The Role of Autophagy in Atherosclerosis

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Volumn 1, Issue , 2014, Pages 79-90

  Michiels, Cédéric F ^a   Schrijvers, Dorien M ^a   De Meyer, Guido R Y ^a   Martinet, Wim ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Apoptosis; Atherosclerosis; Cholesterol; Everolimus; Inflammation

Indexed keywords

EID: 84942940386     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-405530-8.00006-6     Document Type: Chapter

References (34)

1. De Meyer I., Martinet W., Schrijvers D.M., et al. Toll-like receptor 7 stimulation by imiquimod induces macrophage autophagy and inflammation in atherosclerotic plaques. Basic Res. Cardiol. 2012, 107(3):269.
2. Feng B., Yao P.M., Li Y., et al. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat. Cell Biol. 2003, 5:781-792.
3. Frostegård J., Nilsson J., Haegerstrand A., et al. Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937. Proc. Natl. Acad. Sci. U.S.A. 1990, 87(3):904-908.
4. 2+ increase. Cell Signal. 2010, 22(6):914-925.
5. Harris J. Autophagy and cytokines. Cytokine 2011, 56(2):140-144.
6. Hill B.G., Haberzettl P., Ahmed Y. Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells. Biochem. J. 2008, 410:525-534.
7. Kedi X., Yi Y., Ming Y. Autophagy plays a protective role in free cholesterol overload-induced death of smooth muscle cells. J. Lipid Res. 2010, 51(9):2581-2590.
8. Kiffin R., Bandyopadhyay U., Cuervo A.M. Oxidative stress and autophagy. Antioxid. Redox Signal. 2006, 8:152-162.
9. Kurz T., Terman A., Brunk U.T. Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron. Arch. Biochem. Biophys. 2007, 462:220-230.
10. Lee I.H., Cao L., Mostoslavsky R., et al. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 2008, 105(9):3374-3379.
11. Le Guezennec X., Brichkina A., Huang Y.F. Wip1-dependent regulation of autophagy, obesity, and atherosclerosis. Cell Metab. 2012, 16(1):68-80.
12. Lemasters J.J. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res. 2005, 8(1):3-5.
13. Li J., Ni M., Lee B. The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ. 2008, 15:1460-1471.
14. Liao X., Sluimer J.C., Wang Y., et al. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab. 2012, 15(4):545-553.
15. Lum J.J., Bauer D.E., Kong M., et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 2005, 120(2):237-248.
16. Ma L., Zhong J., Zhao Z., et al. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. Cardiovasc. Res. 2011, 92(3):504-513.
17. Martinet W., De Meyer G.R.Y. Autophagy in atherosclerosis: a cell survival and deathphenomenon with therapeutic potential. Circ. Res. 2009, 104(3):304-317.
18. Martinet W., De Bie M., Schrijvers D.M. 7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 2004, 24:2296-2301.
19. Martinet W., Schrijvers D.M., Timmermans J.P. Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells. Br. J. Pharmacol. 2008, 154:1236-1246.
20. Martinet W., Verheye S., De Meyer I., et al. Everolimus triggers cytokine release by macrophages: rationale for stents eluting everolimus and a glucocorticoid. Arterioscler. Thromb. Vasc. Biol. 2012, 32(5):1228-1235.
21. Mizushima N., Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011, 147(4):728-741.
22. Muller C., Salvayre R., Nègre-Salvayre A. Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs. Autophagy. 2011, 7(5):541-543.
23. Ouimet M., Franklin V., Mak E. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 2011, 13(6):655-667.
24. Peter C., Wesselborg S., Herrmann M. Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells. Apoptosis 2010, 15:1007-1028.
25. Prattes S., Hörl G., Hammer A., et al. Intracellular distribution and mobilization of unesterified cholesterol in adipocytes: triglyceride droplets are surrounded by cholesterol-rich ER-like surface layer structures. J. Cell Sci. 2000, 113(17):2977-2989.
26. Razani B., Feng C., Coleman T., et al. Autophagy links inflammasomes to atherosclerotic progression. Cell Metab. 2012, 15(4):534-544.
27. Schrijvers D.M., De Meyer G.R.Y., Kockx M.M. Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2005, 25(6):1256-1261.
28. Singh R., Kaushik S., Wang Y., et al. Autophagy regulates lipid metabolism. Nature 2009, 458(7242):1131-1135.
29. Tabas I. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J. Clin. Invest. 2002, 110(7):905-911.
30. Takeda-Watanabe A., Kitada M., Kanasaki K. SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells. Biochem. Biophys. Res. Commun. 2012, 427(1):191-196.
31. Verheye S., Martinet W., Kockx M.M., et al. Selective clearance of macrophages in atherosclerotic plaques by autophagy. J. Am. Coll. Cardiol. 2007, 49(6):706-715.
32. Walia M., Samson S.E., Schmidt T., et al. Peroxynitrite and nitric oxide differ in their effects on pig coronary artery smooth muscle. Am. J. Physiol. Cell Physiol. 2003, 284(3):C649-C657.
33. Weber C., Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat. Med. 2011, 17(11):1410-1422.
34. Zhang Y.L., Cao Y.J., Zhang X., et al. The autophagy-lysosome pathway: a novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells. Biochem. Biophys. Res. Commun. 2010, 394(2):377-382.