-
3
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 2007; 7: 295-308.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
4
-
-
77957948992
-
Molecular predictive and prognostic markers in colon cancer
-
Winder T, Lenz HJ. Molecular predictive and prognostic markers in colon cancer. Cancer Treat Rev 2010; 36: 550-6.
-
(2010)
Cancer Treat Rev
, vol.36
, pp. 550-556
-
-
Winder, T.1
Lenz, H.J.2
-
5
-
-
69249161778
-
Biological and clinical features in predicting efficacy of epidermal growth factor receptor tyrosine kinase inhibitors: A systematic review and meta-analysis
-
Garassino MC, Borgonovo K, Rossi A, Mancuso A, Martelli O, Tinazzi A, et al. Biological and clinical features in predicting efficacy of epidermal growth factor receptor tyrosine kinase inhibitors: a systematic review and meta-analysis. Anticancer Res 2009; 29: 2691-701.
-
(2009)
Anticancer Res
, vol.29
, pp. 2691-2701
-
-
Garassino, M.C.1
Borgonovo, K.2
Rossi, A.3
Mancuso, A.4
Martelli, O.5
Tinazzi, A.6
-
6
-
-
0034548724
-
Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines
-
Bernhard EJ, Stanbridge EJ, Gupta S, Gupta AK, Soto D, Bakanauskas VJ, et al. Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines. Cancer Res 2000; 60: 6597-600.
-
(2000)
Cancer Res
, vol.60
, pp. 6597-6600
-
-
Bernhard, E.J.1
Stanbridge, E.J.2
Gupta, S.3
Gupta, A.K.4
Soto, D.5
Bakanauskas, V.J.6
-
7
-
-
0023901469
-
Increased resistance to cis-diamminedichloroplatinum(II) in NIH 3T3 cells transformed by ras oncogenes
-
Sklar MD Increased resistance to cis-diamminedichloroplatinum(II) in NIH 3T3 cells transformed by ras oncogenes. Cancer Res 1988; 48: 793-7.
-
(1988)
Cancer Res
, vol.48
, pp. 793-797
-
-
Sklar, M.D.1
-
8
-
-
20544455590
-
Vinorelbine plus cisplatin vs. Observation in resected non-small-cell lung cancer
-
Winton T, Livingston R, Johnson D, Rigas J, Johnston M, Butts C, et al. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med 2005; 352: 2589-97.
-
(2005)
N Engl J Med
, vol.352
, pp. 2589-2597
-
-
Winton, T.1
Livingston, R.2
Johnson, D.3
Rigas, J.4
Johnston, M.5
Butts, C.6
-
9
-
-
84878981521
-
Prognostic value of KRAS mutations in patients with non-small cell lung cancer: A systematic review with meta-analysis
-
Meng D, Yuan M, Li X, Chen L, Yang J, Zhao X, et al. Prognostic value of KRAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis. Lung Cancer 2013; 81: 1-10.
-
(2013)
Lung Cancer
, vol.81
, pp. 1-10
-
-
Meng, D.1
Yuan, M.2
Li, X.3
Chen, L.4
Yang, J.5
Zhao, X.6
-
10
-
-
9044221762
-
Detection of K-ras mutations in lung carcinomas: Relationship to prognosis
-
Keohavong P, DeMichele MA, Melacrinos AC, Landreneau RJ, Weyant RJ, Siegfried JM. Detection of K-ras mutations in lung carcinomas: relationship to prognosis. Clin Cancer Res 1996; 2: 411-8.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 411-418
-
-
Keohavong, P.1
DeMichele, M.A.2
Melacrinos, A.C.3
Landreneau, R.J.4
Weyant, R.J.5
Siegfried, J.M.6
-
11
-
-
84863116014
-
Effect of KRAS oncogene substitutions on protein behavior: Implications for signaling and clinical outcome
-
Ihle NT, Byers LA, Kim ES, Saintigny P, Lee JJ, Blumenschein GR, et al. Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst 2012; 104: 228-39.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 228-239
-
-
Ihle, N.T.1
Byers, L.A.2
Kim, E.S.3
Saintigny, P.4
Lee, J.J.5
Blumenschein, G.R.6
-
12
-
-
19944430434
-
The role of RAS oncogene in survival of patients with lung cancer: Asystematic review of the literature with meta-analysis
-
Mascaux C, Iannino N, Martin B, Paesmans M, Berghmans T, Dusart M, et al. The role of RAS oncogene in survival of patients with lung cancer: asystematic review of the literature with meta-analysis. Br J Cancer 2005; 92: 131-9.
-
(2005)
Br J Cancer
, vol.92
, pp. 131-139
-
-
Mascaux, C.1
Iannino, N.2
Martin, B.3
Paesmans, M.4
Berghmans, T.5
Dusart, M.6
-
13
-
-
84888640423
-
Drug discovery: Pocket of opportunity
-
Bollag G, Zhang C. Drug discovery: pocket of opportunity. Nature 2013; 503: 475-6.
-
(2013)
Nature
, vol.503
, pp. 475-476
-
-
Bollag, G.1
Zhang, C.2
-
14
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008; 14: 1351-6.
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
-
16
-
-
80555157475
-
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers
-
Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, et al. Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. J Clin Invest 2011; 121: 4311-21.
-
(2011)
J Clin Invest
, vol.121
, pp. 4311-4321
-
-
Ebi, H.1
Corcoran, R.B.2
Singh, A.3
Chen, Z.4
Song, Y.5
Lifshits, E.6
-
17
-
-
65649108558
-
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival
-
Singh A, Greninger P, Rhodes D, Koopman L, Violette S, Bardessy N, et al. A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell 2009; 15: 489-500.
-
(2009)
Cancer Cell
, vol.15
, pp. 489-500
-
-
Singh, A.1
Greninger, P.2
Rhodes, D.3
Koopman, L.4
Violette, S.5
Bardessy, N.6
-
18
-
-
79953756460
-
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
-
Collisson EA, Sadanandam A, Olson P, Gibb WJ, Truitt M, Gu S, et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat Med 2011; 17: 500-3.
-
(2011)
Nat Med
, vol.17
, pp. 500-503
-
-
Collisson, E.A.1
Sadanandam, A.2
Olson, P.3
Gibb, W.J.4
Truitt, M.5
Gu, S.6
-
19
-
-
60149095359
-
Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo
-
Shi XH, Liang ZY, Ren XY, Liu TH. Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo. Cancer Gene Ther 2009; 16: 227-36.
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 227-236
-
-
Shi, X.H.1
Liang, Z.Y.2
Ren, X.Y.3
Liu, T.H.4
-
20
-
-
84865620351
-
K-RAS mutant pancreatic tumors show higher sensitivitytoMEKthantoPI3K inhibition in vivo
-
Hofmann I, Weiss A, Elain G, Schwaederle M, Sterker D, Romanet V, et al. K-RAS mutant pancreatic tumors show higher sensitivitytoMEKthantoPI3K inhibition in vivo. PLoS One 2012; 7: e44146.
-
(2012)
PLoS One
, vol.7
-
-
Hofmann, I.1
Weiss, A.2
Elain, G.3
Schwaederle, M.4
Sterker, D.5
Romanet, V.6
-
21
-
-
33846973375
-
Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells
-
Zhang Z, Jiang G, Yang F, Wang J. Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells. Cancer Biol Ther 2006; 5: 1481-6.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 1481-1486
-
-
Zhang, Z.1
Jiang, G.2
Yang, F.3
Wang, J.4
-
22
-
-
59649109230
-
Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
-
Pickl M, Ries CH. Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab. Oncogene 2009; 28: 461-8.
-
(2009)
Oncogene
, vol.28
, pp. 461-468
-
-
Pickl, M.1
Ries, C.H.2
-
23
-
-
77953540958
-
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
-
Weigelt B, Lo AT, Park CC, Gray JW, Bissell MJ. HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat 2010; 122: 35-43.
-
(2010)
Breast Cancer Res Treat
, vol.122
, pp. 35-43
-
-
Weigelt, B.1
Lo, A.T.2
Park, C.C.3
Gray, J.W.4
Bissell, M.J.5
-
24
-
-
34248650697
-
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
-
Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, et al. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 2007; 1: 84-96.
-
(2007)
Mol Oncol
, vol.1
, pp. 84-96
-
-
Kenny, P.A.1
Lee, G.Y.2
Myers, C.A.3
Neve, R.M.4
Semeiks, J.R.5
Spellman, P.T.6
-
25
-
-
79952236235
-
Pancreatic cancer spheres are more than just aggregates of stem markerpositive cells
-
Gaviraghi M, Tunici P, Valensin S, Rossi M, Giordano C, Magnoni L, et al. Pancreatic cancer spheres are more than just aggregates of stem markerpositive cells. Biosci Rep 2011; 31: 45-55.
-
(2011)
Biosci Rep
, vol.31
, pp. 45-55
-
-
Gaviraghi, M.1
Tunici, P.2
Valensin, S.3
Rossi, M.4
Giordano, C.5
Magnoni, L.6
-
26
-
-
84861733799
-
MET: A promising anticancer therapeutic target
-
Peters S, Adjei AA. MET: a promising anticancer therapeutic target. Nat Rev Clin Oncol 2012; 9: 314-26.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 314-326
-
-
Peters, S.1
Adjei, A.A.2
-
28
-
-
17344381429
-
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
-
Schmidt L, Duh FM, Chen F, Kishida T, Glenn G, Choyke P, et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet 1997; 16: 68-73.
-
(1997)
Nat Genet
, vol.16
, pp. 68-73
-
-
Schmidt, L.1
Duh, F.M.2
Chen, F.3
Kishida, T.4
Glenn, G.5
Choyke, P.6
-
29
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012: 487: 505-9.
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
Fridlyand, J.2
Yan, Y.3
Penuel, E.4
Burton, L.5
Chan, E.6
-
30
-
-
84877848587
-
Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition
-
Katayama R, Aoyama A, Yamori T, Qi J, Oh-hara T, Song Y, et al. Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition. Cancer Res 2013; 73: 3087-96.
-
(2013)
Cancer Res
, vol.73
, pp. 3087-3096
-
-
Katayama, R.1
Aoyama, A.2
Yamori, T.3
Qi, J.4
Oh-Hara, T.5
Song, Y.6
-
31
-
-
0030799090
-
Activating mutations for the met tyrosine kinase receptor in human cancer
-
Jeffers M, Schmidt L, Nakaigawa N, Webb CP, Weirich G, Kishida T, et al. Activating mutations for the met tyrosine kinase receptor in human cancer. Proc Natl Acad Sci U S A 1997; 94: 11445-50.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11445-11450
-
-
Jeffers, M.1
Schmidt, L.2
Nakaigawa, N.3
Webb, C.P.4
Weirich, G.5
Kishida, T.6
-
32
-
-
84863229979
-
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer
-
Li Y, Fan S, Koo J, Yue P, Chen ZG, Owonikoko TK, et al. Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer. Cancer Biol Ther 2012; 13: 272-80.
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 272-280
-
-
Li, Y.1
Fan, S.2
Koo, J.3
Yue, P.4
Chen, Z.G.5
Owonikoko, T.K.6
-
33
-
-
0141842674
-
Identification of a cancer stem cell in human brain tumors
-
Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63: 5821-8.
-
(2003)
Cancer Res
, vol.63
, pp. 5821-5828
-
-
Singh, S.K.1
Clarke, I.D.2
Terasaki, M.3
Bonn, V.E.4
Hawkins, C.5
Squire, J.6
-
34
-
-
81855194258
-
c-Met is a marker of pancreatic cancer stem cells and therapeutic target
-
Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, et al. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology 2011; 141: 2218-27.
-
(2011)
Gastroenterology
, vol.141
, pp. 2218-2227
-
-
Li, C.1
Wu, J.J.2
Hynes, M.3
Dosch, J.4
Sarkar, B.5
Welling, T.H.6
-
35
-
-
0026655776
-
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor
-
Rong S, Bodescot M, Blair D, Dunn J, Nakamura T, Mizuno K, et al. Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol 1992; 12: 5152-8.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5152-5158
-
-
Rong, S.1
Bodescot, M.2
Blair, D.3
Dunn, J.4
Nakamura, T.5
Mizuno, K.6
-
36
-
-
84882629652
-
EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis
-
Breindel JL, Haskins JW, Cowell EP, Zhao M, Nguyen DX, Stern DF. EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 2013; 73: 5053-65.
-
(2013)
Cancer Res
, vol.73
, pp. 5053-5065
-
-
Breindel, J.L.1
Haskins, J.W.2
Cowell, E.P.3
Zhao, M.4
Nguyen, D.X.5
Stern, D.F.6
-
37
-
-
0034649157
-
Increase in cap- and IRES-dependent protein synthesis by overproduction of translation initiation factor eIF4G
-
Hayashi S, Nishimura K, Fukuchi-Shimogori T, Kashiwagi K, Igarashi K. Increase in cap- and IRES-dependent protein synthesis by overproduction of translation initiation factor eIF4G. Biochem Biophys Res Commun 2000; 277: 117-23.
-
(2000)
Biochem Biophys Res Commun
, vol.277
, pp. 117-123
-
-
Hayashi, S.1
Nishimura, K.2
Fukuchi-Shimogori, T.3
Kashiwagi, K.4
Igarashi, K.5
-
38
-
-
67650080623
-
Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer
-
Silvera D, Arju R, Darvishian F, Levine PH, Zolfaghari L, Goldberg J, et al. Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer. Nat Cell Biol 2009; 11: 903-8.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 903-908
-
-
Silvera, D.1
Arju, R.2
Darvishian, F.3
Levine, P.H.4
Zolfaghari, L.5
Goldberg, J.6
-
39
-
-
84871292666
-
The soy isoflavone equol may increase cancer malignancy via upregulation of eukaryotic protein synthesis initiation factor eIF4G
-
de la Parra C, Otero-Franqui E, Martinez-Montemayor M, Dharmawardhane S. The soy isoflavone equol may increase cancer malignancy via upregulation of eukaryotic protein synthesis initiation factor eIF4G. J Biol Chem 2012; 287: 41640-50.
-
(2012)
J Biol Chem
, vol.287
, pp. 41640-41650
-
-
De La Parra, C.1
Otero-Franqui, E.2
Martinez-Montemayor, M.3
Dharmawardhane, S.4
-
40
-
-
0035105502
-
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery
-
Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol Cell 2001; 7: 193-203.
-
(2001)
Mol Cell
, vol.7
, pp. 193-203
-
-
Marcotrigiano, J.1
Lomakin, I.B.2
Sonenberg, N.3
Pestova, T.V.4
Hellen, C.U.5
Burley, S.K.6
-
41
-
-
0033200316
-
Translation driven by an eIF4G core domain in vivo
-
De Gregorio E, Preiss T, Hentze MW. Translation driven by an eIF4G core domain in vivo. EMBO J 1999; 18: 4865-74.
-
(1999)
EMBO J
, vol.18
, pp. 4865-4874
-
-
De Gregorio, E.1
Preiss, T.2
Hentze, M.W.3
|