-
2
-
-
33745743619
-
Lipid metabolism and dynamics during phagocytosis
-
Yeung, T., Ozdamar, B., Paroutis, P., Grinstein, S. Lipid metabolism and dynamics during phagocytosis. Curr. Opin. Cell Biol. 18, 429-437 (2006).
-
(2006)
Curr. Opin. Cell Biol
, vol.18
, pp. 429-437
-
-
Yeung, T.1
Ozdamar, B.2
Paroutis, P.3
Grinstein, S.4
-
3
-
-
84876812269
-
Signals from the lysosome: A control centre for cellular clearance and energy metabolism
-
Settembre, C., Fraldi, A., Medina, D. L., Ballabio, A. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat. Rev. Mol. Cell Biol. 14, 283-296 (2013).
-
(2013)
Nat. Rev. Mol. Cell Biol
, vol.14
, pp. 283-296
-
-
Settembre, C.1
Fraldi, A.2
Medina, D.L.3
Ballabio, A.4
-
4
-
-
74049133619
-
Subcellular targeting strategies for drug design and delivery
-
Rajendran, L., Knölker, H.-J., Simons, K. Subcellular targeting strategies for drug design and delivery. Nat. Rev. Drug Discov. 9, 29-42 (2010).
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, pp. 29-42
-
-
Rajendran, L.1
Knölker, H.-J.2
Simons, K.3
-
5
-
-
22144447455
-
Design and development of polymers for gene delivery
-
Pack, D. W., Hoffman, A. S., Pun, S., Stayton, P. S. Design and development of polymers for gene delivery. Nat. Rev. Drug Discov. 4, 581-593 (2005).
-
(2005)
Nat. Rev. Drug Discov
, vol.4
, pp. 581-593
-
-
Pack, D.W.1
Hoffman, A.S.2
Pun, S.3
Stayton, P.S.4
-
6
-
-
40449122225
-
Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
-
Tasciotti, E. et al. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat. Nanotechnol 3, 151-157 (2008).
-
(2008)
Nat. Nanotechnol
, vol.3
, pp. 151-157
-
-
Tasciotti, E.1
-
7
-
-
67649491055
-
Understanding biophysicochemical interactions at the nano-bio interface
-
Nel, A. E. et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater. 8, 543-557 (2009).
-
(2009)
Nat. Mater
, vol.8
, pp. 543-557
-
-
Nel, A.E.1
-
8
-
-
84905718745
-
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
-
Dahlman, J. E. et al. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat. Nanotechnol 9, 648-655 (2014).
-
(2014)
Nat. Nanotechnol
, vol.9
, pp. 648-655
-
-
Dahlman, J.E.1
-
9
-
-
72949121897
-
Sensors and regulators of intracellular pH
-
Casey, J. R., Grinstein, S., Orlowski, J. Sensors and regulators of intracellular pH. Nat. Rev. Mol. Cell Biol. 11, 50-61 (2010).
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 50-61
-
-
Casey, J.R.1
Grinstein, S.2
Orlowski, J.3
-
10
-
-
0029160083
-
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
-
Boussif, O. et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl Acad. Sci. USA 92, 7297-7301 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7297-7301
-
-
Boussif, O.1
-
11
-
-
0020635123
-
Perturbation of vesicular traffic with the carboxylic ionophore monensin
-
Tartakoff, A. M. Perturbation of vesicular traffic with the carboxylic ionophore monensin. Cell 32, 1026-1028 (1983).
-
(1983)
Cell
, vol.32
, pp. 1026-1028
-
-
Tartakoff, A.M.1
-
12
-
-
79955918786
-
Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells
-
Zhou, K. et al. Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells. Angew. Chem. Int. Ed. 50, 6109-6114 (2011).
-
(2011)
Angew. Chem. Int. Ed
, vol.50
, pp. 6109-6114
-
-
Zhou, K.1
-
13
-
-
84860852602
-
Multicolored pH-tunable and activatable fluorescence nanoplatform responsive to physiologic pH stimuli
-
Zhou, K. et al. Multicolored pH-tunable and activatable fluorescence nanoplatform responsive to physiologic pH stimuli. J. Am. Chem. Soc. 134, 7803-7811 (2012).
-
(2012)
J. Am. Chem. Soc
, vol.134
, pp. 7803-7811
-
-
Zhou, K.1
-
14
-
-
84905674424
-
Ultra-pH sensitive nanoprobe library with broad pH tunability and fluorescence emissions
-
Ma, X. et al. Ultra-pH sensitive nanoprobe library with broad pH tunability and fluorescence emissions. J. Am. Chem. Soc. 136, 11085-11092 (2014).
-
(2014)
J. Am. Chem. Soc
, vol.136
, pp. 11085-11092
-
-
Ma, X.1
-
15
-
-
0028132679
-
Ionization of poly (ethylenimine) and poly (allylamine) at various pH's
-
Suh, J., Paik, H.-J., Hwang, B. K. Ionization of poly (ethylenimine) and poly (allylamine) at various pH's. Bioorg. Chem. 22, 318-327 (1994).
-
(1994)
Bioorg. Chem
, vol.22
, pp. 318-327
-
-
Suh, J.1
Paik, H.-J.2
Hwang, B.K.3
-
16
-
-
42949156865
-
Selective suicide of cross-presenting CD8\+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset
-
Lin, M. L. et al. Selective suicide of cross-presenting CD8\+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset. Proc. Natl Acad. Sci. USA 105, 3029-3034 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 3029-3034
-
-
Lin, M.L.1
-
17
-
-
0027160539
-
A rapid and sensitive hemolysis neutralization assay for palytoxin
-
Bignami, G. S. A rapid and sensitive hemolysis neutralization assay for palytoxin. Toxicon 31, 817-820 (1993).
-
(1993)
Toxicon
, vol.31
, pp. 817-820
-
-
Bignami, G.S.1
-
18
-
-
0038731763
-
Acidification and protein traffic
-
Weisz, O. A. Acidification and Protein Traffic. Int. Rev. Cytol. 226, 259-319 (2003).
-
(2003)
Int. Rev. Cytol
, vol.226
, pp. 259-319
-
-
Weisz, O.A.1
-
19
-
-
0037422066
-
Regulated portals of entry into the cell
-
Conner, S. D., Schmid, S. L. Regulated portals of entry into the cell. Nature 422, 37-44 (2003).
-
(2003)
Nature
, vol.422
, pp. 37-44
-
-
Conner, S.D.1
Schmid, S.L.2
-
20
-
-
84892980829
-
A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals
-
Wang, Y. et al. A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. Nat. Mater. 13, 204-212 (2014).
-
(2014)
Nat. Mater
, vol.13
, pp. 204-212
-
-
Wang, Y.1
-
23
-
-
4944246136
-
The evolution of A-F-and V-type ATP synthases and ATPases: Reversals in function and changes in the H\+/ATP coupling ratio
-
Cross, R. L., Muller, V. The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H\+/ATP coupling ratio. FEBS Lett. 576, 1-4 (2004).
-
(2004)
FEBS Lett
, vol.576
, pp. 1-4
-
-
Cross, R.L.1
Muller, V.2
-
24
-
-
0037418211
-
Evidence for rotation of V1-ATPase
-
Imamura, H. et al. Evidence for rotation of V1-ATPase. Proc. Natl Acad. Sci. USA 100, 2312-2315 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 2312-2315
-
-
Imamura, H.1
-
25
-
-
0025980350
-
Distribution and structure of the vacuolar H\+ ATPase in endosomes and lysosomes from LLC-PK1 cells
-
Rodman, J. S., Stahl, P. D., Gluck, S. Distribution and structure of the vacuolar H\+ ATPase in endosomes and lysosomes from LLC-PK1 cells. Exp. Cell Res. 192, 445-452 (1991).
-
(1991)
Exp. Cell Res
, vol.192
, pp. 445-452
-
-
Rodman, J.S.1
Stahl, P.D.2
Gluck, S.3
-
26
-
-
80052233389
-
Endosome maturation
-
Huotari, J., Helenius, A. Endosome maturation. EMBO J. 30, 3481-3500 (2011).
-
(2011)
EMBO J
, vol.30
, pp. 3481-3500
-
-
Huotari, J.1
Helenius, A.2
-
28
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak, Y. et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303 (2010).
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
-
29
-
-
80555143078
-
MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(\+)-ATPase
-
Zoncu, R. et al. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(\+)-ATPase. Science 334, 678-683 (2011).
-
(2011)
Science
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
-
30
-
-
80052841665
-
Regulation of TFEB and V-ATPases by mTORC1
-
Pena-Llopis, S. et al. Regulation of TFEB and V-ATPases by mTORC1. EMBO J. 30, 3242-3258 (2011).
-
(2011)
EMBO J
, vol.30
, pp. 3242-3258
-
-
Pena-Llopis, S.1
-
31
-
-
84857997408
-
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
-
Settembre, C. et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 31, 1095-1108 (2012).
-
(2012)
EMBO J
, vol.31
, pp. 1095-1108
-
-
Settembre, C.1
-
32
-
-
84862539692
-
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
-
Roczniak-Ferguson, A. et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci. Signal. 5, ra42 (2012).
-
(2012)
Sci. Signal
, vol.5
, pp. 42
-
-
Roczniak-Ferguson, A.1
-
33
-
-
84886787846
-
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer
-
Kim, H. S. et al. Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell 155, 552-566 (2013).
-
(2013)
Cell
, vol.155
, pp. 552-566
-
-
Kim, H.S.1
-
34
-
-
84907519033
-
The lysosomal V-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism
-
Zhang, C.-S. et al. The lysosomal V-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metab. 20, 526-540 (2014).
-
(2014)
Cell Metab
, vol.20
, pp. 526-540
-
-
Zhang, C.-S.1
-
35
-
-
10844284696
-
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
-
Ramirez, R. D. et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res. 64, 9027-9034 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 9027-9034
-
-
Ramirez, R.D.1
-
36
-
-
58149357048
-
Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes
-
Urano, Y. et al. Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nat. Med 15, 104-109 (2009).
-
(2009)
Nat. Med
, vol.15
, pp. 104-109
-
-
Urano, Y.1
-
37
-
-
84901036369
-
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer
-
Viola-Villegas, N. T. et al. Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc. Natl Acad. Sci. USA 111, 7254-7259 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 7254-7259
-
-
Viola-Villegas, N.T.1
-
38
-
-
84876020428
-
Family of pH (low) insertion peptides for tumor targeting
-
Weerakkody, D. et al. Family of pH (low) insertion peptides for tumor targeting. Proc. Natl Acad. Sci. USA 110, 5834-5839 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 5834-5839
-
-
Weerakkody, D.1
-
39
-
-
30744478946
-
Micelles for the self-assembly of 'Off-On-Off' fluorescent sensors for pH windows
-
Diaz-Fernandez, Y. et al. Micelles for the self-assembly of 'Off-On-Off' fluorescent sensors for pH windows. Chemistry 12, 921-930 (2006).
-
(2006)
Chemistry
, vol.12
, pp. 921-930
-
-
Diaz-Fernandez, Y.1
-
40
-
-
48849105889
-
Multiplexing sensory molecules map protons near micellar membranes
-
Uchiyama, S., Iwai, K., de Silva, A. P. Multiplexing sensory molecules map protons near micellar membranes. Angew. Chem. Int. Ed. 47, 4667-4669 (2008).
-
(2008)
Angew. Chem. Int. Ed
, vol.47
, pp. 4667-4669
-
-
Uchiyama, S.1
Iwai, K.2
De Silva, A.P.3
-
41
-
-
1842781842
-
Stimuli-responsive polypeptide vesicles by conformation-specific assembly
-
Bellomo, E. G., Wyrsta, M. D., Pakstis, L., Pochan, D. J., Deming, T. J. Stimuli-responsive polypeptide vesicles by conformation-specific assembly. Nat. Mater. 3, 244-248 (2004).
-
(2004)
Nat. Mater
, vol.3
, pp. 244-248
-
-
Bellomo, E.G.1
Wyrsta, M.D.2
Pakstis, L.3
Pochan, D.J.4
Deming, T.J.5
-
42
-
-
47349097049
-
Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance
-
Lee, E. S. et al. Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. J. Control. Release 129, 228-236 (2008).
-
(2008)
J. Control. Release
, vol.129
, pp. 228-236
-
-
Lee, E.S.1
-
43
-
-
14644433029
-
Super pH-sensitive multifunctional polymeric micelle
-
Lee, E. S., Na, K., Bae, Y. H. Super pH-sensitive multifunctional polymeric micelle. Nano Lett. 5, 325-329 (2005).
-
(2005)
Nano Lett
, vol.5
, pp. 325-329
-
-
Lee, E.S.1
Na, K.2
Bae, Y.H.3
-
44
-
-
15244345124
-
PH-responsive copolymer assemblies for controlled release of doxorubicin
-
Gillies, E. R., Frechet, J. M. J. pH-responsive copolymer assemblies for controlled release of doxorubicin. Bioconjug. Chem. 16, 361-368 (2005).
-
(2005)
Bioconjug. Chem
, vol.16
, pp. 361-368
-
-
Gillies, E.R.1
Frechet, J.M.J.2
-
45
-
-
4644264045
-
Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers
-
Gillies, E. R., Jonsson, T. B., Frechet, J. M. Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers. J. Am. Chem. Soc. 126, 11936-11943 (2004).
-
(2004)
J. Am. Chem. Soc
, vol.126
, pp. 11936-11943
-
-
Gillies, E.R.1
Jonsson, T.B.2
Frechet, J.M.3
-
46
-
-
0035847011
-
Cathepsin B activity regulation heparin-like glycosaminoglycans protect human cathepsin B from alkaline ph-induced inactivation
-
Almeida, P. C. et al. Cathepsin B activity regulation heparin-like glycosaminoglycans protect human cathepsin B from alkaline ph-induced inactivation. J. Biol. Chem. 276, 944-951 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 944-951
-
-
Almeida, P.C.1
-
47
-
-
34547690726
-
Immunological properties of engineered nanomaterials
-
Dobrovolskaia, M. A., McNeil, S. E. Immunological properties of engineered nanomaterials. Nat. Nanotechnol 2, 469-478 (2007).
-
(2007)
Nat. Nanotechnol
, vol.2
, pp. 469-478
-
-
Dobrovolskaia, M.A.1
McNeil, S.E.2
-
48
-
-
36849067019
-
Nanocarriers as an emerging platform for cancer therapy
-
Peer, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol 2, 751-760 (2007).
-
(2007)
Nat. Nanotechnol
, vol.2
, pp. 751-760
-
-
Peer, D.1
-
49
-
-
84905385325
-
Chaotropic-anion-induced supramolecular self-assembly of ionic polymeric micelles
-
Li, Y. et al. Chaotropic-anion-induced supramolecular self-assembly of ionic polymeric micelles. Angew. Chem. 53, 8074-8078 (2014).
-
(2014)
Angew. Chem
, vol.53
, pp. 8074-8078
-
-
Li, Y.1
-
50
-
-
0033169080
-
A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells
-
Diwu, Z., Chen, C.-S., Zhang, C., Klaubert, D. H., Haugland, R. P. A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells. Chem. Biol. 6, 411-418 (1999).
-
(1999)
Chem. Biol
, vol.6
, pp. 411-418
-
-
Diwu, Z.1
Chen, C.-S.2
Zhang, C.3
Klaubert, D.H.4
Haugland, R.P.5
-
51
-
-
0018764575
-
Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ
-
Thomas, J. A., Buchsbaum, R. N., Zimniak, A., Racker, E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 18, 2210-2218 (1979).
-
(1979)
Biochemistry
, vol.18
, pp. 2210-2218
-
-
Thomas, J.A.1
Buchsbaum, R.N.2
Zimniak, A.3
Racker, E.4
-
52
-
-
0026650127
-
Quick and accurate method to convert BCECF fluorescence to pHi: Calibration in three different types of cell preparations
-
James-Kracke, M. R. Quick and accurate method to convert BCECF fluorescence to pHi: calibration in three different types of cell preparations. J. Cell. Physiol. 151, 596-603 (1992).
-
(1992)
J. Cell. Physiol
, vol.151
, pp. 596-603
-
-
James-Kracke, M.R.1
-
53
-
-
0028100685
-
Functional characterization of three isoforms of the Na\+/H\+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation
-
Kapus, A., Grinstein, S., Wasan, S., Kandasamy, R., Orlowski, J. Functional characterization of three isoforms of the Na\+/H\+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation. J. Biol. Chem. 269, 23544-23552 (1994).
-
(1994)
J. Biol. Chem
, vol.269
, pp. 23544-23552
-
-
Kapus, A.1
Grinstein, S.2
Wasan, S.3
Kandasamy, R.4
Orlowski, J.5
-
54
-
-
0027418205
-
Measurement of co-localization of objects in dual-colour confocal images
-
Manders, E., Verbeek, F., Aten, J. Measurement of co-localization of objects in dual-colour confocal images. J. Microsc. 169, 375-382 (1993).
-
(1993)
J. Microsc
, vol.169
, pp. 375-382
-
-
Manders, E.1
Verbeek, F.2
Aten, J.3
-
55
-
-
33845764296
-
A guided tour into subcellular colocalization analysis in light microscopy
-
Bolte, S., Cordelières, F. P. A guided tour into subcellular colocalization analysis in light microscopy. J. Microsc. 224, 213-232 (2006).
-
(2006)
J. Microsc
, vol.224
, pp. 213-232
-
-
Bolte, S.1
Cordelières, F.P.2
-
56
-
-
84878396462
-
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
-
Commisso, C. et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497, 633-637 (2013).
-
(2013)
Nature
, vol.497
, pp. 633-637
-
-
Commisso, C.1
|