Pigment epithelium-derived factor, a protective factor for photoreceptors in Vivo

Advances in Experimental Medicine and Biology

Volumn 854, Issue , 2016, Pages 699-706

  Polato, Federica ^a   Becerra, S Patricia ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

Animal models; Neuroprotection; PEDF; Photoreceptor; Retinal degeneration

Indexed keywords

PIGMENT EPITHELIUM DERIVED FACTOR; RECOMBINANT PROTEIN; EYE PROTEIN; NERVE GROWTH FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; PROTECTIVE AGENT; SERINE PROTEINASE INHIBITOR;

APOPTOSIS; CELL DEGENERATION; CELL PROTECTION; DISEASE MODEL; DRUG MECHANISM; DRUG RESPONSE; DRUG TARGETING; HUMAN; IN VIVO STUDY; LIGHT DAMAGE; NEUROPROTECTION; NONHUMAN; PHAGOCYTOSIS; PHOTORECEPTOR; PHOTORECEPTOR CELL; PRIORITY JOURNAL; RETINA DEGENERATION; SIGNAL TRANSDUCTION; ANIMAL; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MUTATION;

ANIMALS; DISEASE MODELS, ANIMAL; EYE PROTEINS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; NERVE GROWTH FACTORS; PHOTORECEPTOR CELLS, VERTEBRATE; PROTECTIVE AGENTS; RETINAL DEGENERATION; SERPINS;

EID: 84943338964     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-17121-0_93     Document Type: Chapter

References (19)

1. Akiyama G, Sakai T, Kuno N et al (2012) Photoreceptor rescue of pigment epithelium-derived factor-impregnated nanoparticles in Royal College of surgeons rats. Mol Vis 18:3079-3086
2. Barnstable CJ, Tombran-Tink J (2004) Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Prog Ret Eye Res 23:561-577
3. Becerra SP (2006) Focus on molecules: pigment epithelium-derived factor (PEDF). Exp Eye Res 82:739-740
4. Becerra SP, Notario V (2013) The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential. Nature Rev Cancer 13:258-271
5. Becerra SP, Fariss RN, Wu YQ et al (2004) Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution. Exp Eye Res 78:223-234
6. Cao W, Tombran-Tink J, Chen W et al (1999) Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death. J Neurosci Res 57:789-800
7. Cayouette M, Smith SB, Becerra SP et al (1999) Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6:523-532
8. Chu XK, Wang Y, Ardeljan D et al (2013) Controversial view of a genetically altered mouse model of focal retinal degeneration. Bioengin 4:130-135
9. D'Cruz PM, Yasumura D, Weir J et al (2000) Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 9:645-651
10. Gal A, Li Y, Thompson DA, Weir J et al (2000) Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nature Genet 26:270-271
11. Imai D, Yoneya S, Gehlbach PL et al (2005) Intraocular gene transfer of pigment epithelium-derived factor rescues photoreceptors from light-induced cell death. J Cell Physiol 202:570-578
12. Miyazaki M, Ikeda Y, Yonemitsu Y et al (2003) Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of surgeons rats. Gene Ther 10:1503-1511
13. Mullen RJ, LaVail MM (1976) Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras. Science 192:799-801
14. Murakami Y, Ikeda Y, Yonemitsu Y et al (2008) Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epitheliumderived factor in a rat model of retinal degeneration. Am J Pathol 173:1326-1338
15. Notari L, Baladron V, Aroca-Aguilar JD et al (2006) Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J Biol Chem 281:38022-38037
16. Sancho-Pelluz J, Arango-Gonzalez B, Kustermann S et al (2008) Photoreceptor cell death mechanisms in inherited retinal degeneration. Mol Neurobiol 38:253-269
17. Sanyal S, De Ruiter A, Hawkins RK (1980) Development and degeneration of retina in rds mutant mice: light microscopy. J Comp Neurol 194:193-207
18. Subramanian P, Locatelli-Hoops S, Kenealey J et al (2013) Pigment epithelium-derived factor (PEDF) prevents retinal cell death via PEDF Receptor (PEDF-R): identification of a functional ligand binding site. J Biol Chem 288:23928-23942
19. Wang Y, Subramanian P, Shen D et al (2013) Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration. ASN Neuro 5:e00126