The link between the appendix and ulcerative colitis: Clinical relevance and potential immunological mechanisms

American Journal of Gastroenterology

Volumn 111, Issue 2, 2016, Pages 163-169

  Sahami, S ^a   Kooij, I A ^a   Meijer, S L ^a   Van Den Brink, G R ^a   Buskens, C J ^a   Te Velde, A A ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A;

APPENDECTOMY; APPENDIX; ARTICLE; B LYMPHOCYTE; CLINICAL TRIAL (TOPIC); CROHN DISEASE; DYSBIOSIS; HUMAN; IMMUNOREGULATION; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW (TOPIC); ULCERATIVE COLITIS; COLITIS, ULCERATIVE; DISEASE COURSE; IMMUNOLOGY; INTESTINE FLORA; MICROBIOLOGY; PROTECTION; SEVERITY OF ILLNESS INDEX;

APPENDECTOMY; APPENDIX; B-LYMPHOCYTES; COLITIS, ULCERATIVE; CROHN DISEASE; DISEASE PROGRESSION; DYSBIOSIS; GASTROINTESTINAL MICROBIOME; HUMANS; IMMUNOGLOBULIN A; NATURAL KILLER T-CELLS; PROTECTIVE FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84942673331     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2015.301     Document Type: Article

References (47)

1. Gebbers J-O, Laissue J-A. Bacterial translocation in the normal human appendix parallels the development of the local immune system. Ann NY Acad Sci 2004; 1029: 337-43
2. Bollinger RR, Barbas AS, Bush EL, et al. Biofi lms in the large bowel suggest an apparent function of the human vermiform appendix. J Theor Biol 2007; 249: 826-31
3. Im G, Modayil R, Lin C, et al. The appendix may protect against clostridium diffi cile recurrence. Clin Gastroenterol Hepatol 2011; 9: 1072-7
4. Sanders NL, Bollinger RR, Lee R, et al. Appendectomy and clostridium diffi -cile colitis: relationships revealed by clinical observations and immunology. World J Gastroenterol 2013; 19: 5607-14
5. Radford-Smith G, Edwards J, Purdie D. Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn?s disease. Gut 2002; 51: 808-13
6. Fisher RE. The primate appendix: a reassessment. Anat Rec 2000; 261 : 228-36
7. Smith HF, Fisher RE, Everett ML, et al. Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix. J Evol Biol 2009; 22: 1984-99
8. Laurin M, Everett ML, Parker W. The cecal appendix: one more immune component with a function disturbed by post-industrial culture. Anat Rec (Hoboken) 2011; 294: 567-79
9. Gilat T, Hacohen D, Lilos P, et al. Childhood factors in ulcerative colitis and Crohn?s disease: an international cooperative study. Scand J Gastroenterol 1987; 22: 1009-24
10. Gent AE, Hellier MD, Grace RH, et al. Infl ammatory bowel disease and domestic hygiene in infancy. Lancet 1994; 343: 766-7
11. Wurzelmann JI, Lyles CM, Sandler RS. Childhood infections and the risk of infl ammatory bowel disease. Dig Dis Sci 1994; 39: 555-60
12. Smithson CM, Radford-Smith G, Jewell GP, et al. Appendectomy and Tonsillectomy in patients with infl ammatory bowel disease. J Clin Gastroenterol 1995; 21: 283-6
13. Feeney MA, Murphy F, Clegg AJ, et al. A case-control study of childhood environmental risk factors for the development of infl ammatory bowel disease. Eur J Gastroenterol Hepatol 2002; 14: 529-34
14. Baron S, Turck D, Leplat C, et al. Environmental risk factors in paediatric infl ammatory bowel diseases: a population based case control study. Gut 2005; 54: 357-63
15. De Saussure P, Clerson P, Prost P-L, et al. Appendectomy, smoking habits and the risk of developing ulcerative colitis: a case control study in private practice setting. Gastroenterol Clin Biol 2007; 31: 493-7
16. Hansen TS, Jess T, Vind I, et al. Environmental factors in infl ammatory bowel disease: a case-control study based on a Danish inception cohort. J Crohns Colitis 2011; 5: 577-84
17. Frisch M, Pedersen BV, Andersson RE, et al. Appendicitis, mesenteric lymphadenitis, and subsequent risk of ulcerative colitis: cohort studies in Sweden and Denmark. BMJ 2009; 338: b716
18. Singhal R, Taylor J, Owoniyi M, et al. The role of appendicectomy in the subsequent development of infl ammatory bowel disease: A UK-based study. Int J Colorectal Dis 2010; 25: 509-13
19. Kurina LM, Goldacre MJ, Yeates D, et al. Appendicectomy, tonsillectomy, and infl ammatory bowel disease: a case-control record linkage study. J Epidemiol Community Health 2002; 56: 551-4
20. Hallas J, Gaist D, Vach W, et al. Appendicectomy has no benefi cial Effect on admission rates in patients with ulcerative colitis. Gut 2004; 53: 351-4
21. Cheluvappa R, Luo AS, Grimm MC, et al. T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis. Clin Exp Immunol 2014; 17: 316-22
22. Cheluvappa R, Luo a S, Palmer C, et al. Protective pathways against colitis mediated by appendicitis and appendectomy. Clin Exp Immunol 2011; 165: 393-400
23. Andersson RE, Olaison G, Tysk C, et al. Appendectomy is followed by increased risk of Crohn?s disease. Gastroenterology 2003; 124: 40-6
24. D?Haens G, Geboes K, Peeters M. Patchy cecal infl ammation associated with distal ulcerative colitis: a prospective endoscopic study. Am J Gastroenterol 1997; 92: 1275-9
25. Rubin DT, Rothe JA. The peri-appendiceal red patch in ulcerative colitis: review of the University of Chicago experience. Dig Dis Sci 2010; 55: 3495-501
26. Naves J, Lorenzo-Zuniga V, Marin L. Long-term outcome of patients with distal ulcerative colitis and infl ammation of the appendiceal orifice. J Gastrointestin Liver Dis 2011; 20: 355-8
27. Park SH, Loft us EV, Yang S-K. Appendiceal skip infl ammation and ulcerative colitis. Dig Dis Sci 2014; 59: 2050-7
28. Jo Y, Matsumoto T, Yada S, et al. Histological and immunological features of appendix in patients with ulcerative colitis. Dig Dis Sci 2003; 48: 99-108
29. Scott IS, Sheaff M, Coumbe A, et al. Appendiceal infl ammation in ulcerative colitis. Histopathology 1998; 33: 168-73
30. Gardenbroek TJ, Eshuis EJ, Ponsioen CIJ, et al. The Effect of appendectomy on the course of ulcerative colitis: a systematic review. Colorectal Dis 2012; 14: 545-53
31. Cosnes J, Carbonnel F, Beaugerie L, et al. Effects of appendicectomy on the course of ulcerative colitis. Gut 2002; 51: 803-7
32. Selby WS, Griffin S, Abraham N, et al. Appendectomy protects against the development of ulcerative colitis but does not aff ect its course. Am J Gastroenterol 2002; 97: 2834-8
33. Lee H-S, Park SH, Yang S-K, et al. Appendectomy and the clinical course of ulcerative colitis: A retrospective cohort study and a nested case-control study from Korea. J Gastroenterol Hepatol 2015; 30: 470-7
34. Bolin TD, Wong S, Crouch R, et al. Appendicectomy as a therapy for ulcerative proctitis. Am J Gastroenterol 2009; 104: 2476-82
35. Mizoguchi A, Mizoguchi E, Chiba C, et al. Role of appendix in the development of infl ammatory bowel disease in TCR-alpha mutant mice. J Exp Med 1996; 184: 707-15
36. Krieglstein CF, Cerwinka WH, Laroux FS, et al. Role of appendix and spleen in experimental colitis. J Surg Res 2001; 101: 166-75
37. Farkas S, Hornung M, Sattler C, et al. Preferential migration of CD62L+ cells into the appendix in mice wiThexperimental chronic colitis. Eur Surg Res 2005; 37: 115-22
38. Dharmani P, Srivastava V, Kissoon-Singh V, et al. Role of intestinal mucins in innate host defense mechanisms against pathogens. J Innate Immun 2009; 1: 123-35
39. Nagalingam NA, Lynch SV. Role of the microbiota in infl ammatory bowel diseases. Infl amm Bowel Dis 2012; 18: 968-84
40. Ohkusa T, Sato N, Ogihara T, et al. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specifi c antibody. J Gastroenterol Hepatol 2002; 17: 849-53
41. Masahata K, Umemoto E, Kayama H, et al. Generation of colonic IgAsecreting cells in the caecal patch. Nat Commun 2014; 5: 3704
42. Palm NW, De Zoete MR, Cullen TW, et al. Immunoglobulin a coating identifi es colitogenic bacteria in infl ammatory bowel disease. Cell 2014; 158: 1000-10
43. Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key Effector Th 2 cytokine in ulcerative colitis that aff ects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005; 129: 550-64
44. Olszak T, An D, Zeissig S, et al. Microbial exposure during early life has persistent Effects on natural killer T cell function. Science 2012; 336 : 489-93
45. Ishimoto Y, Tomiyama-Miyaji C, Watanabe H, et al. Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4+ CD8+ cells and B220+ T cells, in mice. Immunology 2004; 113: 371-7
46. Reinisch W, Panes J, Khurana S, et al. Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: Efficacy and safety from a phase IIa randomised multicentre study. Gut 2015; 64: 894-900
47. Gardenbroek TJ, Pinkney TD, Sahami S, et al. The ACCURE-trial: the Effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicenter trial (NTR2883) and the ACCURE-UK trial: a randomised external pilot trial (ISRCTN56523019). BMC Surg 2015; 15: 30