Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2636-2642

  Alam, M M ^a   Husain, Asif ^a   Hasan, S M ^a   Suruchi, ^a   Anwer, T ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Analgesic; Anti inflammatory; Furanone; Lipid peroxidation; Ulcerogenic

Indexed keywords

3 (2 CHLORO BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (2 NITRO BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (2,4 DICHLORO BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (3 CHLORO BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (3 NITRO BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (3,4 DIMETHOXY BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (4 ACETOXY 3 METHOXY BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (4 CHLORO BENZYLIDENE) 5 (4 CHLORO PHENYL) 1 BENZYL 2(3H) PYRROLONE; 3 (4 CHLORO BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (4 FLUORO BENZYLIDENE) 5 (4 CHLOROPHENYL) 1 BENZYL 2(3H) PYRROLONE; 3 (4 FLUORO BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (4 HYDROXY 3 METHOXY BENZYLIDENE) 5 (4 CHLORO PHENYL) 1 BENZYL 2(3H) PYRROLONE; 3 (4 METHOXY BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (4 NITRO BENZYLIDENE) 5 (4 CHLORO PHENYL) 1 BENZYL 2(3H) PYRROLONE; 3 (4 NITRO BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; 3 (BENZYLIDENE) 5 (4 CHLORO PHENYL) 1 BENZYL 2(3H) PYRROLONE; 3 (BENZYLIDENE) 5 (4 CHLOROPHENYL) 2(3H) FURANONE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; IBUPROFEN; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GASTROINTESTINAL TOXICITY; HOT PLATE TEST; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ULCEROGENESIS; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; EDEMA; FEMALE; FURANS; LIPID PEROXIDATION; MALE; MICE; MOLECULAR STRUCTURE; PAIN MEASUREMENT; PEPTIC ULCER; PYRROLES; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64249160971     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.10.030     Document Type: Article

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