Age-related left ventricular changes and their association with leukocyte telomere length in healthy people

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Akasheva, Dariga U ^a   Plokhova, Ekaterina V ^a   Tkacheva, Olga N ^a   Strazhesko, Irina D ^a   Dudinskaya, Ekaterina N ^a   Kruglikova, Anna S ^a   Pykhtina, Valentina S ^a   Brailova, Natalia V ^a   Pokshubina, Inna A ^a   Sharashkina, Natalia V ^a   Agaltsov, Mikhail V ^a   Skvortsov, Dmitry ^b   Boytsov, Sergey A ^a  

^a NATIONAL MEDICAL RESEARCH CENTER FOR THERAPY AND PREVENTIVE MEDICINE   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; AGING; ARTICLE; ELECTROCARDIOGRAPHY; FEMALE; GENDER; GENE DOSAGE; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE RELAXATION; HEART LEFT VENTRICLE SIZE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HUMAN; LEUKOCYTE TELOMERE LENGTH; MALE; NORMAL HUMAN; PHENOTYPE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; TELOMERE; TRANSTHORACIC ECHOCARDIOGRAPHY; TREADMILL TEST; VOLUNTEER; CARDIAC MUSCLE; HEART VENTRICLE; LEUKOCYTE; METABOLISM; MIDDLE AGED; PATHOLOGY; TELOMERE HOMEOSTASIS;

ADULT; AGED; AGING; FEMALE; HEART VENTRICLES; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MYOCARDIUM; TELOMERE HOMEOSTASIS; VENTRICULAR FUNCTION, LEFT;

EID: 84942926591     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135883     Document Type: Article

References (26)

1. Strait JB, Lakatta EG. Aging-Associated cardiovascular changes and their relationship to heart failure. Heart Fail Clin. 2012; 8(1): 143-164. doi: 10.1016/j.hfc.2011.08.011 PMID: 22108734
2. Nilsson PM, Tufvesson H, Leosdottir M, Melander O. Telomeres and cardiovascular disease risk: An update 2013. Transl Res. 2013; 162(6): 371-380. doi: 10.1016/j.trsl.2013.05.004 PMID: 23748031
3. Leri A, Franco S, Zacheo A, Barlucchi L, Chimenti S, Limana F, et al. Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. EMBO J. 2003; 22: 131-139. PMID: 12505991
4. Hastings R, Li NC, Lacy PS, Patel H, Herbert KE, Stanley AG, et al. Rapid telomere attrition in cardiac tissue of the ageing Wistar rat. Exp Gerontol. 2004; 39: 855-857. PMID: 15130681
5. Takubo K, Aida J, Izumiyama-Shimomura N, Ishikawa N, Sawabe M, Kurabayashi R, et al. Changes of telomere length with aging. Geriatr Gerontol Int. 2010; 10 (Suppl. 1): S197-S206. doi: 10.1111/j.1447-0594.2010.00605.x PMID: 20590834
6. Daniali L, Benetos A, Susser E, Kark JD, Labat C, Kimura M, et al. Telomeres shorten at equivalent rates in somatic tissues of adults. NatCommun. 2013; 4: 1597.
7. Serrano AL, Andrés V. Telomeres and cardiovascular disease: Does size matter? Circ Res. 2004; 94 (5): 575-584. PMID: 15031270
8. Nagueh SF, Appleton CP, Gillebert TC, Marino PM, Oh JK, Smiseth OA, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography. Journal of the American Society of Echocardiography. 2009; 22(2): 107-133. doi: 10.1016/j.echo.2008.11.023 PMID: 19187853
9. Ho Carolyn Y., Solomon Scott D. A Clinician's Guide to Tissue Doppler Imaging. Circulation. 2006; 113: E396-e398. PMID: 16534017
10. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002; 30(10): E47. PMID: 12000852
11. Kawel N, Turkbey EB, Carr JJ, Eng J, Gomes AS, Hundley WG, et al. Normal left ventricular myocardial thickness for middle aged and older subjects with SSFP cardiac MR: The Multi-Ethnic Study of Atherosclerosis. Circ Cardiovasc Imaging. 2012; 5(4): 500-508. doi: 10.1161/CIRCIMAGING.112.973560 PMID: 22705587
12. Ruan Q, Nagueh SF. Effect of age on left ventricular systolic function in humans: A study of systolic isovolumic acceleration rate. Exp Physiol. 2005; 90(4): 527-534. PMID: 15769881
13. Gates PE, Tanaka H, Graves J, Seals DR. Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness. Eur Heart J. 2003; 24(24): 2213-2220. PMID: 14659773
14. Chahal Navtej S., Lim Tiong K., Jain Piyush. Normative reference values for the tissue Doppler imaging parameters of left ventricular function: A population-based study. European Journal of Echocardiography. 2010; 11: 51-56. doi: 10.1093/ejechocard/jep164 PMID: 19910319
15. Cheng S, Fernandes VR, Bluemke DA, McClelland RL, Kronmal RA, Lima JA. Age-related left ventricular remodeling and associated risk for cardiovascular outcomes: The Multi-Ethnic Study of Atherosclerosis. CircCardiovasc Imaging.2009; 2(3): 191-198.
16. Olivetti G, Melissari M, Capasso J, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res. 1991; 68: 1560-1568. PMID: 2036710
17. Ganau A, Saba PS, Roman MJ, de Simone G, Realdi G, Devereux RB. Ageing induces left ventricular concentric remodeling in normotensive subjects. J Hypertens. 1995; 13: 1818-1822. PMID: 8903659
18. Munagala VK, Jacobsen SJ, Mahoney DW, Rodeheffer RJ, Bailey KR, Redfield MM. Association of newer diastolic function parameters with age in healthy subjects: A population-based study. J Am SocEchocardiogr. 2003; 16(10): 1049-1056.
19. Kitzman DW, Gardin JM, Gottdiener JS, Arnold A, Boineau R, Aurigemma G, et al. Importance of heart failure with preserved systolic function in patients > or = 65 years of age (CHS research group; cardiovascular health study). Am J Cardiol. 2001; 87: 413-419. PMID: 11179524
20. Vasan RS, Demissie S, Kimura M, Cupples LA, White C, Gardner JP, et al. Association of leukocyte telomere length with echocardiographic left ventricular mass: The Framingham heart study. Circulation. 2009; 120(13): 1195-202. doi: 10.1161/CIRCULATIONAHA.109.853895 PMID: 19752323
21. Denil SL, Rietzschel ER, De Buyzere ML, Van Daele CM, Seqers P, De Bacquer D, et al. On cross-sectional associations of leukocyte telomere length with cardiac systolic, diastolic and vascular function: The Asklepios study. PLoS One. 2014 Dec 15; 9(12): E115071. doi: 10.1371/journal.pone.0115071 PMID: 25506937
22. Bernhard D, Laufer G. The aging cardiomyocyte: A mini-review. Gerontology. 2008; 54(1): 24-31. doi: 10.1159/000113503 PMID: 18196923
23. Sofie Bekaert, Tim De Meyer, Patrick Van Oostveldt. Telomere Attrition as Ageing Biomarker. Anticancer Research. 2005; 25: 3011-3022. PMID: 16080560
24. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Wals S, et al. Evidence for cardiomyocyte renewal in humans. Science. 2009; 324: 98-102. doi: 10.1126/science.1164680 PMID: 19342590
25. Terai M, Izumiyama-Shimomura N, Aida J, Ishikawa N, Sawabe M, Arai T, et al. Association of telomere shortening in myocardium with heart weight gain and cause of death. Scientific Reports. 2013; 3 (2401): 1-8.
26. Collerton J, Martin-Ruiz C, Kenny A, Barrass K, von Zglinicki T, Kirkwood T, et al. Telomere length is associated with left ventricular function in the oldest old: The Newcastle 851 study. European Heart Journal. 2007; 28: 172-1. PMID: 17215319