메뉴 건너뛰기




Volumn 440, Issue , 2012, Pages 280-289

Occurrence and distribution of multi-class pharmaceuticals and their active metabolites and transformation products in the Ebro River basin (NE Spain)

Author keywords

10,11 epoxi carbamazepine; Ebro river basin; Metabolites; Pharmaceuticals; Transformation products

Indexed keywords

10,11-EPOXI-CARBAMAZEPINE; ACTIVE METABOLITES; ANTINEOPLASTIC; AUTOMATED METHODS; CARBAMAZEPINE; CLARITHROMYCIN; EBRO RIVER BASIN; MULTI-CLASS; OCCURRENCE AND DISTRIBUTION; SALICYLIC ACIDS; TAMOXIFEN; TARGET COMPOUND; TRANSFORMATION PRODUCTS; WWTP EFFLUENT;

EID: 84868697022     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2012.06.027     Document Type: Article
Times cited : (196)

References (43)
  • 1
    • 29144502284 scopus 로고    scopus 로고
    • Household disposal of pharmaceuticals as a pathway for aquatic contamination in the United Kingdom
    • Bound J.P., Voulvoulis N. Household disposal of pharmaceuticals as a pathway for aquatic contamination in the United Kingdom. Environ Health Perspect 2005, 113:1705-1711.
    • (2005) Environ Health Perspect , vol.113 , pp. 1705-1711
    • Bound, J.P.1    Voulvoulis, N.2
  • 2
    • 33845284543 scopus 로고    scopus 로고
    • Occurrence and fate of the cytostatic drugs cyclophosphamide and ifosfamide in wastewater and surface waters
    • Buerge I.J., Buser H.R., Poiger T., Müller M.D. Occurrence and fate of the cytostatic drugs cyclophosphamide and ifosfamide in wastewater and surface waters. Environ Sci Technol 2006, 40:7242-7250.
    • (2006) Environ Sci Technol , vol.40 , pp. 7242-7250
    • Buerge, I.J.1    Buser, H.R.2    Poiger, T.3    Müller, M.D.4
  • 3
    • 0035739423 scopus 로고    scopus 로고
    • Emerging pollutants, and communicating the science of environmental chemistry and mass spectrometry: pharmaceuticals in the environment
    • Daughton C.G. Emerging pollutants, and communicating the science of environmental chemistry and mass spectrometry: pharmaceuticals in the environment. J Am Soc Mass Spectrom 2001, 12:1067-1076.
    • (2001) J Am Soc Mass Spectrom , vol.12 , pp. 1067-1076
    • Daughton, C.G.1
  • 4
    • 0033383635 scopus 로고    scopus 로고
    • Pharmaceuticals and personal care products in the environment: agents of subtle change?
    • Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ Health Perspect 1999, 107:907-938.
    • (1999) Environ Health Perspect , vol.107 , pp. 907-938
    • Daughton, C.G.1    Ternes, T.A.2
  • 5
    • 0043261507 scopus 로고    scopus 로고
    • Concerns about pharmaceuticals in water reuse, groundwater recharge, and animal waste
    • Drewes J.E., Shore L.S. Concerns about pharmaceuticals in water reuse, groundwater recharge, and animal waste. ACS Symp Ser 2001, 791:206-228.
    • (2001) ACS Symp Ser , vol.791 , pp. 206-228
    • Drewes, J.E.1    Shore, L.S.2
  • 6
    • 7044224176 scopus 로고    scopus 로고
    • Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae
    • Eguchi K., Nagase H., Ozawa M., Endoh Y.S., Goto K., Hirata K., et al. Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae. Chemosphere 2004, 57:1733-1738.
    • (2004) Chemosphere , vol.57 , pp. 1733-1738
    • Eguchi, K.1    Nagase, H.2    Ozawa, M.3    Endoh, Y.S.4    Goto, K.5    Hirata, K.6
  • 7
    • 18344384131 scopus 로고    scopus 로고
    • In vitro assessment of modes of toxic action of pharmaceutical in aquatic life
    • Escher B.I., Bramaz N., Eggen R.I.L., Richter M. In vitro assessment of modes of toxic action of pharmaceutical in aquatic life. Environ Sci Technol 2005, 39:3090-3100.
    • (2005) Environ Sci Technol , vol.39 , pp. 3090-3100
    • Escher, B.I.1    Bramaz, N.2    Eggen, R.I.L.3    Richter, M.4
  • 8
    • 79451471150 scopus 로고    scopus 로고
    • Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research
    • Fatta-Kassinos D., Meric S., Nikolaou A. Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research. Anal Bioanal Chem 2011, 399:251-275.
    • (2011) Anal Bioanal Chem , vol.399 , pp. 251-275
    • Fatta-Kassinos, D.1    Meric, S.2    Nikolaou, A.3
  • 9
    • 33845937762 scopus 로고    scopus 로고
    • Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies
    • Göbel A., McArdell C.S., Joss A., Siegrist H., Giger W. Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies. Sci Total Environ 2007, 372:361-371.
    • (2007) Sci Total Environ , vol.372 , pp. 361-371
    • Göbel, A.1    McArdell, C.S.2    Joss, A.3    Siegrist, H.4    Giger, W.5
  • 11
    • 34547945842 scopus 로고    scopus 로고
    • Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the Ebro river basin (northeast Spain)
    • Gros M., Petrović M., Barceló D. Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the Ebro river basin (northeast Spain). Environ Toxicol Chem 2007, 26:1553-1562.
    • (2007) Environ Toxicol Chem , vol.26 , pp. 1553-1562
    • Gros, M.1    Petrović, M.2    Barceló, D.3
  • 12
    • 71549124677 scopus 로고    scopus 로고
    • Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes
    • Gros M., Petrović M., Ginebreda A., Barceló D. Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes. Environ Int 2010, 36:15-26.
    • (2010) Environ Int , vol.36 , pp. 15-26
    • Gros, M.1    Petrović, M.2    Ginebreda, A.3    Barceló, D.4
  • 13
    • 33644919683 scopus 로고    scopus 로고
    • Determination of the stereochemistry of anhydroerythromycin A, the principal degradation product of the antibiotic erythromycin A
    • Hassanzadeh A., Helliwell M., Barber J. Determination of the stereochemistry of anhydroerythromycin A, the principal degradation product of the antibiotic erythromycin A. Org Biomol Chem 2006, 4:1014-1019.
    • (2006) Org Biomol Chem , vol.4 , pp. 1014-1019
    • Hassanzadeh, A.1    Helliwell, M.2    Barber, J.3
  • 14
    • 0037106162 scopus 로고    scopus 로고
    • Tracking persistent pharmaceutical residues from municipal sewage to drinking water
    • Heberer T. Tracking persistent pharmaceutical residues from municipal sewage to drinking water. J Hydrol 2002, 266:175-189.
    • (2002) J Hydrol , vol.266 , pp. 175-189
    • Heberer, T.1
  • 15
    • 80051748642 scopus 로고    scopus 로고
    • Identifying new persistent and bioaccumulative organics among chemicals in commerce II: pharmaceuticals
    • Howard P.H., Muir D.C.G. Identifying new persistent and bioaccumulative organics among chemicals in commerce II: pharmaceuticals. Environ Sci Technol 2011, 45:6938-6946.
    • (2011) Environ Sci Technol , vol.45 , pp. 6938-6946
    • Howard, P.H.1    Muir, D.C.G.2
  • 16
    • 78650548816 scopus 로고    scopus 로고
    • Occurrence and removal of pharmaceuticals and hormones through drinking water treatment
    • Huerta-Fontela M., Galceran M.T., Ventura F. Occurrence and removal of pharmaceuticals and hormones through drinking water treatment. Water Res 2011, 45:1432-1442.
    • (2011) Water Res , vol.45 , pp. 1432-1442
    • Huerta-Fontela, M.1    Galceran, M.T.2    Ventura, F.3
  • 17
    • 84870537633 scopus 로고    scopus 로고
    • Tracing pharmaceuticals in a municipal plant for integrated wastewater and organic solid waste treatment
    • Sci Total Environ in press.
    • Jelic A, Fatone F, Di Fabio S, Petrovic M, Cecchi F, Barcelo D. Tracing pharmaceuticals in a municipal plant for integrated wastewater and organic solid waste treatment. Sci Total Environ in press.
    • Jelic, A.1    Fatone, F.2    Di Fabio, S.3    Petrovic, M.4    Cecchi, F.5    Barcelo, D.6
  • 18
    • 29944432140 scopus 로고    scopus 로고
    • Excretion and ecotoxicity of pharmaceutical and personal care products in the environment
    • Jjemba P.K. Excretion and ecotoxicity of pharmaceutical and personal care products in the environment. Ecotoxicol Environ Saf 2006, 63:113-130.
    • (2006) Ecotoxicol Environ Saf , vol.63 , pp. 113-130
    • Jjemba, P.K.1
  • 19
    • 78149246639 scopus 로고    scopus 로고
    • A tiered procedure for assessing the formation of biotransformation products of pharmaceuticals and biocides during activated sludge treatment
    • Kern S., Baumgartner R., Helbling D.E., Hollender J., Singer H., Loos M.J., et al. A tiered procedure for assessing the formation of biotransformation products of pharmaceuticals and biocides during activated sludge treatment. J Environ Monit 2010, 12:2100-2111.
    • (2010) J Environ Monit , vol.12 , pp. 2100-2111
    • Kern, S.1    Baumgartner, R.2    Helbling, D.E.3    Hollender, J.4    Singer, H.5    Loos, M.J.6
  • 20
    • 79951496270 scopus 로고    scopus 로고
    • Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment
    • Langford K., Thomas K.V. Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment. J Environ Monit 2011, 13:416-421.
    • (2011) J Environ Monit , vol.13 , pp. 416-421
    • Langford, K.1    Thomas, K.V.2
  • 21
    • 78249286535 scopus 로고    scopus 로고
    • Occurrence and fate of the human pharmaceutical metabolite ritalinic acid in the aquatic system
    • Letzel M., Weiss K., Schüssler W., Sengl M. Occurrence and fate of the human pharmaceutical metabolite ritalinic acid in the aquatic system. Chemosphere 2010, 81:1416-1422.
    • (2010) Chemosphere , vol.81 , pp. 1416-1422
    • Letzel, M.1    Weiss, K.2    Schüssler, W.3    Sengl, M.4
  • 23
    • 77951239415 scopus 로고    scopus 로고
    • Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry
    • Liu X., Zhang J., Yin J., Duan H., Wu Y., Shao B. Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry. Anal Bioanal Chem 2010, 396:2977-2985.
    • (2010) Anal Bioanal Chem , vol.396 , pp. 2977-2985
    • Liu, X.1    Zhang, J.2    Yin, J.3    Duan, H.4    Wu, Y.5    Shao, B.6
  • 24
    • 82455171922 scopus 로고    scopus 로고
    • Development of a fast instrumental method for the analysis of pharmaceuticals in environmental and wastewaters based on ultra high performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS)
    • López-Serna R., Petrović M., Barceló D. Development of a fast instrumental method for the analysis of pharmaceuticals in environmental and wastewaters based on ultra high performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS). Chemosphere 2011, 85:1390-1399.
    • (2011) Chemosphere , vol.85 , pp. 1390-1399
    • López-Serna, R.1    Petrović, M.2    Barceló, D.3
  • 25
    • 84870486343 scopus 로고    scopus 로고
    • Direct injection on online TurboFlowTM chromatography-tandem mass spectrometry for the analysis of 58 pharmaceuticals and 19 transformation-products in environmental waters
    • López-Serna R, Petrović M, Barceló D. Direct injection on online TurboFlowTM chromatography-tandem mass spectrometry for the analysis of 58 pharmaceuticals and 19 transformation-products in environmental waters. J Chromatogr A in press.
    • J Chromatogr A in press.
    • López-Serna, R.1    Petrović, M.2    Barceló, D.3
  • 26
    • 37249071315 scopus 로고    scopus 로고
    • Application of liquid chromatography/quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry to the determination of pharmaceuticals and related contaminants in wastewater
    • Martínez Bueno M.J., Agüera A., Gómez M.J., Hernando M.D., García-Reyes J.F., Fernández-Alba A.R. Application of liquid chromatography/quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry to the determination of pharmaceuticals and related contaminants in wastewater. Anal Chem 2007, 79:9372-9384.
    • (2007) Anal Chem , vol.79 , pp. 9372-9384
    • Martínez Bueno, M.J.1    Agüera, A.2    Gómez, M.J.3    Hernando, M.D.4    García-Reyes, J.F.5    Fernández-Alba, A.R.6
  • 27
    • 0042062423 scopus 로고    scopus 로고
    • Determination of carbamazepine and its metabolites in aqueous samples using liquid chromatography-electrospray tandem mass spectrometry
    • Miao X.S., Metcalfe C.D. Determination of carbamazepine and its metabolites in aqueous samples using liquid chromatography-electrospray tandem mass spectrometry. Anal Chem 2003, 75:3731-3738.
    • (2003) Anal Chem , vol.75 , pp. 3731-3738
    • Miao, X.S.1    Metcalfe, C.D.2
  • 28
    • 67349111417 scopus 로고    scopus 로고
    • Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water
    • Mompelat S., Le Bot B., Thomas O. Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water. Environ Int 2009, 35:803-814.
    • (2009) Environ Int , vol.35 , pp. 803-814
    • Mompelat, S.1    Le Bot, B.2    Thomas, O.3
  • 29
    • 34249980891 scopus 로고    scopus 로고
    • Application of advanced MS techniques to analysis and identification of human and microbial metabolites of pharmaceuticals in the aquatic environment
    • Pérez S., Barceló D. Application of advanced MS techniques to analysis and identification of human and microbial metabolites of pharmaceuticals in the aquatic environment. TrAC, Trends Anal Chem 2007, 26:494-514.
    • (2007) TrAC, Trends Anal Chem , vol.26 , pp. 494-514
    • Pérez, S.1    Barceló, D.2
  • 30
    • 0344235284 scopus 로고    scopus 로고
    • Analysis and removal of emerging contaminants in wastewater and drinking water
    • Petrović M., Gonzalez S., Barceló D. Analysis and removal of emerging contaminants in wastewater and drinking water. TrAC-Trends in Analytical Chemistry 2003, 22:685-696.
    • (2003) TrAC-Trends in Analytical Chemistry , vol.22 , pp. 685-696
    • Petrović, M.1    Gonzalez, S.2    Barceló, D.3
  • 31
    • 2942565579 scopus 로고    scopus 로고
    • Endocrine disrupting compounds and other emerging contaminants in the environment: a survey on new monitoring strategies and occurrence data
    • Petrovic M., Eljarrat E., Lopez De Alda M.J., Barceló D. Endocrine disrupting compounds and other emerging contaminants in the environment: a survey on new monitoring strategies and occurrence data. Anal Bioanal Chem 2004, 378:549-562.
    • (2004) Anal Bioanal Chem , vol.378 , pp. 549-562
    • Petrovic, M.1    Eljarrat, E.2    Lopez De Alda, M.J.3    Barceló, D.4
  • 32
    • 32644485467 scopus 로고    scopus 로고
    • The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment
    • Roberts P.H., Thomas K.V. The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment. Sci Total Environ 2006, 356:143-153.
    • (2006) Sci Total Environ , vol.356 , pp. 143-153
    • Roberts, P.H.1    Thomas, K.V.2
  • 33
    • 33846883451 scopus 로고    scopus 로고
    • Trends in the detection of pharmaceutical products, and their impact and mitigation in water and wastewater in North America
    • Robinson I., Junqua G., Van Coillie R., Thomas O. Trends in the detection of pharmaceutical products, and their impact and mitigation in water and wastewater in North America. Anal Bioanal Chem 2007, 387:1143-1151.
    • (2007) Anal Bioanal Chem , vol.387 , pp. 1143-1151
    • Robinson, I.1    Junqua, G.2    Van Coillie, R.3    Thomas, O.4
  • 34
    • 34248532043 scopus 로고    scopus 로고
    • Advantages and limitations of on-line solid phase extraction coupled to liquid chromatography-mass spectrometry technologies versus biosensors for monitoring of emerging contaminants in water
    • Rodriguez-Mozaz S., Lopez de Alda M.J., Barceló D. Advantages and limitations of on-line solid phase extraction coupled to liquid chromatography-mass spectrometry technologies versus biosensors for monitoring of emerging contaminants in water. J Chromatogr A 2007, 1152:97-115.
    • (2007) J Chromatogr A , vol.1152 , pp. 97-115
    • Rodriguez-Mozaz, S.1    Lopez de Alda, M.J.2    Barceló, D.3
  • 36
    • 0023876507 scopus 로고
    • Brachial artery hemodynamic response to acute converting enzyme inhibition by enalaprilat in essential hypertension
    • Simon A.C., Chau N.P., Levenson J. Brachial artery hemodynamic response to acute converting enzyme inhibition by enalaprilat in essential hypertension. Clin Pharmacol Ther 1988, 43:49-54.
    • (1988) Clin Pharmacol Ther , vol.43 , pp. 49-54
    • Simon, A.C.1    Chau, N.P.2    Levenson, J.3
  • 37
    • 3843094824 scopus 로고    scopus 로고
    • Emerging contaminants-pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms
    • Smital T., Luckenbach T., Sauerborn R., Hamdoun A.M., Vega R.L., Epel D. Emerging contaminants-pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms. Mutat Res Fundam Mol Mech Mugag 2004, 552:101-117.
    • (2004) Mutat Res Fundam Mol Mech Mugag , vol.552 , pp. 101-117
    • Smital, T.1    Luckenbach, T.2    Sauerborn, R.3    Hamdoun, A.M.4    Vega, R.L.5    Epel, D.6
  • 39
    • 0020040677 scopus 로고
    • The physiological disposition and metabolism of enalapril maleate in laboratory animals
    • Tocco D.J., DeLuna F.A., Duncan A.E.W. The physiological disposition and metabolism of enalapril maleate in laboratory animals. Drug Metab Dispos 1982, 10:15-19.
    • (1982) Drug Metab Dispos , vol.10 , pp. 15-19
    • Tocco, D.J.1    DeLuna, F.A.2    Duncan, A.E.W.3
  • 40
    • 67650970074 scopus 로고    scopus 로고
    • On-line solid phase extraction LC-MS/MS analysis of pharmaceutical indicators in water: a green alternative to conventional methods
    • Trenholm R.A., Vanderford B.J., Snyder S.A. On-line solid phase extraction LC-MS/MS analysis of pharmaceutical indicators in water: a green alternative to conventional methods. Talanta 2009, 79:1425-1432.
    • (2009) Talanta , vol.79 , pp. 1425-1432
    • Trenholm, R.A.1    Vanderford, B.J.2    Snyder, S.A.3
  • 41
    • 54949092756 scopus 로고    scopus 로고
    • Chemometric assisted solid-phase microextraction for the determination of anti-inflammatory and antiepileptic drugs in river water by liquid chromatography-diode array detection
    • Vera-Candioti L., Gil García M.D., Martínez Galera M., Goicoechea H.C. Chemometric assisted solid-phase microextraction for the determination of anti-inflammatory and antiepileptic drugs in river water by liquid chromatography-diode array detection. J Chromatogr A 2008, 1211:22-32.
    • (2008) J Chromatogr A , vol.1211 , pp. 22-32
    • Vera-Candioti, L.1    Gil García, M.D.2    Martínez Galera, M.3    Goicoechea, H.C.4
  • 42
    • 27644541617 scopus 로고    scopus 로고
    • Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water
    • Vieno N.M., Tuhkanen T., Kronberg L. Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water. Environ Sci Technol 2005, 39:8220-8226.
    • (2005) Environ Sci Technol , vol.39 , pp. 8220-8226
    • Vieno, N.M.1    Tuhkanen, T.2    Kronberg, L.3
  • 43
    • 79953842349 scopus 로고    scopus 로고
    • Occurrence and behavior of pharmaceuticals, steroid hormones, and endocrine-disrupting personal care products in wastewater and the recipient river water of the Pearl River Delta, South China
    • Yu Y., Huang Q., Wang Z., Zhang K., Tang C., Cui J., et al. Occurrence and behavior of pharmaceuticals, steroid hormones, and endocrine-disrupting personal care products in wastewater and the recipient river water of the Pearl River Delta, South China. J Environ Monit 2011, 13:871-878.
    • (2011) J Environ Monit , vol.13 , pp. 871-878
    • Yu, Y.1    Huang, Q.2    Wang, Z.3    Zhang, K.4    Tang, C.5    Cui, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.