Increased peripheral blood pro-inflammatory/cytotoxic lymphocytes in children with bronchiectasis

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Hodge, G ^a   Upham, J W ^b   Chang, A B ^c,d   Baines, K J ^e,f   Yerkovich, S T ^b   Pizzutto, S J ^c   Hodge, S ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^e HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^f UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GAMMA INTERFERON; GRANZYME B; PERFORIN; TUMOR NECROSIS FACTOR ALPHA; GRANZYME; TUMOR NECROSIS FACTOR;

ARTICLE; BACTERIUM DETECTION; BRONCHIECTASIS; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC LYMPHOCYTE; ENZYME BLOOD LEVEL; ENZYME SYNTHESIS; ETHNIC DIFFERENCE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; INDIGENOUS AUSTRALIAN; INFLAMMATORY CELL; LUNG LAVAGE; LYMPHOCYTE COUNT; MALE; MORAXELLA CATARRHALIS; NATURAL KILLER CELL; NATURAL KILLER T CELL; PRESCHOOL CHILD; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; AUSTRALIA; BLOOD; BRONCHOALVEOLAR LAVAGE FLUID; CASE CONTROL STUDY; CYTOLOGY; CYTOTOXIC T LYMPHOCYTE; INFANT; INFLAMMATION; METABOLISM; POPULATION GROUP; T LYMPHOCYTE;

AUSTRALIA; BRONCHIECTASIS; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; GRANZYMES; HUMANS; INFANT; INFLAMMATION; INTERFERON-GAMMA; KILLER CELLS, NATURAL; MALE; PERFORIN; POPULATION GROUPS; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84942693659     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133695     Document Type: Article

References (26)

1. Singleton RJ, Valery PC, Morris P, Byrnes CA, Grimwood K, Redding G et al (2014) Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis. Paediatr Pulmonol 49:189-200
2. Steinfort DP, Brady S, Weisinger HS, Einsiedel L. (2008) Bronchiectasis in Central Australia: a young face to an old disease. Respir Med 102(4):574-578
3. Chalmers JD, Smith MP, McHugh BJ, Doherty C, Govan JR, Hill AT (2012) Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis. Am J RespirCritCarMed 186:657-65.
4. Balkwill F, Mantovani A. (2001) Inflammation and cancer: back to Virchow? Lancet 357:539-45 PMID: 11229684
5. Coussens LM, Werb Z. (2002) Inflammation and cancer. Nature 420:860-7. PMID: 12490959
6. Kuper H., Adami H. O., and Trichopoulos D. (2000). Infections as a major preventable cause of human cancer. J. Intern. Med. 248, 171-183. PMID: 10971784
7. Liao KP, Solomon DH. (2014) Mechanistic insights into the link between inflammation and cardiovascular disease: rheumatoid arthritis as a human model of inflammation. CircCardiovasc Imaging. 7(4):575-7. doi: 10.1161/CIRCIMAGING.114.002235 PMID: 25027451
8. Wilson CB, Jones PW, O'Leary CJ, Hansell DM, Dowling RB, Cole P et al (1998) Systemic markers of inflammation in stable bronchiectasis. EurRespirJ 12:820-24. PMID: 9817152
9. Kiechl S, Egger G, Mayr M, Wiedermann CJ, Bonora E, Oberhollenzer F et al (2001) Chronic infections and the risk of carotid atheroscerosis. Prosperctive results from a large population study. Circulation 103:1064-70. PMID: 11222467
10. Australian Institute of Health and Welfare (2011) A snapshot of osteoporosis in Australia 2011. Arthritis series no. 15Cat. No. PHE 137. Canberra: AIHW.
11. Hodge G, Nairn J, Holmes M, Reynolds P, Hodge S (2007) Increased intracellular Th1 pro-inflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelieal T cells of COPD subjects. Clin and Exp Immunol 150:22-29.
12. Hodge S, Hodge G, Nairn J, Holmes M, Reynolds PN (2006) Increased airway granzyme b and perforin in current and ex-smoking COPD subjects. COPD 3:179-87. PMID: 17361498
13. Hodge G, Mukaro V, Holmes M, Reynolds P, Hodge S (2013) Enhanced cytotoxic function of natural killer and natural killer T-like cells with associated decreased CD94 (Kp43) in the chronic obstructive pulmonary disease airway. Respirology 18:369-76. doi: 10.1111/j.1440-1843.2012.02287.x PMID: 23062183
14. Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN et al AMAZES Study Research Group (2014). Altered sputum granzyme B and granzyme B/PI9 in patients with non-eosinophilic asthma. Respirology 19(2):280-7. doi: 10.1111/resp. 12213 PMID: 24372772
15. Hodge G, Hodge S, Liew C, Chambers DC, Hopkins P, Reynolds PN, et al (2010). Time post-lung transplant correlates with increasing peripheral blood T-cell granzyme B and pro-inflammatory cytokines. Clin Exp Immunol 161(3):584-90 doi: 10.1111/j.1365-2249.2010.04186.x PMID: 20528884
16. Martinez-Garcia MA, Perpina-Tordera M, Roman-Sanchez P, Soler-Cataluna JJ, Carratala A, Yago M et al (2008) Association between bronchiectasis, systemic inflammation, and tumour necrosis factor a. Arch Bronconeumol 44:8-14. PMID: 18221721
17. Chang AB, Gaffney JT, Eastburn MM, Faoagali J, Cox NC, Masters IB (2005) Cough quality in children: a comparison of subjective vs. bronchoscopic findings. RespirRes 6:3. PMID: 15638942
18. Chang AB, Masel JP, Boyce NC, Wheaton G, Torzillo PJ (2003) Non-CF bronchiectasis: clinical and HRCT evaluation. Paediat Pulmonol 35:477-83.
19. Pizzutto SJ, Yerkovich ST, Upham JW, Hales BJ, Thomas WR, Chang AB et al (2014). Children with Chronic Suppurative Lung Disease Have a Reduced Capacity to Synthesize Interferon-Gamma In Vitro in Response to Non-Typeable Haemophilus influenzae. PLoSONE 9(8):e104236.
20. Silva JR, Jones JA, Cole PJ, Poulter LW (1989) The immunological component of the cellular inflammatory infiltrate in bronchiectasis. Thorax 44:668-73. PMID: 2678579
21. Barnes PJ, Celli BR. Systemic manifestations and comorbidities in COPD (2009) EurRespir J 33:1165-85. doi: 10.1183/09031936.00128008 PMID: 19407051
22. Ergan Arsava B, Coplu L (2011) Does airway colonization cause systemic inflammation in bronchiectasis. TuberkToraks 59:340-7. PMID: 22233303
23. Kyaw T, Winship A, Tay C, Kanellakis P, Hosseini H, Cao A et al (2013) Cytotoxic and proinflammatory CD8+ T lymphocytes promote development of vulnerable atherosclerotic plaques in Apo-deficient mice. Circulation 127:1028-39. doi: 10.1161/CIRCULATIONAHA.112.001347 PMID: 23395974
24. Zhao W, Lui Y, Cahill CM, Yang W, Rogers JT, Huang X (2009) The role of T cells in osteoporosis, an update. Int J Clin Exp Pathol 2:544-52. PMID: 19636401
25. Selathura A, Deswerte V, Kanellakis P, Tipping P, Toh BH, Bobik A et al (2014) Natural killer (NK) cells augment atherosclerosis by cytotoxic-dependent mechanisms. Cardiovasc Res 102:128-37 doi: 10. 1093/cvr/cvu016 PMID: 24469537
26. Sevenoaks MJ, Stockley RA (2006) Chronic obstructive pulmonary disease, inflammation and co-morbidity - a common inflammatory phenotype. RespirRes 7:70-8. PMID: 16669999