A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

EMBO Molecular Medicine

Volumn 7, Issue 10, 2015, Pages 1337-1349

  Marcoux, Julien ^a,b,g   Mangione, P Patrizia ^c,d   Porcari, Riccardo ^c   Degiacomi, Matteo T ^a   Verona, Guglielmo ^c,d   Taylor, Graham W ^c   Giorgetti, Sofia ^d   Raimondi, Sara ^d   Sanglier Cianférani, Sarah ^b   Benesch, Justin Lp ^a   Cecconi, Ciro ^e,f   Naqvi, Mohsin M ^f   Gillmore, Julian D ^c   Hawkins, Philip N ^c   Stoppini, Monica ^d   Robinson, Carol V ^a   Pepys, Mark B ^c   Bellotti, Vittorio ^c,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF PAVIA   (Italy)

^e CNR   (Italy)

^f UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^g INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Amyloid; Mechano enzymatic cleavage; Transthyretin

Indexed keywords

AMYLOID; PEPTIDE FRAGMENT; PREALBUMIN; PROTEIN VARIANT; TAFAMIDIS; TETRAMER;

ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STABILITY; SHEAR STRESS; AMYLOID NEUROPATHIES, FAMILIAL; CHEMISTRY; HUMAN; METABOLISM;

AMYLOID NEUROPATHIES, FAMILIAL; HUMANS; PEPTIDE FRAGMENTS; PREALBUMIN; PROTEOLYSIS;

EID: 84942432257     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201505357     Document Type: Article

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