Role of a TPA-responsive element in hepcidin transcription induced by the bone morphogenetic protein pathway

Biochemical and Biophysical Research Communications

Volumn 466, Issue 2, 2015, Pages 162-166

  Kanamori, Yohei ^a   Murakami, Masaru ^b   Matsui, Tohru ^a   Funaba, Masayuki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b AZABU UNIVERSITY   (Japan)

Author keywords

AP 1; BMP; Hepcidin; TPA Responsive element

Indexed keywords

6 [4 (1 PIPERAZINYL)PHENYL] 3 (4 QUINOLINYL)PYRAZOLO[1,5 A]PYRIMIDINE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; HEPCIDIN; INTERLEUKIN 6; LUCIFERASE; PROTEIN C FOS; TPA RESPONSIVE ELEMENT; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; PHORBOL 13 ACETATE 12 MYRISTATE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; STEADY STATE; TRANSCRIPTION INITIATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM;

BONE MORPHOGENETIC PROTEINS; HEP G2 CELLS; HEPCIDINS; HUMANS; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC;

EID: 84942296450     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.08.123     Document Type: Article

References (25)

1. M.W. Hentze, M.U. Muckenthaler, B. Galy, and C. Camaschella Two to tango: regulation of mammalian iron metabolism Cell 142 2010 24 38
2. D. Meynard, J.L. Babitt, and H.Y. Lin The liver: conductor of systemic iron balance Blood 123 2014 168 176
3. M. Nairz, D. Haschka, E. Demetz, and G. Weiss Iron at the interface of immunity and infection Front. Pharmacol. 5 2014 152
4. J. Arezes, G. Jung, V. Gabayan, E. Valore, P. Ruchala, P.A. Gulig, T. Ganz, E. Nemeth, and Y. Bulut Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus Cell Host Microbe 17 2015 47 57
5. L. Kautz, D. Meynard, A. Monnier, V. Darnaud, R. Bouvet, R.H. Wang, C. Deng, S. Vaulont, J. Mosser, H. Coppin, and M.P. Roth Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver Blood 112 2008 1503 1509
6. P.B. Yu, C.C. Hong, C. Sachidanandan, J.L. Babitt, D.Y. Deng, S.A. Hoyng, H.Y. Lin, K.D. Bloch, and R.T. Peterson Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism Nat. Chem. Biol. 4 2008 33 41
7. B. Andriopoulos Jr., E. Corradini, Y. Xia, S.A. Faasse, S. Chen, L. Grgurevic, M.D. Knutson, A. Pietrangelo, S. Vukicevic, H.Y. Lin, and J.L. Babitt BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism Nat. Genet. 41 2009 482 487
8. J. Truksa, P. Lee, and E. Beutler Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness Blood 113 2009 688 695
9. D.M. Wrighting, and N.C. Andrews Interleukin-6 induces hepcidin expression through STAT3 Blood 108 2006 3204 3209
10. J. Kanda, T. Uchiyama, N. Tomosugi, M. Higuchi, T. Uchiyama, and H. Kawabata Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines Int. J. Hematol. 90 2009 545 552
11. Y. Kanamori, M. Murakami, T. Matsui, and M. Funaba The regulation of hepcidin expression by serum treatment: requirements of the BMP response element and STAT- and AP-1-binding sites Gene 551 2014 119 126
12. T. Imamura, M. Takase, A. Nishihara, E. Oeda, J. Hanai, M. Kawabata, and K. Miyazono Smad6 inhibits signalling by the TGF-β superfamily Nature 389 1997 622 626
13. P.B. Yu, D.Y. Deng, C.S. Lai, C.C. Hong, G.D. Cuny, M.L. Bouxsein, D.W. Hong, P.M. McManus, T. Katagiri, C. Sachidanandan, N. Kamiya, T. Fukuda, Y. Mishina, R.T. Peterson, and K.D. Bloch BMP type I receptor inhibition reduces heterotopic ossification Nat. Med. 14 2008 1363 1369
14. M. Murakami, H. Kawachi, K. Ogawa, Y. Nishino, and M. Funaba Receptor expression modulates the specificity of transforming growth factor-β signaling pathways Genes Cells 14 2009 469 482
15. Y. Kanamori, M. Murakami, T. Matsui, and M. Funaba Hepcidin expression in liver cells: evaluation of mRNA levels and transcriptional regulation Gene 546 2014 50 55
16. E.M. Duran, P. Shapshak, J. Worley, A. Minagar, F. Ziegler, S. Haliko, I. Moleon-Borodowsky, and P.A. Haslett Presenilin-1 detection in brain neurons and FOXP3 in peripheral blood mononuclear cells: normalizer gene selection for real time reverse transcriptase pcr using the deltadeltaCt method Front. Biosci. 10 2005 2955 2965
17. J. Truksa, P. Lee, and E. Beutler The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters Blood Cells Mol. Dis. 39 2007 255 262
18. E. Shaulian, and M. Karin AP-1 as a regulator of cell life and death Nat. Cell Biol. 4 2002 E131 E136
19. J. Hess, P. Angel, and M. Schorpp-Kistner AP-1 subunits: quarrel and harmony among siblings J. Cell Sci. 117 2004 5965 5973
20. G. Murakami, T. Watabe, K. Takaoka, K. Miyazono, and T. Imamura Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads Mol. Biol. Cell 14 2003 2809 2817
21. H.L. Lee, T. Yi, K. Baek, A. Kwon, H.R. Hwang, A.S. Qadir, H.J. Park, K.M. Woo, H.M. Ryoo, G.S. Kim, and J.H. Baek Tumor necrosis factor-α enhances the transcription of Smad ubiquitination regulatory factor 1 in an activating protein-1- and Runx2-dependent manner J. Cell. Physiol. 228 2013 1076 1086
22. E.M. Egorina, T.A. Sovershaev, J.B. Hansen, and M.A. Sovershaev BMP-2 inhibits TF expression in human monocytes by shutting down MAPK signaling and AP-1 transcriptional activity Thromb. Res. 129 2012 e106 e111
23. J. Du, S. Yang, D. An, F. Hu, W. Yuan, C. Zhai, and T. Zhu BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1 Cell Res. 19 2009 487 496
24. S.Y. Lee, J. Yoon, M.H. Lee, S.K. Jung, D.J. Kim, A.M. Bode, J. Kim, and Z. Dong The role of heterodimeric AP-1 protein comprised of JunD and c-Fos proteins in hematopoiesis J. Biol. Chem. 287 2012 31342 31348
25. A. Hiyama, S.S. Gogate, S. Gajghate, J. Mochida, I.M. Shapiro, and M.V. Risbud BMP-2 and TGF-β stimulate expression of β1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs J. Bone Min. Res. 25 2010 1179 1190