RAGE siRNA-mediated gene silencing provides cardioprotection against ventricular arrhythmias in acute ischemia and reperfusion

Journal of Controlled Release

Volumn 217, Issue , 2015, Pages 315-326

  Park, Hyelim ^a,b   Ku, Sook Hee ^c   Park, Hyewon ^a   Hong, Jueun ^d   Kim, Dongkyu ^a,c   Choi, Bum Rak ^e   Pak, Hui Nam ^a   Lee, Moon Hyoung ^a   Mok, Hyejung ^f   Jeong, Ji Hoon ^g   Choi, Donghoon ^a   Kim, Sun Hwa ^c   Joung, Boyoung ^a,b  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

^d Korea Testing and Research Institute   (South Korea)

^e BROWN UNIVERSITY   (United States)

^f Konkuk University   (South Korea)

^g Sungkyunkwan University   (South Korea)

Author keywords

Arrhythmia; Connexin43; Ischemia reperfusion injury; Receptor for advanced glycation end products; siRNA; Wnt1

Indexed keywords

CELL DEATH; ELECTROPHYSIOLOGY; GENE TRANSFER; GENES; GLYCOSYLATION;

ADVANCED GLYCATION END PRODUCTS; ARRHYTHMIA; CONNEXIN-43; ISCHEMIA/REPERFUSION; SIRNA; WNT1;

DISEASES;

ADVANCED GLYCATION END PRODUCT RECEPTOR; CONNEXIN 43; DEOXYCHOLIC ACID; POLYETHYLENEIMINE; SMALL INTERFERING RNA; WNT PROTEIN; CONNEXIN 43 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ELECTROPHYSIOLOGY; GENE SILENCING; HEART CONDUCTION; HEART MUSCLE POTENTIAL; HEART PROTECTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; INFLAMMATION; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ARRHYTHMIAS, CARDIAC; CARDIAC MUSCLE; CELL LINE; COMPLICATION; GENE TRANSFER; GENETICS; METABOLISM; MYOCARDIAL REPERFUSION INJURY; SPRAGUE DAWLEY RAT; WNT SIGNALING PATHWAY;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; ARRHYTHMIAS, CARDIAC; CELL LINE; CONNEXIN 43; GENE TRANSFER TECHNIQUES; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; WNT SIGNALING PATHWAY;

EID: 84943193880     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.09.006     Document Type: Article

References (34)

1. R. Bolli, L. Becker, G. Gross, R. Mentzer Jr., D. Balshaw, and D.A. Lathrop Myocardial protection at a crossroads: the need for translation into clinical therapy Circ Res 95 2004 125 134
2. P.R. Maroko, J.K. Kjekshus, B.E. Sobel, T. Watanabe, J.W. Covell, J. Ross Jr., and E. Braunwald Factors influencing infarct size following experimental coronary artery occlusions Circulation 43 1971 67 82
3. K.A. Reimer, J.E. Lowe, M.M. Rasmussen, and R.B. Jennings The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs Circulation 56 1977 786 794
4. T. Kislinger, C. Fu, B. Huber, W. Qu, A. Taguchi, S.Du. Yan, M. Hofmann, S.F. Yan, M. Pischetsrieder, D. Stern, and A.M. Schmidt N-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression J Biol Chem 274 1999 31740 31749
5. A. Aleshin, R. Ananthakrishnan, Q. Li, R. Rosario, Y. Lu, W. Qu, F. Song, S. Bakr, M. Szabolcs, V. D'Agati, R. Liu, S. Homma, A.M. Schmidt, S.F. Yan, and R. Ramasamy RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model Am J Physiol Heart Circ Physiol 294 2008 H1823 H1832
6. L.G. Bucciarelli, M. Kaneko, R. Ananthakrishnan, E. Harja, L.K. Lee, Y.C. Hwang, S. Lerner, S. Bakr, Q. Li, Y. Lu, F. Song, W. Qu, T. Gomez, Y.S. Zou, S.F. Yan, A.M. Schmidt, and R. Ramasamy Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury Circulation 113 2006 1226 1234
7. A.G. Kleber, and Y. Rudy Basic mechanisms of cardiac impulse propagation and associated arrhythmias Physiol Rev 84 2004 431 488
8. N.J. Severs, S.R. Coppen, E. Dupont, H.-I. Yeh, Y.-S. Ko, and T. Matsushita Gap junction alterations in human cardiac disease Cardiovasc Res 62 2004 368 377
9. D.E. Gutstein, G.E. Morley, H. Tamaddon, D. Vaidya, M.D. Schneider, J. Chen, K.R. Chien, H. Stuhlmann, and G.I. Fishman Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43 Circ Res 88 2001 333 339
10. D.L. Lerner, K.A. Yamada, R.B. Schuessler, and J.E. Saffitz Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice Circulation 101 2000 547 552
11. Z. Ai, A. Fischer, D.C. Spray, A.M.C. Brown, and G.I. Fishman Wnt-1 regulation of connexin43 in cardiac myocytes J Clin Invest 105 2000 161 171
12. G. Li, J. Xu, and Z. Li Receptor for advanced glycation end products inhibits proliferation in osteoblast through suppression of Wnt, PI3K and ERK signaling Biochem Biophys Res Commun 423 2012 684 689
13. K.-H. Lin, J.-Y. Guh, J.-F. Mo, S.-J. Chiou, C.-C. Hwang, and L.-Y. Chuang Advanced glycation end-product-inhibited cell proliferation and protein expression of β-catenin and cyclin D1 are dependent on glycogen synthase kinase 3β in LLC-PK1 cells Arch Biochem Biophys 477 2008 27 32
14. J. Hong, S.H. Ku, M.S. Lee, J.H. Jeong, H. Mok, D. Choi, and S.H. Kim Cardiac RNAi therapy using RAGE siRNA/deoxycholic acid-modified polyethylenimine complexes for myocardial infarction Biomaterials 35 2014 7562 7573
15. D. Kim, J. Hong, H.H. Moon, H.Y. Nam, H. Mok, J.H. Jeong, S.W. Kim, D. Choi, and S.H. Kim Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia-reperfusion injury: use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier J Control Release 168 2013 125 134
16. B. Joung, L. Tang, M. Maruyama, S. Han, Z. Chen, M. Stucky, L.R. Jones, M.C. Fishbein, J.N. Weiss, P.S. Chen, and S.F. Lin Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation Circulation 119 2009 788 796
17. G. Salama, S.M. Hwang, Simultaneous optical mapping of intracellular free calcium and action potentials from Langendorff perfused hearts, Current protocols in cytometry, Chapter 12 (2009) Unit 12.17.
18. I.R. Efimov, D.T. Huang, J.M. Rendt, and G. Salama Optical mapping of repolarization and refractoriness from intact hearts Circulation 90 1994 1469 1480
19. O. Ziv, E. Morales, Y.K. Song, X. Peng, K.E. Odening, A.E. Buxton, A. Karma, G. Koren, and B.R. Choi Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome J Physiol 587 2009 4661 4680
20. J.K. Donahue Gene therapy for ventricular tachyarrhythmias Gene Ther 19 2012 600 605
21. L.J. Motloch, and F.G. Akar Gene therapy to restore electrophysiological function in heart failure Expert Opin Biol Ther 15 2015 803 817
22. F. Prunier, Y. Kawase, D. Gianni, C. Scapin, S.B. Danik, P.T. Ellinor, R.J. Hajjar, and F. del Monte Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2 + ATPase pump overexpression in a porcine model of ischemia reperfusion Circulation 118 2008 614 624
23. D.H. Lau, C. Clausen, E.A. Sosunov, I.N. Shlapakova, E.P. Anyukhovsky, P. Danilo, T.S. Rosen, C. Kelly, H.S. Duffy, M.J. Szabolcs, M. Chen, R.B. Robinson, J. Lu, S. Kumari, I.S. Cohen, and M.R. Rosen Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study Circulation 119 2009 19 27
24. T. Chavakis, A. Bierhaus, and P.P. Nawroth RAGE (receptor for advanced glycation end products): a central player in the inflammatory response Microb. Infect. 6 2004 1219 1225
25. M. Andrassy, H.C. Volz, J.C. Igwe, B. Funke, S.N. Eichberger, Z. Kaya, S. Buss, F. Autschbach, S.T. Pleger, I.K. Lukic, F. Bea, S.E. Hardt, P.M. Humpert, M.E. Bianchi, H. Mairbäurl, P.P. Nawroth, A. Remppis, H.A. Katus, and A. Bierhaus High-mobility group box-1 in ischemia-reperfusion injury of the heart Circulation 117 2008 3216 3226
26. N. Mahajan, and V. Dhawan Receptor for advanced glycation end products (RAGE) in atrial fibrillation Int J Cardiol 168 2013 5072 5073
27. Q. Zhang, G. Li, and T. Liu Receptor for advanced glycation end products (RAGE): novel biomarker and therapeutic target for atrial fibrillation Int J Cardiol 168 2013 4802 4804
28. S.Y. Chae, H.J. Kim, M.S. Lee, Y.L. Jang, Y. Lee, S.H. Lee, K. Lee, S.H. Kim, H.T. Kim, S.C. Chi, T.G. Park, and J.H. Jeong Energy-independent intracellular gene delivery mediated by polymeric biomimetics of cell-penetrating peptides Macromol Biosci 11 2011 1169 1174
29. C. Vozzi, E. Dupont, S.R. Coppen, H.-I. Yeh, and N.J. Severs Chamber-related differences in connexin expression in the human heart J Mol Cell Cardiol 31 1999 991 1003
30. K. Dawson, M. Aflaki, and S. Nattel Role of the Wnt-frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential J Physiol 591 2013 1409 1432
31. K. Otero, F. Martinez, A. Beltran, D. Gonzalez, B. Herrera, G. Quintero, R. Delgado, and A. Rojas Albumin-derived advanced glycation end-products trigger the disruption of the vascular endothelial cadherin complex in cultured human and murine endothelial cells Biochem J 359 2001 567 574
32. G. Esposito, C. Scuderi, J. Lu, C. Savani, D. De Filippis, T. Iuvone, L. Steardo Jr., V. Sheen, and L. Steardo S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells J Cell Mol Med 12 2008 914 927
33. W. Roell, T. Lewalter, P. Sasse, Y.N. Tallini, B.-R. Choi, M. Breitbach, R. Doran, U.M. Becher, S.-M. Hwang, T. Bostani, J. von Maltzahn, A. Hofmann, S. Reining, B. Eiberger, B. Gabris, A. Pfeifer, A. Welz, K. Willecke, G. Salama, J.W. Schrickel, M.I. Kotlikoff, and B.K. Fleischmann Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia Nature 450 2007 819 824
34. A. Schmidt, C.F. Azevedo, A. Cheng, S.N. Gupta, D.A. Bluemke, T.K. Foo, G. Gerstenblith, R.G. Weiss, E. Marbán, G.F. Tomaselli, J.A.C. Lima, and K.C. Wu Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction Circulation 115 2007 2006 2014