메뉴 건너뛰기




Volumn 63, Issue 9, 2015, Pages 1757-1765

Treated behavioral symptoms and mortality in medicare beneficiaries in nursing homes with Alzheimer's disease and related dementias

Author keywords

antipsychotics; behavioral symptoms; dementia; Medicare; nursing home

Indexed keywords

ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; NEUROLEPTIC AGENT;

EID: 84942191577     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.13606     Document Type: Conference Paper
Times cited : (12)

References (50)
  • 2
    • 0037329371 scopus 로고    scopus 로고
    • Prevalence and correlates of behavioral and psychiatric symptoms in community-dwelling elders with dementia or mild cognitive impairment: The Memory and Medical Care Study
    • Chan DC, Kasper JD, Black BS, et al., Prevalence and correlates of behavioral and psychiatric symptoms in community-dwelling elders with dementia or mild cognitive impairment: The Memory and Medical Care Study. Int J Geriatr Psychiatry 2003; 18: 174-182.
    • (2003) Int J Geriatr Psychiatry , vol.18 , pp. 174-182
    • Chan, D.C.1    Kasper, J.D.2    Black, B.S.3
  • 3
    • 0037174346 scopus 로고    scopus 로고
    • Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the Cardiovascular Health Study
    • Lyketsos CG, Lopez O, Jones B, et al., Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the Cardiovascular Health Study. JAMA 2002; 288: 1475-1483.
    • (2002) JAMA , vol.288 , pp. 1475-1483
    • Lyketsos, C.G.1    Lopez, O.2    Jones, B.3
  • 4
    • 82455218980 scopus 로고    scopus 로고
    • Monitoring quality of care for nursing home residents with behavioral and psychological symptoms related to dementia
    • Nazir A, Arling G, Perkins AJ, et al., Monitoring quality of care for nursing home residents with behavioral and psychological symptoms related to dementia. J Am Med Dir Assoc 2011; 12: 660-667.
    • (2011) J Am Med Dir Assoc , vol.12 , pp. 660-667
    • Nazir, A.1    Arling, G.2    Perkins, A.J.3
  • 6
    • 28844506296 scopus 로고    scopus 로고
    • Prevalence of physical and verbal aggressive behaviours and associated factors among older adults in long-term care facilities
    • Voyer P, Verreault R, Azizah GM, et al., Prevalence of physical and verbal aggressive behaviours and associated factors among older adults in long-term care facilities. BMC Geriatr 2005; 5: 13.
    • (2005) BMC Geriatr , vol.5 , pp. 13
    • Voyer, P.1    Verreault, R.2    Azizah, G.M.3
  • 7
    • 7444270285 scopus 로고    scopus 로고
    • A systematic review of the association between the behavioral and psychological symptoms of dementia and burden of care
    • Black W, Almeida OP,. A systematic review of the association between the behavioral and psychological symptoms of dementia and burden of care. Int Psychogeriatr 2004; 16: 295-315.
    • (2004) Int Psychogeriatr , vol.16 , pp. 295-315
    • Black, W.1    Almeida, O.P.2
  • 8
    • 27744449550 scopus 로고    scopus 로고
    • Characteristics associated with behavioral symptoms related to dementia in long-term care residents
    • Boustani M, Zimmerman S, Williams CS, et al., Characteristics associated with behavioral symptoms related to dementia in long-term care residents. Gerontologist 2005; 45 (Suppl 1): 56-61.
    • (2005) Gerontologist , vol.45 , pp. 56-61
    • Boustani, M.1    Zimmerman, S.2    Williams, C.S.3
  • 9
    • 84898788193 scopus 로고    scopus 로고
    • Management of neuropsychiatric symptoms of dementia in clinical settings: Recommendations from a multidisciplinary expert panel
    • Kales HC, Gitlin LN, Lyketsos CG, et al., Management of neuropsychiatric symptoms of dementia in clinical settings: Recommendations from a multidisciplinary expert panel. J Am Geriatr Soc 2014; 62: 762-769.
    • (2014) J Am Geriatr Soc , vol.62 , pp. 762-769
    • Kales, H.C.1    Gitlin, L.N.2    Lyketsos, C.G.3
  • 11
    • 84874224020 scopus 로고    scopus 로고
    • Therapeutic approaches in the management of behavioral and psychological symptoms of dementia in the elderly
    • Drouillard N, Mithani A, Chan PKY,. Therapeutic approaches in the management of behavioral and psychological symptoms of dementia in the elderly. B C Med J 2013; 55: 90-95.
    • (2013) B C Med J , vol.55 , pp. 90-95
    • Drouillard, N.1    Mithani, A.2    Chan, P.K.Y.3
  • 12
    • 26844538114 scopus 로고    scopus 로고
    • Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials
    • Schneider LS, Dagerman KS, Insel P,. Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials. JAMA 2005; 294: 1934-1943.
    • (2005) JAMA , vol.294 , pp. 1934-1943
    • Schneider, L.S.1    Dagerman, K.S.2    Insel, P.3
  • 13
    • 34250631300 scopus 로고    scopus 로고
    • Antipsychotic drug use and mortality in older adults with dementia
    • Gill SS, Bronskill SE, Normand S-LT, et al., Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med 2007; 146: 775-786.
    • (2007) Ann Intern Med , vol.146 , pp. 775-786
    • Gill, S.S.1    Bronskill, S.E.2    Normand, S.-L.3
  • 14
    • 33644922637 scopus 로고    scopus 로고
    • Efficacy and adverse effects of atypical antipsychotics for dementia: Meta-analysis of randomized, placebo-controlled trials
    • Schneider LS, Dagerman K, Insel PS,. Efficacy and adverse effects of atypical antipsychotics for dementia: Meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry 2006; 14: 191-210.
    • (2006) Am J Geriatr Psychiatry , vol.14 , pp. 191-210
    • Schneider, L.S.1    Dagerman, K.2    Insel, P.S.3
  • 15
    • 79954531093 scopus 로고    scopus 로고
    • The Food and Drug Administration, [on-line]. Available at Accessed January 15, 2014.
    • Public Health Advisory: Deaths With Antipsychotics in Elderly Patients With Behavioral Disturbances. The Food and Drug Administration, 2005 [on-line]. Available at http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/drugsafetyinformationforheathcareprofessionals/publichealthadvisories/ucm053171.htm Accessed January 15, 2014.
    • (2005) Public Health Advisory: Deaths with Antipsychotics in Elderly Patients with Behavioral Disturbances
  • 16
    • 72449156732 scopus 로고    scopus 로고
    • The Food and Drug Administration, [on-line]. Available at Accessed January 15, 2014.
    • Information for Healthcare Professionals: Conventional Antipsychotics. The Food and Drug Administration, 2008 [on-line]. Available at http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm124830.htm Accessed January 15, 2014.
    • (2008) Information for Healthcare Professionals: Conventional Antipsychotics
  • 17
    • 40549112334 scopus 로고    scopus 로고
    • ACNP White Paper: Update on use of antipsychotic drugs in elderly persons with dementia
    • Jeste DV, Blazer D, Casey D, et al., ACNP White Paper: Update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology 2007; 33: 957-970.
    • (2007) Neuropsychopharmacology , vol.33 , pp. 957-970
    • Jeste, D.V.1    Blazer, D.2    Casey, D.3
  • 18
    • 21044434325 scopus 로고    scopus 로고
    • FDA warns antipsychotic drugs may be risky for elderly
    • Kuehn BM,. FDA warns antipsychotic drugs may be risky for elderly. JAMA 2005; 293: 2453-2462.
    • (2005) JAMA , vol.293 , pp. 2453-2462
    • Kuehn, B.M.1
  • 19
    • 35748963236 scopus 로고    scopus 로고
    • Mortality risk in patients with dementia treated with antipsychotics versus other psychiatric medications
    • Kales H, Valenstein M, Kim H, et al., Mortality risk in patients with dementia treated with antipsychotics versus other psychiatric medications. Am J Psychiatry 2007; 164: 1568-1576.
    • (2007) Am J Psychiatry , vol.164 , pp. 1568-1576
    • Kales, H.1    Valenstein, M.2    Kim, H.3
  • 20
    • 84882252478 scopus 로고    scopus 로고
    • Evaluation of the FDA warning against prescribing citalopram at doses exceeding 40 mg
    • Zivin K, Pfeiffer PN, Bohnert AS, et al., Evaluation of the FDA warning against prescribing citalopram at doses exceeding 40 mg. Am J Psychiatry 2013; 170: 642-650.
    • (2013) Am J Psychiatry , vol.170 , pp. 642-650
    • Zivin, K.1    Pfeiffer, P.N.2    Bohnert, A.S.3
  • 21
    • 79953002348 scopus 로고    scopus 로고
    • Antidepressants for agitation and psychosis in dementia
    • Seitz DP, Adunuri N, Gill SS, et al., Antidepressants for agitation and psychosis in dementia. Cochrane Database Syst Rev 2011; 2: CD008191.
    • (2011) Cochrane Database Syst Rev , vol.2 , pp. CD008191
    • Seitz, D.P.1    Adunuri, N.2    Gill, S.S.3
  • 22
    • 84894122063 scopus 로고    scopus 로고
    • Effect of citalopram on agitation in Alzheimer disease: The CitAD randomized clinical trial
    • Porsteinsson AP, Drye LT, Pollock BG, et al., Effect of citalopram on agitation in Alzheimer disease: The CitAD randomized clinical trial. JAMA 2014; 311: 682-691.
    • (2014) JAMA , vol.311 , pp. 682-691
    • Porsteinsson, A.P.1    Drye, L.T.2    Pollock, B.G.3
  • 23
    • 84894488056 scopus 로고    scopus 로고
    • CCWdata.org. [on-line]. Available at Accessed January 21, 2014.
    • CCWdata.org. The Chronic Conditions Data Warehouse [on-line]. Available at https://www.ccwdata.org Accessed January 21, 2014.
    • The Chronic Conditions Data Warehouse
  • 24
    • 79959753442 scopus 로고    scopus 로고
    • Long Term Care Minimum Data Set (MDS). [on-line]. Available at Order/IdentifiableDataFiles/LongTermCareMinimumDataSetMDS.html Accessed January 15, 2014.
    • Long Term Care Minimum Data Set (MDS). The Centers for Medicare and Medicaid Services, 2012 [on-line]. Available at http://www.cms.gov/Research-Statistics-Data-and-Systems/Files-for Order/IdentifiableDataFiles/LongTermCareMinimumDataSetMDS.html Accessed January 15, 2014.
    • (2012) The Centers for Medicare and Medicaid Services
  • 25
    • 42649087357 scopus 로고    scopus 로고
    • Prevalence of behavioral symptoms: Comparison of the Minimum Data Set assessments with research instruments
    • Bharucha AJ, Vasilescu M, Dew MA, et al., Prevalence of behavioral symptoms: Comparison of the Minimum Data Set assessments with research instruments. J Am Med Dir Assoc 2008; 9: 244-250.
    • (2008) J Am Med Dir Assoc , vol.9 , pp. 244-250
    • Bharucha, A.J.1    Vasilescu, M.2    Dew, M.A.3
  • 27
    • 84918502497 scopus 로고    scopus 로고
    • Algorithm for identifying nursing home days using Medicare claims and Minimum Data Set assessment data
    • Mar 13. [Epub ahead of print].
    • Wei Y-J, Simoni-Wastila L, Zuckerman IH, et al., Algorithm for identifying nursing home days using Medicare claims and Minimum Data Set assessment data. Med Care 2014; Mar 13. [Epub ahead of print].
    • (2014) Med Care
    • Wei, Y.-J.1    Simoni-Wastila, L.2    Zuckerman, I.H.3
  • 28
    • 0142157169 scopus 로고    scopus 로고
    • Evaluating medication effects outside of clinical trials: New-user designs
    • Ray WA,. Evaluating medication effects outside of clinical trials: New-user designs. Am J Epidemiol 2003; 158: 915-920.
    • (2003) Am J Epidemiol , vol.158 , pp. 915-920
    • Ray, W.A.1
  • 29
    • 4444292273 scopus 로고    scopus 로고
    • Risk adjustment of Medicare capitation payments using the CMS-HCC model
    • Pope GC, Kautter J, Ellis RP, et al., Risk adjustment of Medicare capitation payments using the CMS-HCC model. Health Care Financ Rev 2004; 25: 119-141.
    • (2004) Health Care Financ Rev , vol.25 , pp. 119-141
    • Pope, G.C.1    Kautter, J.2    Ellis, R.P.3
  • 31
    • 0028075511 scopus 로고
    • The MDS Cognition Scale: A valid instrument for identifying and staging nursing home residents with dementia using the Minimum Data Set
    • Hartmaier SL, Sloane PD, Guess HA, et al., The MDS Cognition Scale: A valid instrument for identifying and staging nursing home residents with dementia using the Minimum Data Set. J Am Geriatr Soc 1994; 42: 1173-1179.
    • (1994) J Am Geriatr Soc , vol.42 , pp. 1173-1179
    • Hartmaier, S.L.1    Sloane, P.D.2    Guess, H.A.3
  • 32
    • 0037241774 scopus 로고    scopus 로고
    • The MDS-CHESS Scale: A new measure to predict mortality in institutionalized older people
    • Hirdes JP, Frijters DH, Teare GF,. The MDS-CHESS Scale: A new measure to predict mortality in institutionalized older people. J Am Geriatr Soc 2003; 51: 96-100.
    • (2003) J Am Geriatr Soc , vol.51 , pp. 96-100
    • Hirdes, J.P.1    Frijters, D.H.2    Teare, G.F.3
  • 33
    • 80053215338 scopus 로고    scopus 로고
    • Antipsychotic drug use since the FDA black box warning: Survey of nursing home policies
    • Lester P, Kohen I, Stefanacci RG, et al., Antipsychotic drug use since the FDA black box warning: Survey of nursing home policies. J Am Med Dir Assoc 2011; 12: 573-577.
    • (2011) J Am Med Dir Assoc , vol.12 , pp. 573-577
    • Lester, P.1    Kohen, I.2    Stefanacci, R.G.3
  • 34
    • 84866140666 scopus 로고    scopus 로고
    • Impact of the Food and Drug Administration's antipsychotic black box warning on psychotropic drug prescribing in elderly patients with dementia in outpatient and office-based settings
    • Desai VC, Heaton PC, Kelton CM,. Impact of the Food and Drug Administration's antipsychotic black box warning on psychotropic drug prescribing in elderly patients with dementia in outpatient and office-based settings. Alzheimers Dement 2012; 8: 453-457.
    • (2012) Alzheimers Dement , vol.8 , pp. 453-457
    • Desai, V.C.1    Heaton, P.C.2    Kelton, C.M.3
  • 35
    • 79951493422 scopus 로고    scopus 로고
    • Trends in antipsychotic use in dementia 1999-2007
    • Kales HC, Zivin K, Kim HM, et al., Trends in antipsychotic use in dementia 1999-2007. Arch Gen Psychiatry 2011; 68: 190-197.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 190-197
    • Kales, H.C.1    Zivin, K.2    Kim, H.M.3
  • 37
    • 33749618085 scopus 로고    scopus 로고
    • Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease
    • Schneider LS, Tariot PN, Dagerman KS, et al., Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med 2006; 355: 1525-1538.
    • (2006) N Engl J Med , vol.355 , pp. 1525-1538
    • Schneider, L.S.1    Tariot, P.N.2    Dagerman, K.S.3
  • 38
    • 46749095495 scopus 로고    scopus 로고
    • Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: Phase 1 outcomes from the CATIE-AD effectiveness trial
    • Sultzer D, Davis S, Tariot P, et al., Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: Phase 1 outcomes from the CATIE-AD effectiveness trial. Am J Psychiatry 2008; 165: 844-854.
    • (2008) Am J Psychiatry , vol.165 , pp. 844-854
    • Sultzer, D.1    Davis, S.2    Tariot, P.3
  • 39
    • 21044448981 scopus 로고    scopus 로고
    • The course of neuropsychiatric symptoms in dementia. Part I: Findings from the two-year longitudinal Maasbed study
    • Aalten P, de Vugt ME, Jaspers N, et al., The course of neuropsychiatric symptoms in dementia. Part I: Findings from the two-year longitudinal Maasbed study. Int J Geriatr Psychiatry 2005; 20: 523-530.
    • (2005) Int J Geriatr Psychiatry , vol.20 , pp. 523-530
    • Aalten, P.1    De Vugt, M.E.2    Jaspers, N.3
  • 40
    • 1442357988 scopus 로고    scopus 로고
    • A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: The neuropsychiatric inventory median cutoff is a predictor of clinical outcome
    • Ballard CG, Thomas A, Fossey J, et al., A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: The neuropsychiatric inventory median cutoff is a predictor of clinical outcome. J Clin Psychiatry 2004; 65: 114-119.
    • (2004) J Clin Psychiatry , vol.65 , pp. 114-119
    • Ballard, C.G.1    Thomas, A.2    Fossey, J.3
  • 41
    • 58649100881 scopus 로고    scopus 로고
    • The Dementia Antipsychotic Withdrawal Trial (DART-AD): Long-term follow-up of a randomised placebo-controlled trial
    • Ballard C, Hanney ML, Theodoulou M, et al., The Dementia Antipsychotic Withdrawal Trial (DART-AD): Long-term follow-up of a randomised placebo-controlled trial. Lancet Neurol 2009; 8: 151-157.
    • (2009) Lancet Neurol , vol.8 , pp. 151-157
    • Ballard, C.1    Hanney, M.L.2    Theodoulou, M.3
  • 42
    • 43249092442 scopus 로고    scopus 로고
    • A randomised, blinded, placebo-controlled trial in dementia patients continuing or stopping neuroleptics (the DART-AD trial)
    • Ballard C, Lana MM, Theodoulou M, et al., A randomised, blinded, placebo-controlled trial in dementia patients continuing or stopping neuroleptics (the DART-AD trial). PLoS Med 2008; 5: e76.
    • (2008) PLoS Med , vol.5 , pp. e76
    • Ballard, C.1    Lana, M.M.2    Theodoulou, M.3
  • 43
    • 21744449949 scopus 로고    scopus 로고
    • The quality of antipsychotic drug prescribing in nursing homes
    • Briesacher BA, Limcangco MR, Simoni-Wastila L, et al., The quality of antipsychotic drug prescribing in nursing homes. Arch Intern Med 2005; 165: 1280-1285.
    • (2005) Arch Intern Med , vol.165 , pp. 1280-1285
    • Briesacher, B.A.1    Limcangco, M.R.2    Simoni-Wastila, L.3
  • 44
    • 66549103973 scopus 로고    scopus 로고
    • Association of antipsychotic use with hospital events and mortality among Medicare beneficiaries residing in long-term care facilities
    • Simoni-Wastila L, Ryder PT, Qian J, et al., Association of antipsychotic use with hospital events and mortality among Medicare beneficiaries residing in long-term care facilities. Am J Geriatr Psychiatry 2009; 17: 417-427.
    • (2009) Am J Geriatr Psychiatry , vol.17 , pp. 417-427
    • Simoni-Wastila, L.1    Ryder, P.T.2    Qian, J.3
  • 45
    • 84906091601 scopus 로고    scopus 로고
    • Quality of psychopharmacological medication prescribing and mortality in Medicare beneficiaries in nursing homes
    • Wei Y-J, Simoni-Wastila L, Zuckerman IH, et al., Quality of psychopharmacological medication prescribing and mortality in Medicare beneficiaries in nursing homes. J Am Geriatr Soc 2014; 62: 1490-1504.
    • (2014) J Am Geriatr Soc , vol.62 , pp. 1490-1504
    • Wei, Y.-J.1    Simoni-Wastila, L.2    Zuckerman, I.H.3
  • 46
    • 84863115465 scopus 로고    scopus 로고
    • Risk of mortality among individual antipsychotics in patients with dementia
    • Kales HC, Kim HM, Zivin K, et al., Risk of mortality among individual antipsychotics in patients with dementia. Am J Psychiatry 2012; 169: 71-79.
    • (2012) Am J Psychiatry , vol.169 , pp. 71-79
    • Kales, H.C.1    Kim, H.M.2    Zivin, K.3
  • 47
    • 0027985334 scopus 로고
    • The Neuropsychiatric Inventory comprehensive assessment of psychopathology in dementia
    • Cummings JL, Mega M, Gray K, et al., The Neuropsychiatric Inventory comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308-2308.
    • (1994) Neurology , vol.44 , pp. 2308-2308
    • Cummings, J.L.1    Mega, M.2    Gray, K.3
  • 49
    • 39749137351 scopus 로고    scopus 로고
    • The MDS Challenging Behavior Profile for long-term care
    • Gerritsen D, Achterberg W, Steverink N, et al., The MDS Challenging Behavior Profile for long-term care. Aging Ment Health 2008; 12: 116-123.
    • (2008) Aging Ment Health , vol.12 , pp. 116-123
    • Gerritsen, D.1    Achterberg, W.2    Steverink, N.3
  • 50
    • 57149139837 scopus 로고    scopus 로고
    • The Aggressive Behavior Scale: A new scale to measure aggression based on the Minimum Data Set
    • Perlman CM, Hirdes JP,. The Aggressive Behavior Scale: A new scale to measure aggression based on the Minimum Data Set. J Am Geriatr Soc 2008; 56: 2298-2303.
    • (2008) J Am Geriatr Soc , vol.56 , pp. 2298-2303
    • Perlman, C.M.1    Hirdes, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.