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Volumn 14, Issue 6, 2015, Pages 385-395

EphA2 as a Diagnostic Imaging Target in Glioblastoma: A Positron Emission Tomography/Magnetic Resonance Imaging Study

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COMPUTER AIDED DIAGNOSIS; IMAGE ENHANCEMENT; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; MONOCLONAL ANTIBODIES; PATIENT TREATMENT; POSITRONS; TUMORS;

EID: 84942863596     PISSN: 15353508     EISSN: 15360121     Source Type: Journal    
DOI: 10.2310/7290.2015.00008     Document Type: Article
Times cited : (26)

References (49)
  • 2
    • 84860723389 scopus 로고    scopus 로고
    • Diffusion MRI at 25: Exploring brain tissue structure and function
    • Le Bihan D, Johansen-Berg H. Diffusion MRI at 25: exploring brain tissue structure and function. Neuroimage 2012;61: 324-41, doi:10.1016/j.neuroimage.2011.11.006.
    • (2012) Neuroimage , vol.61 , pp. 324-341
    • Le Bihan., D.1    Johansen-Berg, H.2
  • 3
    • 49949099765 scopus 로고    scopus 로고
    • Applications of real-time fMRI
    • Decharms RC. Applications of real-time fMRI. Nat Rev Neurosci 2008;9:720-9, doi:10.1038/nrn2414.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 720-729
    • Decharms, R.C.1
  • 4
    • 0036794518 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI in clinical oncology: Current status and future directions
    • Padhani AR. Dynamic contrast-enhanced MRI in clinical oncology: current status and future directions. J Magn Reson Imaging 2002;16:407-22, doi:10.1002/jmri.10176.
    • (2002) J Magn Reson Imaging , vol.16 , pp. 407-422
    • Padhani, A.R.1
  • 5
    • 84860750674 scopus 로고    scopus 로고
    • PET radiotracers for molecular imaging in the brain: Past, present and future
    • Zimmer L, Luxen A. PET radiotracers for molecular imaging in the brain: past, present and future. Neuroimage 2012;61:363-70, doi:10.1016/j.neuroimage.2011.12.037.
    • (2012) Neuroimage , vol.61 , pp. 363-370
    • Zimmer, L.1    Luxen, A.2
  • 6
    • 3042741075 scopus 로고    scopus 로고
    • Neuroimaging in glioma therapy
    • Henson JW, Gonzalez RG. Neuroimaging in glioma therapy. Expert Rev Neurother 2004;4:665-71, doi:10.1586/14737175.4.4.665.
    • (2004) Expert Rev Neurother , vol.4 , pp. 665-671
    • Henson, J.W.1    Gonzalez, R.G.2
  • 7
    • 0030612046 scopus 로고    scopus 로고
    • 3-[I-123]Iodo-alphamethyltyrosine and [methyl-C-11]-L-methionine uptake in cerebral gliomas: A comparative study using SPECT and PET
    • Langen KJ, Ziemons K, Kiwit JCW, et al. 3-[I-123]Iodo-alphamethyltyrosine and [methyl-C-11]-L-methionine uptake in cerebral gliomas: A comparative study using SPECT and PET. J Nucl Med 1997;38:517-22.
    • (1997) J Nucl Med , vol.38 , pp. 517-522
    • Langen, K.J.1    Ziemons, K.2    Kiwit, J.C.W.3
  • 8
    • 0242323753 scopus 로고    scopus 로고
    • Brain tumour imaging with PET: A comparison between [F-18]fluorodopa and [C-11] methionine
    • Becherer A, Karanikas G, Szabo M, et al. Brain tumour imaging with PET: A comparison between [F-18]fluorodopa and [C-11] methionine. Eur J Nucl Med Mol Imaging 2003;30:1561-7, doi:10.1007/s00259-003-1259-1.
    • (2003) Eur J Nucl Med Mol Imaging , vol.30 , pp. 1561-1567
    • Becherer, A.1    Karanikas, G.2    Szabo, M.3
  • 9
    • 79851498484 scopus 로고    scopus 로고
    • Correlation of 6-F-18- fluoro-L-Dopa PET uptake with proliferation and tumor grade in newly diagnosed and recurrent gliomas
    • Fueger BJ, Czernin J, Cloughesy T, et al. Correlation of 6-F-18- fluoro-L-Dopa PET uptake with proliferation and tumor grade in newly diagnosed and recurrent gliomas. J Nucl Med 2010;51: 1532-8, doi:10.2967/jnumed.110.078592.
    • (2010) J Nucl Med , vol.51 , pp. 1532-1538
    • Fueger, B.J.1    Czernin, J.2    Cloughesy, T.3
  • 10
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-7, doi:10.1038/256495a0.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 11
    • 0036255688 scopus 로고    scopus 로고
    • Targeted therapy of cancer with radiolabeled antibodies
    • Goldenberg DM. Targeted therapy of cancer with radiolabeled antibodies. J Nucl Med 2002;43:693-713.
    • (2002) J Nucl Med , vol.43 , pp. 693-713
    • Goldenberg, D.M.1
  • 12
    • 0037615120 scopus 로고    scopus 로고
    • Advancing role of radiolabeled antibodies in the therapy of cancer
    • Goldenberg DM. Advancing role of radiolabeled antibodies in the therapy of cancer. Cancer Immunol Immun 2003;52:281-96.
    • (2003) Cancer Immunol Immun , vol.52 , pp. 281-296
    • Goldenberg, D.M.1
  • 13
    • 33846549106 scopus 로고    scopus 로고
    • Advances in cancer therapy with radiolabeled monoclonal antibodies
    • Goldenberg DM, Sharkey RM. Advances in cancer therapy with radiolabeled monoclonal antibodies. Q J Nucl Med Mol Imaging 2006;50:248-64.
    • (2006) Q J Nucl Med Mol Imaging , vol.50 , pp. 248-264
    • Goldenberg, D.M.1    Sharkey, R.M.2
  • 14
    • 84904872413 scopus 로고    scopus 로고
    • PET imaging using radiolabled antibodies: Future direction in tumor diagnosis and correlate applications
    • Salsano M, Treglia G. PET imaging using radiolabled antibodies: future direction in tumor diagnosis and correlate applications. Res Rep Nucl Med 2013;3:9-17.
    • (2013) Res Rep Nucl Med , vol.3 , pp. 9-17
    • Salsano, M.1    Treglia, G.2
  • 15
    • 84883821225 scopus 로고    scopus 로고
    • Antibody therapeutics in cancer
    • Sliwkowski MX, Mellman I. Antibody therapeutics in cancer. Science 2013;341:1192-8, doi:10.1126/science.1241145.
    • (2013) Science , vol.341 , pp. 1192-1198
    • Sliwkowski, M.X.1    Mellman, I.2
  • 16
    • 77649114060 scopus 로고    scopus 로고
    • Eph receptors and ephrins in cancer: Bidirectional signalling and beyond
    • Pasquale EB. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer 2010;10:165-80, doi:10.1038/nrc2806.
    • (2010) Nat Rev Cancer , vol.10 , pp. 165-180
    • Pasquale, E.B.1
  • 17
    • 0023607638 scopus 로고
    • A novel putative tyrosine kinase receptor encoded by the Eph gene
    • Hirai H, Maru Y, Hagiwara K, et al. A novel putative tyrosine kinase receptor encoded by the Eph gene. Science 1987;238: 1717-20, doi:10.1126/science.2825356.
    • (1987) Science , vol.238 , pp. 1717-1720
    • Hirai, H.1    Maru, Y.2    Hagiwara, K.3
  • 18
    • 41149084179 scopus 로고    scopus 로고
    • Eph-ephrin bidirectional signaling in physiology and disease
    • Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell 2008;133:38-52, doi:10.1016/j.cell.2008.03.011.
    • (2008) Cell , vol.133 , pp. 38-52
    • Pasquale, E.B.1
  • 19
    • 20344396123 scopus 로고    scopus 로고
    • EPH receptor signalling casts a wide net on cell behaviour
    • Pasquale EB. EPH receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 2005;6:462-75, doi:10.1038/nrm1662.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 462-475
    • Pasquale, E.B.1
  • 20
    • 33845332412 scopus 로고    scopus 로고
    • A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma
    • Liu FH, Park PJ, Lai W, et al. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res 2006;66: 10815-23, doi:10.1158/0008-5472.CAN-06-1408.
    • (2006) Cancer Res , vol.66 , pp. 10815-10823
    • Liu, F.H.1    Park, P.J.2    Lai, W.3
  • 21
    • 38749092525 scopus 로고    scopus 로고
    • Increased expression of EphA2 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients
    • Wang LF, Fokas E, Bieker M, et al. Increased expression of EphA2 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. Oncol Rep 2008;19: 151-6, doi:10.3892/or.19.1.151.
    • (2008) Oncol Rep , vol.19 , pp. 151-156
    • Wang, L.F.1    Fokas, E.2    Bieker, M.3
  • 22
    • 75149129568 scopus 로고    scopus 로고
    • Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy
    • Zhuang GL, Brantley-Sieders DM, Vaught D, et al. Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res 2010;70:299-308, doi:10.1158/0008-5472.CAN-09-1845.
    • (2010) Cancer Res , vol.70 , pp. 299-308
    • Zhuang, G.L.1    Brantley-Sieders, D.M.2    Vaught, D.3
  • 23
    • 27144524979 scopus 로고    scopus 로고
    • The clinical significance of EphA2 and Ephrin A-1 in epithelial ovarian carcinomas
    • Han LQ, Dong ZM, Qiao YH, et al. The clinical significance of EphA2 and Ephrin A-1 in epithelial ovarian carcinomas. Gynecol Oncol 2005;99:278-86, doi:10.1016/j.ygyno.2005.06.036.
    • (2005) Gynecol Oncol , vol.99 , pp. 278-286
    • Han, L.Q.1    Dong, Z.M.2    Qiao, Y.H.3
  • 24
    • 28844447276 scopus 로고    scopus 로고
    • EphA2 as a target for ovarian cancer therapy
    • Landen CN, Kinch MS, Sood AK. EphA2 as a target for ovarian cancer therapy. Expert Opin Ther Targets 2005;9:1179-87, doi:10.1517/14728222.9.6.1179.
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 1179-1187
    • Landen, C.N.1    Kinch, M.S.2    Sood, A.K.3
  • 25
    • 77955081786 scopus 로고    scopus 로고
    • EphA2 as a promoter of melanoma tumorigenicity
    • Margaryan NV, Strizzi L, Abbott DE, et al. EphA2 as a promoter of melanoma tumorigenicity. Cancer Biol Ther 2009;8:275-84, doi:10.4161/cbt.8.3.7485.
    • (2009) Cancer Biol Ther , vol.8 , pp. 275-284
    • Margaryan, N.V.1    Strizzi, L.2    Abbott, D.E.3
  • 26
    • 4143123295 scopus 로고    scopus 로고
    • EphA2 expression is associated with aggressive features in ovarian carcinoma
    • Thaker PH, Deavers M, Celestino J, et al. EphA2 expression is associated with aggressive features in ovarian carcinoma. Clin Cancer Res 2004;10:5145-50, doi:10.1158/1078-0432.CCR-03- 0589.
    • (2004) Clin Cancer Res , vol.10 , pp. 5145-5150
    • Thaker, P.H.1    Deavers, M.2    Celestino, J.3
  • 27
    • 48849108415 scopus 로고    scopus 로고
    • Eph, a protein family coming of age: More confusion, insight, or complexity?
    • Lackmann M, Boyd AW. Eph, a protein family coming of age: more confusion, insight, or complexity?. Science Signaling 2008; 1:1-16, doi:10.1126/stke.115re2.
    • (2008) Science Signaling , vol.1 , pp. 1-16
    • Lackmann, M.1    Boyd, A.W.2
  • 28
    • 33644667332 scopus 로고    scopus 로고
    • EphA2 as a gliomaassociated antigen: A novel target for glioma vaccines
    • Hatano M, Eguchi J, Tatsumi T, et al. EphA2 as a gliomaassociated antigen: A novel target for glioma vaccines. Neoplasia 2005;7:717-22, doi:10.1593/neo.05277.
    • (2005) Neoplasia , vol.7 , pp. 717-722
    • Hatano, M.1    Eguchi, J.2    Tatsumi, T.3
  • 29
  • 30
    • 27644466229 scopus 로고    scopus 로고
    • EphA2 as a novel molecular marker and target in glioblastoma multiforme
    • Wykosky J, Gibo DM, Stanton C, Debinski W. EphA2 as a novel molecular marker and target in glioblastoma multiforme. Mol Cancer Res 2005;3:541-51, doi:10.1158/1541-7786.MCR-05-0056.
    • (2005) Mol Cancer Res , vol.3 , pp. 541-551
    • Wykosky, J.1    Gibo, D.M.2    Stanton, C.3    Debinski, W.4
  • 31
    • 84876447249 scopus 로고    scopus 로고
    • Glioma surgical aspirate: A viable source of tumor tissue for experimental research
    • Day B, Stringer B, Wilson J, et al. Glioma surgical aspirate: A viable source of tumor tissue for experimental research. Cancers 2013;5: 357-71, doi:10.3390/cancers5020357.
    • (2013) Cancers , vol.5 , pp. 357-371
    • Day, B.1    Stringer, B.2    Wilson, J.3
  • 32
    • 84871053738 scopus 로고    scopus 로고
    • Eph receptors and ephrins as targets for cancer therapy
    • Xi HQ, Wu XS, Wei B, Chen L. Eph receptors and ephrins as targets for cancer therapy. J Cell Mol Med 2012;16:2894-909, doi:10.1111/j.1582-4934.2012.01612.x.
    • (2012) J Cell Mol Med , vol.16 , pp. 2894-2909
    • Xi, H.Q.1    Wu, X.S.2    Wei, B.3    Chen, L.4
  • 33
    • 84863291820 scopus 로고    scopus 로고
    • Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells
    • Wang S, Placzek WJ, Stebbins JL, et al. Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells. J Med Chem 2012;55:2427-36, doi:10.1021/jm201743s.
    • (2012) J Med Chem , vol.55 , pp. 2427-2436
    • Wang, S.1    Placzek, W.J.2    Stebbins, J.L.3
  • 34
    • 56449085913 scopus 로고    scopus 로고
    • A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo
    • Jackson D, Gooya J, Mao SL, et al. A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo. Cancer Res 2008;68:9367-74, doi:10.1158/0008-5472.CAN-08- 1933.
    • (2008) Cancer Res , vol.68 , pp. 9367-9374
    • Jackson, D.1    Gooya, J.2    Mao, S.L.3
  • 35
    • 23044497596 scopus 로고    scopus 로고
    • Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: Potential as EphA3-specific tumortargeting reagents
    • Vearing C, Lee FT, Wimmer-Kleikamp S, et al. Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumortargeting reagents. Cancer Res 2005;65:6745-54, doi:10.1158/0008-5472.CAN-05-0758.
    • (2005) Cancer Res , vol.65 , pp. 6745-6754
    • Vearing, C.1    Lee, F.T.2    Wimmer-Kleikamp, S.3
  • 36
    • 36148975921 scopus 로고    scopus 로고
    • Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice
    • Cai WB, Ebrahimnejad A, Chen K, et al. Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice. Eur J Nucl Med Mol Imaging 2007;34:2024-36, doi:10.1007/s00259-007-0503-5.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 2024-2036
    • Cai, W.B.1    Ebrahimnejad, A.2    Chen, K.3
  • 37
    • 79851481921 scopus 로고    scopus 로고
    • In vivo small-animal PET/CT of EphB4 receptors using Cu-64-labeled peptide
    • Xiong CY, Huang MA, Zhang R, et al. In vivo small-animal PET/CT of EphB4 receptors using Cu-64-labeled peptide. J Nucl Med 2011;52:241-8, doi:10.2967/jnumed.110.081943.
    • (2011) J Nucl Med , vol.52 , pp. 241-248
    • Xiong, C.Y.1    Huang, M.A.2    Zhang, R.3
  • 38
    • 79957918283 scopus 로고    scopus 로고
    • Peptide-conjugated polymeric micellar nanoparticles for dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts
    • Zhang R, Xiong CY, Huang M, et al. Peptide-conjugated polymeric micellar nanoparticles for dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts. Biomaterials 2011; 32:5872-9, doi:10.1016/j.biomaterials.2011.04.070.
    • (2011) Biomaterials , vol.32 , pp. 5872-5879
    • Zhang, R.1    Xiong, C.Y.2    Huang, M.3
  • 39
    • 84868139584 scopus 로고
    • Fluorine-18 radiolabeling and radiopharmacological characterization of abenzodioxolylpyrimidine-based radiotracer targeting the receptor tyrosine kinase EphB4
    • Mamat C, Mosch B, Neuber C, et al. Fluorine-18 radiolabeling and radiopharmacological characterization of abenzodioxolylpyrimidine-based radiotracer targeting the receptor tyrosine kinase EphB4. Chemmedchem 2012;7:1991-2003, doi:10.1002/cmdc.201200264.
    • (1991) Chemmedchem 2012 , vol.7
    • Mamat, C.1    Mosch, B.2    Neuber, C.3
  • 40
    • 76749101197 scopus 로고    scopus 로고
    • U87MG decoded: The genomic sequence of a cytogenetically aberrant human cancer cell line
    • Clark MJ, Homer N, O'Connor BD, et al. U87MG decoded: The genomic sequence of a cytogenetically aberrant human cancer cell line. Plos Genet 2010;6:1-16, doi:10.1371/journal.pgen. 1000832.
    • (2010) Plos Genet , vol.6 , pp. 1-16
    • Clark, M.J.1    Homer, N.2    O'Connor, B.D.3
  • 41
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RGW, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110, doi:10.1016/j.ccr.2009.12.020.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.W.1    Hoadley, K.A.2    Purdom, E.3
  • 42
    • 66049085403 scopus 로고    scopus 로고
    • Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens
    • Pollard SM, Yoshikawa K, Clarke ID, et al. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 2009; 4:568-80, doi:10.1016/j.stem.2009.03.014.
    • (2009) Cell Stem Cell , vol.4 , pp. 568-580
    • Pollard, S.M.1    Yoshikawa, K.2    Clarke, I.D.3
  • 43
    • 0021512252 scopus 로고
    • Conjugation of antibodies with bifunctional chelating-agents - isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal-ions
    • Meares CF, McCall MJ, Reardan DT, et al. Conjugation of antibodies with bifunctional chelating-agents - isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal-ions. Anal Biochem 1984;142: 68-78, doi:10.1016/0003-2697(84)90517-7.
    • (1984) Anal Biochem , vol.142 , pp. 68-78
    • Meares, C.F.1    McCall, M.J.2    Reardan, D.T.3
  • 44
    • 41849093686 scopus 로고    scopus 로고
    • Simultaneous PETMRI: A new approach for functional and morphological imaging
    • Judenhofer MS, Wehrl HF, Newport DF, et al. Simultaneous PETMRI: A new approach for functional and morphological imaging. Nat Med 2008;14:459-65, doi:10.1038/nm1700.
    • (2008) Nat Med , vol.14 , pp. 459-465
    • Judenhofer, M.S.1    Wehrl, H.F.2    Newport, D.F.3
  • 45
    • 80051733729 scopus 로고    scopus 로고
    • Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates
    • Ait-Mohand S, Fournier P, Dumulon-Perreault VR, et al. Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates. Bioconj Chem 2011;22:1729-35, doi:10.1021/bc2002665.
    • (2011) Bioconj Chem , vol.22 , pp. 1729-1735
    • Ait-Mohand, S.1    Fournier, P.2    Dumulon-Perreault, V.R.3
  • 46
    • 84861166770 scopus 로고    scopus 로고
    • Comparison of Cu-64- complexing bifunctional chelators for radioimmunoconjugation: Labeling efficiency, specific activity, and in vitro/in vivo stability
    • Cooper MS, Ma MT, Sunassee K, et al. Comparison of Cu-64- complexing bifunctional chelators for radioimmunoconjugation: labeling efficiency, specific activity, and in vitro/in vivo stability. Bioconj Chem 2012;23:1029-39, doi:10.1021/bc300037w.
    • (2012) Bioconj Chem , vol.23 , pp. 1029-1039
    • Cooper, M.S.1    Ma, M.T.2    Sunassee, K.3
  • 47
    • 83055173264 scopus 로고    scopus 로고
    • Positron emission tomography imaging of CD105 expression with a Cu-64-labeled monoclonal antibody: NOTA is superior to DOTA
    • Zhang Y, Hong H, Engle JW, et al. Positron emission tomography imaging of CD105 expression with a Cu-64-labeled monoclonal antibody: NOTA is superior to DOTA. Plos One 2011;6:1-7.
    • (2011) Plos One , vol.6 , pp. 1-7
    • Zhang, Y.1    Hong, H.2    Engle, J.W.3
  • 48
    • 84866170999 scopus 로고    scopus 로고
    • Differential effects of predosing on tumor and tissue uptake of an In-111-labeled anti- TENB2 antibody-drug conjugate
    • Boswell CA, Mundo EE, Zhang C, et al. Differential effects of predosing on tumor and tissue uptake of an In-111-labeled anti- TENB2 antibody-drug conjugate. J Nucl Med 2012;53:1454-61, doi:10.2967/jnumed.112.103168.
    • (2012) J Nucl Med , vol.53 , pp. 1454-1461
    • Boswell, C.A.1    Mundo, E.E.2    Zhang, C.3
  • 49
    • 84859708396 scopus 로고    scopus 로고
    • Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice
    • Bumbaca D, Xiang H, Boswell CA, et al. Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice. Br J Pharmacol 2012;166:368-77, doi:10.1111/j.1476-5381.2011.01777.x.
    • (2012) Br J Pharmacol , vol.166 , pp. 368-377
    • Bumbaca, D.1    Xiang, H.2    Boswell, C.A.3


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