
-
-
Baker, S.J.1
Preisinger, A.C.2
Jessup, J.M.3
Paraskeva, C.4
Markowitz, S.5
Willson, J.K.6
-
37
-
-
84867817838
-
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
-
Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012; 367: 1596–1606.
-
(2012)
N Engl J Med
, vol.367
, pp. 1596-1606
-
-
Liao, X.1
Lochhead, P.2
Nishihara, R.3
Morikawa, T.4
Kuchiba, A.5
Yamauchi, M.6
-
38
-
-
0031872995
-
Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production
-
O'Hara RJ, Greenman J, MacDonald AW, Gaskell KM, Topping KP, Duthie GS et al. Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production. Clin Cancer Res 1998; 4: 1943–1948.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 1943-1948
-
-
O'hara, R.J.1
Greenman, J.2
Macdonald, A.W.3
Gaskell, K.M.4
Topping, K.P.5
Duthie, G.S.6
-
39
-
-
18444404007
-
Circulating levels of interleukin-10 and interleukin-6 in gastric and colon cancer patients before and after surgery: Relationship with radicality and outcome
-
Galizia G, Lieto E, De Vita F, Romano C, Orditura M, Castellano P et al. Circulating levels of interleukin-10 and interleukin-6 in gastric and colon cancer patients before and after surgery: relationship with radicality and outcome. J Interferon Cytokine Res 2002; 22: 473–482.
-
(2002)
J Interferon Cytokine Res
, vol.22
, pp. 473-482
-
-
Galizia, G.1
Lieto, E.2
de Vita, F.3
Romano, C.4
Orditura, M.5
Castellano, P.6
-
40
-
-
0036176551
-
Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery
-
Galizia G, Orditura M, Romano C, Lieto E, Castellano P, Pelosio L et al. Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery. Clin Immunol 2002; 102: 169–178.
-
(2002)
Clin Immunol
, vol.102
, pp. 169-178
-
-
Galizia, G.1
Orditura, M.2
Romano, C.3
Lieto, E.4
Castellano, P.5
Pelosio, L.6
-
41
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335–2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
-
42
-
-
0036332684
-
Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer
-
Cassano A, Bagala C, Battelli C, Schinzari G, Quirino M, Ratto C et al. Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer. Anticancer Res 2002; 22: 2179–2184.
-
(2002)
Anticancer Res
, vol.22
, pp. 2179-2184
-
-
Cassano, A.1
Bagala, C.2
Battelli, C.3
Schinzari, G.4
Quirino, M.5
Ratto, C.6
-
43
-
-
33846662478
-
Overexpression of soluble vascular endothelial growth factor receptor 1 in col-orectal cancer: Association with progression and prognosis
-
Yamaguchi T, Bando H, Mori T, Takahashi K, Matsumoto H, Yasutome M et al. Overexpression of soluble vascular endothelial growth factor receptor 1 in col-orectal cancer: Association with progression and prognosis. Cancer Sci 2007; 98: 405–410.
-
(2007)
Cancer Sci
, vol.98
, pp. 405-410
-
-
Yamaguchi, T.1
Bando, H.2
Mori, T.3
Takahashi, K.4
Matsumoto, H.5
Yasutome, M.6
-
44
-
-
80054122779
-
EGFR-and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies
-
Poindessous V, Ouaret D, El Ouadrani K, Battistella A, Megalophonos VF, Kamsu-Kom N et al. EGFR-and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies. Clin Cancer Res 2011; 17: 6522–6530.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6522-6530
-
-
Poindessous, V.1
Ouaret, D.2
El Ouadrani, K.3
Battistella, A.4
Megalophonos, V.F.5
Kamsu-Kom, N.6
-
45
-
-
34147130694
-
The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
-
Tabernero J. The role of VEGF and EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents. Mol Cancer Res 2007; 5: 203–220.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 203-220
-
-
Tabernero, J.1
-
46
-
-
84893461612
-
PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17
-
Karapetis CS, Jonker D, Daneshmand M, Hanson JE, O'Callaghan CJ, Marginean C et al. PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17. Clin Cancer Res 2014; 20: 744–753.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 744-753
-
-
Karapetis, C.S.1
Jonker, D.2
Daneshmand, M.3
Hanson, J.E.4
O'callaghan, C.J.5
Marginean, C.6
-
47
-
-
84876290460
-
PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: A meta-analysis
-
Wu S, Gan Y, Wang X, Liu J, Li M, Tang Y. PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: a meta-analysis. J Cancer Res Clin Oncol 2013; 139: 891–900.
-
(2013)
J Cancer Res Clin Oncol
, vol.139
, pp. 891-900
-
-
Wu, S.1
Gan, Y.2
Wang, X.3
Liu, J.4
Li, M.5
Tang, Y.6
-
48
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010; 11: 753–762.
-
(2010)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
de Roock, W.1
Claes, B.2
Bernasconi, D.3
de Schutter, J.4
Biesmans, B.5
Fountzilas, G.6
-
49
-
-
52049090365
-
Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21
-
Zhu CQ, da Cunha Santos G, Ding K, Sakurada A, Cutz JC, Liu N et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol 2008; 26: 4268–4275.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4268-4275
-
-
Zhu, C.Q.1
da Cunha Santos, G.2
Ding, K.3
Sakurada, A.4
Cutz, J.C.5
Liu, N.6
-
50
-
-
33750571170
-
Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of sur-vivin expression counteract the antitumor action of erlotinib
-
Morgillo F, Woo JK, Kim ES, Hong WK, Lee HY. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of sur-vivin expression counteract the antitumor action of erlotinib. Cancer Res 2006; 66: 10100–10111.
-
(2006)
Cancer Res
, vol.66
, pp. 10100-10111
-
-
Morgillo, F.1
Woo, J.K.2
Kim, E.S.3
Hong, W.K.4
Lee, H.Y.5
-
51
-
-
70349148288
-
Van Bergen En Henegouwen PM, Roovers RC. Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: Implications for cancer therapy
-
van der Veeken J, Oliveira S, Schiffelers RM, Storm G, van Bergen En Henegouwen PM, Roovers RC. Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: implications for cancer therapy. Curr Cancer Drug Targets 2009; 9: 748–760.
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 748-760
-
-
van der Veeken, J.1
Oliveira, S.2
Schiffelers, R.M.3
Storm, G.4
-
52
-
-
0035920139
-
Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases
-
He H, Levitzki A, Zhu HJ, Walker F, Burgess A, Maruta H. Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases. The Journal of biological chemistry 2001; 276: 26741–26744.
-
(2001)
The Journal of Biological Chemistry
, vol.276
, pp. 26741-26744
-
-
He, H.1
Levitzki, A.2
Zhu, H.J.3
Walker, F.4
Burgess, A.5
Maruta, H.6
-
53
-
-
0034805908
-
Receptor heterodimerization: Essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
-
Saito Y, Haendeler J, Hojo Y, Yamamoto K, Berk BC. Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation. Mol Cell Biol 2001; 21: 6387–6394.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6387-6394
-
-
Saito, Y.1
Haendeler, J.2
Hojo, Y.3
Yamamoto, K.4
Berk, B.C.5
-
54
-
-
79955675804
-
Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression
-
Ware KE, Marshall ME, Heasley LR, Marek L, Hinz TK, Hercule P et al. Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression. PLoS ONE 5: e14117.
-
Plos ONE
, vol.5
, pp. e14117
-
-
Ware, K.E.1
Marshall, M.E.2
Heasley, L.R.3
Marek, L.4
Hinz, T.K.5
Hercule, P.6
-
55
-
-
84875438921
-
A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral onco-gene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines
-
Singleton KR, Kim J, Hinz TK, Marek LA, Casas-Selves M, Hatheway C et al. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral onco-gene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines. Mol Pharmacol 83: 882–893.
-
Mol Pharmacol
, vol.83
, pp. 882-893
-
-
Singleton, K.R.1
Kim, J.2
Hinz, T.K.3
Marek, L.A.4
Casas-Selves, M.5
Hatheway, C.6
-
56
-
-
79956205502
-
Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis
-
Larsen AK, Ouaret D, El Ouadrani K, Petitprez A. Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Ther 131: 80–90.
-
Pharmacol Ther
, vol.131
, pp. 80-90
-
-
Larsen, A.K.1
Ouaret, D.2
El Ouadrani, K.3
Petitprez, A.4
-
57
-
-
74549133965
-
Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epi-thelial cancer development
-
Lichtenberger BM, Tan PK, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epi-thelial cancer development. Cell 140: 268–279.
-
Cell
, vol.140
, pp. 268-279
-
-
Lichtenberger, B.M.1
Tan, P.K.2
Niederleithner, H.3
Ferrara, N.4
Petzelbauer, P.5
Sibilia, M.6
-
58
-
-
84930754589
-
A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/ panitumumab monotherapy
-
Saridaki Z, Weidhaas JB, Lenz HJ, Laurent-Puig P, Jacobs B, De Schutter J et al. A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/ panitumumab monotherapy. Clin Cancer Res 2014; 20: 4499–4510.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 4499-4510
-
-
Saridaki, Z.1
Weidhaas, J.B.2
Lenz, H.J.3
Laurent-Puig, P.4
Jacobs, B.5
de Schutter, J.6
-
59
-
-
79960098041
-
MicroRNA signatures: Novel biomarker for colorectal cancer?
-
Luo X, Burwinkel B, Tao S, Brenner H. MicroRNA signatures: novel biomarker for colorectal cancer? Cancer Epidemiol, Biomarker Prev 2011; 20: 1272–1286.
-
(2011)
Cancer Epidemiol, Biomarker Prev
, vol.20
, pp. 1272-1286
-
-
Luo, X.1
Burwinkel, B.2
Tao, S.3
Brenner, H.4
-
60
-
-
33644853907
-
The colorectal microRNAome
-
Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T et al. The colorectal microRNAome. Proc Natl Acad Sci USA 2006; 103: 3687–3692.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3687-3692
-
-
Cummins, J.M.1
He, Y.2
Leary, R.J.3
Pagliarini, R.4
Diaz, L.A.5
Sjoblom, T.6
-
61
-
-
84893210980
-
MicroRNA signature in metastatic colorectal cancer patients treated with anti-EGFR mono-clonal antibodies
-
Cappuzzo F, Sacconi A, Landi L, Ludovini V, Biagioni F, D'Incecco A et al. MicroRNA signature in metastatic colorectal cancer patients treated with anti-EGFR mono-clonal antibodies. Clin Colorect Cancer 2014; 13: 37–45 e34.
-
(2014)
Clin Colorect Cancer
, vol.13
, pp. 37-45
-
-
Cappuzzo, F.1
Sacconi, A.2
Landi, L.3
Ludovini, V.4
Biagioni, F.5
D'incecco, A.6
-
62
-
-
84862877840
-
High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease
-
Ruzzo A, Graziano F, Vincenzi B, Canestrari E, Perrone G, Galluccio N et al. High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease. The Oncologist 2012; 17: 823–829.
-
(2012)
The Oncologist
, vol.17
, pp. 823-829
-
-
Ruzzo, A.1
Graziano, F.2
Vincenzi, B.3
Canestrari, E.4
Perrone, G.5
Galluccio, N.6
|