Association of antipsychotic use with hospital events and mortality among medicare beneficiaries residing in long-term care facilities

American Journal of Geriatric Psychiatry

Volumn 17, Issue 5, 2009, Pages 417-427

  Simoni Wastila, Linda ^a   Ryder, Priscilla T ^a   Qian, Jingjing ^a   Zuckerman, Ilene H ^a   Shaffer, Thomas ^a   Zhao, Lirong ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Antipsychotic medications; Drug trends; Long term care; Medicare beneficiaries

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CENTRAL STIMULANT AGENT; HYPNOTIC AGENT; MOOD STABILIZER; NEUROLEPTIC AGENT;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG USE; FEMALE; HOSPITAL; HUMAN; HUMAN EXPERIMENT; LONG TERM CARE; MALE; MEDICARE; MORTALITY; PREVALENCE; RESIDENTIAL HOME; TREATMENT OUTCOME; UNITED STATES; DEMOGRAPHY; DRUG UTILIZATION; HEALTH INSURANCE; HOSPITALIZATION; MIDDLE AGED; NURSING HOME; PRESCRIPTION; PROPORTIONAL HAZARDS MODEL; PSYCHOSIS; RETROSPECTIVE STUDY; STATISTICS;

AGED; AGED, 80 AND OVER; ANTIPSYCHOTIC AGENTS; DRUG PRESCRIPTIONS; DRUG UTILIZATION; FEMALE; HOSPITALIZATION; HUMANS; INSURANCE, LONG-TERM CARE; LONG-TERM CARE; MALE; MEDICARE; MIDDLE AGED; MORTALITY; NURSING HOMES; PREVALENCE; PROPORTIONAL HAZARDS MODELS; PSYCHOTIC DISORDERS; RESIDENCE CHARACTERISTICS; RETROSPECTIVE STUDIES; UNITED STATES;

EID: 66549103973     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e31819b8936     Document Type: Article

References (25)

1. Shorr RI, Fought RL, Ray WA: Changes in antipsychotic drug use in nursing homes during implementation of the OBRA-87 regulations. JAMA 1994; 271:358-362
2. Kamble P, Chen H, Sherer J, et al: Antipsychotic drug use among elderly nursing home residents in the United States. Am J Geriatr Pharmacother 2008; 6:187-197
3. Dewa CS, Remington G, Herrmann N, et al: How much are atypical antipsychotic agents being used, and do they reach the populations who need them? A Canadian experience. Clin Ther 2002; 24:1466-1476
4. Food and Drug Administration: FDA Public Health Advisory: Deaths with Antipsychotics in Elderly Patients with Behavioral Disturbances. Washington, DC, Department of Health and Human Services, 2005
5. Zuckerman IH, Langenberg P, Baumgarten M, et al: Inappropriate drug use and risk of transition to nursing homes among community-dwelling older adults. Med Care 2006; 44:722-730
6. Selbaek G, Kirkevold O, Engedal K: The course of psychiatric and behavioral symptoms and the use of psychotropic medication in patients with dementia in Norwegian nursing homes - a 12-month follow-up study. Am J Geriatr Psychiatry 2008; 16:528-536
7. Wang PS, Brookhart MA, Setoguchi S, et al: Psychotropic medication use for behavioral symptoms of dementia. Curr Neurol Neurosci Rep 2006; 6:490-495
8. Wang PS, Schneeweiss S, Avorn J, et al: Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med 2005; 353:2335-2341
9. Rochon PA, Normand SL, Gomes T, et al: Antipsychotic therapy and short-term serious events in older adults with dementia. Arch Intern Med 2008; 168:1090-1096
10. Gill SS, Bronskill SE, Normand SL, et al: Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med 2007; 146:775-786
11. Raivio MM, Laurila JV, Strandberg TE, et al: Neither atypical nor conventional antipsychotics increase mortality or hospital admissions among elderly patients with dementia: a two-year prospective study. Am J Geriatr Psychiatry 2007; 15:416-424
12. Barak Y, Baruch Y, Mazeh D, et al: Cardiac and cerebrovascular morbidity and mortality associated with antipsychotic medications in elderly psychiatric inpatients. Am J Geriatr Psychiatry 2007; 15:354-356
13. Liperoti R, Gambassi G, Lapane KL, et al: Conventional and atypical antipsychotics and the risk of hospitalization for ventricular arrhythmias or cardiac arrest. Arch Intern Med 2005; 165:696-701
14. Barnett MJ, Perry PJ, Alexander B, et al: Risk of mortality associated with antipsychotic and other neuropsychiatric drugs in pneumonia patients. J Clin Psychopharmacol 2006; 26:182-187
15. Schneeweiss S, Setoguchi S, Brookhart A, et al: Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ 2007; 176:627-632
16. Hollis J, Grayson D, Forrester L, et al: Antipsychotic medication dispensing and risk of death in veterans and war widows 65 years and older. Am J Geriatr Psychiatry 2007; 15:932-941
17. Trifiro G, Verhamme KM, Ziere G, et al: All-cause mortality associated with atypical and typical antipsychotics in demented outpatients. Pharmacoepidemiol Drug Saf 2007; 16:538-544
18. Schneider LS, Dagerman KS, Insel P: Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 2005; 294:1934-1943
19. Aparasu RR, Jano E, Johnson MM, et al: Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients. Am J Geriatr Pharmacother 2008; 6:198-204
20. Nonino F, De Girolamo G, Gamberini L, et al: Survival among elderly Italian patients with dementia treated with atypical antipsychotics: observational study. Neurol Sci 2006; 27:375-380
21. Suh GH, Shah A: Effect of antipsychotics on mortality in elderly patients with dementia: a 1-year prospective study in a nursing home. Int Psychogeriatr 2005; 17:429-441
22. Adler GS: A profile of the Medicare Current Beneficiary Survey. Health Care Financ Rev 1994; 15:153-163
23. Briesacher BA, Limcangco MR, Simoni-Wastila L, et al: The quality of antipsychotic drug prescribing in nursing homes. Arch Intern Med 2005; 165:1280-1285
24. Hollis J, Forrester L, Brodaty H, et al: Risk of death associated with antipsychotic drug dispensing in residential aged care facilities. Aust N Z J Psychiatry 2007; 41:751-758
25. Schneider LS, Dagerman K, Insel PS: Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry 2006; 14:191-210