메뉴 건너뛰기




Volumn 290, Issue 40, 2015, Pages 24509-24518

Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CELL MEMBRANES; ENZYME ACTIVITY; NICOTINE; PROTEINS;

EID: 84943328549     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.647248     Document Type: Article
Times cited : (36)

References (58)
  • 2
    • 0031976619 scopus 로고    scopus 로고
    • Nicotinic receptor subtypes in the developing chick brain: Appearance of a species containing the α4, β2, and α5 gene products
    • Conroy, W. G., and Berg, D. K. (1998) Nicotinic receptor subtypes in the developing chick brain: appearance of a species containing the α4, β2, and α5 gene products. Mol. Pharmacol. 53, 392-401
    • (1998) Mol. Pharmacol. , vol.53 , pp. 392-401
    • Conroy, W.G.1    Berg, D.K.2
  • 3
    • 0026593533 scopus 로고
    • A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment
    • Flores, C. M., and Rogers., S. W., Pabreza, L. A., Wolfe, B. B., and Kellar, K. J. (1992) A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Mol. Pharmacol. 41, 31-37
    • (1992) Mol. Pharmacol. , vol.41 , pp. 31-37
    • Flores, C.M.1    Rogers, S.W.2    Pabreza, L.A.3    Wolfe, B.B.4    Kellar, K.J.5
  • 4
    • 0023751963 scopus 로고
    • Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies
    • Whiting, P. J., and Lindstrom, J. M. (1988) Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies. J. Neurosci. 8, 3395-3404
    • (1988) J. Neurosci. , vol.8 , pp. 3395-3404
    • Whiting, P.J.1    Lindstrom, J.M.2
  • 5
    • 0345131682 scopus 로고    scopus 로고
    • Identification of four classes of brain nicotinic receptors using β mutant mice
    • Zoli, M., Léna, C, Picciotto, M. R., and Changeux, J. P. (1998) Identification of four classes of brain nicotinic receptors using β mutant mice. J. Neurosci. 18, 4461-4472
    • (1998) J. Neurosci. , vol.18 , pp. 4461-4472
    • Zoli, M.1    Léna, C.2    Picciotto, M.R.3    Changeux, J.P.4
  • 6
    • 33846314737 scopus 로고    scopus 로고
    • Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons
    • Azam, L., Chen, Y., and Leslie, F. M. (2007) Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons. Neuroscience 144, 1347-1360
    • (2007) Neuroscience , vol.144 , pp. 1347-1360
    • Azam, L.1    Chen, Y.2    Leslie, F.M.3
  • 8
    • 58349087441 scopus 로고    scopus 로고
    • Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons
    • Yang, K., Hu, J., Lucero, L., Liu, Q., Zheng, C, Zhen, X., Jin, G., Lukas, R. J., and Wu, J. (2009) Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. J. Physiol. 587, 345-361
    • (2009) J. Physiol. , vol.587 , pp. 345-361
    • Yang, K.1    Hu, J.2    Lucero, L.3    Liu, Q.4    Zheng, C.5    Zhen, X.6    Jin, G.7    Lukas, R.J.8    Wu, J.9
  • 9
    • 41149145063 scopus 로고    scopus 로고
    • It is not "either/or": Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
    • Picciotto, M. R., and Addy., N. A., Mineur, Y. S., and Brunzell, D. H. (2008) It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Prog. Neurobiol. 84, 329-342
    • (2008) Prog. Neurobiol. , vol.84 , pp. 329-342
    • Picciotto, M.R.1    Addy, N.A.2    Mineur, Y.S.3    Brunzell, D.H.4
  • 10
    • 58149385076 scopus 로고    scopus 로고
    • Crucial role of α4 and α6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration
    • Pons, S., Fattore, L., Cossu, G., Tolu, S., Porcu, E., McIntosh, J. M., Changeux, J. P., Maskos, U., and Fratta, W. (2008) Crucial role of α4 and α6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration. J. Neurosci. 28, 12318-12327
    • (2008) J. Neurosci. , vol.28 , pp. 12318-12327
    • Pons, S.1    Fattore, L.2    Cossu, G.3    Tolu, S.4    Porcu, E.5    McIntosh, J.M.6    Changeux, J.P.7    Maskos, U.8    Fratta, W.9
  • 11
    • 0023950487 scopus 로고
    • Evidence that tobacco smoking increases the density of (-)-[3H]nicotine binding sites in human brain
    • Benwell, M. E., and Balfour., D. J., and Anderson, J. M. (1988) Evidence that tobacco smoking increases the density of (-)-[3H]nicotine binding sites in human brain. J. Neurochem. 50, 1243-1247
    • (1988) J. Neurochem. , vol.50 , pp. 1243-1247
    • Benwell, M.E.1    Balfour, D.J.2    Anderson, J.M.3
  • 13
    • 0020642784 scopus 로고
    • Effects of chronic nicotine infusion on tolerance development and nicotinic receptors
    • Marks, M. J., and Burch., J. B., and Collins, A. C. (1983) Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. J. Pharmacol. Exp. Ther. 226, 817-825
    • (1983) J. Pharmacol. Exp. Ther. , vol.226 , pp. 817-825
    • Marks, M.J.1    Burch, J.B.2    Collins, A.C.3
  • 14
    • 0344258434 scopus 로고    scopus 로고
    • Increased nicotinic receptors in brains from smokers: Membrane binding and autoradiography studies
    • Perry, D. C, Dávila-García, M. I., Stockmeier, C. A., and Kellar, K. J. (1999) Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. J. Pharmacol. Exp. Ther. 289, 1545-1552
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 1545-1552
    • Perry, D.C.1    Dávila-García, M.I.2    Stockmeier, C.A.3    Kellar, K.J.4
  • 15
    • 0020641301 scopus 로고
    • Nicotinic cholinergic receptor binding sites in the brain: Regulation in vivo
    • Schwartz, R. D., and Kellar, K. J. (1983) Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science 220, 214-216
    • (1983) Science , vol.220 , pp. 214-216
    • Schwartz, R.D.1    Kellar, K.J.2
  • 16
    • 65549132734 scopus 로고    scopus 로고
    • Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery
    • Lester, H. A., Xiao, C, Srinivasan, R., and Son., C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., and Wang, J. C. (2009) Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. AAPS J. 11, 167-177
    • (2009) AAPS J. , vol.11 , pp. 167-177
    • Lester, H.A.1    Xiao, C.2    Srinivasan, R.3    Son, C.D.4    Miwa, J.5    Pantoja, R.6    Banghart, M.R.7    Dougherty, D.A.8    Goate, A.M.9    Wang, J.C.10
  • 17
    • 84874267789 scopus 로고    scopus 로고
    • Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein
    • Liu, Q., Emadi, S., Shen, J.-X., and Sierks., M. R., and Wu, J. (2013) Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein. PLoS ONE 8, e55886
    • (2013) PLoS ONE , vol.8
    • Liu, Q.1    Emadi, S.2    Shen, J.-X.3    Sierks, M.R.4    Wu, J.5
  • 19
    • 77958147569 scopus 로고    scopus 로고
    • ∗ nicotinic receptors both regulate dopamine signaling with increased nigrostriatal damage: Relevance to Parkinson's disease
    • ∗ nicotinic receptors both regulate dopamine signaling with increased nigrostriatal damage: relevance to Parkinson's disease. Mol. Pharmacol. 78, 971-980
    • Mol. Pharmacol. , vol.78 , pp. 971-980
    • Perez, X.A.1    Bordia, T.2    McIntosh, J.M.3    Quik, M.4
  • 20
    • 38449098712 scopus 로고    scopus 로고
    • Neuroprotection via nAChRs: The role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease
    • Picciotto, M. R., and Zoli, M. (2008) Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Front. Biosci. 13, 492-504
    • (2008) Front. Biosci. , vol.13 , pp. 492-504
    • Picciotto, M.R.1    Zoli, M.2
  • 21
    • 84878155554 scopus 로고    scopus 로고
    • α4β2 nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats
    • Quik, M., Campos, C, Bordia, T., Strachan, J.-P., Zhang, J., and McIntosh., J. M., Letchworth, S., and Jordan, K. (2013) α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats. Neuropharmacology 71, 191-203
    • (2013) Neuropharmacology , vol.71 , pp. 191-203
    • Quik, M.1    Campos, C.2    Bordia, T.3    Strachan, J.-P.4    Zhang, J.5    McIntosh, J.M.6    Letchworth, S.7    Jordan, K.8
  • 22
    • 34247578066 scopus 로고    scopus 로고
    • Nicotine neuroprotection against nigrostriatal damage: Importance of the animal model
    • Quik, M., O'Neill, M., and Perez, X. A. (2007) Nicotine neuroprotection against nigrostriatal damage: importance of the animal model. Trends Pharmacol. Sci. 28, 229-235
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 229-235
    • Quik, M.1    O'Neill, M.2    Perez, X.A.3
  • 23
    • 24044449279 scopus 로고    scopus 로고
    • Exocytic trafficking is required for nicotine-induced up-regulation of α4 β2 nicotinic acetylcholine receptors
    • Darsow, T., and Booker., T. K., Piña-Crespo, J. C, and Heinemann, S. F. (2005) Exocytic trafficking is required for nicotine-induced up-regulation of α4 β2 nicotinic acetylcholine receptors. J. Biol. Chem. 280, 18311-18320
    • (2005) J. Biol. Chem. , vol.280 , pp. 18311-18320
    • Darsow, T.1    Booker, T.K.2    Piña-Crespo, J.C.3    Heinemann, S.F.4
  • 24
    • 84856978299 scopus 로고    scopus 로고
    • Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms
    • Govind, A. P., Walsh, H., and Green, W. N (2012) Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms. J. Neurosci. 32, 2227-2238
    • (2012) J. Neurosci. , vol.32 , pp. 2227-2238
    • Govind, A.P.1    Walsh, H.2    Green, W.N.3
  • 25
    • 20444368757 scopus 로고    scopus 로고
    • Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism
    • Vallejo, Y. F., Buisson, B., Bertrand, D., and Green, W. N. (2005) Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism. J. Neurosci. 25, 5563-5572
    • (2005) J. Neurosci. , vol.25 , pp. 5563-5572
    • Vallejo, Y.F.1    Buisson, B.2    Bertrand, D.3    Green, W.N.4
  • 26
    • 27844472836 scopus 로고    scopus 로고
    • Nicotine acts as a pharmacological chaperone to up-regulate human α4β2 acetylcholine receptors
    • Kuryatov, A., Luo, J., Cooper, J., and Lindstrom, J. (2005) Nicotine acts as a pharmacological chaperone to up-regulate human α4β2 acetylcholine receptors. Mol. Pharmacol. 68, 1839-1851
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1839-1851
    • Kuryatov, A.1    Luo, J.2    Cooper, J.3    Lindstrom, J.4
  • 29
    • 0037289747 scopus 로고    scopus 로고
    • Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors
    • Nelson, M. E., Kuryatov, A., Choi, C H., Zhou, Y., and Lindstrom, J. (2003) Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors. Mol. Pharmacol. 63, 332-341
    • (2003) Mol. Pharmacol. , vol.63 , pp. 332-341
    • Nelson, M.E.1    Kuryatov, A.2    Choi, C.H.3    Zhou, Y.4    Lindstrom, J.5
  • 30
    • 84909619794 scopus 로고    scopus 로고
    • Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum
    • Nichols, W. A., and Henderson., B. J., Yu, C, and Parker., R. L., Richards, C I., Lester, H. A., and Miwa, J. M. (2014) Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum. J. Biol. Chem. 289, 31423-31432
    • (2014) J. Biol. Chem. , vol.289 , pp. 31423-31432
    • Nichols, W.A.1    Henderson, B.J.2    Yu, C.3    Parker, R.L.4    Richards, C.I.5    Lester, H.A.6    Miwa, J.M.7
  • 31
    • 0032891247 scopus 로고    scopus 로고
    • Structural and phylogenetic characterization of human SLURP-1, the first secreted Mammalian member of the ly-6/uPARprotein superfamily
    • Adermann, K., Wattler, F., Wattler, S., Heine, G., Meyer, M., Forssmann, W. G., and Nehls, M. (1999) Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPARprotein superfamily. Protein Sci. 8, 810-819
    • (1999) Protein Sci. , vol.8 , pp. 810-819
    • Adermann, K.1    Wattler, F.2    Wattler, S.3    Heine, G.4    Meyer, M.5    Forssmann, W.G.6    Nehls, M.7
  • 33
    • 0037075542 scopus 로고    scopus 로고
    • Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1
    • Ibañez-Tallon, I., Miwa, J. M., Wang, H. L., Adams, N. C, Crabtree, G. W., Sine, S. M., and Heintz, N (2002) Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron 33, 893-903
    • (2002) Neuron , vol.33 , pp. 893-903
    • Ibañez-Tallon, I.1    Miwa, J.M.2    Wang, H.L.3    Adams, N.C.4    Crabtree, G.W.5    Sine, S.M.6    Heintz, N.7
  • 35
    • 84923338903 scopus 로고    scopus 로고
    • Ly6h regulates trafficking of α7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling
    • Puddifoot, C. A., Wu, M., Sung, R. J., and Joiner, W. J. (2015) Ly6h regulates trafficking of α7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling. J. Neurosci. 35, 3420-3430
    • (2015) J. Neurosci. , vol.35 , pp. 3420-3430
    • Puddifoot, C.A.1    Wu, M.2    Sung, R.J.3    Joiner, W.J.4
  • 36
    • 84896549341 scopus 로고    scopus 로고
    • SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission
    • Wu, M., and Robinson., J. E., and Joiner, W. J. (2014) SLEEPLESS Is a Bifunctional Regulator of Excitability and Cholinergic Synaptic Transmission. Curr. Biol. 24, 621-629
    • (2014) Curr. Biol. , vol.24 , pp. 621-629
    • Wu, M.1    Robinson, J.E.2    Joiner, W.J.3
  • 38
    • 45749089286 scopus 로고    scopus 로고
    • Persistent expression of pax3 in the neural crest causes cleft palate and defective osteogenesis in mice
    • Wu, M., Li, J., Engleka, K. A., Zhou, B., Lu, M. M., Plotkin, J. B., and Epstein, J. A. (2008) Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. J. Clin. Invest. 118, 2076-2087
    • (2008) J. Clin. Invest. , vol.118 , pp. 2076-2087
    • Wu, M.1    Li, J.2    Engleka, K.A.3    Zhou, B.4    Lu, M.M.5    Plotkin, J.B.6    Epstein, J.A.7
  • 40
    • 44349135549 scopus 로고    scopus 로고
    • Conserved structural determinants in three-fingered protein domains
    • Galat, A., Gross, G., Drevet, P., Sato, A., and Ménez, A. (2008) Conserved structural determinants in three-fingered protein domains. FEBS J 275, 3207-3225
    • (2008) FEBS J , vol.275 , pp. 3207-3225
    • Galat, A.1    Gross, G.2    Drevet, P.3    Sato, A.4    Ménez, A.5
  • 41
    • 33847029091 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
    • Dani, J. A., and Bertrand, D. (2007) Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 47, 699-729
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 699-729
    • Dani, J.A.1    Bertrand, D.2
  • 42
    • 0347064158 scopus 로고    scopus 로고
    • Assembly of α4β2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: Effects of localization, trafficking, and nicotine-induced upregulation in clonal Mammalian cells and in cultured midbrain neurons
    • Nashmi, R., and Dickinson., M. E., McKinney, S., Jareb, M., Labarca, C, and Fraser., S. E., and Lester, H. A. (2003) Assembly of α4β2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. J. Neurosci. 23, 11554-11567
    • (2003) J. Neurosci. , vol.23 , pp. 11554-11567
    • Nashmi, R.1    Dickinson, M.E.2    McKinney, S.3    Jareb, M.4    Labarca, C.5    Fraser, S.E.6    Lester, H.A.7
  • 43
    • 78650873492 scopus 로고    scopus 로고
    • Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning
    • Srinivasan, R., Pantoja, R., Moss, F. J., Mackey, E. D. W., Son, C. D., Miwa, J., and Lester, H. A. (2011) Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. J. Gen. Physiol. 137, 59-79
    • (2011) J. Gen. Physiol. , vol.137 , pp. 59-79
    • Srinivasan, R.1    Pantoja, R.2    Moss, F.J.3    Mackey, E.D.W.4    Son, C.D.5    Miwa, J.6    Lester, H.A.7
  • 44
    • 84861420190 scopus 로고    scopus 로고
    • Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response
    • Srinivasan, R., and Richards., C. I., Xiao, C, Rhee, D., Pantoja, R., Dougherty, D. A., Miwa, J. M., and Lester, H. A. (2012) Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response. Mol. Pharmacol. 81, 759-769
    • (2012) Mol. Pharmacol. , vol.81 , pp. 759-769
    • Srinivasan, R.1    Richards, C.I.2    Xiao, C.3    Rhee, D.4    Pantoja, R.5    Dougherty, D.A.6    Miwa, J.M.7    Lester, H.A.8
  • 45
    • 47749139631 scopus 로고    scopus 로고
    • Identification of SLEEPLESS, a sleep-promoting factor
    • Koh, K., and Joiner., W. J., Wu, M. N, Yue, Z., and Smith., C. J., and Sehgal, A. (2008) Identification of SLEEPLESS, a sleep-promoting factor. Science 321, 372-376
    • (2008) Science , vol.321 , pp. 372-376
    • Koh, K.1    Joiner, W.J.2    Wu, M.N.3    Yue, Z.4    Smith, C.J.5    Sehgal, A.6
  • 46
    • 78649442213 scopus 로고    scopus 로고
    • Lynx1, a cholinergic brake, limits plasticity in adult visual cortex
    • Morishita, H., and Miwa., J. M., Heintz, N, and Hensch, T. K. (2010) Lynx1, a cholinergic brake, limits plasticity in adult visual cortex. Science 330, 1238-1240
    • (2010) Science , vol.330 , pp. 1238-1240
    • Morishita, H.1    Miwa, J.M.2    Heintz, N.3    Hensch, T.K.4
  • 48
    • 0031870973 scopus 로고    scopus 로고
    • Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
    • Auerbach, A., and Akk, G. (1998) Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism. J. Gen. Physiol. 112, 181-197
    • (1998) J. Gen. Physiol. , vol.112 , pp. 181-197
    • Auerbach, A.1    Akk, G.2
  • 49
    • 0347659028 scopus 로고    scopus 로고
    • Nicotine is highly effective at producing desensitization of rat α4β2 neuronal nicotinic receptors
    • Paradiso, K. G., and Steinbach, J. H. (2003) Nicotine is highly effective at producing desensitization of rat α4β2 neuronal nicotinic receptors. J Physiol 553, 857-871
    • (2003) J Physiol , vol.553 , pp. 857-871
    • Paradiso, K.G.1    Steinbach, J.H.2
  • 51
    • 18444411922 scopus 로고    scopus 로고
    • Crystal structure of a cbtx-AChBP complex reveals essential interactions between snake α-neurotoxins and nicotinic receptors
    • Bourne, Y., and Talley., T. T., Hansen, S. B., Taylor, P., and Marchot, P. (2005) Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake α-neurotoxins and nicotinic receptors. EMBO J. 24, 1512-1522
    • (2005) EMBO J. , vol.24 , pp. 1512-1522
    • Bourne, Y.1    Talley, T.T.2    Hansen, S.B.3    Taylor, P.4    Marchot, P.5
  • 52
    • 34547520128 scopus 로고    scopus 로고
    • Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 A resolution
    • Dellisanti, C. D., Yao, Y., Stroud, J. C., Wang, Z.-Z., and Chen, L. (2007) Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 A resolution. Nat Neurosci. 10, 953-962
    • (2007) Nat Neurosci. , vol.10 , pp. 953-962
    • Dellisanti, C.D.1    Yao, Y.2    Stroud, J.C.3    Wang, Z.-Z.4    Chen, L.5
  • 53
    • 84881515004 scopus 로고    scopus 로고
    • Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera
    • Huang, S., Li, S.-X., Bren, N, Cheng, K., Gomoto, R., Chen, L., and Sine, S. M. (2013) Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera. Biochem. J. 454, 303-310
    • (2013) Biochem. J. , vol.454 , pp. 303-310
    • Huang, S.1    Li, S.-X.2    Bren, N.3    Cheng, K.4    Gomoto, R.5    Chen, L.6    Sine, S.M.7
  • 54
    • 84922212251 scopus 로고    scopus 로고
    • Three-finger snake neurotoxins and ly6 proteins targeting nicotinic acetylcholine receptors: Pharmacological tools and endogenous modulators
    • Tsetlin, V. I. (2015) Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators. Trends Pharmacol. Sci. 36, 109-123
    • (2015) Trends Pharmacol. Sci. , vol.36 , pp. 109-123
    • Tsetlin, V.I.1
  • 55
    • 77953230225 scopus 로고    scopus 로고
    • Effects of varenicline and mecamylamine on the acquisition, expression, and reinstatement of nicotine-conditioned place preference by drug priming in rats
    • Biala, G., Staniak, N, and Budzynska, B. (2010) Effects of varenicline and mecamylamine on the acquisition, expression, and reinstatement of nicotine-conditioned place preference by drug priming in rats. Naunyn Schmiedebergs Arch. Pharmacol. 381, 361-370
    • (2010) Naunyn Schmiedebergs Arch. Pharmacol. , vol.381 , pp. 361-370
    • Biala, G.1    Staniak, N.2    Budzynska, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.