Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells

Toxicology and Industrial Health

Volumn 31, Issue 10, 2015, Pages 960-966

  Yeh, Chung Hsin ^a   Shih, Hung Che ^b,c   Hong, Hui Mei ^b   Lee, Shiuan Shinn ^b   Yang, Ming Ling ^b   Chen, Chun Jung ^d,e   Kuan, Yu Hsiang ^b,c  

^a SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e TUNGHAI UNIVERSITY   (Taiwan)

Author keywords

antiinflammation; BV2 microglial cells; Jak; STAT; Wogonin

Indexed keywords

CYTOKINE; FOCAL ADHESION KINASE 1; GAMMA INTERFERON; INTERLEUKIN 6; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; LIPOPOLYSACCHARIDE; MESSENGER RNA; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; WOGONIN; FLAVANONE DERIVATIVE; JANUS KINASE; STAT PROTEIN;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; MICROGLIA; NEUROPROTECTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECTS; METABOLISM; MOUSE;

ANIMALS; CELL LINE; CYTOKINES; FLAVANONES; JANUS KINASES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 84942418274     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713485886     Document Type: Article

References (32)

1. Adalbert R, Coleman MP (2012) Axon pathology in age-related neurodegenerative disorders. Neuropathology and Applied Neurobiology. Epub ahead of print 10 October 2010. DOI: 10.1111/j.1365-2990.2012.01308.x.
2. Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience 8: 57–69.
3. Braunstein J, Brutsaert S, Olson R et al. (2003) C. STATs dimerize in the absence of phosphorylation. Journal of Biological Chemistry 78: 34133–34140.
4. Chi YS, Cheon BS, Kim HP (2001) Effect of wogonin, a plant flavone from scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells Biochemical Pharmacology 61: 1195–1203.
5. Claudinon J, Monier MN, Lamaze C (2007) Interfering with interferon receptor sorting and trafficking: impact on signaling. Biochimie 89: 735–743.
6. Ghoreschi K, Laurence A, O’Shea JJ (2009) Janus kinases in immune cell signaling Immunological Reviews 228: 273–287.
7. Held TK, Weihua X, Yuan L et al. (1999) Gamma interferon augments macrophage activation by lipopolysaccharide by two distinct mechanisms, at the signal transduction level and via an autocrine mechanism involving tumor necrosis factor alpha and interleukin-1. Infection and Immunity 67: 206–212.
8. Huang CH, Yang ML, Tsai CH et al. (2013) Ginkgo biloba leaves extract (EGb 761) attenuates lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and NF-κB-dependent matrix metalloproteinase-9 pathway. Phytomedicine 20: 303–309.
9. Huang GC, Chow JM, Shen SC et al. (2007) Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. International Immunopharmacology 7: 1054–1063.
10. Kao TK, Ou YC, Raung SL et al. (2010) Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia. Life Sciences 86: 315–321.
11. Kettenmann H, Hanisch UK, Noda M et al. (2011) Physiology of microglia. Physiological Reviews 91: 461–553.
12. Kiu H, Nicholson SE (2012) Biology and significance of the JAK/STAT signalling pathways. Growth Factors 30: 88–106.
13. Klampfer L (2006) Signal transducers and activators of transcription (STATs): novel targets of chemopreventive and chemotherapeutic drugs. Current Cancer Drug Targets 6: 107–121.
14. Kuo MY, Liao MF, Chen FL et al. (2011) Luteolin attenuates the pulmonary inflammatory response involves abilities of antioxidation and inhibition of MAPK and NFκB pathways in mice with endotoxin-induced acute lung injury. Food and Chemical Toxicology 49: 2660–2666.
15. Kuan YH, Huang FM, Li YC et al. (2012a) Proinflammatory activation of macrophages by bisphenol A-glycidyl-methacrylate involved NFκB activation via PI3K/Akt pathway. Food and Chemical Toxicology 50: 4003–4009.
16. Kuan YH, Li YC, Huang FM et al. (2012b) The upregulation of tumour necrosis factor-α and surface antigens expression on macrophages by bisphenol A-glycidyl-methacrylate. International Endodontic Journal 45: 619–626.
17. Lee H, Kim YO, Kim H et al. (2003) Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB Journal 17: 1943–1944.
18. Leonard WJ (2001) Role of Jak kinases and STATs in cytokine signal transduction. International Journal of Hematology 73: 271–277.
19. Li YC, Kuan YH, Huang FM et al. (2012b) The role of DNA damage and caspase activation in cytotoxicity and genotoxicity of macrophages induced by bisphenol-A-glycidyldimethacrylate. International Endodontic Journal 45: 499–507.
20. Li YC, Yeh CH, Yang ML et al. (2012a) Luteolin suppresses inflammatory mediator expression by blocking the Akt/NFκB pathway in acute lung injury induced by lipopolysaccharide in mice. Evidence-Based Complementary and Alternative Medicine 2012: 383608.
21. Mertens C, Zhong M, Krishnaraj R et al. (2006) Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes and Development 20: 3372–3381.
22. Minogue AM, Barrett JP, Lynch MA (2012) LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner. Journal of Neuroinflammation 9: 126.
23. Piao HZ, Choi IY, Park JS et al. (2008) Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity. International Immunopharmacology 8: 1658–1662.
24. Qin H, Holdbrooks AT, Liu Y et al. (2012) SOCS3 deficiency promotes M1 macrophage polarization and inflammation. Journal of Immunology 189: 3439–3448.
25. Rossol M, Heine H, Meusch U et al. (2011) LPS-induced cytokine production in human monocytes and macrophages. Critical Reviews in Immunology 31: 379–446.
26. Samavati L, Rastogi R, Du W et al. (2009) STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria. Molecular Immunology 46: 1867–1877.
27. Schindler C, Levy DE, Decker T (2007) JAK-STAT signaling: from interferons to cytokines. Journal of Biological Chemistry 282: 20059–20063.
28. Schindler C, Plumlee C (2008) Interferons pen the JAK-STAT pathway. Seminars in Cell and Developmental Biology 19: 311–318.
29. Shang X, He X, He X et al. (2010) The genus Scutellaria an ethnopharmacological and phytochemical review. Journal of Ethnopharmacology 128: 279–313.
30. Tai MC, Tsang SY, Chang LY et al. (2005) Therapeutic potential of wogonin: a naturally occurring flavonoid. CNS Drug Reviews 11: 141–150.
31. Wakabayashi I, Yasui K (2000) Wogonin inhibits inducible prostaglandin E2 production in macrophages. European Journal of Pharmacology 406: 477–481.
32. Yu H, Jove R (2004) The STATs of cancer--new molecular targets come of age. Nature Reviews Cancer 4: 97–105.