Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression

Laboratory Investigation

Volumn 95, Issue 10, 2015, Pages 1130-1144

  Miyao, Masashi ^a   Kotani, Hirokazu ^a   Ishida, Tokiko ^a   Kawai, Chihiro ^a   Manabe, Sho ^a   Abiru, Hitoshi ^a   Tamaki, Keiji ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; BILIRUBIN; CD31 ANTIGEN; CD34 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; FATTY ACID; GLUCOSE; INTERLEUKIN 1BETA; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM CELL; FIBROGENESIS; HEPATOMEGALY; HYPERLIPIDEMIA; INSULIN RESISTANCE; KUPFFER CELL; LIVER CELL; LIVER FIBROSIS; LIVER SINUSOIDAL ENDOTHELIAL CELL; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; STELLATE CELL; TRIACYLGLYCEROL BLOOD LEVEL; ADVERSE EFFECTS; ANIMAL; BLOOD; C57BL MOUSE; COMPARATIVE STUDY; DISEASE MODEL; GERMFREE ANIMAL; HYPERLIPIDEMIAS; IMMUNOCHEMISTRY; IMMUNOLOGY; LIPID DIET; LIVER; LIVER CIRRHOSIS; MACROPHAGE ACTIVATION; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, ABDOMINAL; PATHOLOGY; VASCULAR ENDOTHELIUM; VASCULARIZATION; VITAMIN DEFICIENCY;

ANIMALS; BIOMARKERS; CHOLINE DEFICIENCY; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; HEPATIC STELLATE CELLS; HYPERLIPIDEMIAS; IMMUNOCHEMISTRY; INSULIN RESISTANCE; KUPFFER CELLS; LIVER; LIVER CIRRHOSIS; MACROPHAGE ACTIVATION; MALE; MICE, INBRED C57BL; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, ABDOMINAL; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 84942814048     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2015.95     Document Type: Article

References (30)

1. Chalasani N, Younossi Z, Lavine JE et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012;142:1592-1609.
2. Gaidos JK, Hillner BE, Sanyal AJ. A decision analysis study of the value of a liver biopsy in nonalcoholic steatohepatitis. Liver Int 2008;28:650-658.
3. Wisse E, De Zanger RB, Charels K et al. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 1985;5:683-692.
4. Braet F, Wisse E. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. Comp Hepatol 2002;1:1.
5. Schaffner F, Poper H. Capillarization of hepatic sinusoids in man. Gastroenterology 1963;44:239-242.
6. Xie G, Choi SS, Syn WK et al. Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. Gut 2013;62:299-309.
7. Lee YA, Wallace MC, Friedman SL. Pathobiology of liver fibrosis: a translational success story. Gut 2015;64:830-841.
8. Miyao M, Ozeki M, Abiru H et al. Bile canalicular abnormalities in the early phase of a mouse model of sclerosing cholangitis. Dig Liver Dis 2013;45:216-225.
9. Xie G, Wang X, Wang L et al. Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology 2012;142:918-927.
10. Brock RW, Dorman RB. Obesity, insulin resistance and hepatic perfusion. Microcirculation 2007;14:339-347.
11. Miller AM, Wang H, Park O et al. Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury. Alcohol Clin Exp Res 2010;34:719-725.
12. Leclercq IA, Da Silva Morais A, Schroyen B et al. Insulin resistence in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol 2007;47:142-156.
13. Takahashi Y, Soejima Y, Fukusato T. Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol 2012;18:2300-2308.
14. Denda A, Kitayama W, Kishida H et al. Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet. Jpn J Cancer Res 2002;93:125-132.
15. Caballero F, Fernández A, Matías N et al. Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem 2010;285:18528-18536.
16. NIH. Guide for the Care and Use of Laboratory Animals. National Academy Press: National Academy of Science, 1996, ISBN: 0-309-05377-3.
17. Kleiner DE, Brunt EM, Van Natta M et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321.
18. Stankovi MN, Mladenovi DR, Durii I et al. Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease. Arch Med Res 2014;45:116-124.
19. Clapper JR, Hendricks MD, Gu G et al. Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment. Am J Physiol Gastrointest Liver Physiol 2013;305:G483-G495.
20. Ioannou GN, Haigh WG, Thorning D et al. Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis. J Lipid Res 2013;54:1326-1334.
21. Le Couteur DG, Cogger VC, Markus AM et al. Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology 2001;33: 537-543.
22. Deleve LD, Wang X, Guo Y. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology 2008;48:920-930.
23. DeLeve LD. Liver sinusoidal endothelial cells and liver regeneration. J Clin Invest 2013;123:1861-1866.
24. Furrer K, Rickenbacher A, Tian Y et al. Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGFdependent pathway. Proc Natl Acad Sci USA 2011;108:2945-2950.
25. Tosello-Trampont AC, Landes SG, Nguyen V et al. Kupffer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-alpha production. J Biol Chem 2012;287:40161-40172.
26. Pasarín M, La Mura V, Gracia-Sancho J et al. Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD. PLoS One 2012;7:e32785.
27. DeLeve LD, Wang X, Hu L et al. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol 2004;287:G757-G763.
28. Dill MT, Rothweiler S, Djonov V et al. Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice. Gastroenterology 2012;142:967-977.
29. Le Couteur DG, Fraser R, Cogger VC et al. Hepatic pseudocapillarisation and atherosclerosis in ageing. Lancet 2002;359:1612-1615.
30. Fraser R, Dobbs BR, Rogers GW. Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis. Hepatology 1995;21:863-874.