Choline deficiency impairs intestinal lipid metabolism in the lactating rat

Journal of Nutritional Biochemistry

Volumn 26, Issue 10, 2015, Pages 1077-1083

  da Silva, Robin P ^a   Kelly, Karen B ^a   Lewis, Erin D ^a   Leonard, Kelly Ann ^a   Goruk, Sue ^a   Curtis, Jonathan M ^a   Vine, Donna F ^a   Proctor, Spencer D ^a   Field, Catherine J ^a   Jacobs, René L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Choline; Intestine; Lipid metabolism; Phospholipids; Triacylglycerol

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL CITRATE LYASE; ACYL COENZYME A DESATURASE; ACYLGLYCEROL PALMITOYLTRANSFERASE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLINE; CHYLOMICRON; LOW DENSITY LIPOPROTEIN RECEPTOR; LYASE; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SCAVENGER RECEPTOR B; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; FATTY ACID; LIPID; LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIETARY INTAKE; ESTERIFICATION; FATTY ACID OXIDATION; FEMALE; INTESTINE CELL; INTESTINE INJURY; INTESTINE MUCOSA; INTESTINE VILLUS; JEJUNUM; LACTATION; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPID STORAGE; MORPHOLOGY; NONHUMAN; RAT; SMALL INTESTINE ABSORPTION; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN DEFICIENCY; WEIGHT REDUCTION; ANIMAL; BLOOD; CHEMISTRY; DIET; INTESTINE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTPRANDIAL STATE; PREGNANCY; SPRAGUE DAWLEY RAT;

ANIMALS; CHOLINE; CHOLINE DEFICIENCY; DIET; ESTERIFICATION; FATTY ACIDS; FEMALE; INTESTINAL MUCOSA; INTESTINES; JEJUNUM; LACTATION; LIPID METABOLISM; LIPIDS; LIPOPROTEINS; POSTPRANDIAL PERIOD; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; WEIGHT LOSS;

EID: 84942549525     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2015.04.015     Document Type: Article

References (40)

1. Buchman A.L., Ament M.E., Sohel M., Dubin M., Jenden D.J., Roch M., et al. Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trial. JPEN J Parenter Enteral Nutr 2001, 25:260-268.
2. Zeisel S.H., Da Costa K.A., Franklin P.D., Alexander E.A., Lamont J.T., Sheard N.F., et al. Choline, an essential nutrient for humans. FASEB J 1991, 5:2093-2098.
3. Lewis E.D., Subhan F.B., Bell R.C., McCargar L.J., Curtis J.M., Jacobs R.L., et al. Estimation of choline intake from 24h dietary intake recalls and contribution of egg and milk consumption to intake among pregnant and lactating women in Alberta. Br J Nutr 2014, 112:112-121.
4. Cho E., Zeisel S.H., Jacques P., Selhub J., Dougherty L., Colditz G.A., et al. Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr 2006, 83:905-911.
5. Caudill M.A. Pre- and postnatal health: evidence of increased choline needs. J Am Diet Assoc 2010, 110:1198-1206.
6. Vance D.E. Physiological roles of phosphatidylethanolamine N-methyltransferase. Biochim Biophys Acta 1831, 2013:626-632.
7. Zeisel S.H., Epstein M.F., Wurtman R.J. Elevated choline concentration in neonatal plasma. Life Sci 1980, 26:1827-1831.
8. Chao C.K., Pomfret E.A., Zeisel S.H. Uptake of choline by rat mammary-gland epithelial cells. Biochem J 1988, 254:33-38.
9. Ilcol Y.O., Ozbek R., Hamurtekin E., Ulus I.H. Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk. J Nutr Biochem 2005, 16:489-499.
10. Zeisel S.H., Mar M.H., Zhou Z., da Costa K.A. Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J Nutr 1995, 125:3049-3054.
11. Garner S.C., Mar M.H., Zeisel S.H. Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet. J Nutr 1995, 125:2851-2858.
12. Zeisel S.H. A brief history of choline. Ann Nutr Metab 2012, 61:254-258.
13. Fisher M.C., Zeisel S.H., Mar M.H., Sadler T.W. Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology 2001, 64:114-122.
14. Li Z., Agellon L.B., Allen T.M., Umeda M., Jewell L., Mason A., et al. The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab 2006, 3:321-331.
15. Shaw G.M., Carmichael S.L., Yang W., Selvin S., Schaffer D.M. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol 2004, 160:102-109.
16. Meck W.H., Williams C.L. Perinatal choline supplementation increases the threshold for chunking in spatial memory. Neuroreport 1997, 8:3053-3059.
17. Chen M., Peyrin-Biroulet L., George A., Coste F., Bressenot A., Bossenmeyer-Pourie C., et al. Methyl deficient diet aggravates experimental colitis in rats. J Cell Mol Med 2011, 15:2486-2497.
18. Bressenot A., Pooya S., Bossenmeyer-Pourie C., Gauchotte G., Germain A., Chevaux J.B., et al. Methyl donor deficiency affects small-intestinal differentiation and barrier function in rats. Br J Nutr 2013, 109:667-677.
19. Takahashi Y., Mizunuma T., Kishino Y. Effects of choline deficiency and phosphatidylcholine on fat absorption in rats. J Nutr Sci Vitaminol 1982, 28:139-147.
20. Takahashi Y., Mizunuma T., Kishino Y. Ultracytochemical studies on fat absorption by choline-deficient rats. Acta Histochem Cytochem 1982, 15:90-101.
21. Reeves P.G., Nielsen F.H., Fahey G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993, 123:1939-1951.
22. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
23. Myher J.J., Kuksis A. Determination of plasma total lipid profiles by capillary gas-liquid chromatography. J Biochem Biophys Methods 1984, 10:13-23.
24. Noga A.A., Vance D.E. Insights into the requirement of phosphatidylcholine synthesis for liver function in mice. J Lipid Res 2003, 44:1998-2005.
25. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37:911-917.
26. Xiong Y., Zhao Y.Y., Goruk S., Oilund K., Field C.J., Jacobs R.L., et al. Validation of an LC-MS/MS method for the quantification of choline-related compounds and phospholipids in foods and tissues. J Chromatogr B Anal Technol Biomed Life Sci 2012, 911:170-179.
27. Vine D.F., Takechi R., Russell J.C., Proctor S.D. Impaired postprandial apolipoprotein-B48 metabolism in the obese, insulin-resistant JCR:LA-cp rat: increased atherogenicity for the metabolic syndrome. Atherosclerosis 2007, 190:282-290.
28. Steere M., Mansbach C.M. The contribution of serum phosphatidylcholine and lysophosphatidylcholine to lymph phosphatidylcholine. Biochim Biophys Acta 1980, 620:462-471.
29. Pomfret E.A., daCosta K.A., Zeisel S.H. Effects of choline deficiency and methotrexate treatment upon rat liver. J Nutr Biochem 1990, 1:533-541.
30. Mansbach C.M. The origin of chylomicron phosphatidylcholine in the rat. J Clin Invest 1977, 60:411-420.
31. McMahon K.E., Farrell P.M. Effect of choline deficiency on lung phospholipid concentrations in the rat. J Nutr 1986, 116:936-943.
32. Vance D.E., Ridgway N.D. The methylation of phosphatidylethanolamine. Prog Lipid Res 1988, 27:61-79.
33. Mansbach C.M., Arnold A. Steady-state kinetic analysis of triacylglycerol delivery into mesenteric lymph. Am J Physiol 1986, 251:G263-G269.
34. Minahk C., Kim K.W., Nelson R., Trigatti B., Lehner R., Vance D.E. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 2008, 283:6449-6458.
35. Lehner R., Lian J., Quiroga A.D. Lumenal lipid metabolism: implications for lipoprotein assembly. Arterioscler Thromb Vasc Biol 2012, 32:1087-1093.
36. Zhao Y., Su B., Jacobs R.L., Kennedy B., Francis G.A., Waddington E., et al. Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol 2009, 29:1349-1355.
37. Nelson D.W., Gao Y., Yen M.I., Yen C.L. Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance. J Biol Chem 2014, 289:17338-17349.
38. Tsuchida T., Fukuda S., Aoyama H., Taniuchi N., Ishihara T., Ohashi N., et al. MGAT2 deficiency ameliorates high-fat diet-induced obesity and insulin resistance by inhibiting intestinal fat absorption in mice. Lipids Health Dis 2012, 11:75.
39. Zeisel S.H. Choline deficiency. J Nutr Biochem 1990, 1:332-349.
40. Niebergall L.J., Jacobs R.L., Chaba T., Vance D.E. Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. Biochim Biophys Acta 1811, 2011:1177-1185.