Appendiceal Skip Inflammation and Ulcerative Colitis

Digestive Diseases and Sciences

Volumn 59, Issue 9, 2014, Pages 2050-2057

  Park, Sang Hyoung ^a   Loftus, Edward V ^b   Yang, Suk Kyun ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b MAYO CLINIC   (United States)

Author keywords

Appendiceal orifice inflammation; Peri appendiceal red patch; Skip lesion; Ulcerative colitis

Indexed keywords

APPENDECTOMY; APPENDICEAL ORIFICE INFLAMMATION; APPENDIX DISEASE; APPENDIX TUMOR; ASCENDING COLON; COLON RESECTION; COLONOSCOPY; CYSTADENOMA; DESCENDING COLON; DISEASE COURSE; GASTROINTESTINAL ENDOSCOPY; HISTOPATHOLOGY; HUMAN; INFLAMMATION; PANCOLITIS; PATHOPHYSIOLOGY; PERIAPPENDICEAL RED PATCH; PRIORITY JOURNAL; RECTUM; RELAPSE; REMISSION; REVIEW; SIGMOID; THERAPY EFFECT; TRANSVERSE COLON; ULCERATIVE COLITIS;

APPENDICEAL NEOPLASMS; APPENDICITIS; CD4-CD8 RATIO; COLITIS, ULCERATIVE; COLON; COLONOSCOPY; HUMANS; INTESTINAL MUCOSA; RISK FACTORS;

EID: 84907881645     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-014-3129-z     Document Type: Review

References (48)

1. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy and protection against ulcerative colitis. N Engl J Med. 2001;344:808–814.
2. Nam SW, Yang SK, Jung HY, et al. Appendectomy and the risk of developing ulcerative colitis: results after control of smoking factor. Korean J Gastroenterol. 1998;32:55–60.
3. Rutgeerts P, D’Haens G, Hiele M, Geboes K, Vantrappen G. Appendectomy protects against ulcerative colitis. Gastroenterology. 1994;106:1251–1253.
4. Mizoguchi A, Mizoguchi E, Chiba C, Bhan AK. Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice. J Exp Med. 1996;184:707–715.
5. Krieglstein CF, Cerwinka WH, Laroux FS, et al. Role of appendix and spleen in experimental colitis. J Surg Res. 2001;101:166–175.
6. Lumb G, Protheroe RH. Ulcerative colitis; a pathologic study of 152 surgical specimens. Gastroenterology. 1958;34:381–407.
7. Cohen T, Pfeffer RB, Valensi Q. “Ulcerative appendicitis” occurring as a skip lesion in chronic ulcerative colitis; report of a case. Am J Gastroenterol. 1974;62:151–155.
8. Jahadi MR, Shaw ML. The pathology of the appendix in ulcerative colitis. Dis Colon Rectum. 1976;19:345–349.
9. Goldblum JR, Appelman HD. Appendiceal involvement in ulcerative colitis. Mod Pathol. 1992;5:607–610.
10. Kahn E, Markowitz J, Daum F. The appendix in inflammatory bowel disease in children. Mod Pathol. 1992;5:380–383.
11. Shalygina NB, Kanshina OA, Kanshin NN. Involvement of the appendix in the inflammatory process in severe nonspecific chronic ulcerative colitis in children. Arkh Patol. 1989;51:24–26.
12. Davison AM, Dixon MF. The appendix as a ‘skip lesion’ in ulcerative colitis. Histopathology. 1990;16:93–95.
13. Groisman GM, George J, Harpaz N. Ulcerative appendicitis in universal and nonuniversal ulcerative colitis. Mod Pathol. 1994;7:322–325.
14. Kroft SH, Stryker SJ, Rao MS. Appendiceal involvement as a skip lesion in ulcerative colitis. Mod Pathol. 1994;7:912–914.
15. Scott IS, Sheaff M, Coumbe A, Feakins RM, Rampton DS. Appendiceal inflammation in ulcerative colitis. Histopathology. 1998;33:168–173.
16. Perry WB, Opelka FG, Smith D, et al. Discontinuous appendiceal involvement in ulcerative colitis: pathology and clinical correlation. J Gastrointest Surg. 1999;3:141–144.
17. Bernstein CN, Shanahan F, Anton PA, Weinstein WM. Patchiness of mucosal inflammation in treated ulcerative colitis: a prospective study. Gastrointest Endosc. 1995;42:232–237.
18. Saitoh M, Itoh Y, Yoshino K, et al. A case of appendicitis with ulcerative colitis, so-called “ulcerative appendicitis”. Gastroenterol Endosc. 1993;35:1879–1886.
19. Takizawa H, Koike M, Hirose S, Asakura H. Appendiceal involvement in patients with ulcerative colitis. Dig Endosc. 1997;9:217–221.
20. D’Haens G, Geboes K, Peeters M, Baert F, Ectors N, Rutgeerts P. Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study. Am J Gastroenterol. 1997;92:1275–1279.
21. Okawa K, Aoki T, Sano K, Harihara S, Kitano A, Kuroki T. Ulcerative colitis with skip lesions at the mouth of the appendix: a clinical study. Am J Gastroenterol. 1998;93:2405–2410.
22. Horie H, Konishi F, Togashi K, Kashiwagi H, Kanazawa K. Significance of periappendiceal inflammation in the patients with distal ulcerative colitis. Dig Endosc. 1999;11:119–124.
23. Yang SK, Jung HY, Kang GH, et al. Appendiceal orifice inflammation as a skip lesion in ulcerative colitis: an analysis in relation to medical therapy and disease extent. Gastrointest Endosc. 1999;49:743–747.
24. Yamagishi N, Iizuka B, Nakamura T, Suzuki S, Hayashi N. Clinical and colonoscopic investigation of skipped periappendiceal lesions in ulcerative colitis. Scand J Gastroenterol. 2002;37:177–182.
25. Matsumoto T, Nakamura S, Shimizu M, Iida M. Significance of appendiceal involvement in patients with ulcerative colitis. Gastrointest Endosc. 2002;55:180–185.
26. Mutinga ML, Odze RD, Wang HH, Hornick JL, Farraye FA. The clinical significance of right-sided colonic inflammation in patients with left-sided chronic ulcerative colitis. Inflamm Bowel Dis. 2004;10:215–219.
27. Ladefoged K, Munck LK, Jorgensen F, Engel P. Skip inflammation of the appendiceal orifice: a prospective endoscopic study. Scand J Gastroenterol. 2005;40:1192–1196.
28. Byeon JS, Yang SK, Myung SJ, et al. Clinical course of distal ulcerative colitis in relation to appendiceal orifice inflammation status. Inflamm Bowel Dis. 2005;11:366–371.
29. Rubin DT, Rothe JA. The peri-appendiceal red patch in ulcerative colitis: review of the University of Chicago experience. Dig Dis Sci. 2010;55:3495–3501.
30. Naves JE, Lorenzo-Zuniga V, Marin L, et al. Long-term outcome of patients with distal ulcerative colitis and inflammation of the appendiceal orifice. J Gastrointest Liver Dis. 2011;20:355–358.
31. Matsushita M, Takakuwa H, Matsubayashi Y, Nishio A, Ikehara S, Okazaki K. Appendix is a priming site in the development of ulcerative colitis. World J Gastroenterol. 2005;11:4869–4874.
32. Farkas SA, Hornung M, Sattler C, et al. Preferential migration of CD62L cells into the appendix in mice with experimental chronic colitis. Eur Surg Res. 2005;37:115–122.
33. Kawachiya T, Oshitani N, Jinno Y, et al. Significance of increased proliferation of immature plasma cells in the appendix of patients with ulcerative colitis. Int J Mol Med. 2005;15:417–423.
34. Park SH, Yang SK, Kim MJ, et al. Long term follow-up of appendiceal and distal right-sided colonic inflammation. Endoscopy. 2012;44:95–98.
35. Yantiss RK, Sapp HL, Farraye FA, et al. Histologic predictors of pouchitis in patients with chronic ulcerative colitis. Am J Surg Pathol. 2004;28:999–1006.
36. Okazaki K, Onodera H, Watanabe N, et al. A patient with improvement of ulcerative colitis after appendectomy. Gastroenterology. 2000;119:502–506.
37. Jo Y, Matsumoto T, Yada S, et al. Histological and immunological features of appendix in patients with ulcerative colitis. Dig Dis Sci. 2003;48:99–108.
38. Bolin TD, Wong S, Crouch R, Engelman JL, Riordan SM. Appendicectomy as a therapy for ulcerative proctitis. Am J Gastroenterol. 2009;104:2476–2482.
39. Bageacu S, Coatmeur O, Lemaitre JP, et al. Appendicectomy as a potential therapy for refractory ulcerative proctitis. Aliment Pharmacol Ther. 2011;34:257–258.
40. Selby WS, Griffin S, Abraham N, Solomon MJ. Appendectomy protects against the development of ulcerative colitis but does not affect its course. Am J Gastroenterol. 2002;97:2834–2838.
41. Jarnerot G, Andersson M, Franzen L. Laparoscopic appendectomy in patients with refractory ulcerative colitis. Gastroenterology. 2001;120:1562–1563.
42. Moreira VF, Milicua JM, Garcia Sanchez A, et al. Ulcerative colitis, pericholangitis and cancer of the appendix. Rev Clin Esp. 1979;154:237–241.
43. Odze RD, Medline P, Cohen Z. Adenocarcinoma arising in an appendix involved with chronic ulcerative colitis. Am J Gastroenterol. 1994;89:1905–1907.
44. Zannoni U, Masci C, Bazzocchi R, et al. Cancer of the appendix in long-standing ulcerative colitis: a case report. Tumori. 1997;83:958–959.
45. Lakatos PL, Gyori G, Halasz J, et al. Mucocele of the appendix: an unusual cause of lower abdominal pain in a patient with ulcerative colitis. A case report and review of literature. World J Gastroenterol. 2005;11:457–459.
46. Villanueva Saenz E, Perez-Aguirre J, Belmonte MC, Martinez PH, Marquez RM, Carranza RJ. Appendix adenocarcinoma associated with ulcerative colitis: a case report and literature review. Tech Coloproctol. 2006;10:54–56.
47. Takeda Y, Nakase H, Mikami S, et al. Possible link between ulcerative colitis and in situ adenocarcinoma of an appendiceal mucocele: importance of inflammation in the appendiceal orifice related to UC. Inflamm Bowel Dis. 2008;14:873–874.
48. Orta L, Trindade AJ, Luo J, Harpaz N. Appendiceal mucinous cystadenoma is a neoplastic complication of IBD: case-control study of primary appendiceal neoplasms. Inflamm Bowel Dis. 2009;15:415–421.