Macrolides Promote CCL2-Mediated Macrophage Recruitment and Clearance of Nasopharyngeal Pneumococcal Colonization in Mice

Journal of Infectious Diseases

Volumn 212, Issue 7, 2015, Pages 1150-1159

  Iwanaga, Naoki ^a   Nakamura, Shigeki ^a   Oshima, Kazuhiro ^a   Kajihara, Toshiki ^a   Takazono, Takahiro ^a   Miyazaki, Taiga ^a   Izumikawa, Koichi ^a   Yanagihara, Katsunori ^b   Sugawara, Akihiro ^c   Sunazuka, Toshiaki ^c   Omura, Satoshi ^c   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

CCL2; colonization; macrolides; macrophage; Streptococcus pneumoniae

Indexed keywords

BETA INTERFERON; CYTOKINE; EM 900; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; MACROLIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CCL2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COLONIZATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE SILENCING; INNATE IMMUNITY; INOCULATION; MORTALITY; MOUSE; NASOPHARYNX; NONHUMAN; PERITONEUM MACROPHAGE; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; SURVIVAL; UPPER RESPIRATORY TRACT; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GERMFREE ANIMAL; IMMUNOLOGY; MACROPHAGE; METABOLISM; MICROBIOLOGY; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTIONS;

ANIMALS; ANTI-BACTERIAL AGENTS; CELLS, CULTURED; CHEMOKINE CCL2; FEMALE; IMMUNITY, INNATE; INTERFERON-BETA; MACROLIDES; MACROPHAGES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; NASOPHARYNX; NF-KAPPA B; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTIONS; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; STREPTOCOCCUS PNEUMONIAE;

EID: 84943387040     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv157     Document Type: Article

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