Design and Synthesis of Butenolide-based Novel Benzyl Pyrrolones: Their TNF-α based Molecular Docking with in vivo and in vitro Anti-inflammatory Activity

Chemical Biology and Drug Design

Volumn 86, Issue 4, 2015, Pages 619-625

  Ali, Yakub ^a   Alam, Mohammad Sarwar ^a   Hamid, Hinna ^a   Husain, Asif ^b   Shafi, Syed ^a   Dhulap, Abhijeet ^c   Hussain, Firasat ^d   Bano, Sameena ^a   Kharbanda, Chetna ^a   Nazreen, Syed ^a   Haider, Saqlain ^a  

^a HAMDARD UNIVERSITY   (India)

^b HAMDARD UNIVERSITY   (India)

^c CSIR Unit for Research and Development of Information Products   (India)

^d UNIVERSITY OF DELHI   (India)

Author keywords

analgesic; anti inflammatory; benzyl pyrrolones; hepatotoxicity; immunohistochemistry; TNF ; ulcerogenic

Indexed keywords

3 (4 FLUORO BENZYLIDENE) 5 (4 FLUORO PHENYL) 2 CHLORO BENZYL 2(3H) PYRROLONE; 3 (4 FLUORO BENZYLIDENE) 5 (4 FLUORO PHENYL)FLUORO BENZYL 2(3H) PYRROLONE; ANTIINFLAMMATORY AGENT; BENZYL DERIVATIVE; BUTENOLIDE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CARRAGEENAN; GAMMA BUTYROLACTONE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CARRAGEENAN-INDUCED PAW EDEMA; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER TOXICITY; MASS SPECTROMETRY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; ULCEROGENESIS; WRITHING TEST; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG EFFECTS; FEMALE; LIVER; MALE; METABOLISM; PRECLINICAL STUDY; PROCEDURES; STOMACH ULCER; SYNTHESIS;

4-BUTYROLACTONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FEMALE; LIPID PEROXIDATION; LIVER; MALE; MICE; MOLECULAR DOCKING SIMULATION; RATS; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84942503295     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12522     Document Type: Article

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