메뉴 건너뛰기




Volumn 2, Issue 1, 2015, Pages

Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84943400336     PISSN: None     EISSN: 2054345X     Source Type: Journal    
DOI: 10.1038/hgv.2015.9     Document Type: Article
Times cited : (42)

References (62)
  • 1
    • 84881572631 scopus 로고    scopus 로고
    • More information is available online
    • Cancer Facts and Statistics. More information is available online: http://www. cancer.org/research/cancerfactsstatistics/. The American Cancer Society 2014.
    • Cancer Facts and Statistics
  • 2
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxa-liplatin failure in patients with metastatic colorectal cancer
    • Sobrero AF, Maurel J, Fehrenbacher L, Scheithauer W, Abubakr YA, Lutz MP et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxa-liplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 2311–2319.
    • (2008) J Clin Oncol , vol.26 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3    Scheithauer, W.4    Abubakr, Y.A.5    Lutz, M.P.6
  • 3
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25: 1658–1664.
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6
  • 5
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337–345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 6
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008; 26: 374–379.
    • (2008) J Clin Oncol , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3    Cayre, A.4    Le Corre, D.5    Buc, E.6
  • 9
    • 79957523828 scopus 로고    scopus 로고
    • KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
    • De Roock W, De Vriendt V, Normanno N, Ciardiello F, Tejpar S. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol 2011; 12: 594–603.
    • (2011) Lancet Oncol , vol.12 , pp. 594-603
    • de Roock, W.1    de Vriendt, V.2    Normanno, N.3    Ciardiello, F.4    Tejpar, S.5
  • 10
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 2009; 27: 5924–5930.
    • (2009) J Clin Oncol , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.B.5    Lecomte, T.6
  • 11
    • 25144491785 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: An immunohistochemical and chromogenic in situ hybridization study
    • Shia J, Klimstra DS, Li AR, Qin J, Saltz L, Teruya-Feldstein J et al. Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study. Modern Pathol 2005; 18: 1350–1356.
    • (2005) Modern Pathol , vol.18 , pp. 1350-1356
    • Shia, J.1    Klimstra, D.S.2    Li, A.R.3    Qin, J.4    Saltz, L.5    Teruya-Feldstein, J.6
  • 12
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005; 23: 1803–1810.
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3    Shah, M.4    Schwartz, G.K.5    Tse, A.6
  • 13
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22: 1201–1208.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer, P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 15
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003; 21: 2787–2799.
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 16
    • 66749120729 scopus 로고    scopus 로고
    • A gene expression predictor of response to EGFR-targeted therapy stratifies progression-free survival to cetuximab in KRAS wild-type metastatic colorectal cancer
    • Balko JM, Black EP. A gene expression predictor of response to EGFR-targeted therapy stratifies progression-free survival to cetuximab in KRAS wild-type metastatic colorectal cancer. BMC cancer 2009; 9: 145.
    • (2009) BMC Cancer , vol.9
    • Balko, J.M.1    Black, E.P.2
  • 17
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S, Garrett CR, Meropol NJ, Basik M, Harbison CT, Wu S et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007; 25: 3230–3237.
    • (2007) J Clin Oncol , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3    Basik, M.4    Harbison, C.T.5    Wu, S.6
  • 18
    • 84873027952 scopus 로고    scopus 로고
    • Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes
    • Pentheroudakis G, Kotoula V, De Roock W, Kouvatseas G, Papakostas P, Makatsoris T et al. Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC cancer 2013; 13: 49.
    • (2013) BMC Cancer , vol.13
    • Pentheroudakis, G.1    Kotoula, V.2    de Roock, W.3    Kouvatseas, G.4    Papakostas, P.5    Makatsoris, T.6
  • 19
    • 40949135397 scopus 로고    scopus 로고
    • PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
    • Jhawer M, Goel S, Wilson AJ, Montagna C, Ling YH, Byun DS et al. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res 2008; 68: 1953–1961.
    • (2008) Cancer Res , vol.68 , pp. 1953-1961
    • Jhawer, M.1    Goel, S.2    Wilson, A.J.3    Montagna, C.4    Ling, Y.H.5    Byun, D.S.6
  • 20
    • 84898016427 scopus 로고    scopus 로고
    • Oncofinder, a new method for the analysis of intracellular signaling pathway activation using transcriptomic data
    • Buzdin AA, Zhavoronkov AA, Korzinkin MB, Venkova LS, Zenin AA, Smirnov PY et al. Oncofinder, a new method for the analysis of intracellular signaling pathway activation using transcriptomic data. Front Genet 2014; 5: 55.
    • (2014) Front Genet , vol.5 , pp. 55
    • Buzdin, A.A.1    Zhavoronkov, A.A.2    Korzinkin, M.B.3    Venkova, L.S.4    Zenin, A.A.5    Smirnov, P.Y.6
  • 22
    • 84910088739 scopus 로고    scopus 로고
    • Signaling pathway activation profiles make better markers of cancer than expression of individual genes
    • Borisov NM, Terekhanova NV, Aliper AM, Venkova LS, Smirnov PY, Roumiantsev S et al. Signaling pathway activation profiles make better markers of cancer than expression of individual genes. Oncotarget 2014; 5: 10198–10205.
    • (2014) Oncotarget , vol.5 , pp. 10198-10205
    • Borisov, N.M.1    Terekhanova, N.V.2    Aliper, A.M.3    Venkova, L.S.4    Smirnov, P.Y.5    Roumiantsev, S.6
  • 23
    • 33846946523 scopus 로고    scopus 로고
    • Personal mouse colonies give hope for pancreatic cancer patients
    • Garber K. Personal mouse colonies give hope for pancreatic cancer patients. J Natl Cancer Inst 2007; 99: 105–107.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 105-107
    • Garber, K.1
  • 24
    • 84856695586 scopus 로고    scopus 로고
    • Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft
    • Morelli MP, Calvo E, Ordonez E, Wick MJ, Viqueira BR, Lopez-Casas PP et al. Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft. J Clin Oncol 2012; 30: e45–e48.
    • (2012) J Clin Oncol , vol.30 , pp. e45-e48
    • Morelli, M.P.1    Calvo, E.2    Ordonez, E.3    Wick, M.J.4    Viqueira, B.R.5    Lopez-Casas, P.P.6
  • 27
    • 84902545660 scopus 로고    scopus 로고
    • Patient-derived xenografts for individualized care in advanced sarcoma
    • Stebbing J, Paz K, Schwartz GK, Wexler LH, Maki R, Pollock RE et al. Patient-derived xenografts for individualized care in advanced sarcoma. Cancer 2014; 120: 2006–2015.
    • (2014) Cancer , vol.120 , pp. 2006-2015
    • Stebbing, J.1    Paz, K.2    Schwartz, G.K.3    Wexler, L.H.4    Maki, R.5    Pollock, R.E.6
  • 28
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002; 30: 207–210.
    • (2002) Nucleic Acids Res , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 30
    • 1342288026 scopus 로고    scopus 로고
    • Affy-analysis of Affymetrix GeneChip data at the probe level
    • Gautier L, Cope L, Bolstad BM, Irizarry RA. affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 2004; 20: 307–315.
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3    Irizarry, R.A.4
  • 31
    • 33846923608 scopus 로고    scopus 로고
    • Inducing pairwise gene interactions from time-series data by EDA based bayesian network
    • Dai C, Liu J. Inducing pairwise gene interactions from time-series data by EDA based bayesian network. Conf Proc IEEE Eng Med Bio Soc 2005; 7: 7746–7749.
    • (2005) Conf Proc IEEE Eng Med Bio Soc , vol.7 , pp. 7746-7749
    • Dai, C.1    Liu, J.2
  • 32
    • 77950571895 scopus 로고    scopus 로고
    • Gene expression-based prognostic signatures in lung cancer: Ready for clinical use?
    • Subramanian J, Simon R. Gene expression-based prognostic signatures in lung cancer: ready for clinical use? J Natl Cancer Inst 2010; 102: 464–474.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 464-474
    • Subramanian, J.1    Simon, R.2
  • 34
    • 0032521433 scopus 로고    scopus 로고
    • Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
    • Sparks AB, Morin PJ, Vogelstein B, Kinzler KW. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998; 58: 1130–1134.
    • (1998) Cancer Res , vol.58 , pp. 1130-1134
    • Sparks, A.B.1    Morin, P.J.2    Vogelstein, B.3    Kinzler, K.W.4
  • 35
    • 84863230264 scopus 로고    scopus 로고
    • Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling
    • Horst D, Chen J, Morikawa T, Ogino S, Kirchner T, Shivdasani RA. Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling. Cancer Res 2012; 72: 1547–1556.
    • (2012) Cancer Res , vol.72 , pp. 1547-1556
    • Horst, D.1    Chen, J.2    Morikawa, T.3    Ogino, S.4    Kirchner, T.5    Shivdasani, R.A.6
  • 36
    • 0025634118 scopus 로고
    • P53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
    • Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JK et al. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 1990; 50: 7717–7722.
    • (1990) Cancer Res , vol.50 , pp. 7717-7722
    • Baker, S.J.1    Preisinger, A.C.2    Jessup, J.M.3    Paraskeva, C.4    Markowitz, S.5    Willson, J.K.6
  • 38
    • 0031872995 scopus 로고    scopus 로고
    • Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production
    • O'Hara RJ, Greenman J, MacDonald AW, Gaskell KM, Topping KP, Duthie GS et al. Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production. Clin Cancer Res 1998; 4: 1943–1948.
    • (1998) Clin Cancer Res , vol.4 , pp. 1943-1948
    • O'hara, R.J.1    Greenman, J.2    Macdonald, A.W.3    Gaskell, K.M.4    Topping, K.P.5    Duthie, G.S.6
  • 39
    • 18444404007 scopus 로고    scopus 로고
    • Circulating levels of interleukin-10 and interleukin-6 in gastric and colon cancer patients before and after surgery: Relationship with radicality and outcome
    • Galizia G, Lieto E, De Vita F, Romano C, Orditura M, Castellano P et al. Circulating levels of interleukin-10 and interleukin-6 in gastric and colon cancer patients before and after surgery: relationship with radicality and outcome. J Interferon Cytokine Res 2002; 22: 473–482.
    • (2002) J Interferon Cytokine Res , vol.22 , pp. 473-482
    • Galizia, G.1    Lieto, E.2    de Vita, F.3    Romano, C.4    Orditura, M.5    Castellano, P.6
  • 40
    • 0036176551 scopus 로고    scopus 로고
    • Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery
    • Galizia G, Orditura M, Romano C, Lieto E, Castellano P, Pelosio L et al. Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery. Clin Immunol 2002; 102: 169–178.
    • (2002) Clin Immunol , vol.102 , pp. 169-178
    • Galizia, G.1    Orditura, M.2    Romano, C.3    Lieto, E.4    Castellano, P.5    Pelosio, L.6
  • 41
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335–2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 42
    • 0036332684 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer
    • Cassano A, Bagala C, Battelli C, Schinzari G, Quirino M, Ratto C et al. Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer. Anticancer Res 2002; 22: 2179–2184.
    • (2002) Anticancer Res , vol.22 , pp. 2179-2184
    • Cassano, A.1    Bagala, C.2    Battelli, C.3    Schinzari, G.4    Quirino, M.5    Ratto, C.6
  • 43
    • 33846662478 scopus 로고    scopus 로고
    • Overexpression of soluble vascular endothelial growth factor receptor 1 in col-orectal cancer: Association with progression and prognosis
    • Yamaguchi T, Bando H, Mori T, Takahashi K, Matsumoto H, Yasutome M et al. Overexpression of soluble vascular endothelial growth factor receptor 1 in col-orectal cancer: Association with progression and prognosis. Cancer Sci 2007; 98: 405–410.
    • (2007) Cancer Sci , vol.98 , pp. 405-410
    • Yamaguchi, T.1    Bando, H.2    Mori, T.3    Takahashi, K.4    Matsumoto, H.5    Yasutome, M.6
  • 44
    • 80054122779 scopus 로고    scopus 로고
    • EGFR-and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies
    • Poindessous V, Ouaret D, El Ouadrani K, Battistella A, Megalophonos VF, Kamsu-Kom N et al. EGFR-and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies. Clin Cancer Res 2011; 17: 6522–6530.
    • (2011) Clin Cancer Res , vol.17 , pp. 6522-6530
    • Poindessous, V.1    Ouaret, D.2    El Ouadrani, K.3    Battistella, A.4    Megalophonos, V.F.5    Kamsu-Kom, N.6
  • 45
    • 34147130694 scopus 로고    scopus 로고
    • The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
    • Tabernero J. The role of VEGF and EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents. Mol Cancer Res 2007; 5: 203–220.
    • (2007) Mol Cancer Res , vol.5 , pp. 203-220
    • Tabernero, J.1
  • 46
    • 84893461612 scopus 로고    scopus 로고
    • PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17
    • Karapetis CS, Jonker D, Daneshmand M, Hanson JE, O'Callaghan CJ, Marginean C et al. PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17. Clin Cancer Res 2014; 20: 744–753.
    • (2014) Clin Cancer Res , vol.20 , pp. 744-753
    • Karapetis, C.S.1    Jonker, D.2    Daneshmand, M.3    Hanson, J.E.4    O'callaghan, C.J.5    Marginean, C.6
  • 47
    • 84876290460 scopus 로고    scopus 로고
    • PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: A meta-analysis
    • Wu S, Gan Y, Wang X, Liu J, Li M, Tang Y. PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: a meta-analysis. J Cancer Res Clin Oncol 2013; 139: 891–900.
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 891-900
    • Wu, S.1    Gan, Y.2    Wang, X.3    Liu, J.4    Li, M.5    Tang, Y.6
  • 48
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010; 11: 753–762.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • de Roock, W.1    Claes, B.2    Bernasconi, D.3    de Schutter, J.4    Biesmans, B.5    Fountzilas, G.6
  • 49
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21
    • Zhu CQ, da Cunha Santos G, Ding K, Sakurada A, Cutz JC, Liu N et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol 2008; 26: 4268–4275.
    • (2008) J Clin Oncol , vol.26 , pp. 4268-4275
    • Zhu, C.Q.1    da Cunha Santos, G.2    Ding, K.3    Sakurada, A.4    Cutz, J.C.5    Liu, N.6
  • 50
    • 33750571170 scopus 로고    scopus 로고
    • Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of sur-vivin expression counteract the antitumor action of erlotinib
    • Morgillo F, Woo JK, Kim ES, Hong WK, Lee HY. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of sur-vivin expression counteract the antitumor action of erlotinib. Cancer Res 2006; 66: 10100–10111.
    • (2006) Cancer Res , vol.66 , pp. 10100-10111
    • Morgillo, F.1    Woo, J.K.2    Kim, E.S.3    Hong, W.K.4    Lee, H.Y.5
  • 51
    • 70349148288 scopus 로고    scopus 로고
    • Van Bergen En Henegouwen PM, Roovers RC. Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: Implications for cancer therapy
    • van der Veeken J, Oliveira S, Schiffelers RM, Storm G, van Bergen En Henegouwen PM, Roovers RC. Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: implications for cancer therapy. Curr Cancer Drug Targets 2009; 9: 748–760.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 748-760
    • van der Veeken, J.1    Oliveira, S.2    Schiffelers, R.M.3    Storm, G.4
  • 52
    • 0035920139 scopus 로고    scopus 로고
    • Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases
    • He H, Levitzki A, Zhu HJ, Walker F, Burgess A, Maruta H. Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases. The Journal of biological chemistry 2001; 276: 26741–26744.
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 26741-26744
    • He, H.1    Levitzki, A.2    Zhu, H.J.3    Walker, F.4    Burgess, A.5    Maruta, H.6
  • 53
    • 0034805908 scopus 로고    scopus 로고
    • Receptor heterodimerization: Essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
    • Saito Y, Haendeler J, Hojo Y, Yamamoto K, Berk BC. Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation. Mol Cell Biol 2001; 21: 6387–6394.
    • (2001) Mol Cell Biol , vol.21 , pp. 6387-6394
    • Saito, Y.1    Haendeler, J.2    Hojo, Y.3    Yamamoto, K.4    Berk, B.C.5
  • 54
    • 79955675804 scopus 로고    scopus 로고
    • Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression
    • Ware KE, Marshall ME, Heasley LR, Marek L, Hinz TK, Hercule P et al. Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression. PLoS ONE 5: e14117.
    • Plos ONE , vol.5 , pp. e14117
    • Ware, K.E.1    Marshall, M.E.2    Heasley, L.R.3    Marek, L.4    Hinz, T.K.5    Hercule, P.6
  • 55
    • 84875438921 scopus 로고    scopus 로고
    • A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral onco-gene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines
    • Singleton KR, Kim J, Hinz TK, Marek LA, Casas-Selves M, Hatheway C et al. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral onco-gene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines. Mol Pharmacol 83: 882–893.
    • Mol Pharmacol , vol.83 , pp. 882-893
    • Singleton, K.R.1    Kim, J.2    Hinz, T.K.3    Marek, L.A.4    Casas-Selves, M.5    Hatheway, C.6
  • 56
    • 79956205502 scopus 로고    scopus 로고
    • Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis
    • Larsen AK, Ouaret D, El Ouadrani K, Petitprez A. Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Ther 131: 80–90.
    • Pharmacol Ther , vol.131 , pp. 80-90
    • Larsen, A.K.1    Ouaret, D.2    El Ouadrani, K.3    Petitprez, A.4
  • 57
    • 74549133965 scopus 로고    scopus 로고
    • Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epi-thelial cancer development
    • Lichtenberger BM, Tan PK, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epi-thelial cancer development. Cell 140: 268–279.
    • Cell , vol.140 , pp. 268-279
    • Lichtenberger, B.M.1    Tan, P.K.2    Niederleithner, H.3    Ferrara, N.4    Petzelbauer, P.5    Sibilia, M.6
  • 58
    • 84930754589 scopus 로고    scopus 로고
    • A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/ panitumumab monotherapy
    • Saridaki Z, Weidhaas JB, Lenz HJ, Laurent-Puig P, Jacobs B, De Schutter J et al. A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/ panitumumab monotherapy. Clin Cancer Res 2014; 20: 4499–4510.
    • (2014) Clin Cancer Res , vol.20 , pp. 4499-4510
    • Saridaki, Z.1    Weidhaas, J.B.2    Lenz, H.J.3    Laurent-Puig, P.4    Jacobs, B.5    de Schutter, J.6
  • 61
    • 84893210980 scopus 로고    scopus 로고
    • MicroRNA signature in metastatic colorectal cancer patients treated with anti-EGFR mono-clonal antibodies
    • Cappuzzo F, Sacconi A, Landi L, Ludovini V, Biagioni F, D'Incecco A et al. MicroRNA signature in metastatic colorectal cancer patients treated with anti-EGFR mono-clonal antibodies. Clin Colorect Cancer 2014; 13: 37–45 e34.
    • (2014) Clin Colorect Cancer , vol.13 , pp. 37-45
    • Cappuzzo, F.1    Sacconi, A.2    Landi, L.3    Ludovini, V.4    Biagioni, F.5    D'incecco, A.6
  • 62
    • 84862877840 scopus 로고    scopus 로고
    • High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease
    • Ruzzo A, Graziano F, Vincenzi B, Canestrari E, Perrone G, Galluccio N et al. High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease. The Oncologist 2012; 17: 823–829.
    • (2012) The Oncologist , vol.17 , pp. 823-829
    • Ruzzo, A.1    Graziano, F.2    Vincenzi, B.3    Canestrari, E.4    Perrone, G.5    Galluccio, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.