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Volumn 99, Issue 325, 2015, Pages 63-72

The use of animal models in multiple myeloma

Author keywords

5T2MM; 5T33MM; 5TGM1; BALB c; C57BL KalwRij; Murine model of myeloma; Osteolysis; Pristane; SCID; SCID hu; Xenograft

Indexed keywords

BONE MARROW CELL; CANCER THERAPY; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; HUMAN; IN VITRO STUDY; MOUSE MODEL; MULTIPLE MYELOMA; NOD SCID MOUSE; NONHUMAN; OSTEOLYSIS; PLASMA CELL; PLASMACYTOMA; REVIEW; SCID MOUSE; ANIMAL; ANIMAL MODEL; BAGG ALBINO MOUSE; BONE TRANSPLANTATION; C57BL MOUSE; CANCER TRANSPLANTATION; CELL CLONE; CHEMICALLY INDUCED; DRUG EFFECTS; FETAL TISSUE TRANSPLANTATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONOBESE DIABETIC MOUSE; OSTEOBLAST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT; TRANSPLANTATION; TUMOR MICROENVIRONMENT; XENOGRAFT;

EID: 84942980995     PISSN: 12860115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.morpho.2015.01.003     Document Type: Review
Times cited : (12)

References (82)
  • 1
    • 62549117773 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Roodman GD. Pathogenesis of myeloma bone disease. Leukemia 2009;23:435-41.
    • (2009) Leukemia , vol.23 , pp. 435-441
    • Roodman, G.D.1
  • 2
    • 43149089554 scopus 로고    scopus 로고
    • The pathogenesis of thebone disease of multiple myeloma
    • Edwards CM, Zhuang J, Mundy GR. The pathogenesis of thebone disease of multiple myeloma. Bone 2008;42:1007-13.
    • (2008) Bone , vol.42 , pp. 1007-1013
    • Edwards, C.M.1    Zhuang, J.2    Mundy, G.R.3
  • 3
    • 0034284054 scopus 로고    scopus 로고
    • Cell-cell contact between mar-row stromal cells and myeloma cells via VCAM-1 andalpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity
    • Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, et al. Cell-cell contact between mar-row stromal cells and myeloma cells via VCAM-1 andalpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity. Blood 2000;96:1953-60.
    • (2000) Blood , vol.96 , pp. 1953-1960
    • Michigami, T.1    Shimizu, N.2    Williams, P.J.3    Niewolna, M.4    Dallas, S.L.5    Mundy, G.R.6
  • 4
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprote-gerin/osteoprotegerin ligand system in the human bonemarrow environment
    • Giuliani N, Bataille R, Mancini C, Lazzaretti M, Barille S. Myeloma cells induce imbalance in the osteoprote-gerin/osteoprotegerin ligand system in the human bonemarrow environment. Blood 2001;98:3527-33.
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3    Lazzaretti, M.4    Barille, S.5
  • 5
    • 0027133422 scopus 로고
    • Adhesion of human myeloma-derived cell lines to bonemarrow stromal cells stimulates interleukin-6 secretion
    • Uchiyama H, Barut BA, Mohrbacher AF, Chauhan D, Anderson KC. Adhesion of human myeloma-derived cell lines to bonemarrow stromal cells stimulates interleukin-6 secretion. Blood 1993;82:3712-20.
    • (1993) Blood , vol.82 , pp. 3712-3720
    • Uchiyama, H.1    Barut, B.A.2    Mohrbacher, A.F.3    Chauhan, D.4    Anderson, K.C.5
  • 6
    • 0033034054 scopus 로고    scopus 로고
    • Potential role of insulin-like growth factor binding protein-4 in the uncouplingof bone turnover in multiple myeloma
    • Feliers D, WoodruffK, Abboud S. Potential role of insulin-like growth factor binding protein-4 in the uncouplingof bone turnover in multiple myeloma. Br J Haematol 1999;104:715-22.
    • (1999) Br J Haematol , vol.104 , pp. 715-722
    • Feliers, D.1    Woodruff, K.2    Abboud, S.3
  • 7
    • 27644473781 scopus 로고    scopus 로고
    • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
    • Oshima T, Abe M, Asano J, Hara T, Kitazoe K, Sekimoto E, et al. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood 2005;106:3160-5.
    • (2005) Blood , vol.106 , pp. 3160-3165
    • Oshima, T.1    Abe, M.2    Asano, J.3    Hara, T.4    Kitazoe, K.5    Sekimoto, E.6
  • 8
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the develop-ment of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B, et al. The role of the Wnt-signaling antagonist DKK1 in the develop-ment of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-94.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3    Rasmussen, E.4    Ma, Y.5    Barlogie, B.6
  • 9
    • 23744507989 scopus 로고    scopus 로고
    • IL-3 is a potential inhibitor of osteoblast differentiationin multiple myeloma
    • Ehrlich LA, Chung HY, Ghobrial I, Choi SJ, Morandi F, Colla S, et al. IL-3 is a potential inhibitor of osteoblast differentiationin multiple myeloma. Blood 2005;106:1407-14.
    • (2005) Blood , vol.106 , pp. 1407-1414
    • Ehrlich, L.A.1    Chung, H.Y.2    Ghobrial, I.3    Choi, S.J.4    Morandi, F.5    Colla, S.6
  • 10
    • 23744498205 scopus 로고    scopus 로고
    • Myeloma cells block RUNX2/CBFA1 activity in human bonemarrow osteoblast progenitors and inhibit osteoblast formationand differentiation
    • Giuliani N, Colla S, Morandi F, Lazzaretti M, Sala R, Bonomini S, et al. Myeloma cells block RUNX2/CBFA1 activity in human bonemarrow osteoblast progenitors and inhibit osteoblast formationand differentiation. Blood 2005;106:2472-83.
    • (2005) Blood , vol.106 , pp. 2472-2483
    • Giuliani, N.1    Colla, S.2    Morandi, F.3    Lazzaretti, M.4    Sala, R.5    Bonomini, S.6
  • 11
    • 33947605189 scopus 로고    scopus 로고
    • HGF inhibits BMP-induced osteoblastogen-esis: possible implications for the bone disease of multiplemyeloma
    • Standal T, Abildgaard N, Fagerli UM, Stordal B, Hjertner O, Borset M, et al. HGF inhibits BMP-induced osteoblastogen-esis: possible implications for the bone disease of multiplemyeloma. Blood 2007;109:3024-30.
    • (2007) Blood , vol.109 , pp. 3024-3030
    • Standal, T.1    Abildgaard, N.2    Fagerli, U.M.3    Stordal, B.4    Hjertner, O.5    Borset, M.6
  • 12
    • 0035072851 scopus 로고    scopus 로고
    • Mouse plasma-cytoma: an experimental model of human multiple myeloma
    • Gado K, Silva S, Paloczi K, Domjan G, Falus A. Mouse plasma-cytoma: an experimental model of human multiple myeloma. Haematologica 2001;86:227-36.
    • (2001) Haematologica , vol.86 , pp. 227-236
    • Gado, K.1    Silva, S.2    Paloczi, K.3    Domjan, G.4    Falus, A.5
  • 13
    • 0031001374 scopus 로고    scopus 로고
    • Experimental plasmacytomagenesis in mice
    • Potter M. Experimental plasmacytomagenesis in mice. Hematol Oncol Clin North Am 1997;11:323-47.
    • (1997) Hematol Oncol Clin North Am , vol.11 , pp. 323-347
    • Potter, M.1
  • 14
    • 84863016051 scopus 로고    scopus 로고
    • Global gene expression profiling in mouseplasma cell tumor precursor and bystander cells reveals poten-tial intervention targets for plasma cell neoplasia
    • LeGrand J, Park ES, Wang H, Gupta S, Owens Jr JD, Nel-son PJ, et al. Global gene expression profiling in mouseplasma cell tumor precursor and bystander cells reveals poten-tial intervention targets for plasma cell neoplasia. Blood 2012;119:1018-28.
    • (2012) Blood , vol.119 , pp. 1018-1028
    • LeGrand, J.1    Park, E.S.2    Wang, H.3    Gupta, S.4    Owens, J.D.5    Nel-son, P.J.6
  • 15
    • 35448946833 scopus 로고    scopus 로고
    • Gene expression profiling reveals different path-ways related to Abl and other genes that cooperate with c-Mycin a model of plasma cell neoplasia
    • Park ES, Shaughnessy Jr JD, Gupta S, Wang H, Lee JS, Woo HG, et al. Gene expression profiling reveals different path-ways related to Abl and other genes that cooperate with c-Mycin a model of plasma cell neoplasia. BMC Genomics 2007;8:302.
    • (2007) BMC Genomics , vol.8 , pp. 302
    • Park, E.S.1    Shaughnessy, J.D.2    Gupta, S.3    Wang, H.4    Lee, J.S.5    Woo, H.G.6
  • 16
    • 0026767880 scopus 로고
    • Plasmacytomagenesis in mice: model ofneoplastic development dependent upon chromosomal translo-cations
    • Potter M, Wiener F. Plasmacytomagenesis in mice: model ofneoplastic development dependent upon chromosomal translo-cations. Carcinogenesis 1992;13:1681-97.
    • (1992) Carcinogenesis , vol.13 , pp. 1681-1697
    • Potter, M.1    Wiener, F.2
  • 17
    • 0347320792 scopus 로고    scopus 로고
    • BCL2 acceleratesinflammation-induced BALB/c plasmacytomas and promotesnovel tumors with coexisting T(12;15) and T(6;15) transloca-tions
    • Silva S, Kovalchuk AL, Kim JS, Klein G, Janz S. BCL2 acceleratesinflammation-induced BALB/c plasmacytomas and promotesnovel tumors with coexisting T(12;15) and T(6;15) transloca-tions. Cancer Res 2003;63:8656-63.
    • (2003) Cancer Res , vol.63 , pp. 8656-8663
    • Silva, S.1    Kovalchuk, A.L.2    Kim, J.S.3    Klein, G.4    Janz, S.5
  • 18
    • 0034517587 scopus 로고    scopus 로고
    • The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex inthe pathogenesis of multiple myeloma
    • Barille S, Bataille R, Amiot M. The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex inthe pathogenesis of multiple myeloma. Eur Cytokine Netw 2000;11:546-51.
    • (2000) Eur Cytokine Netw , vol.11 , pp. 546-551
    • Barille, S.1    Bataille, R.2    Amiot, M.3
  • 19
    • 0029069307 scopus 로고
    • Interleukin6 is essential for in vivo development of B lineage neoplasms
    • Hilbert DM, Kopf M, Mock BA, Kohler G, RudikoffS. Interleukin6 is essential for in vivo development of B lineage neoplasms. J Exp Med 1995;182:243-8.
    • (1995) J Exp Med , vol.182 , pp. 243-248
    • Hilbert, D.M.1    Kopf, M.2    Mock, B.A.3    Kohler, G.4    Rudikoff, S.5
  • 20
    • 0030929261 scopus 로고    scopus 로고
    • Defective development of pristane-oil-inducedplasmacytomas in interleukin-6-deficient BALB/c mice
    • Lattanzio G, Libert C, Aquilina M, Cappelletti M, Ciliberto G, Musiani P, et al. Defective development of pristane-oil-inducedplasmacytomas in interleukin-6-deficient BALB/c mice. Am JPathol 1997;151:689-96.
    • (1997) Am JPathol , vol.151 , pp. 689-696
    • Lattanzio, G.1    Libert, C.2    Aquilina, M.3    Cappelletti, M.4    Ciliberto, G.5    Musiani, P.6
  • 21
    • 84859895325 scopus 로고    scopus 로고
    • Persistency withzoledronic acid is associated with clinical benefit in patientswith multiple myeloma
    • Henk HJ, Teitelbaum A, Perez JR, Kaura S. Persistency withzoledronic acid is associated with clinical benefit in patientswith multiple myeloma. Am J Hematol 2012;87:490-5.
    • (2012) Am J Hematol , vol.87 , pp. 490-495
    • Henk, H.J.1    Teitelbaum, A.2    Perez, J.R.3    Kaura, S.4
  • 22
    • 18844432791 scopus 로고    scopus 로고
    • The bisphosphonate zoledronic acid inhibits the developmentof plasmacytoma induced in BALB/c mice by intraperitonealinjection of pristane
    • Avcu F, Ural AU, Yilmaz MI, Ozcan A, Ide T, Kurt B, et al. The bisphosphonate zoledronic acid inhibits the developmentof plasmacytoma induced in BALB/c mice by intraperitonealinjection of pristane. Eur J Haematol 2005;74:496-500.
    • (2005) Eur J Haematol , vol.74 , pp. 496-500
    • Avcu, F.1    Ural, A.U.2    Yilmaz, M.I.3    Ozcan, A.4    Ide, T.5    Kurt, B.6
  • 23
    • 0030019981 scopus 로고    scopus 로고
    • Development of an in vivo model of human multiplemyeloma bone disease
    • Alsina M, Boyce B, Devlin RD, Anderson JL, Craig F, Mundy GR, et al. Development of an in vivo model of human multiplemyeloma bone disease. Blood 1996;87:1495-501.
    • (1996) Blood , vol.87 , pp. 1495-1501
    • Alsina, M.1    Boyce, B.2    Devlin, R.D.3    Anderson, J.L.4    Craig, F.5    Mundy, G.R.6
  • 24
    • 0032930729 scopus 로고    scopus 로고
    • Marked osteoblastopenia and reduced boneformation in a model of multiple myeloma bone disease insevere combined immunodeficiency mice
    • Hjorth-Hansen H, Seifert MF, Borset M, Aarset H, Ostlie A, Sundan A, et al. Marked osteoblastopenia and reduced boneformation in a model of multiple myeloma bone disease insevere combined immunodeficiency mice. J Bone Miner Res 1999;14:256-63.
    • (1999) J Bone Miner Res , vol.14 , pp. 256-263
    • Hjorth-Hansen, H.1    Seifert, M.F.2    Borset, M.3    Aarset, H.4    Ostlie, A.5    Sundan, A.6
  • 25
    • 0142188727 scopus 로고    scopus 로고
    • Fluorescence imaging of multiple myeloma cellsin a clinically relevant SCID/NOD in vivo model: biologic andclinical implications
    • Mitsiades CS, Mitsiades NS, Bronson RT, Chauhan D, Munshi N, Treon SP, et al. Fluorescence imaging of multiple myeloma cellsin a clinically relevant SCID/NOD in vivo model: biologic andclinical implications. Cancer Res 2003;63:6689-96.
    • (2003) Cancer Res , vol.63 , pp. 6689-6696
    • Mitsiades, C.S.1    Mitsiades, N.S.2    Bronson, R.T.3    Chauhan, D.4    Munshi, N.5    Treon, S.P.6
  • 26
    • 0034142369 scopus 로고    scopus 로고
    • Myeloma progenitors in the blood of patients withaggressive or minimal disease: engraftment and self-renewalof primary human myeloma in the bone marrow of NOD SCIDmice
    • Pilarski LM, Hipperson G, Seeberger K, Pruski E, Coupland RW, Belch AR. Myeloma progenitors in the blood of patients withaggressive or minimal disease: engraftment and self-renewalof primary human myeloma in the bone marrow of NOD SCIDmice. Blood 2000;95:1056-65.
    • (2000) Blood , vol.95 , pp. 1056-1065
    • Pilarski, L.M.1    Hipperson, G.2    Seeberger, K.3    Pruski, E.4    Coupland, R.W.5    Belch, A.R.6
  • 27
    • 0030821607 scopus 로고    scopus 로고
    • New xenograft model of multiple myeloma andefficacy of a humanized antibody against human interleukin-6receptor
    • Tsunenari T, Koishihara Y, Nakamura A, Moriya M, Ohkawa H, Goto H, et al. New xenograft model of multiple myeloma andefficacy of a humanized antibody against human interleukin-6receptor. Blood 1997;90:2437-44.
    • (1997) Blood , vol.90 , pp. 2437-2444
    • Tsunenari, T.1    Koishihara, Y.2    Nakamura, A.3    Moriya, M.4    Ohkawa, H.5    Goto, H.6
  • 28
    • 0028933658 scopus 로고
    • Establishment of a novel myeloma cell line KPMM2carrying t(3;14)(q21;q32), which proliferates specifically inresponse to interleukin-6 through an autocrine mechanism
    • Goto H, Shimazaki C, Tatsumi T, Yamagata N, Fujita N, Tsuchiya M, et al. Establishment of a novel myeloma cell line KPMM2carrying t(3;14)(q21;q32), which proliferates specifically inresponse to interleukin-6 through an autocrine mechanism. Leukemia 1995;9:711-8.
    • (1995) Leukemia , vol.9 , pp. 711-718
    • Goto, H.1    Shimazaki, C.2    Tatsumi, T.3    Yamagata, N.4    Fujita, N.5    Tsuchiya, M.6
  • 29
    • 0035664488 scopus 로고    scopus 로고
    • Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bonedisease
    • Choi SJ, Oba Y, Gazitt Y, Alsina M, Cruz J, Anderson J, et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bonedisease. J Clin Invest 2001;108:1833-41.
    • (2001) J Clin Invest , vol.108 , pp. 1833-1841
    • Choi, S.J.1    Oba, Y.2    Gazitt, Y.3    Alsina, M.4    Cruz, J.5    Anderson, J.6
  • 30
    • 0035052888 scopus 로고    scopus 로고
    • Ibandronate decreases bone disease development andosteoclast stimulatory activity in an in vivo model of humanmyeloma
    • Cruz JC, Alsina M, Craig F, Yoneda T, Anderson JL, Dallas M, et al. Ibandronate decreases bone disease development andosteoclast stimulatory activity in an in vivo model of humanmyeloma. Exp Hematol 2001;29:441-7.
    • (2001) Exp Hematol , vol.29 , pp. 441-447
    • Cruz, J.C.1    Alsina, M.2    Craig, F.3    Yoneda, T.4    Anderson, J.L.5    Dallas, M.6
  • 31
    • 0037303260 scopus 로고    scopus 로고
    • RANK-Fc: a therapeutic antagonist for RANK-L in myeloma
    • Sordillo EM, Pearse RN. RANK-Fc: a therapeutic antagonist for RANK-L in myeloma. Cancer 2003;97:802-12.
    • (2003) Cancer , vol.97 , pp. 802-812
    • Sordillo, E.M.1    Pearse, R.N.2
  • 35
    • 0032532608 scopus 로고    scopus 로고
    • Primary myeloma cellsgrowing in SCID-hu mice: a model for studying the biol-ogy and treatment of myeloma and its manifestations
    • Yaccoby S, Barlogie B, Epstein J. Primary myeloma cellsgrowing in SCID-hu mice: a model for studying the biol-ogy and treatment of myeloma and its manifestations. Blood 1998;92:2908-13.
    • (1998) Blood , vol.92 , pp. 2908-2913
    • Yaccoby, S.1    Barlogie, B.2    Epstein, J.3
  • 37
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerincytokine axis to trigger bone destruction and promote tumorprogression
    • Pearse RN, Sordillo EM, Yaccoby S, Wong BR, Liau DF, Colman N, et al. Multiple myeloma disrupts the TRANCE/osteoprotegerincytokine axis to trigger bone destruction and promote tumorprogression. PNAS 2001;98:11581-6.
    • (2001) PNAS , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3    Wong, B.R.4    Liau, D.F.5    Colman, N.6
  • 39
    • 8844264524 scopus 로고    scopus 로고
    • The SCID-rab model: a novel in vivo systemfor primary human myeloma demonstrating growth of CD138-expressing malignant cells
    • Yata K, Yaccoby S. The SCID-rab model: a novel in vivo systemfor primary human myeloma demonstrating growth of CD138-expressing malignant cells. Leukemia 2004;18:1891-7.
    • (2004) Leukemia , vol.18 , pp. 1891-1897
    • Yata, K.1    Yaccoby, S.2
  • 40
    • 0018128194 scopus 로고
    • Idiopathicparaproteinaemia. I. Studies in an animal model-the ageingC57BL/KaLwRij mouse
    • Radl J, Hollander CF, van den Berg P, de Glopper E. Idiopathicparaproteinaemia. I. Studies in an animal model-the ageingC57BL/KaLwRij mouse. Clin Exp Immunol 1978;33:395-402.
    • (1978) Clin Exp Immunol , vol.33 , pp. 395-402
    • Radl, J.1    Hollander, C.F.2    van den Berg, P.3    de Glopper, E.4
  • 41
    • 0033020874 scopus 로고    scopus 로고
    • Multiple myeloma and related disorders. Lessons froman animal model
    • Radl J. Multiple myeloma and related disorders. Lessons froman animal model. Pathol Biol (Paris) 1999;47:109-14.
    • (1999) Pathol Biol (Paris) , vol.47 , pp. 109-114
    • Radl, J.1
  • 43
    • 0030749836 scopus 로고    scopus 로고
    • Organ involvement and phenotypic adhesionprofile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRijmouse
    • Vanderkerken K, De Raeve H, Goes E, Van Meirvenne S, Radl J, Van Riet I, et al. Organ involvement and phenotypic adhesionprofile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRijmouse. Br J Cancer 1997;76:451-60.
    • (1997) Br J Cancer , vol.76 , pp. 451-460
    • Vanderkerken, K.1    De Raeve, H.2    Goes, E.3    Van Meirvenne, S.4    Radl, J.5    Van Riet, I.6
  • 44
    • 0030977162 scopus 로고    scopus 로고
    • A murine model ofhuman myeloma bone disease
    • Garrett IR, Dallas S, Radl J, Mundy GR. A murine model ofhuman myeloma bone disease. Bone 1997;20:515-20.
    • (1997) Bone , vol.20 , pp. 515-520
    • Garrett, I.R.1    Dallas, S.2    Radl, J.3    Mundy, G.R.4
  • 45
    • 7944231931 scopus 로고    scopus 로고
    • Visualization of 5T33 myeloma cells in the C57BL/KaLwRijmouse: establishment of a new syngeneic murine model ofmultiple myeloma
    • Alici E, Konstantinidis KV, Aints A, Dilber MS, Abedi-Valugerdi M. Visualization of 5T33 myeloma cells in the C57BL/KaLwRijmouse: establishment of a new syngeneic murine model ofmultiple myeloma. Exp Hematol 2004;32:1064-72.
    • (2004) Exp Hematol , vol.32 , pp. 1064-1072
    • Alici, E.1    Konstantinidis, K.V.2    Aints, A.3    Dilber, M.S.4    Abedi-Valugerdi, M.5
  • 47
    • 18144451249 scopus 로고    scopus 로고
    • In vivo induction of insulin-like growth factor-Ireceptor and CD44v6 confers homing and adhesion to murinemultiple myeloma cells
    • Asosingh K, Gunthert U, Bakkus MH, De Raeve H, Goes E, VanRiet I, et al. In vivo induction of insulin-like growth factor-Ireceptor and CD44v6 confers homing and adhesion to murinemultiple myeloma cells. Cancer Res 2000;60:3096-104.
    • (2000) Cancer Res , vol.60 , pp. 3096-3104
    • Asosingh, K.1    Gunthert, U.2    Bakkus, M.H.3    De Raeve, H.4    Goes, E.5    VanRiet, I.6
  • 49
    • 0034968397 scopus 로고    scopus 로고
    • Osteolytic bone lesions in the 5T2 multiple myeloma model:radiographic, scanning electron microscopy and microtomo-graphic studies
    • Libouban H, Moreau MF, Lesourd M, Baslé MF, Chappard D. Osteolytic bone lesions in the 5T2 multiple myeloma model:radiographic, scanning electron microscopy and microtomo-graphic studies. J Histotechnol 2001;24:81-6.
    • (2001) J Histotechnol , vol.24 , pp. 81-86
    • Libouban, H.1    Moreau, M.F.2    Lesourd, M.3    Baslé, M.F.4    Chappard, D.5
  • 50
    • 0030056093 scopus 로고    scopus 로고
    • Follow-up of bone lesions in an experimental multiplemyeloma mouse model: description of an in vivo techniqueusing radiography dedicated for mammography
    • Vanderkerken K, Goes E, De Raeve H, Radl J, Van Camp B. Follow-up of bone lesions in an experimental multiplemyeloma mouse model: description of an in vivo techniqueusing radiography dedicated for mammography. Br J Cancer 1996;73:1463-5.
    • (1996) Br J Cancer , vol.73 , pp. 1463-1465
    • Vanderkerken, K.1    Goes, E.2    De Raeve, H.3    Radl, J.4    Van Camp, B.5
  • 51
    • 1642333882 scopus 로고    scopus 로고
    • Selec-tion of a highly aggressive myeloma cell line by an alteredbone microenvironment in the C57BL/KaLwRij mouse
    • Libouban H, Moreau MF, Basle MF, Bataille R, Chappard D. Selec-tion of a highly aggressive myeloma cell line by an alteredbone microenvironment in the C57BL/KaLwRij mouse. BiochemBiophys Res Commun 2004;316:859-66.
    • (2004) BiochemBiophys Res Commun , vol.316 , pp. 859-866
    • Libouban, H.1    Moreau, M.F.2    Basle, M.F.3    Bataille, R.4    Chappard, D.5
  • 53
    • 0035895055 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits the development of osteolyticbone disease in multiple myeloma
    • Croucher PI, Shipman CM, Lippitt J, Perry M, Asosingh K, Hijzen A, et al. Osteoprotegerin inhibits the development of osteolyticbone disease in multiple myeloma. Blood 2001;98:3534-40.
    • (2001) Blood , vol.98 , pp. 3534-3540
    • Croucher, P.I.1    Shipman, C.M.2    Lippitt, J.3    Perry, M.4    Asosingh, K.5    Hijzen, A.6
  • 54
    • 84865603486 scopus 로고    scopus 로고
    • Soluble rank ligand produced by myeloma cellscauses generalised bone loss in multiple myeloma
    • Buckle CH, De Leenheer E, Lawson MA, Yong K, Rabin N, Perry M, et al. Soluble rank ligand produced by myeloma cellscauses generalised bone loss in multiple myeloma. PLoS One 2012;7:e 41127.
    • (2012) PLoS One , vol.7
    • Buckle, C.H.1    De Leenheer, E.2    Lawson, M.A.3    Yong, K.4    Rabin, N.5    Perry, M.6
  • 55
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappa B ligand-osteoprotegerin ratio predicts survival in mul-tiple myeloma: proposal for a novel prognostic index
    • Terpos E, Szydlo R, Apperley JF, Hatjiharissi E, Politou M, Meletis J, et al. Soluble receptor activator of nuclear factor kappa B ligand-osteoprotegerin ratio predicts survival in mul-tiple myeloma: proposal for a novel prognostic index. Blood 2003;102:1064-9.
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3    Hatjiharissi, E.4    Politou, M.5    Meletis, J.6
  • 56
    • 0038579121 scopus 로고    scopus 로고
    • Dual effects of macrophage inflam-matory protein-1alpha on osteolysis and tumor burden inthe murine 5TGM1 model of myeloma bone disease
    • Oyajobi BO, Franchin G, Williams PJ, Pulkrabek D, Gupta A, Munoz S, et al. Dual effects of macrophage inflam-matory protein-1alpha on osteolysis and tumor burden inthe murine 5TGM1 model of myeloma bone disease. Blood 2003;102:311-9.
    • (2003) Blood , vol.102 , pp. 311-319
    • Oyajobi, B.O.1    Franchin, G.2    Williams, P.J.3    Pulkrabek, D.4    Gupta, A.5    Munoz, S.6
  • 57
    • 84892586114 scopus 로고    scopus 로고
    • Myeloma plasma cells alter the bone marrow microen-vironment by stimulating the proliferation of mesenchymalstromal cells
    • Noll JE, Williams SA, Tong CM, Wang H, Quach JM, Purton LE, et al. Myeloma plasma cells alter the bone marrow microen-vironment by stimulating the proliferation of mesenchymalstromal cells. Haematologica 2014;99:163-71.
    • (2014) Haematologica , vol.99 , pp. 163-171
    • Noll, J.E.1    Williams, S.A.2    Tong, C.M.3    Wang, H.4    Quach, J.M.5    Purton, L.E.6
  • 58
    • 0041331741 scopus 로고    scopus 로고
    • Increased bone remodeling due to ovariectomy dramaticallyincreases tumoral growth in the 5T2 multiple myeloma mousemodel
    • Libouban H, Moreau MF, Baslé MF, Bataille R, Chappard D. Increased bone remodeling due to ovariectomy dramaticallyincreases tumoral growth in the 5T2 multiple myeloma mousemodel. Bone 2003;33:283-92.
    • (2003) Bone , vol.33 , pp. 283-292
    • Libouban, H.1    Moreau, M.F.2    Baslé, M.F.3    Bataille, R.4    Chappard, D.5
  • 59
    • 80955178752 scopus 로고    scopus 로고
    • Dietary calcium deficiency increases osteolysis and mod-ifies gene expression profile in an animal model of multiplemyeloma
    • Libouban H, Le Drevo MA, Moreau MF, Baslé MF, Chappard D. Dietary calcium deficiency increases osteolysis and mod-ifies gene expression profile in an animal model of multiplemyeloma. Calcif Tissue Int 2008;82:S35.
    • (2008) Calcif Tissue Int , vol.82 , pp. S35
    • Libouban, H.1    Le Drevo, M.A.2    Moreau, M.F.3    Baslé, M.F.4    Chappard, D.5
  • 62
    • 0029114293 scopus 로고
    • Assess-ment of the therapeutic potential of cytokines, cytotoxic drugsand effector cell populations for the treatment of multiplemyeloma using the 5T33 murine myeloma model
    • Manning LS, Chamberlain NL, Leahy MF, Cordingley FT. Assess-ment of the therapeutic potential of cytokines, cytotoxic drugsand effector cell populations for the treatment of multiplemyeloma using the 5T33 murine myeloma model. Immunol Cell Biol 1995;73:326-32.
    • (1995) Immunol Cell Biol , vol.73 , pp. 326-332
    • Manning, L.S.1    Chamberlain, N.L.2    Leahy, M.F.3    Cordingley, F.T.4
  • 63
    • 0025985310 scopus 로고
    • Immune regulationof mouse 5T2 multiple myelom. I. Immune response to 5T2 MMidiotype
    • Croese JW, Vissinga CS, Boersma WJ, Radl J. Immune regulationof mouse 5T2 multiple myeloma. I. Immune response to 5T2 MMidiotype. Neoplasma 1991;38:457-66.
    • (1991) Neoplasma , vol.38 , pp. 457-466
    • Croese, J.W.1    Vissinga, C.S.2    Boersma, W.J.3    Radl, J.4
  • 64
    • 0021907418 scopus 로고
    • Influence of treatment with APD-bisphosphonate on the bone lesions in the mouse 5T2 multiplemyeloma
    • Radl J, Croese JW, Zurcher C, van den Enden-Vieveen MH, Brondijk RJ, Kazil M, et al. Influence of treatment with APD-bisphosphonate on the bone lesions in the mouse 5T2 multiplemyeloma. Cancer 1985;55:1030-40.
    • (1985) Cancer , vol.55 , pp. 1030-1040
    • Radl, J.1    Croese, J.W.2    Zurcher, C.3    van den Enden-Vieveen, M.H.4    Brondijk, R.J.5    Kazil, M.6
  • 65
    • 0033105769 scopus 로고    scopus 로고
    • Ibandronate reduces osteolytic lesions but not tumorburden in a murine model of myeloma bone disease
    • Dallas SL, Garrett IR, Oyajobi BO, Dallas MR, Boyce BF, Bauss F, et al. Ibandronate reduces osteolytic lesions but not tumorburden in a murine model of myeloma bone disease. Blood 1999;93:1697-706.
    • (1999) Blood , vol.93 , pp. 1697-1706
    • Dallas, S.L.1    Garrett, I.R.2    Oyajobi, B.O.3    Dallas, M.R.4    Boyce, B.F.5    Bauss, F.6
  • 66
    • 0242308942 scopus 로고    scopus 로고
    • Zoledronic acid treatment of 5T2MM-bearing miceinhibits the development of myeloma bone disease: evidencefor decreased osteolysis, tumor burden and angiogenesis, andincreased survival
    • Croucher PI, De Hendrik R, Perry MJ, Hijzen A, Shipman CM, Lip-pitt J, et al. Zoledronic acid treatment of 5T2MM-bearing miceinhibits the development of myeloma bone disease: evidencefor decreased osteolysis, tumor burden and angiogenesis, andincreased survival. J Bone Miner Res 2003;18:482-92.
    • (2003) J Bone Miner Res , vol.18 , pp. 482-492
    • Croucher, P.I.1    De Hendrik, R.2    Perry, M.J.3    Hijzen, A.4    Shipman, C.M.5    Lip-pitt, J.6
  • 67
    • 33947161063 scopus 로고    scopus 로고
    • Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is asso-ciated with a modulation of myeloma in vivo
    • Edwards CM, Mueller G, Roelofs AJ, Chantry A, Perry M, Rus-sell RG, et al. Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is asso-ciated with a modulation of myeloma in vivo. Int J Cancer 2007;120:1657-63.
    • (2007) Int J Cancer , vol.120 , pp. 1657-1663
    • Edwards, C.M.1    Mueller, G.2    Roelofs, A.J.3    Chantry, A.4    Perry, M.5    Rus-sell, R.G.6
  • 68
    • 0033397214 scopus 로고    scopus 로고
    • Zoledronate is a potent inhibitor of myeloma cellgrowth and secretion of IL-6 and MMP-1 by the tumoral envi-ronment
    • Derenne S, Amiot M, Barillé S, Collette M, Robillard N, Berthaud P, et al. Zoledronate is a potent inhibitor of myeloma cellgrowth and secretion of IL-6 and MMP-1 by the tumoral envi-ronment. J Bone Miner Res 1999;14:2048-56.
    • (1999) J Bone Miner Res , vol.14 , pp. 2048-2056
    • Derenne, S.1    Amiot, M.2    Barillé, S.3    Collette, M.4    Robillard, N.5    Berthaud, P.6
  • 69
    • 84910650339 scopus 로고    scopus 로고
    • Unwrapping microcomputed tomographicimages for measuring cortical osteolytic lesions in the 5T2murine model of myeloma treated by bisphosphonate
    • N'Diaye M, Libouban H, Aguado E, Bouvard B, Audran M, Chappard D. Unwrapping microcomputed tomographicimages for measuring cortical osteolytic lesions in the 5T2murine model of myeloma treated by bisphosphonate. Micron 2015;68:98-106.
    • (2015) Micron , vol.68 , pp. 98-106
    • N'Diaye, M.1    Libouban, H.2    Aguado, E.3    Bouvard, B.4    Audran, M.5    Chappard, D.6
  • 70
    • 84904968136 scopus 로고    scopus 로고
    • Novel therapeutic targets in myelomabone disease
    • Webb SL, Edwards CM. Novel therapeutic targets in myelomabone disease. Br J Pharmacol 2014;171:3765-76.
    • (2014) Br J Pharmacol , vol.171 , pp. 3765-3776
    • Webb, S.L.1    Edwards, C.M.2
  • 71
    • 0038819051 scopus 로고    scopus 로고
    • Selective inhibitors of the osteoblast proteasomestimulate bone formation in vivo and in vitro
    • Garrett IR, Chen D, Gutierrez G, Zhao M, Escobedo A, Rossini G, et al. Selective inhibitors of the osteoblast proteasomestimulate bone formation in vivo and in vitro. J Clin Invest 2003;111:1771-82.
    • (2003) J Clin Invest , vol.111 , pp. 1771-1782
    • Garrett, I.R.1    Chen, D.2    Gutierrez, G.3    Zhao, M.4    Escobedo, A.5    Rossini, G.6
  • 72
    • 67650456888 scopus 로고    scopus 로고
    • Bortezomib alone or in combination with the his-tone deacetylase inhibitor JNJ-26481585: effect on myelomabone disease in the 5T2MM murine model of myeloma
    • Deleu S, Lemaire M, Arts J, Menu E, Van Valckenborgh E, Vande Broek I, et al. Bortezomib alone or in combination with the his-tone deacetylase inhibitor JNJ-26481585: effect on myelomabone disease in the 5T2MM murine model of myeloma. Cancer Res 2009;69:5307-11.
    • (2009) Cancer Res , vol.69 , pp. 5307-5311
    • Deleu, S.1    Lemaire, M.2    Arts, J.3    Menu, E.4    Van Valckenborgh, E.5    Vande Broek, I.6
  • 73
    • 84893383953 scopus 로고    scopus 로고
    • Parathyroid hormone receptor mediates the anti-myelomaeffect of proteasome inhibitors
    • Zangari M, Berno T, Yang Y, Zeng M, Xu H, Pappas L, et al. Parathyroid hormone receptor mediates the anti-myelomaeffect of proteasome inhibitors. Bone 2014;61:39-43.
    • (2014) Bone , vol.61 , pp. 39-43
    • Zangari, M.1    Berno, T.2    Yang, Y.3    Zeng, M.4    Xu, H.5    Pappas, L.6
  • 74
    • 84887362097 scopus 로고    scopus 로고
    • 213Bi radioimmunotherapy with an anti-mCD138 monoclonal antibody in a murine model of multiplemyeloma
    • Cherel M, Gouard S, Gaschet J, Sai-Maurel C, Bruchertseifer F, Morgenstern A, et al. 213Bi radioimmunotherapy with an anti-mCD138 monoclonal antibody in a murine model of multiplemyeloma. J Nucl Med 2013;54:1597-604.
    • (2013) J Nucl Med , vol.54 , pp. 1597-1604
    • Cherel, M.1    Gouard, S.2    Gaschet, J.3    Sai-Maurel, C.4    Bruchertseifer, F.5    Morgenstern, A.6
  • 75
    • 84898880326 scopus 로고    scopus 로고
    • Comparative analysis of multiplemyeloma treatment by CD138 antigen targeting with bismuth-213 and melphalan chemotherapy
    • Gouard S, Pallardy A, Gaschet J, Faivre-Chauvet A, Bruchert-seifer F, Morgenstern A, et al. Comparative analysis of multiplemyeloma treatment by CD138 antigen targeting with bismuth-213 and melphalan chemotherapy. Nucl Med Biol 2014;41Suppl.:e30-5.
    • (2014) Nucl Med Biol , vol.41 , pp. e30-e35
    • Gouard, S.1    Pallardy, A.2    Gaschet, J.3    Faivre-Chauvet, A.4    Bruchert-seifer, F.5    Morgenstern, A.6
  • 77
    • 0015509142 scopus 로고
    • Ineffectiveness of fluoridetherapy in multiple myeloma
    • Harley JB, Schilling A, Glidewell O. Ineffectiveness of fluoridetherapy in multiple myeloma. N Engl J Med 1972;286:1283-8.
    • (1972) N Engl J Med , vol.286 , pp. 1283-1288
    • Harley, J.B.1    Schilling, A.2    Glidewell, O.3
  • 78
    • 0016724341 scopus 로고
    • Multiple-myelomabone disease. The comparative effect of sodium fluorideand calcium carbonate or placebo
    • Kyle RA, Jowsey J, Kelly PJ, Taves DR. Multiple-myelomabone disease. The comparative effect of sodium fluorideand calcium carbonate or placebo. N Engl J Med 1975;293:1334-8.
    • (1975) N Engl J Med , vol.293 , pp. 1334-1338
    • Kyle, R.A.1    Jowsey, J.2    Kelly, P.J.3    Taves, D.R.4
  • 79
    • 78650875646 scopus 로고    scopus 로고
    • Consequences of daily administered parathyroid hormone onmyeloma growth, bone disease, and molecular profiling ofwhole myelomatous bone
    • Pennisi A, Ling W, Li X, Khan S, Wang Y, Barlogie B, et al. Consequences of daily administered parathyroid hormone onmyeloma growth, bone disease, and molecular profiling ofwhole myelomatous bone. PLoS One 2010:5.
    • (2010) PLoS One , pp. 5
    • Pennisi, A.1    Ling, W.2    Li, X.3    Khan, S.4    Wang, Y.5    Barlogie, B.6
  • 81
    • 41949093576 scopus 로고    scopus 로고
    • Increasing Wnt signaling in the bone mar-row microenvironment inhibits the development of myelomabone disease and reduces tumor burden in bone in vivo
    • Edwards CM, Edwards JR, Lwin ST, Esparza J, Oyajobi BO, McCluskey B, et al. Increasing Wnt signaling in the bone mar-row microenvironment inhibits the development of myelomabone disease and reduces tumor burden in bone in vivo. Blood 2008;111:2833-42.
    • (2008) Blood , vol.111 , pp. 2833-2842
    • Edwards, C.M.1    Edwards, J.R.2    Lwin, S.T.3    Esparza, J.4    Oyajobi, B.O.5    McCluskey, B.6
  • 82
    • 61849137831 scopus 로고    scopus 로고
    • Inhibiting Dickkopf-1 (Dkk1) removes sup-pression of bone formation and prevents the development ofosteolytic bone disease in multiple myeloma
    • Heath DJ, Chantry AD, Buckle CH, Coulton L, Shaughnessy Jr JD, Evans HR, et al. Inhibiting Dickkopf-1 (Dkk1) removes sup-pression of bone formation and prevents the development ofosteolytic bone disease in multiple myeloma. J Bone Miner Res 2009;24:425-36.
    • (2009) J Bone Miner Res , vol.24 , pp. 425-436
    • Heath, D.J.1    Chantry, A.D.2    Buckle, C.H.3    Coulton, L.4    Shaughnessy, J.D.5    Evans, H.R.6


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