BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

Nature Neuroscience

Volumn 18, Issue 10, 2015, Pages 1464-1473

  Korb, Erica ^a   Herre, Margo ^a   Zucker Scharff, Ilana ^a   Darnell, Robert B ^a   Allis, C David ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; BET PROTEIN BRD4; PROTEIN; UNCLASSIFIED DRUG; (+)-JQ1 COMPOUND; AZEPINE DERIVATIVE; BRD4 PROTEIN, MOUSE; NUCLEAR PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE;

ADULT; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; LEARNING; MALE; MEMORY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; SEIZURE SUSCEPTIBILITY; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONFOCAL MICROSCOPY; DRUG EFFECTS; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SEIZURE; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; AZEPINES; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MEMORY; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NEURONS; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SEIZURES; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TRIAZOLES;

EID: 84942505530     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.4095     Document Type: Article

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