Risk assessment of persistent pharmaceuticals in biosolids: Dealing with uncertainty

Journal of Hazardous Materials

Volumn 302, Issue , 2016, Pages 72-81

  García Santiago, Xela ^a   Franco Uría, Amaya ^a   Omil, Francisco ^a   Lema, Juan M ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Biosolids; Persistent pharmaceuticals; Risk assessment; Uncertainty

Indexed keywords

BIOLOGICAL MATERIALS; BIOSOLIDS; RISK PERCEPTION; SENSITIVITY ANALYSIS; SEWAGE TREATMENT PLANTS; SOIL POLLUTION;

APPLICATION RATES; CARBAMAZEPINE; DATA AVAILABILITY; HAZARD INDICES; PROBABILISTIC ASSESSMENTS; SCREENING LEVEL; SLUDGE CONCENTRATION; UNCERTAINTY;

RISK ASSESSMENT;

CARBAMAZEPINE; CIPROFLOXACIN; FLUOXETINE; MICONAZOLE; NAPROXEN; TRICLOSAN; DRUG; FERTILIZER; SEWAGE; SOIL POLLUTANT;

BIOSOLID; DRUG; ENVIRONMENTAL FATE; PERSISTENT ORGANIC POLLUTANT; POLLUTANT REMOVAL; PPCP; RECYCLING; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SEWAGE TREATMENT; SLUDGE; UNCERTAINTY ANALYSIS;

ARTICLE; BIOACCUMULATION; BIOSOLID; CLASSIFICATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL IMPACT; HAZARD ASSESSMENT; HYGIENE PRODUCT; PHARMACEUTICAL AND PERSONAL CARE PRODUCT; RISK ASSESSMENT; SCREENING; SEWAGE TREATMENT PLANT; SLUDGE; UNCERTAINTY; WASTE WATER RECYCLING; ANALYSIS; SEWAGE; SOIL POLLUTANT;

FERTILIZERS; PHARMACEUTICAL PREPARATIONS; RISK ASSESSMENT; SEWAGE; SOIL POLLUTANTS;

EID: 84943170513     PISSN: 03043894     EISSN: 18733336     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2015.09.035     Document Type: Article

References (87)

1. Sanderson H., Johnson D.J., Reitsma T., Brain R.A., Wilson C.J., Solomon K.R. Ranking and prioritization of environmental risks of pharmaceuticals in surface waters. Regul. Toxicol. Pharm. 2004, 39:158-183.
2. Loraine G.A., Pettigrove M.E. Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in Southern California. Environ. Sci. Technol. 2006, 40:687-695.
3. Suárez S., Lema J.M., Omil F. Pre-treatment of hospital wastewater by coagulation-flocculation and flotation. Bioresour. Technol. 2009, 100:2138-2146.
4. Cabeza Y., Candela L., Ronen D., Teijon G. Monitoring the occurrence of emerging contaminants in treated wastewater and groundwater between 2008 and 2010. The Baix Llobregat (Barcelona, Spain). J. Hazard. Mater. 2012, 239-240:32-39.
5. Sengupta A., Lyons J.M., Smith D.J., Drewes J.E., Snyder S.A., Heil A., Maruya K.A. The occurrence and fate of chemicals of emerging concern in coastal urban rivers receiving discharge of treated municipal wastewater effluent. Environ. Toxicol. Chem. 2014, 33:350-358.
6. Webb S., Ternes T., Gibert M., Olejniczak K. Indirect human exposure to pharmaceuticals via drinking water. Toxicol. Lett. 2003, 142:157-167.
7. Hernando M.D., Mezcua M., Fernández-Alba A.R., Barceló D. Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 2006, 69:334-342.
8. Bruce G.M., Pleus R.C., Snyder S.A. Toxicological relevance of pharmaceuticals in drinking water. Environ. Sci. Technol. 2010, 44:5619-5626.
9. Bu Q., Wang B., Huang J., Deng S., Yu G. Pharmaceuticals and personal care products in the aquatic environment in China: a review. J. Hazard. Mater. 2013, 262:189-211.
10. Boxall A.B.A., Keller V.D.J., Straub J.O., Monteiro S.C., Fussell R., Williams R.J. Exploiting monitoring data in environmental exposure modelling and risk assessment of pharmaceuticals. Environ. Int. 2014, 73:176-185.
11. Al Aukidy M., Verlicchi P., Jelic A., Petrovic M., Barcelò D. Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy. Sci. Total Environ. 2012, 438:15-25.
12. Stuart M., Lapworth D., Crane E., Hart A. Review of risk from potential emerging contaminants in UK groundwater. Sci. Total Environ. 2012, 416:1-21.
13. Backhaus T., Karlsson M. Screening level mixture risk assessment of pharmaceuticals in STP effluents. Water Res. 2014, 49:157-165.
14. Vulliet E., Cren-Olivé C. Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption. Environ. Pollut. 2011, 159:2929-2934.
15. López-Serna R., Petrovic M., Barceló D. Occurrence and distribution of multi-class pharmaceuticals and their active metabolites and transformation products in the Ebro River basin (NE Spain). Sci. Total Environ. 2012, 440:280-289.
16. Houtman C.J., Kroesbergen J., Lekkerkerker-Teunissen K., van der Hoek J.P. Human health risk assessment of the mixture of pharmaceuticals in Dutch drinking water and its sources based on frequent monitoring data. Sci. Total Environ. 2014, 496:54-62.
17. Stevens J.L., Jones K.C. Quantification of PCDD/F concentrations in animal manure and comparison of the effects of the application of cattle manure and sewage sludge to agricultural land on human exposure to PCDD/Fs. Chemosphere 2003, 50:1183-1191.
18. Franco A., Schuhmacher M., Roca E., Domingo J.L. Application of cattle manure as fertilizer in pastureland: estimating the incremental risk due to metal accumulation employing a multicompartment model. Environ. Int. 2006, 32:724-732.
19. Passuello A., Mari M., Nadal M., Schuhmacher M., Domingo J.L. POP accumulation in the food chain: Integrated risk model for sewage sludge application in agricultural soils. Environ. Int. 2010, 36:577-583.
20. EC, European Commission, Final report on heavy metals and organic compounds from wastes used as organic fertilisers, ENV.A.2./ETU/2001/0024, July 2004.
21. Gielen G.J.H.P., van den Heuvel M.R., Clinton P.W., Greenfield L.G. Factors impacting on pharmaceutical leaching following sewage application to land. Chemosphere 2009, 74:537-542.
22. Langdon K.A., Warne M.St.J., Smernik R.J., Shareef A., Kookana R.S. Field dissipation of 4-nonylphenol, 4-t-octylphenol, triclosan and bisphenol A following land application of biosolids. Chemosphere 2012, 86:1050-1058.
23. Cunningham V.L., Perino C., D'Aco V.J., Hartmann A., Bechter R. Human health risk assessment of carbamazepine in surface waters of North America and Europe. Regul. Toxicol. Pharm. 2010, 56:343-351.
24. Carter L.J., Garman C.D., Ryan J., Dowle A., Bergström E., Thomas-Oates J., Boxall A.B.A. Fate and uptake of pharmaceuticals in soil-earthworm systems. Environ. Sci. Technol. 2014, 48:5955-5963.
25. Lapen D.R., Topp E., Metcalfe C.D., Li H., Edwards M., Gottschall N., Bolton P., Curnoe W., Payne M., Beck A. Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids. Sci. Total Environ. 2008, 399:50-65.
26. Wu C., Spongberg A.L., Witter J.D., Fang M., Czajkowski K.P. Uptake of pharmaceutical and personal care products by soybean plants from soils applied with biosolids and irrigated with contaminated water. Environ. Sci. Technol. 2010, 44:6157-6161.
27. Wu C., Spongberg A.L., Witter J.D., Sridhar B.B.M. Transfer of wastewater associated pharmaceuticals and personal care products to crop plants from biosolids treated soil. Ecotoxicol. Environ. Saf. 2012, 85:104-109.
28. Carter L.J., Harris E., Williams M., Ryan J.J., Kookana R.S., Boxall A.B.A. Fate and uptake of pharmaceuticals in soil-plant systems. J. Agric. Food Chem. 2014, 62:816-825.
29. Sabourin L., Duenk P., Bonte-Gelok S., Payne M., Lapen D.R., Topp E. Uptake of pharmaceuticals, hormones and parabens into vegetables grown in soil fertilized with municipal biosolids. Sci. Total Environ. 2012, 431:233-236.
30. Pannu M.W., Toor G.S., O'Connor G.A., Wilson P.C. Toxicity and bioaccumulation of biosolids-borne triclosan in food crops. Environ. Toxicol. Chem. 2012, 31:2130-2137.
31. Karnjanapiboonwong A., Chase D.A., Cañas J.E., Jackson W.A., Maul J.D., Morse A.N., Anderson T.A. Uptake of 17α-ethynylestradiol and triclosan in pintobean, Phaseolus vulgaris. Ecotoxicol. Environ. Saf. 2011, 74:1336-1342.
32. Ying G.-G., Kookana R.S. Triclosan in wastewaters and biosolids from Australian wastewater treatment plants. Environ. Int. 2007, 33:199-205.
33. Snyder E.H., O'Connor G.A. Risk assessment of land-applied biosolids-borne triclocarban (TCC). Sci. Total Environ. 2013, 442:437-444.
34. Prosser R.S., Trapp S., Sibley P.K. Modeling uptake of selected pharmaceuticals and personal care products into food crops from biosolids-amended soil. Environ. Sci. Technol. 2014, 48:11397-11404.
35. Suárez S., Lema J.M., Omil F. Removal of pharmaceutical and personal care productys (PPCPs) under nitrifying and denitrifying and denitrifying conditions. Water Res. 2010, 44:3214-3224.
36. Alvariño T., Suárez S., Lema J.M., Omil F. Understanding the removal mechanisms of PPCPs and the influence of main technological parameters in anaerobic UASB and aerobic CAS reactors. J. Hazard. Mater. 2014, 278:506-513.
37. EC, European Commission, Technical Guidance Document (TGD) on Risk Assessment, EUR 20418 EN/1, 2003.
38. Kinney C.A., Furlong E.T., Zaugg S.D., Burkhardt M.R., Werner S.L., Cahill J.D., Jorgensen G.R. Survey of organic wastewater contaminants in biosolids destined for land application. Environ. Sci. Technol. 2006, 40:7207-7215.
39. Martín J., Santos J.L., Aparicio I., Alonso E. Multi-residue method for the analysis of pharmaceutical compounds in sewage sludge, compost and sediments by sonication-assisted extraction and LC determination. J. Sep. Sci. 2010, 33:1760-1766.
40. McClellan K., Halden R.U. Pharmaceuticals and personal care products in archived U.S. biosolids from the 2001 EPA national sewage sludge survey. Water Res. 2010, 44:658-668.
41. Gottschall N., Topp E., Metcalfe C., Edwards M., Payne M., Kleywegt S., Russell P., Lapen D.R. Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field. Chemosphere 2012, 87:194-203.
42. Yu Y., Wu L. Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography-mass spectrometry. Talanta 2012, 89:258-263.
43. Morais S.A., Deleure-Matos C., Gabarrell X., Bánquez P. Multimedia fate modelling and comparative impact on freshwater ecosystems of pharmaceuticals from biosolids-amended soils. Chemosphere 2013, 93:252-262.
44. Drillia P., Stamatelatou K., Lyberatos G. Fate and mobility of pharmaceuticals in solid matrices. Chemosphere 2005, 60:1034-1044.
45. Williams C.F., Williams C.F., Adamsen F.J. Sorption-desorption of carbamazepine from irrigated soils. J. Environ. Qual. 2006, 35:1779-1783.
46. Barron L., Havel J., Purcell M., Szpak M., Kelleher B., Paull B. Predicting sorption of pharmaceuticals and personal care products onto soil and digested sludge using artificial neural networks. Analyst 2009, 134:663-670.
47. Calisto V., Esteves V.I. Adsorption of the antiepileptic carbamazepine onto agricultural soils. J. Environ. Monit. 2012, 14:1597-1603.
48. Walters E., McClellan K., Halden R.U. Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolids-soil mixtures in outdoor mesocosms. Water Res. 2010, 44:6011-6020.
49. Monteiro S.C., Boxall A.B.A. Factors affecting the degradation of pharmaceuticals in agricultural soils. Environ. Toxicol. Chem. 2009, 28:2546-2554.
50. Li J., Dodgen L., Ye Q., Gan J. Degradation kinetics and metabolites of carbamazepine in soil. Environ. Sci. Technol. 2013, 47:3678-3684.
51. Yamamoto H., Hayashi A., Nakamura Y., Sekizawa J. Fate and partitioning of selected pharmaceuticals in aquatic environment. Environ. Sci. 2005, 12:347-358.
52. Kwon J., Armbrust K.L. Aqueous solubility, n-octanol-water partition coefficient, and sorption of five selective serotonin reuptake inhibitors to sediments and soils. Bull. Environ. Contam. Toxicol. 2008, 81:128-135.
53. Redshaw C.H., Cooke M.P., Talbot H.M., McGrath S., Rowland S.J. Low biodegradability of fluoxetine HCl, diazepam and their human metabolites in sewage sludge-amended soil. J. Soils Sediments 2008, 8:217-230.
54. Olofsson U., Brorström-Lundén E., Kylin H., Haglund P. Comprehensive mass flow analysis of Swedish sludge contaminants. Chemosphere 2013, 90:28-35.
55. Wu C., Spongberg A.L., Witter J.D. Adsorption and degradation of triclosan and triclocarban in soils and biosolids-amended soils. J. Agric. Food Chem. 2009, 57:4900-4905.
56. Yu Y., Liu Y., Wu L. Sorption and degradation of pharmaceuticals and personal care products (PPCPs) in soils. Environ. Sci. Pollut. Res. 2013, 20:4261-4267.
57. Lozano N., Rice C.P., Ramirez M., Torrents A. Fate of triclosan in agricultural soils after biosolid applications. Chemosphere 2010, 78:760-766.
58. Lindberg R.H., Fick J., Tysklind M. Screening of antimycotics in Swedish sewage treatment plants-waters and sludge. Water Res. 2010, 44:649-657.
59. Subedi B., Lee S., Moon H.-B., Kannan K. Emission of artificial sweeteners, select pharmaceuticals, and personal care products through sewage sludge from wastewater treatment plants in Korea. Environ. Int. 2014, 68:33-40.
60. Chen Z.-F., Ying G.-G., Ma Y.-B., Lai H.-J., Chen F., Pan C.-G. Typical azole biocides in biosolid-amended soils and plants following biosolid applications. J. Agric. Food Chem. 2013, 61:6198-6206.
61. Golet E.M., Strehler A., Alder A.C., Giger W. Determination of fluoroquinolone antibacterial agents in sewage sludge and sludge-treated soil using accelerated slvent extraction followed by solid-phase extraction. Anal. Chem. 2002, 74:5455-5462.
62. Nowara A., Burhenne J., Spiteller M. Binding of fluoroquinolone carboxylic acid derivatives to clay minerals. J. Agric. Food Chem. 1997, 45:1459-1463.
63. Uslu M.O., Yediler A., Balcioğlu I.A., Schulte-Hostede S. Analysis and sorption behavior of fluoroquinolones in solid matrices. Water Air Soil Pollut. 2008, 190:55-63.
64. Eggen T., Asp T.N., Grave K., Hormazabal V. Uptake and translocation of metformin, ciprofloxacin and narasin in forage- and crop plants. Chemosphere 2011, 85:26-33.
65. Topp E., Hendel J.G., Lapen D.R., Chapman R. Fate of the nonesteroidal anti-inflammatory drug naproxen in agricultural soil receiving liquid municipal biosolids. Environ. Toxicol. Chem. 2008, 27:2005-2010.
66. Montero M.T., Freixas J., Hernández-Borrell J. Expression of the partition coefficients of a homologous series of 6-fluoroquinolones. Int. J. Pharm. 1997, 149:161-170.
67. VKM (Norwegian Scientific Committee for Food Safety), Risk assessment of contaminants in sewage sludge applied on Norwegian soils, Opinion from the Panel on Contaminants in the Norwegian Scientific Committee for Food Safety, August 2009.
68. Rein A., Legind C.N., Trapp S. New concepts for dynamic plant uptake models. SAR QSAR Environ. Res. 2011, 22:191-215.
69. Hendriks A.J., Smítková H., Huijbregts M.A.J. A new twist on an old regression: transfer of chemicals to beef and milk in human and ecological risk assessment. Chemosphere 2007, 70:46-56.
70. Eckstein J., Riedmueller S.T. YASAI: yet another add-in for teaching elementary Monte Carlo simulation in excel. Inf. Trans. Educ. 2002, 12-26. 10.1287/ited.2.2.12.
71. Washington State, Department of Ecology, Models and tools supported by the Department of Ecology, Last accessed on (23.03.15). http://www.ecy.wa.gov/programs/eap/models.html.
72. Franco A., Trapp S. Estimation of the soil-water partition coefficient normalized to organic carbon for ionizable organic chemicals. Environ. Toxicol. Chem. 2008, 27:1994-2004.
73. Higgins C.P., Paesani Z.J., Abbott Chalew T.E., Halden R.U., Hundal L.S. Persistence of triclocarban and triclosan in soils after land application of biosolids and bioaccumulation in Eisenia foetida. Environ. Toxicol. Chem. 2011, 30:556-563.
74. Waria M., O'Connor G.A., Toor G.S. Biodegradation of triclosan in biosolids-amended soils. Environ. Toxicol. Chem. 2011, 30:2488-2496.
75. Chen W., Xu J., Lu S., Jiao W., Wu L., Chang A.C. Fates and transport of PPCPs in soil receiving reclaimed water irrigation. Chemosphere 2013, 93:2621-2630.
76. Wu X., Ernst F., Conkle J.L., Gan J. Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables. Environ. Int. 2013, 60:15-22.
77. Allmyr M., Adolfsson-Erici M., McLachlan M.S., Sandborgh-Englund G. Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. Sci. Total Environ. 2006, 372:87-93.
78. Toms L.-M.L., Allmyr M., Mueller J.F., Adolfsson-Erici M., McLachlan M., Murby J., Harden F.A. Triclosan in individual human milk samples from Australia. Chemosphere 2011, 85:1682-1686.
79. Geens T., Neels H., Covaci A. Distribution of bisphenol-A, triclosan and n-nonylphenol in human adipose tissue, liver and brain. Chemosphere 2012, 87:796-802.
80. Travis C.C., Arms A.D. Bioconcentration of organics in beef, milk, and vegetation. Environ. Sci. Technol. 1988, 22:271-274.
81. US EPA (U.S. Environmental Protection Agency), Methodology for predicting cattle biotransfer factors, EPA Contract Number 68-W-03-042. Research Triangle Institute, September 2005.
82. US EPA (U.S. Environmental Protection Agency), Guidelines for the health risk assessment of chemical mixtures, EPA/630/R-98/002, September 1986, http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm%3Fdeid=22567.
83. US EPA (U.S. Environmental Protection Agency), Risk Assessment Guidance for Superfund (RAGS) Part A, EPA/540/1-89/002 December 1989, http://www.epa.gov/swerrims/riskassessment/ragsa/index.htm.
84. Backhaus T., Faust M. Predictive environmental risk assessment of chemical mixtures: a conceptual framework. Environ. Sci. Technol. 2012, 46:2564-2573.
85. Tsadilas C.D., Matsi T., Barbayiannis N., Dimoyiannis D. Influence of sewage sludge application on soil properties and on the distribution and availability of heavy metals fractions. Commun. Soil Sci. Plant 1995, 26:2603-2619.
86. US EPA (U.S. Environmental Protection Agency), Risk Assessment Forum White Paper: Probabilistic Risk Assessment Methods and Case Studies, EPA/100/R-14/004, July 2014.
87. Rosenbaum R.K., McKone T.E., Jolliet O. CKow: a dynamic model for chemical transfer to meat and milk. Environ. Sci. Technol. 2009, 43:8191-8198.