An Accurate in Vitro Model of the E. coli Envelope

Angewandte Chemie - International Edition

Volumn 54, Issue 41, 2015, Pages 11952-11955

  Clifton, Luke A ^b   Holt, Stephen A ^c   Hughes, Arwel V ^b   Daulton, Emma L ^b   Arunmanee, Wanatchaporn ^a   Heinrich, Frank ^d,e   Khalid, Syma ^f   Jefferies, Damien ^f   Charlton, Timothy R ^b   Webster, John R P ^b   Kinane, Christian J ^b   Lakey, Jeremy H ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b RUTHERFORD APPLETON LABORATORY   (United Kingdom)

^c AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^d CARNEGIE MELLON UNIVERSITY   (United States)

^e NATIONAL INSTITUTE OF STANDARDS   (United States)

^f UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

antibiotics; drug discovery; Gram negative bacteria; membranes; structure activity relationships

Indexed keywords

ANTIBIOTICS; CHEMOTHERAPY; ESCHERICHIA COLI; MEMBRANES;

ANTIBACTERIAL PROTEINS; ASYMMETRIC BILAYERS; ASYMMETRIC MODELS; DRUG DISCOVERY; GRAM-NEGATIVE BACTERIA; ISOTOPIC LABELING; NEUTRON REFLECTIVITY; STRUCTURE ACTIVITY RELATIONSHIPS;

BACTERIA;

ANTIINFECTIVE AGENT; ARTIFICIAL MEMBRANE; ESCHERICHIA COLI PROTEIN; LIPID BILAYER; OUTER MEMBRANE PROTEIN; PHOSPHOLIPID;

ANTIBIOTIC RESISTANCE; ARTIFICIAL MEMBRANE; CHEMISTRY; CYTOLOGY; DRUG DEVELOPMENT; DRUG EFFECTS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMAN; LIPID BILAYER; MICROBIOLOGY; MOLECULAR MODEL;

ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; DRUG DISCOVERY; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; HUMANS; LIPID BILAYERS; MEMBRANES, ARTIFICIAL; MODELS, MOLECULAR; PHOSPHOLIPIDS;

EID: 84942826141     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201504287     Document Type: Article

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