Impact of the Food and Drug Administration's antipsychotic black box warning on psychotropic drug prescribing in elderly patients with dementia in outpatient and office-based settings

Alzheimer's and Dementia

Volumn 8, Issue 5, 2012, Pages 453-457

  Desai, Vibha C A ^a   Heaton, Pamela C ^a   Kelton, Christina M L ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Atypical antipsychotics; Black box warning; BPSD; Dementia

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CHOLINESTERASE INHIBITOR; PSYCHOTROPIC AGENT;

AGED; AGING; ARTICLE; BEHAVIOR DISORDER; DEMENTIA; DRUG INFORMATION; DRUG USE; FOOD AND DRUG ADMINISTRATION; HEALTH SURVEY; HUMAN; MAJOR CLINICAL STUDY; MENTAL DISEASE; OUTPATIENT; PRESCRIPTION; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; AGING; ANTIPSYCHOTIC AGENTS; DEMENTIA; DRUG LABELING; FEMALE; GERIATRICS; HUMANS; MALE; OUTPATIENTS; RISK MANAGEMENT; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84866140666     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2011.08.004     Document Type: Article

References (20)

1. 2010 Alzheimer's diseases: facts and figures. Available at: http://www.alz.org/documents-custom/report-alzfactsfigures2010.pdf. pp. 7-8.
2. C. Lyketsos, O. Lopez, B. Jones, A. Fitzpatrick, J. Breitner, and S. DeKosky Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study JAMA 288 2002 1475 1483
3. D. Chan, J. Kasper, B. Black, and P. Rabins Prevalence and correlates of behavioral and psychiatric symptoms in community-dwelling elders with dementia or mild cognitive impairment: the Memory and Medical Care Study Int J Geriatr Psychiatry 18 2003 174 182 (Pubitemid 36236242)
4. R. Liperoti, C. Pedone, and A. Corsonello Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD) Curr Neuropharmacol 6 2008 117 124 (Pubitemid 352024796)
5. A. Wimo, B. Winblad, and L. Jönsson An estimate of the total worldwide societal costs of dementia in 2005 Alzheimers Dement 3 2007 81 91 (Pubitemid 46586163)
6. N. Ikedaa, R. Shinagawaa, T. Toyotaa, T. Matsumotoa, H. Adachia, and N. Tanabea Caregiver burden associated with behavioral and psychological symptoms of dementia in elderly people in the local community Dement Geriatr Cogn Disord 23 2007 219 224
7. S. Banerjee, S. Smith, D. Lamping, R.H. Harwood, B. Foley, and P. Smith Quality of life in dementia: more than just cognition. An analysis of associations with quality of life in dementia J Neurol Neurosurg Psychiatry 77 2006 146 148 (Pubitemid 43220831)
8. I. Glick, S. Murray, P. Vasudevan, S. Marder, and R. Hu Treatment with atypical antipsychotics: new indications and new populations J Psychiatr Res 35 2001 187 191 (Pubitemid 32666214)
9. L. Schneider, K. Dagerman, and P. Insel Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials JAMA 294 2005 1934 1943 (Pubitemid 41464695)
10. S. Gill, S. Bronskill, S. Normand, G.M. Anderson, K. Sykora, and K. Lam Antipsychotic drug use and mortality in older adults with dementia Ann Intern Med 146 2007 775 786 (Pubitemid 351650498)
11. E. Dorsey, A. Rabbani, S. Gallagher, R. Conti, and G. Alexander Impact of FDA black box advisory on antipsychotic medication use Arch Intern Med 170 2010 96 103
12. C. Salzman, D. Jeste, R. Meyer, J. Cohen-Mansfield, J. Cummings, and G.T. Grossberg Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy J Clin Psychiatry 69 2008 889 898 (Pubitemid 351944940)
13. D.V. Jeste, D. Blazer, D. Casey, T. Meeks, C. Salzman, L. Schneider, P. Tariot, and K. Yaffe ACNP white paper: update on use of antipsychotic drugs in elderly persons with dementia Neuropsychopharmacology 33 2007 957 970 (Pubitemid 351367549)
14. S. Schneeweiss, S. Setoguchi, A. Brookhart, C. Dormuth, and P. Wang Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients CMAJ 176 2007 627 632 (Pubitemid 46426056)
15. J. Rodda, S. Morgan, and Z. Walker Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine Int Psychogeriatr 21 2009 813 824
16. C. Lyketsos, L. DelCampo, M. Steinberg, Q. Miles, C.D. Steele, and C. Munro Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS Arch Gen Psychiatry 60 2003 737 746 (Pubitemid 36818637)
17. M. Omerovic, H. Hampel, S. Teipel, and K. Buerger Pharmacological treatment of Alzheimer's dementia: state of the art and current dilemmas World J Biol Psychiatry 9 2008 69 75 (Pubitemid 351250523)
18. D. Pinheiro Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD) Encephale 34 2008 409 415
19. D. Guay Newer antiepileptic drugs in the management of agitation/aggression in patients with dementia or developmental disability Consult Pharm 22 2007 1004 1034 (Pubitemid 350291261)
20. H. Allain, S. Schück, D. Bentué-Ferrer, M. Bourin, M. Vercelletto, J.M. Reymann, and E. Polard Anxiolytics in the treatment of behavioral and psychological symptoms of dementia Int Psychogeriatr 12 2000 281 289 (Pubitemid 30599701)