New xenograft model of multiple myeloma and efficacy of a humanized antibody against human interleukin-6 receptor

Blood

Volumn 90, Issue 6, 1997, Pages 2437-2444

  Tsunenari, Toshiaki ^b   Koishihara, Yasuo ^b   Nakamura, Akito ^b   Moriya, Miki ^b   Ohkawa, Hiroyuki ^b   Goto, Hideo ^b   Shimazaki, Chihiro ^b   Nakagawa, Masao ^b   Ohsugi, Yoshiyuki ^b   Kishimoto, Tadamitsu ^b   Akamatsu, Ken Ichi ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; M PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG EFFICACY; GENE TARGETING; GROWTH REGULATION; HISTOPATHOLOGY; MALE; MOUSE; MULTIPLE MYELOMA; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; TUMOR LOCALIZATION; XENOGRAFT;

EID: 0030821607     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.6.2437     Document Type: Article

References (32)

1. Kyle RA: Multiple myeloma, review of 869 cases. Mayo Clin Proc 50:29, 1975
2. Durie BGM, Salmon SE: A clinical staging system for multiple myeloma. Cancer 36:842, 1975
3. Bataille R: Pathophysiology of human plasmacytomas, in Klein B (ed): Cytokines in Human Multiple Myeloma. Austin, TX, R.G. Landes, 1994, p 1
4. Kyle RA: Newer approaches to the therapy of multiple myeloma. Blood 76:1678, 1990
5. Kyle RA: Why better prognostic factors for multiple myeloma are needed. Blood 83:1713, 1994
6. Kishimoto T: The biology of interleukin-6. Blood 74:1, 1989
7. Hirano T, Akira S, Taga T, Kishimoto T: Biological and clinical aspects of interleukin-6. Immunol Today 11:443, 1990
8. Klein B: Growth factors in human multiple myeloma, in Klein B (ed): Cytokines in Human Multiple Myeloma. Austin, TX, R.G. Landes, 1994, p 47
9. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T: Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83, 1988
10. Klein B, Zhang XG, Jourdan M, Content J, Houssiau F, Aarden L, Piechaczyk M, Bataille R: Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 73:517, 1989
11. Okuno Y, Takahashi T, Suzuki A, Ichiba S, Nakamura K, Fukumoto M, Okada T, Okada H, Imura H: Establishment and characterization of four myeloma cell lines which are responsive to interleukin-6 for their growth. Leukemia 5:585, 1991
12. Shimizu S, Yoshioka R, Hirose Y, Sugai S, Tachibana J, Konda S: Establishment of two interleukin-6 (B cell stimulatory factor/interferon β2)-dependent human bonemarrow-derived myeloma cell lines. J Exp Med 169:339, 1989
13. Goto H, Shimazaki C, Tatsumi T, Yamagata N, Hirata T, Ashihara E, Oku N, Inaba T, Fujita N, Koishihara Y, Ohsugi Y, Nakagawa M: Mouse anti-human interleukin-6 receptor monoclonal antibody inhibits proliferation of fresh human myeloma cells in vitro. Jpn J Cancer Res 85:958, 1994
14. Hardin J, MacLeod S, Grigorieva I, Chang R, Barlogie B, Xiao H, Epstein J: Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood 84:3063, 1994
15. Melinda M, Schwarze K, Hawley RG: Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL. Cancer Res 55:2262, 1995
16. Klein B, Wijdenes J, Zhang XG, Jourdan M, Boiron JM, Brochier J, Liaytard J, Merlin M, Clement C, Morel-Fournier B, Lu ZY, Mannoni P, Sany J, Bataille R: Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 78:1988, 1991
17. Bataille R, Barlogie B, Lu ZY, Rossi JF, Lavabre-Bertrand T, Beck T, Wijdenes J, Brochier J, Klein B: Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood 86:685, 1995
18. Sato K, Tsuchiya M, Saldanha J, Koishihara Y, Ohsugi Y, Kishimoto T, Bendig MM: Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. Cancer Res 53:851, 1993
19. Feo-Zuppardi FJ, Taylor CW, Iwato K, Lopez MHA, Grogan TM, Odeleye A, Hersh EM, Salomon SE: Long-term engraftment of fresh human myeloma cells in SCID mice. Blood 80:2843, 1992
20. Huang YW, Richardson JA, Tong AW, Zhang BQ, Stone MJ, Vitetta ES: Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease. Cancer Res 53:1392, 1993
21. Urashima M, Chauhan D, Uchiyama H, Freeman GJ, Anderson KC: CD40 ligand triggered interleukin-6 secretion in multiple myeloma. Blood 85:1903, 1995
22. Tsunenari T, Akamatsu K, Kaiho S, Sato K, Tsuchiya M, Koishihara Y, Kishimoto T, Ohsugi Y: Therapeutic potential of humanized anti-interleukin-6 receptor antibody: antitumor activity in xenograft model of multiple myeloma. Anticancer Res 16:2537, 1996
23. Goto H, Shimazaki C, Tatsumi T, Fujita N, Tsuchiya M, Koishihara Y, Ohsugi Y, Nakagawa M: Establishment of novel myeloma cell line KPMM2 carrying t(3;14)(q21;q32), which proliferates specifically in response to interleukin-6 through an autocrine mechanism. Leukemia 9:711, 1995
24. Suzuki H, Yasukawa K, Saito T, Goitsuka R, Hasegawa A, Ohsugi Y, Taga T, Kishimoto T: Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo. Eur J Immunol 22:1989, 1992
25. Kawano MM, Huang N, Harada H, Harada Y, Sakai A, Tanaka H, Iwato K, Kuramoto A: Identification of immature and mature myeloma cells in the bone marrow of human myelomas. Blood 82:564, 1993
26. Pellat-Deceunynck C, Barille S, Puthier D, Rapp MJ, Harousseau JL, Bataille R, Amiot M: Adhesion molecules on human myeloma cells: significant changes in expression related to malignancy, tumor spreading, and immortalization. Cancer Res 55:3647, 1995
27. Huang N, Kawano MM, Harada H, Harada Y, Sakai A, Kuramoto A, Niwa O: Heterogeneous expression of a novel MPC-1 antigen on myeloma cells: Possible involvement of MPC-1 antigen in the adhesion of mature myeloma cells to bone marrow stromal cells. Blood 82:3721, 1993
28. Huang N, Kawano MM, Mahmoud MS, Mihara K, Tsujimoto T, Niwa O, Kuramoto A: Expression of CD21 antigen on myeloma cells and its involvement in their adhesion to bone marrow stromal cells. Blood 85:3704, 1995
29. Huang YW, Richardson JA, Vitetta ES: Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells. Cancer Res 55:610, 1995
30. Uchiyama H, Barut BA, Mohrbacher AF, Chauhan D, Anderson KC: Adhesion of human myeloma-derived cell line to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 82:3712, 1993
31. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC: Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science 257:88, 1992
32. Udagawa N, Takahashi N, Katagiri T, Tamura T, Wada S, Findlay DM, Martin TJ, Hirota H, Taga T, Kishimoto T, Suda T: Interleukin (IL-6) induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med 182:1461, 1995