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Volumn 85, Issue 14, 2015, Pages 1240-1249

Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; FLUTEMETAMOL F 18; TAU PROTEIN; AMYLOID BETA PROTEIN;

EID: 84943227798     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000001991     Document Type: Article
Times cited : (265)

References (40)
  • 1
    • 79956084514 scopus 로고    scopus 로고
    • The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease
    • Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 270-279
    • (2011) Alzheimers Dement , vol.7 , pp. 270-279
    • Albert, M.S.1    DeKosky, S.T.2    Dickson, D.3
  • 2
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease
    • Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 280-292
    • (2011) Alzheimers Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3
  • 3
    • 84893778864 scopus 로고    scopus 로고
    • Semagacestat's fall: Where next for ad therapies
    • Blennow K, Zetterberg H, Haass C, Finucane T. Semagacestat's fall: where next for AD therapies? Nat Med 2013; 19: 1214-1215
    • (2013) Nat Med , vol.19 , pp. 1214-1215
    • Blennow, K.1    Zetterberg, H.2    Haass, C.3    Finucane, T.4
  • 4
    • 84943242972 scopus 로고    scopus 로고
    • Eli Lilly and Company). In: ClinicalTrials.gov [Internet]. Bethesda MD: National Library of Medicine. Cited January 20 Available at
    • Eli Lilly and Company. Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo (EXPEDITION 3). In: ClinicalTrials.gov [Internet]. Bethesda, MD: National Library of Medicine. Cited January 20, 2015. Available at: https://clinicaltrials.gov/ct2/show/NCT01900665. NLM Identifier: NCT01900665
    • (2015) Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo (EXPEDITIon 3
  • 5
    • 84892710970 scopus 로고    scopus 로고
    • Antiamyloid therapy for Alzheimer's disease are we on the right road
    • Karran E, Hardy J. Antiamyloid therapy for Alzheimer's disease: are we on the right road? N Engl J Med 2014; 370: 377-378
    • (2014) N Engl J Med , vol.370 , pp. 377-378
    • Karran, E.1    Hardy, J.2
  • 6
    • 84863598082 scopus 로고    scopus 로고
    • Csf biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
    • Seppala TT, Nerg O, Koivisto AM, et al. CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings. Neurology 2012; 78: 1568-1575
    • (2012) Neurology , vol.78 , pp. 1568-1575
    • Seppala, T.T.1    Nerg, O.2    Koivisto, A.M.3
  • 7
    • 81355164296 scopus 로고    scopus 로고
    • Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology
    • Wolk DA, Grachev ID, Buckley C, et al. Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology. Arch Neurol 2011; 68: 1398-1403
    • (2011) Arch Neurol , vol.68 , pp. 1398-1403
    • Wolk, D.A.1    Grachev, I.D.2    Buckley, C.3
  • 8
    • 77949423619 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    • Blennow K, Hampel H, Weiner M, Zetterberg H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 2010; 6: 131-144
    • (2010) Nat Rev Neurol , vol.6 , pp. 131-144
    • Blennow, K.1    Hampel, H.2    Weiner, M.3    Zetterberg, H.4
  • 9
    • 33750589818 scopus 로고    scopus 로고
    • Csf phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
    • Buerger K, Ewers M, Pirttila T, et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain 2006; 129: 3035-3041
    • (2006) Brain , vol.129 , pp. 3035-3041
    • Buerger, K.1    Ewers, M.2    Pirttila, T.3
  • 10
    • 77949555201 scopus 로고    scopus 로고
    • Pittsburgh compound-b and Alzheimer's disease biomarkers in csf, plasma and urine: An exploratory study
    • Degerman Gunnarsson M, Lindau M, Wall A, et al. Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: an exploratory study. Dement Geriatr Cogn Disord 2010; 29: 204-212
    • (2010) Dement Geriatr Cogn Disord , vol.29 , pp. 204-212
    • Degerman Gunnarsson, M.1    Lindau, M.2    Wall, A.3
  • 11
    • 33644832047 scopus 로고    scopus 로고
    • Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid abeta42 in humans
    • Fagan AM, Mintun MA, Mach RH, et al. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol 2006; 59: 512-519
    • (2006) Ann Neurol , vol.59 , pp. 512-519
    • Fagan, A.M.1    Mintun, M.A.2    Mach, R.H.3
  • 12
    • 77949425172 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease
    • Fagan AM, Mintun MA, Shah AR, et al. Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. EMBO Mol Med 2009; 1: 371-380
    • (2009) EMBO Mol Med , vol.1 , pp. 371-380
    • Fagan, A.M.1    Mintun, M.A.2    Shah, A.R.3
  • 13
    • 77949701876 scopus 로고    scopus 로고
    • High pib retention in Alzheimer's disease is an early event with complex relationship with csf biomarkers and functional parameters
    • Forsberg A, Almkvist O, Engler H, Wall A, Langstrom B, Nordberg A. High PiB retention in Alzheimer's disease is an early event with complex relationship with CSF biomarkers and functional parameters. Curr Alzheimer Res 2010; 7: 56-66
    • (2010) Curr Alzheimer Res , vol.7 , pp. 56-66
    • Forsberg, A.1    Almkvist, O.2    Engler, H.3    Wall, A.4    Langstrom, B.5    Nordberg, A.6
  • 14
    • 67349227896 scopus 로고    scopus 로고
    • Beta amyloid in Alzheimer's disease: Increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid
    • Grimmer T, Riemenschneider M, Forstl H, et al. Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid. Biol Psychiatry 2009; 65: 927-934
    • (2009) Biol Psychiatry , vol.65 , pp. 927-934
    • Grimmer, T.1    Riemenschneider, M.2    Forstl, H.3
  • 15
    • 70350152831 scopus 로고    scopus 로고
    • Relationships between biomarkers in aging and dementia
    • Jagust WJ, Landau SM, Shaw LM, et al. Relationships between biomarkers in aging and dementia. Neurology 2009; 73: 1193-1199
    • (2009) Neurology , vol.73 , pp. 1193-1199
    • Jagust, W.J.1    Landau, S.M.2    Shaw, L.M.3
  • 16
    • 53849132759 scopus 로고    scopus 로고
    • Pet amyloid ligand [11c] uptake and cerebrospinal fluid betaamyloid in mild cognitive impairment
    • Koivunen J, Pirttila T, Kemppainen N, et al. PET amyloid ligand [11C]PIB uptake and cerebrospinal fluid betaamyloid in mild cognitive impairment. Dement Geriatr Cogn Disord 2008; 26: 378-383
    • (2008) Dement Geriatr Cogn Disord , vol.26 , pp. 378-383
    • Koivunen, J.1    Pirttila, T.2    Kemppainen, N.3
  • 17
    • 84892918273 scopus 로고    scopus 로고
    • Comparing pet imaging and csf measurements of ab
    • Landau SM, Lu M, Joshi AD, et al. Comparing PET imaging and CSF measurements of Ab. Ann Neurol 2013; 74: 826-836
    • (2013) Ann Neurol , vol.74 , pp. 826-836
    • Landau, S.M.1    Lu, M.2    Joshi, A.D.3
  • 18
    • 84927957367 scopus 로고    scopus 로고
    • Independent information from cerebrospinal fluid b-Amyloid and florbetapir imaging in Alzheimer's disease
    • Mattsson N, Insel P, Donohue M, et al. Independent information from cerebrospinal fluid b-Amyloid and florbetapir imaging in Alzheimer's disease. Brain 2015; 138: 772-783
    • (2015) Brain , vol.138 , pp. 772-783
    • Mattsson, N.1    Insel, P.2    Donohue, M.3
  • 19
    • 84928107166 scopus 로고    scopus 로고
    • Diagnostic accuracy of csf ab42 and florbetapir pet for Alzheimer's disease
    • Mattsson N, Insel P, Landau S, et al. Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer's disease. Ann Clin Transl Neurol 2014; 1: 534-543
    • (2014) Ann Clin Transl Neurol , vol.1 , pp. 534-543
    • Mattsson, N.1    Insel, P.2    Landau, S.3
  • 20
    • 84907978955 scopus 로고    scopus 로고
    • Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid beta-Amyloid 42: A cross-validation study against amyloid positron emission tomography
    • Palmqvist S, Zetterberg H, Blennow K, et al. Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid beta-Amyloid 42: a cross-validation study against amyloid positron emission tomography. JAMA Neurol 2014; 71: 1282-1289
    • (2014) JAMA Neurol , vol.71 , pp. 1282-1289
    • Palmqvist, S.1    Zetterberg, H.2    Blennow, K.3
  • 21
    • 69449085355 scopus 로고    scopus 로고
    • Relationship of cerebrospinal fluid markers to 11cpib and 18f-fddnp binding
    • Tolboom N, van der Flier WM, Yaqub M, et al. Relationship of cerebrospinal fluid markers to 11CPiB and 18F-FDDNP binding. J Nucl Med 2009; 50: 1464-1470
    • (2009) J Nucl Med , vol.50 , pp. 1464-1470
    • Tolboom, N.1    Van Der Flier, W.M.2    Yaqub, M.3
  • 22
    • 79952740168 scopus 로고    scopus 로고
    • Transforming cerebrospinal fluid abeta42 measures into calculated pittsburgh compound b units of brain abeta amyloid
    • Weigand SD, Vemuri P, Wiste HJ, et al. Transforming cerebrospinal fluid Abeta42 measures into calculated Pittsburgh Compound B units of brain Abeta amyloid. Alzheimers Dement 2011; 7: 133-141
    • (2011) Alzheimers Dement , vol.7 , pp. 133-141
    • Weigand, S.D.1    Vemuri, P.2    Wiste, H.J.3
  • 23
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to Alzheimer's disease: Recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease
    • McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 263-269
    • (2011) Alzheimers Dement , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3
  • 24
    • 0345700786 scopus 로고    scopus 로고
    • Physical activity of subjects aged 50-64 years involved in the european prospective investigation into cancer and nutrition (epic
    • Haftenberger M, Schuit AJ, Tormo MJ, et al. Physical activity of subjects aged 50-64 years involved in the European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr 2002; 5: 1163-1176
    • (2002) Public Health Nutr , vol.5 , pp. 1163-1176
    • Haftenberger, M.1    Schuit, A.J.2    Tormo, M.J.3
  • 25
    • 68249141258 scopus 로고    scopus 로고
    • Phase 1 study of the pittsburgh compound b derivative 18f-flutemetamol in healthy volunteers and patients with probable Alzheimer disease
    • Nelissen N, Van Laere K, Thurfjell L, et al. Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J Nucl Med 2009; 50: 1251-1259
    • (2009) J Nucl Med , vol.50 , pp. 1251-1259
    • Nelissen, N.1    Van Laere, K.2    Thurfjell, L.3
  • 26
    • 84881461022 scopus 로고    scopus 로고
    • Implementation and validation of an adaptive template registration method for 18f-flutemetamol imaging data
    • Lundqvist R, Lilja J, Thomas BA, et al. Implementation and validation of an adaptive template registration method for 18F-flutemetamol imaging data. J Nucl Med 2013; 54: 1472-1478
    • (2013) J Nucl Med , vol.54 , pp. 1472-1478
    • Lundqvist, R.1    Lilja, J.2    Thomas, B.A.3
  • 27
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosen WG, Mohs RC, Davis KL A new rating scale for Alzheimer's disease. Am J Psychiatry 1984; 141: 1356-1364
    • (1984) Am J Psychiatry , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2    Davis, K.L.3
  • 28
    • 65249159879 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    • Shaw LM, Vanderstichele H, Knapik-Czajka M, et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol 2009; 65: 403-413
    • (2009) Ann Neurol , vol.65 , pp. 403-413
    • Shaw, L.M.1    Vanderstichele, H.2    Knapik-Czajka, M.3
  • 29
    • 79952709519 scopus 로고    scopus 로고
    • Proc: An opensource package for r and s1 to analyze and compare roc curves
    • Robin X, Turck N, Hainard A, et al. pROC: an opensource package for R and S1 to analyze and compare ROC curves. BMC Bioinformatics 2011; 12: 77
    • (2011) BMC Bioinformatics , vol.12 , pp. 77
    • Robin, X.1    Turck, N.2    Hainard, A.3
  • 30
    • 70450203033 scopus 로고    scopus 로고
    • Mixtools: An r package for analyzing finite mixture models
    • Benaglia T, Chauveau D, Hunter DR, Young D. Mixtools: an R package for analyzing finite mixture models. J Stat Softw 2009; 32: 1-29
    • (2009) J Stat Softw , vol.32 , pp. 1-29
    • Benaglia, T.1    Chauveau, D.2    Hunter, D.R.3    Young, D.4
  • 31
    • 33947223454 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/beta-Amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
    • Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid tau/beta-Amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol 2007; 64: 343-349
    • (2007) Arch Neurol , vol.64 , pp. 343-349
    • Fagan, A.M.1    Roe, C.M.2    Xiong, C.3    Mintun, M.A.4    Morris, J.C.5    Holtzman, D.M.6
  • 32
    • 32544435900 scopus 로고    scopus 로고
    • Association between csf biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study
    • Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 2006; 5: 228-234
    • (2006) Lancet Neurol , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4    Blennow, K.5    Minthon, L.6
  • 33
    • 78650464378 scopus 로고    scopus 로고
    • Evaluation of csf biomarkers as predictors of Alzheimer's disease: A clinical follow-up study of 4.7 years
    • Hertze J, Minthon L, Zetterberg H, Vanmechelen E, Blennow K, Hansson O. Evaluation of CSF biomarkers as predictors of Alzheimer's disease: a clinical follow-up study of 4.7 years. J Alzheimers Dis 2010; 21: 1119-1128
    • (2010) J Alzheimers Dis , vol.21 , pp. 1119-1128
    • Hertze, J.1    Minthon, L.2    Zetterberg, H.3    Vanmechelen, E.4    Blennow, K.5    Hansson, O.6
  • 34
    • 62449262536 scopus 로고    scopus 로고
    • Cerebrospinal fluid {beta}-Amyloid 42 and tau proteins as biomarkers of Alzheimer-Type pathologic changes in the brain
    • Tapiola T, Alafuzoff I, Herukka SK, et al. Cerebrospinal fluid {beta}-Amyloid 42 and tau proteins as biomarkers of Alzheimer-Type pathologic changes in the brain. Arch Neurol 2009; 66: 382-389
    • (2009) Arch Neurol , vol.66 , pp. 382-389
    • Tapiola, T.1    Alafuzoff, I.2    Herukka, S.K.3
  • 35
    • 84908222292 scopus 로고    scopus 로고
    • Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: Findings from neuropathological and neuroimaging studies
    • Thal DR, Attems J, Ewers M. Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies. J Alzheimers Dis 2014; 42: S421-S429
    • (2014) J Alzheimers Dis , vol.42 , pp. S421-S429
    • Thal, D.R.1    Attems, J.2    Ewers, M.3
  • 36
    • 84855304100 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of beta-Amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia
    • Buchhave P, Minthon L, Zetterberg H, Wallin AK, Blennow K, Hansson O. Cerebrospinal fluid levels of beta-Amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012; 69: 98-106
    • (2012) Arch Gen Psychiatry , vol.69 , pp. 98-106
    • Buchhave, P.1    Minthon, L.2    Zetterberg, H.3    Wallin, A.K.4    Blennow, K.5    Hansson, O.6
  • 37
    • 77955453909 scopus 로고    scopus 로고
    • Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people
    • De Meyer G, Shapiro F, Vanderstichele H, et al. Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people. Arch Neurol 2010; 67: 949-956
    • (2010) Arch Neurol , vol.67 , pp. 949-956
    • De Meyer, G.1    Shapiro, F.2    Vanderstichele, H.3
  • 38
    • 84872463342 scopus 로고    scopus 로고
    • Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia
    • Le Bastard N, Coart E, Vanderstichele H, Vanmechelen E, Martin JJ, Engelborghs S. Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia. J Alzheimers Dis 2013; 33: 117-131
    • (2013) J Alzheimers Dis , vol.33 , pp. 117-131
    • Le Bastard, N.1    Coart, E.2    Vanderstichele, H.3    Vanmechelen, E.4    Martin, J.J.5    Engelborghs, S.6
  • 39
    • 84922779468 scopus 로고    scopus 로고
    • The centiloid project: Standardizing quantitative amyloid plaque estimation by pet
    • e1-4
    • Klunk WE, Koeppe RA, Price JC, et al. The Centiloid project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement 2015; 11: 1-15.e1-4
    • (2015) Alzheimers Dement , vol.11 , pp. 1-15
    • Klunk, W.E.1    Koeppe, R.A.2    Price, J.C.3
  • 40
    • 84856008210 scopus 로고    scopus 로고
    • Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's biomarkers standardization initiative
    • Vanderstichele H, Bibl M, Engelborghs S, et al. Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimers Dement 2012; 8: 65-73
    • (2012) Alzheimers Dement , vol.8 , pp. 65-73
    • Vanderstichele, H.1    Bibl, M.2    Engelborghs, S.3


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