Ablation of Chop transiently enhances photoreceptor survival but does not prevent retinal degeneration in transgenic mice expressing human P23H rhodopsin

Advances in Experimental Medicine and Biology

Volumn 854, Issue , 2016, Pages 185-191

  Chiang, Wei Chieh ^a   Joseph, Victory ^a   Yasumura, Douglas ^c   Matthes, Michael T ^c   Lewin, Alfred S ^d   Gorbatyuk, Marina S ^e   Ahern, Kelly ^c   Lavail, Matthew M ^f   Lin, Jonathan H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chop; ER stress; P23H; Photoreceptor cell death; Retinal degeneration; Rhodopsin; Transgenic mice; Unfolded protein response; UPR

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; RHODOPSIN; DDIT3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; MOUSE; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA DEGENERATION; SIGNAL TRANSDUCTION; ANIMAL; DEFICIENCY; ELECTRORETINOGRAPHY; GENE EXPRESSION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; RETINA ROD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; CELL SURVIVAL; ELECTRORETINOGRAPHY; GENE EXPRESSION; HUMANS; MICE, KNOCKOUT; MICE, TRANSGENIC; RETINAL DEGENERATION; RETINAL ROD PHOTORECEPTOR CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHODOPSIN; TRANSCRIPTION FACTOR CHOP; TRANSGENES;

EID: 84943303099     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-17121-0_25     Document Type: Chapter

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