Fibroblast growth factor 9 is a novel modulator of negative affect

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 38, 2015, Pages 11953-11958

  Aurbach, Elyse L ^a,b   Inui, Edny Gula ^a   Turner, Cortney A ^a   Hagenauer, Megan H ^a   Prater, Katherine E ^a,b   Li, Jun Z ^a   Absher, Devin ^c   Shah, Najmul ^a   Blandino, Peter ^a   Bunney, William E ^c   Myers, Richard M ^d   Barchas, Jack D ^e   Schatzberg, Alan F ^f   Watson, Stanley J ^a   Akil, Huda ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f STANFORD UNIVERSITY   (United States)

Author keywords

Affect; Anxiety; Fibroblast growth factor 9; Hippocampus; Major depression

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; ENHANCED GREEN FLUORESCENT PROTEIN; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 9; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; GLIAL DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; NEUROTROPHIC FACTOR; UNCLASSIFIED DRUG; SMALL INTERFERING RNA;

ADULT; AFFECT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; AUTORADIOGRAPHY; CONFERENCE PAPER; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; DOWN REGULATION; EMOTIONALITY; FOLLOW UP; FORCED SWIM TEST; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LOCOMOTION; MAJOR DEPRESSION; MALE; MENTAL STRESS; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SOCIAL AVOIDANCE BEHAVIOR; SOCIAL INTERACTION TEST; SOCIAL STRESS; STRESS; UPREGULATION; AGED; ANIMAL; AVOIDANCE BEHAVIOR; CASE CONTROL STUDY; COMPLICATION; DEMOGRAPHY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; LENTIVIRINAE; METABOLISM; MICROINJECTION; MIDDLE AGED; POSTMORTEM CHANGE; SPRAGUE DAWLEY RAT; VERY ELDERLY; YOUNG ADULT;

ADULT; AFFECT; AGED; AGED, 80 AND OVER; ANIMALS; ANXIETY; AVOIDANCE LEARNING; CASE-CONTROL STUDIES; DEMOGRAPHY; DENTATE GYRUS; DEPRESSIVE DISORDER, MAJOR; FEMALE; FIBROBLAST GROWTH FACTOR 9; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; LENTIVIRUS; MALE; MICROINJECTIONS; MIDDLE AGED; POSTMORTEM CHANGES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RNA, SMALL INTERFERING; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84942913316     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1510456112     Document Type: Article

References (34)

1. Turner CA, Watson SJ, Akil H (2012) The fibroblast growth factor family: Neuromodulation of affective behavior. Neuron 76(1):160-174.
2. Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59(12):1116-1127.
3. Evans SJ, et al. (2004) Dysregulation of the fibroblast growth factor system in major depression. Proc Natl Acad Sci USA 101(43):15506-15511.
4. Bernard R, et al. (2011) Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psychiatry 16(6):634-646.
5. Gaughran F, Payne J, Sedgwick PM, Cotter D, Berry M (2006) Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. Brain Res Bull 70(3):221-227.
6. Turner CA, Calvo N, Frost DO, Akil H, Watson SJ (2008) The fibroblast growth factor system is downregulated following social defeat. Neurosci Lett 430(2):147-150.
7. Turner CA, Gula EL, Taylor LP, Watson SJ, Akil H (2008) Antidepressant-like effects of intracerebroventricular FGF2 in rats. Brain Res 1224:63-68.
8. Elsayed M, et al. (2012) Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression. Biol Psychiatry 72(4):258-265.
9. Mallei A, Shi B, Mocchetti I (2002) Antidepressant treatments induce the expression of basic fibroblast growth factor in cortical and hippocampal neurons. Mol Pharmacol 61(5):1017-1024.
10. Bachis A, Mallei A, Cruz MI, Wellstein A, Mocchetti I (2008) Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factorbinding protein in neurons. Neuropharmacology 55(7):1114-1120.
11. Gómez-Pinilla F, Dao L, Choi J, Ryba EA (2000) Diazepam induces FGF-2 mRNA in the hippocampus and striatum. Brain Res Bull 53(3):283-289.
12. Perez JA, Clinton SM, Turner CA, Watson SJ, Akil H (2009) A new role for FGF2 as an endogenous inhibitor of anxiety. J Neurosci 29(19):6379-6387.
13. Turner CA, Clinton SM, Thompson RC, Watson SJ, Jr, Akil H (2011) Fibroblast growth factor-2(FGF2) augmentation early in life alters hippocampal development and rescues the anxiety phenotype in vulnerable animals. Proc Natl Acad Sci USA 108(19):8021-8025.
14. Eren-Koçak E, Turner CA, Watson SJ, Akil H (2011) Short-hairpin RNA silencing of endogenous fibroblast growth factor 2 in rat hippocampus increases anxiety behavior. Biol Psychiatry 69(6):534-540.
15. Salaria S, et al. (2006) Microarray analysis of cultured human brain aggregates following cortisol exposure: Implications for cellular functions relevant to mood disorders. Neurobiol Dis 23(3):630-636.
16. Tagashira S, Ozaki K, Ohta M, Itoh N (1995) Localization of fibroblast growth factor-9 mRNA in the rat brain. Brain Res Mol Brain Res 30(2):233-241.
17. Nakamura S, et al. (1997) Motor neurons in human and rat spinal cord synthesize fibroblast growth factor-9. Neurosci Lett 221(2-3):181-184.
18. Todo T, et al. (1998) Neuronal localization of fibroblast growth factor-9 immunoreactivity in human and rat brain. Brain Res 783(2):179-187.
19. Garcès A, Nishimune H, Philippe J-M, Pettmann B, deLapeyrière O (2000) FGF9: A motoneuron survival factor expressed by medial thoracic and sacral motoneurons. J Neurosci Res 60(1):1-9.
20. Lin Y, et al. (2009) Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. Dev Biol 329(1):44-54.
21. Nakamura S, et al. (1999) Glial expression of fibroblast growth factor-9 in rat central nervous system. Glia 28(1):53-65.
22. Goetz R, Mohammadi M (2013) Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol 14(3):166-180.
23. Ornitz DM, et al. (1996) Receptor specificity of the fibroblast growth factor family. J Biol Chem 271(25):15292-15297.
24. Huang J-Y, Hong Y-T, Chuang J-I (2009) Fibroblast growth factor 9 prevents MPP+-induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro. J Neurochem 109(5):1400-1412.
25. Kanda T, et al. (2000) Self-secretion of fibroblast growth factor-9 supports basal forebrain cholinergic neurons in an autocrine/paracrine manner. Brain Res 876(1-2):22-30.
26. Lum M, Turbic A, Mitrovic B, Turnley AM (2009) Fibroblast growth factor-9 inhibits astrocyte differentiation of adult mouse neural progenitor cells. J Neurosci Res 87(10):2201-2210.
27. Li JZ, et al. (2004) Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum Mol Genet 13(6):609-616.
28. Chaudhury S, et al. (2014) FGF2 is a target and a trigger of epigenetic mechanisms associated with differences in emotionality: Partnership with H3K9me3. Proc Natl Acad Sci USA 111(32):11834-11839.
29. Lamers F, et al. (2011) Comorbidity patterns of anxiety and depressive disorders in a large cohort study: The Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 72(3):341-348.
30. American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, Washington, DC), 4th Ed.
31. Li JZ, et al. (2013) Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci USA 110(24):9950-9955.
32. Tomita H, et al. (2004) Effect of agonal and postmortem factors on gene expression profile: Quality control in microarray analyses of postmortem human brain. Biol Psychiatry 55(4):346-352.
33. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Δ Δ C (T)) Method. Methods 25(4):402-408.
34. Kabbaj M, Devine DP, Savage VR, Akil H (2000) Neurobiological correlates of individual differences in novelty-seeking behavior in the rat: Differential expression of stress-related molecules. J Neurosci 20(18):6983-6988.