Histological, ultrastructural and immunohistochemical studies on the protective effect of ginger extract against cisplatin-induced nephrotoxicity in male rats

Toxicology and Industrial Health

Volumn 31, Issue 10, 2015, Pages 869-880

  Ali, Doaa A ^a   Abdeen, Ahmed M ^a   Ismail, Mohammed F ^a   Mostafa, Mai A ^a  

^a Mansoura University   (Egypt)

Author keywords

Cisplatin nephrotoxicity; ginger extract; histology; immunohistochemistry; TEM

Indexed keywords

BAX PROTEIN, RAT; CISPLATIN; PLANT EXTRACT; PROTECTIVE AGENT; PROTEIN BAX; CREATININE; GINGER EXTRACT;

ACUTE KIDNEY FAILURE; ANIMAL; BODY WEIGHT; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GINGER; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; PATHOLOGY; RAT; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HISTOLOGY; HISTOPATHOLOGY; KIDNEY DISTAL TUBULE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NEPHROTOXICITY; NONHUMAN; PODOCYTE; PROTEIN EXPRESSION; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL;

ACUTE KIDNEY INJURY; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BODY WEIGHT; CISPLATIN; GINGER; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS;

EID: 84942417232     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713483198     Document Type: Article

References (49)

1. Ahmed RS, Suke SG, Seth V, Chakraborti A, Tripathi AK, Banerjee BD (2008) Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane induced oxidative stress in rats. Phytotherapy Research 22: 902–906.
2. Ajith TA, Aswathy MS, Hema U (2008) Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food and Chemical Toxicology 46: 3178–3181.
3. Ajith TA, Nivitha V, Usha S (2007) Zingiber officinale Roscoe alone and in combination with α-tocopherol protect the kidney against cisplatin-induced acute renal failure. Food and Chemical Toxicology 45: 921–927.
4. Ali BH, Al-Moundhri MS (2006) Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food and Chemical Toxicology 44: 1173–1183.
5. Arakawa M, Yamanaka N (1991) Collagenofibrotic Glomerulopathy: A New Type of Primary Glomerulopathy Revealing Massive Collagen Deposits in the Renal Glomerulus. Nigata, Japan: Nishimura Co. Ltd, pp. 3–8.
6. Atessahin A, Yilmaz S, Karahan I, Ceribasi AO, Karaoglu A (2005) Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology 212: 116–123.
7. Badary OA, Abdel-Maksoud S, Ahmed WA (2005) Naringenin attenuates cisplatin nephrotoxicity in rats. Life Science 76: 2125–2135.
8. Baliga R, Ueda N, Walker PD (1997) Oxidant mechanisms in toxic acute renal failure. American Journal of Kidney Diseases 29: 465–477.
9. Bohman SO, Jaremko G, Bohlin AB (1984) Foot process fusion and glomerular filtration rate in minimal change nephrotic syndrome. Kidney International 25: 696–700.
10. Borrego A, Zamora Z, Gonzalez R, Romay CH, Menendez S, Hernandez F (2004). Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats. Mediators of Inflammation 13: 13–19.
11. Chirino YI, Hernandez-Pando R, Pedraza-Chaverri J (2004) Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats. BMC Pharmacology 4: 20–29.
12. Choudhury D, Das A, Bhattacharya A, Chakrabarti G (2010) Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells. Food and Chemical Toxicology 48: 2872–2880.
13. Crossman CO (1937) A modification of Mallory’s connective tissue stain with discussion of the principle involved. Anatomical Record 69: 33–38.
14. Daugaard G, Abildgaard U (1989) Cisplatin nephrotoxicity: a review. Cancer Chemotherapy and Pharmacology 25: 1–9.
15. Dechao L, Eisaku U, Tsuyoshi K, Tetsuya Y, Tokio O (2004) Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation an ubiquitination. Cancer Science 95: 644–650.
16. El-Sharaky AS, Newairy AA, Kamel MA, Eweda SM (2009) Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. Food and Chemical Toxicology 47: 1584–1590.
17. Falconer IR (1999) An overview of problems caused by toxic blue-green algae (Cyanobacteria) in drinking and recreational water. Environmental Toxicology 14: 5–12.
18. Fawcett JK, Scott JE (1960) A rapid and precise method for the determination of urea. Journal of Clinical Pathology 13: 156–159.
19. Ferrara N (2004) Vascular endothelial growth factor: basic science and clinical progress. Endocrine Review 25: 581–611.
20. Fouad AA, Morsy MA, Gomaa W (2008) Protective effect of carnosine against cisplatin-induced nephrotoxicity in mice. Environmental Toxicology and Pharmacology 25: 292–297.
21. Gonzalez R, Borrego A, Zamora Z, Romay CH (2004) Reversion by ozone treatment of acute nephrotoxicity induced by cisplatin in rats. Mediators of Inflammation 13: 1–6.
22. Gupta YK, Sharma SS (1996) Antiemetic activity of antioxidants against cisplatin induced emesis in dogs. Environmental Toxicology and Pharmacology 1: 179–184.
23. Gupta YK, Sharma SS (1998) Reversal of cisplatin-induced delay in gastric emptying in rats by ginger (Zingiber officinale). Journal of Ethnopharmacology 62: 49–55.
24. Hassan I, Chibber S, Naseem I (2010) Ameliorative effect of riboflavin on the cisplatin induced nephrotoxicity and hepatotoxicity under photoillumination. Food and Chemical Toxicology 48: 2052–2058.
25. Heinegard DZ, Tiderstrom G (1973) Determination of serum creatinine by a direct coloriometric method. Clinica Chimica Acta 43: 305–310.
26. Jitoe A, Masuda C, Telnjeh IGP, Suprata N, Gara IW, Nakatani N (1992) Antioxidant activity of tropical ginger extract and analysis of the contained curcumenoid. Journal of Agricultural and Food Chemistry 40: 1337–1340.
27. Jones DB (1982) Ultrastructure of human acute renal failure. Laboratory Investigation 46: 254–264.
28. Kamtchouing P, Mbongue Fandio GY, Dimo T, Jatsa HB (2002) Evaluation of androgenic activity of Zingiber officinale and Pentadiplandra brazzeana in male rats. Asian Journal of Andrology 4: 299–301.
29. Khanom F, Kayahara H, Hirota M, Tadasa K (2003) Superoxide scavenging and tyrosinase inhibitory active compound in Ginger (Zingiber officinales Rosc.). Pakistan Journal of Biological Science 6: 1996–2000.
30. Kourilsky O, Solez K, Morel-Maroger L, Whelton A, Srear JD (1982) The pathology of acute renal failure due to interstitial nephritis in man with comments on the role of interstitial inflammation and sex in gentamicin nephrotoxicity. Medicine 61: 258–268.
31. Lantz RC, Chen GJ, Sarihan M, Slyom AM, Jolad SD, Timmermann BN (2007) The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 14: 123–128.
32. Lau AH (1999) Apoptosis induced by cisplatin nephrotoxic injury. Kidney International 56: 1295–1298.
33. Lee R, Song J, Park M, Kang S, Kim Y, Jung J (2001) Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells. Biochemical Pharmacology 62: 1013–1023.
34. Masuda Y, Kikuzaki H, Hisamoto M, Nakatani N (2004) Antioxidant properties of gingerol related compounds from ginger. Biofactors 21: 293–296.
35. Nitha B, Janardhanan KK (2008) Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice. Food and Chemical Toxicology 46: 3193–3199.
36. Ogungbe IV, Lawal AO (2008) The protective effect of ethanolic extracts of garlic and ascorbic acid on cadmium-induced oxidative stress. Journal of Biological Science 8(1): 181–185.
37. Pace A, Savarese A, Picardo M (2003) Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy. Journal of Clinical Oncology 21: 927–931.
38. Perez RP (1998) Cellular and molecular determinants of cisplatin resistance. European Journal of Cancer 34: 1535–1542.
39. Ramesh G, Reeves WB (2005) p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. American Journal of Physiology – Renal Physiology 289: F166–F174.
40. Robbins ME, Bywaters TB, Jaenke RS (1992) Long-term studies of cisplatin-induced reductions in porcine renal functional reserve. Cancer Chemotherapy and Pharmacology 29: 309–315.
41. Saad AA, Youssef MI, El-Shennawy LK (2009) Cisplatin induced damage in kidney genomic DNA and nephrotoxicity in male rats: the protective effect of grape seed proanthocyanidin extract. Food and Chemical Toxicology 47: 1499–1506.
42. Seiler MW, Rennke HG, Venkatachalam MA (1977) Pathogenesis of polycation-induced alterations (“fusion”) of glomerular epithelium. Laboratory Investigation 36: 48–61.
43. Shati AA, Elsaid FG (2009) Effects of water extracts of thyme (Thymus vulgaris) and ginger (Zingiber officinale Roscoe) on alcohol abuse. Food and Chemical Toxicology 47: 1945–1949.
44. Sheikh-Hamad D, Cacini W, Bucley AR, Isaac J, Truong LD, Chui T (2004) Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney. Archives of Toxicology 78: 147–155.
45. Shukla Y, Singh M (2007) Cancer preventive properties of ginger: a brief review. Food and Chemical Toxicology 45: 683–690.
46. Taghizadeh AA, Shirpor A, Farshid A et al. (2007) The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rat. Food Chemistry 101: 148–153.
47. Turk G, Atessahin A, Sonmez M, Ceribasi AO, Yuce A (2008) Improvement of cisplatin-induced injuries to sperm quality, the oxidant–antioxidant system, and the histological structure of the rat testis by ellagic acid. Fertility and Sterility 89: 1474–1481.
48. Wu YJ, Muldoon LL, Neuwelt EA (2005) The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway. Journal of Pharmacology and Experimental Therapeutics 312: 424–431.
49. Zhang JG, Lindup WE (1994) Cisplatin nephrotoxicity decreases mitochondrial protein sulphydryl concentration and calcium uptake by mitochondria from rat renal cortical slices. Biochemical Pharmacology 47: 1127–1135.