Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors

Journal of Medicinal Chemistry

Volumn 58, Issue 18, 2015, Pages 7501-7511

  Zhao, Yu ^a   Yang, Chuntao ^b   Organ, Chelsea ^c   Li, Zhen ^c   Bhushan, Shashi ^c   Otsuka, Hiro ^c   Pacheco, Armando ^a   Kang, Jianming ^a   Aguilar, Hector C ^a   Lefer, David J ^c   Xian, Ming ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN SULFIDE; THIOL DERIVATIVE; TROPONIN I; BENZAMIDE DERIVATIVE; CARDIOTONIC AGENT; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; REPERFUSION INJURY; STRUCTURE ACTIVITY RELATION; ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HEART VENTRICLE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MYOBLAST; MYOCARDIAL REPERFUSION INJURY; RAT; SYNTHESIS;

ANIMALS; BENZAMIDES; CARDIOTONIC AGENTS; CELL LINE; DRUG DESIGN; HEART VENTRICLES; HYDROGEN PEROXIDE; HYDROGEN SULFIDE; L-LACTATE DEHYDROGENASE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, INBRED C57BL; MYOBLASTS, CARDIAC; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 84942357931     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01033     Document Type: Article

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