Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus

Cell Reports

Volumn 12, Issue 11, 2015, Pages 1842-1852

  Mijušković, Martina ^a,b,c   Chou, Yi Fan ^a,b   Gigi, Vered ^a,b,d   Lindsay, Cory R ^a,b,e   Shestova, Olga ^a,b   Lewis, Susanna M ^a,b   Roth, David B ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d BOSTON CONSULTING GROUP   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE H3; JANUS KINASE 1; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAG2 PROTEIN; DNA BINDING PROTEIN; RAG2 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

AGPAT9 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CHROMATIN; CONTROLLED STUDY; GENE; GENE DELETION; GENE LOCUS; GENE REARRANGEMENT; IKZF1 GENE; JAK1 GENE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NOTCH1 GENE; PHLDA1 GENE; PRIORITY JOURNAL; PTEN GENE; STRUCTURE ACTIVITY RELATION; THYMUS LYMPHOMA; TRAT1 GENE; VDJ RECOMBINATION; WILD TYPE; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENETICS; LYMPHOMA; METABOLISM; THYMOMA;

ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; LYMPHOMA; MICE; MICE, INBRED C57BL; THYMUS NEOPLASMS; TUMOR SUPPRESSOR PROTEINS; V(D)J RECOMBINATION;

EID: 84942816504     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.08.034     Document Type: Article

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