Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture

Neuroscience

Volumn 310, Issue , 2015, Pages 73-90

  Li, W W ^a,b   Guo, T Z ^a   Shi, X ^a,b   Sun, Y ^a,b   Wei, T ^a   Clark, D J ^a,b   Kingery, W S ^a  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Astrocytes; Complex regional pain syndrome; Fracture; Microglia; Substance P

Indexed keywords

2 AMINOADIPIC ACID; LANEPITANT; MINOCYCLINE; SUBSTANCE P; AMINO ACID RECEPTOR BLOCKING AGENT; ANTIINFLAMMATORY AGENT;

ADULT; ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL ACTIVATION; COMPLEX REGIONAL PAIN SYNDROME; CONTROLLED STUDY; EDEMA; ELECTROSTIMULATION; GLIA CELL; HIND PAW; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MOUSE; NERVE STIMULATION; NOCICEPTION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SENSITIZATION; SPINAL CORD DORSAL HORN; TIBIA FRACTURE; ANIMAL; COMPLEX REGIONAL PAIN SYNDROMES; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GLIA; HYPERALGESIA; METABOLISM; PAIN MEASUREMENT; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPINAL CORD; SPRAGUE DAWLEY RAT; TIME FACTOR;

2-AMINOADIPIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS; COMPLEX REGIONAL PAIN SYNDROMES; DISEASE MODELS, ANIMAL; EDEMA; EXCITATORY AMINO ACID ANTAGONISTS; HYPERALGESIA; MALE; MINOCYCLINE; NEUROGLIA; NOCICEPTION; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPINAL CORD; SUBSTANCE P; TIBIAL FRACTURES; TIME FACTORS;

EID: 84942749065     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.09.036     Document Type: Article

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