Fetal programming and epigenetic mechanisms in arterial hypertension

Current Opinion in Cardiology

Volumn 30, Issue 4, 2015, Pages 393-397

  Scherrer, Urs ^a,b   Rimoldi, Stefano F ^a   Sartori, Claudio ^c   Messerli, Franz H ^a,d   Rexhaj, Emrush ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSIDAD DE TARAPACÁ   (Chile)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Epigenetics; Hypertension; In vitro fertilization; Preeclampsia; Vascular dysfunction

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN;

ARTERIAL PRESSURE; DIASTOLIC BLOOD PRESSURE; DNA METHYLATION; ELEVATED BLOOD PRESSURE; EMBRYONIC AND FETAL FUNCTIONS; EPIGENETICS; FERTILIZATION IN VITRO; FETAL PROGRAMMING; FETUS; HUMAN; HYPERTENSION; HYPOXIC LUNG VASOCONSTRICTION; INSULIN RESISTANCE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PREECLAMPSIA; PREMATURE AGING; PREMATURE VASCULAR AGING; PRIORITY JOURNAL; PROGENY; REVIEW; SYSTEMIC CIRCULATION; SYSTOLIC BLOOD PRESSURE; FEMALE; FETUS DEVELOPMENT; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; PREGNANCY;

EPIGENESIS, GENETIC; FEMALE; FETAL DEVELOPMENT; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; HYPERTENSION; PREGNANCY;

EID: 84942617386     PISSN: 02684705     EISSN: 15317080     Source Type: Journal    
DOI: 10.1097/HCO.0000000000000192     Document Type: Review

References (34)

1. Cowley AW Jr, Nadeau JH, Baccarelli A, et al. Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension. Hypertension 2012; 59:899-905.
2. Stephan S, Lim EA. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study. Lancet 2012; 380:2224-2260.
3. Frazer KA, Murray SS, Schork NJ, Topol EJ. Human genetic variation and its contribution to complex traits. Nat Rev Genet 2009; 10:241-251.
4. Havlik RJ, Garrison RJ, Feinleib M, et al. Blood pressure aggregation in families. Am J Epidemiol 1979; 110:304-312.
5. Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature 2009; 461:747-753.
6. Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci USA 2012; 109:1193-1198.
7. Millis RM. Epigenetics and hypertension. Curr Hypertens Rep 2011; 13: 21-28.
8. Rexhaj E, Paoloni-Giacobino A, Rimoldi SF, et al. Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span. J Clin Invest 2013; 123:5052-5060.
9. Barker DJ. The fetal and infant origins of disease. Eur J Clin Invest 1995; 25:457-463.
10. Ost A, Lempradl A, Casas E, et al. Paternal diet defines offspring chromatin state and intergenerational obesity. Cell 2014; 159:1352-1364.
11. Roseboom TJ, van der Meulen JH, Osmond C, et al. Coronary heart disease after prenatal exposure to the Dutch famine. Heart 2000; 84:595-598.
12. Van Abeelen AF, Veenendaal MV, Painter RC, et al. The fetal origins of hypertension: a systematic review and meta-analysis of the evidence from animal experiments of maternal undernutrition. J Hypertens 2012; 30:2255-2267.
13. Baccarelli A, Rienstra M, Benjamin EJ. Cardiovascular epigenetics: basic concepts and results from animal and human studies. Circ Cardiovasc Genet 2010; 3:567-573.
14. Yazbek SN, Spiezio SH, Nadeau JH, Buchner DA. Ancestral paternal genotype controls body weight and food intake for multiple generations. Hum Mol Genet 2010; 19:4134-4144.
15. Lane M, Robker RL, Robertson SA. Parenting from before conception. Science 2014; 345:756-760.
16. Kamphuis E, van Wely M, Repping S, et al. Should the individual preterm birth risk be incorporated into the embryo transfer policy in in vitro fertilisation? A decision analysis. BJOG 2015; 122:825-833.
17. Rimoldi SF, Sartori C, Rexhaj E, et al. Antioxidants improve vascular function in children conceived by assisted reproductive technologies: a randomized double-blind placebo-controlled trial. Eur J Prev Cardiol 2014. [Epub ahead of print]
18. Rimoldi SF, Sartori C, Rexhaj E, et al. Vascular dysfunction in children conceived by assisted reproductive technologies: underlying mechanisms and future implications. Swiss Med Wkly 2014; 144:w13973.
19. Scherrer U, Rimoldi SF, Rexhaj E, et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation 2012; 125:1890-1896.
20. Von Arx R, Allemann Y, Sartori C, et al. Right ventricular dysfunction in children and adolescents conceived by assisted reproductive technologies. J Appl Physiol. (in press) doi:10. 1152/japplphysiol. 00533. 2014.
21. Ceelen M, van Weissenbruch MM, Vermeiden JP, et al. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metab 2008; 93:1682-1688.
22. Rexhaj E, Von Arx R, Cerny D, et al. Assisted reproductive technologiesinduced premature vascular ageing persists and evolves into arterial hypertension in adolescents. FASEB J 2015; 29:957. 9.
23. Chen X, Wang Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation 2008; 117: 3171-3180.
24. Ferrannini E, Buzzigoli G, Bonadonna R, et al. Insulin resistance in essential hypertension. N Engl J Med 1987; 317:350-357.
25. Cook S, Scherrer U. Insulin resistance, a new target for nitric oxide-delivery drugs. Fundam Clin Pharmacol 2002; 16:441-453.
26. Scherrer U, Randin D, Vollenweider P, et al. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 1994; 94:2511-2515.
27. Scherrer U, Sartori C. Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation 1997; 96:4104-4113.
28. Scherrer U, Rexhaj E, Allemann Y, et al. Cardiovascular dysfunction in children conceived by assisted reproductive technologies. Eur Heart J. (in press). This article outlines in a comprehensive manner the most relevant studies in fetal programming of premature vascular ageing induced by assisted reproductive technologies.
29. Lewandowski AJ, Leeson P. Preeclampsia, prematurity and cardiovascular health in adult life. Early Human Develop 2014; 90:725-729.
30. Langley-Evans SC. Developmental programming of health and disease. Proc Nutr Soc 2006; 65:97-105.
31. Jayet PY, Rimoldi SF, Stuber T, et al. Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia. Circulation 2010; 122:488-494.
32. Lazdam M, de la Horra A, Pitcher A, et al. Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism? Hypertension 2010; 56:159-165.
33. Kajantie E, Eriksson JG, Osmond C, et al. Preeclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study. Stroke 2009; 40:1176-1180.
34. Rexhaj E, Bloch J, Jayet PY, et al. Fetal programming of pulmonary vascular dysfunction in mice: role of epigenetic mechanisms. Am J Physiol Heart Circ Physiol 2011; 301:H247-H252.